Basic and applied studies of chrononutrition based on development of functional foods and nutrients

• Project/Area Number: 26220201
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Eating habits
• Research Institution: Waseda University
• Principal Investigator: 柴田 重信 早稲田大学, 理工学術院, 教授 (10162629)
• Co-Investigator(Kenkyū-buntansha): 高橋 将記 早稲田大学, 重点領域研究機構, 次席研究員(研究院講師) (30711189) ; 折原 芳波 早稲田大学, 理工学術院, 講師(任期付) (60450623) ; 田原 優 早稲田大学, 高等研究所, 助教 (80707399)
• Project Period (FY): 2014-05-30 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥116,870,000 (Direct Cost: ¥89,900,000、Indirect Cost: ¥26,970,000); Fiscal Year 2018: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000); Fiscal Year 2017: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000); Fiscal Year 2016: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000); Fiscal Year 2015: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000); Fiscal Year 2014: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
• Keywords: 体内時計 / 時間栄養学 / 機能性食品 / 肥満 / 腸内細菌 / 人介入試験 / マウス試験 / 農林水産物 / メタボリック / 健康科学 / 腸内細菌多様性 / 栄養素 / 食事パターン / メタボリックシンドローム / サルコペニア / ヒト介入試験 / 食品 / 生理学 / 食品科学 / 栄養 / 概日時計 / 概日リズム / 代謝 / 骨格筋 / 抗肥満 / 運動

Outline of Annual Research Achievements

体内時計作用栄養学の視点で以下の実験成果を得た。2型糖尿病モデルマウスと、慢性腎疾患（CKD）モデルマウスを作成した。2型糖尿病マウスは肝臓の時計遺伝子の発現リズムの振幅が低下する傾向が見られた。これらのマウスに、ヒトの糖尿病食やCKD食を与えたところ、基本的には、体内時計の同調をもたらした。つまり、ヒトの糖尿病やCKDの治療食でも、末梢の体内時計は十分に同調させることが可能であることが分かった。
夜食症のモデルマウスでは、うつ病の症状が出やすいことを見つけ、この作用には脳の5-HT2b受容体のリズム性の発現がかかわっていることを見出した。そこで、夜食症のヒトは体内時計がずれている可能性を調べた。4時間おきに4－5本の髭の毛母細胞からmRNAを抽出し、Per3、Rev-erbα、Rev-erbβ遺伝子発現リズムを評価した。その結果、睡眠後退者の髭の時計遺伝子発現は有意に後退したが、正常者や夜食症は後退せず、位相は個人差が大きかった。
次に、日勤務者、1日の徹夜者、8時間おきのシフトワーク者に分類し、時計遺伝子発現リズムに変化があるか否かについて調べた。その結果、一過性の徹夜勤務では遺伝子発現にはほとんど影響を及ぼさず、シフトワーク者はリズムの位相が大きく乱れ、また、遺伝子発現の絶対量が低かった。つまりシフトワークは体内時計に負荷がかかることが明らかになった。
イヌリンや菊芋などの水溶性食物繊維を豊富に有する食材は、血糖値の増加を抑制し、腸内細菌の多様性をもたらすことが知られている。そこで、粉末菊芋5gを朝食時に摂取するか、夕食時に摂取するかを夫々15名の被験者に介入試験した。その結果、朝の摂取は、24時間の血糖値の上昇を抑止し、さらに昼食・夕食の血糖値の上昇を抑制した（セカンドミール効果）。また、便秘指数も朝摂取が改善させ、腸内細菌に対する作用も朝摂取で顕著であった。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Assessment Rating

Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Research Products

• [Int'l Joint Research] UCLA(米国)
• [Int'l Joint Research] 南洋工科大学(シンガポール)
• [Int'l Joint Research] UCLA(USA)
• [Int'l Joint Research] SP(Singapore)
• [Int'l Joint Research] UCLA(USA)
• [Journal Article] Phase resetting of circadian peripheral clocks using human and rodent diets in mouse models of type 2 diabetes and chronic kidney disease. (2019)
  • Author(s): Yasuda S, Iwami S, Tamura K, Ikeda Y, Kamagata M, Sasaki H, Haraguchi A, Miyamatsu M, Hanashi S, Takato Y, Shibata S.
  • Journal Title: Chronobiology International Volume: 未定 Pages: 1-19
  • Peer Reviewed
• [Journal Article] Correlation among clock gene expression rhythms, sleep quality, and meal conditions in delayed sleep-wake phase disorder and night eating syndrome. (2019)
  • Author(s): Haraguchi A, Komada Y, Inoue Y, Shibata S.
  • Journal Title: Chronobiol Int. Volume: 未定 Pages: 1-14
  • DOI: 10.1080/07420528.2019.1585366
  • Peer Reviewed / Open Access
• [Journal Article] The effect of night shift work on the expression of clock genes in beard hair follicle cells. (2019)
  • Author(s): Hattammaru M, Tahara Y, Kikuchi T, Okajima K, Konishi K, Nakajima S, Sato K, Otsuka K, Sakura H, Shibata S, Nakaoka T.
  • Journal Title: Sleep Medicine Volume: 未定
  • DOI: 10.1016/j.sleep.2019.01.005
  • Peer Reviewed / Open Access
• [Journal Article] Systemic oscillator-driven and nutrient-responsive hormonal regulation of daily expression rhythms for gluconeogenic enzyme genes in the mouse liver (2019)
  • Author(s): Taira A, Arita E, Matsumoto E, Oohira A, Iwase K, Hiwasa T, Yokote K, Shibata S, Takiguchi M.
  • Journal Title: Chronobiology International Volume: 36(5). Pages: 591-615
  • DOI: 10.1080/07420528.2019.1570246
  • Peer Reviewed
• [Journal Article] A low-protein diet eliminates the circadian rhythm of serum insulin and hepatic lipid metabolism in mice. (2019)
  • Author(s): Yokota SI, Nakamura K, Ando M, Haraguchi A, Omori K, Shibata S.
  • Journal Title: J Nutr Biochem. Volume: 63 Pages: 177-185
  • DOI: 10.1016/j.jnutbio.2018.10.004
  • Peer Reviewed / Open Access
• [Journal Article] Social jetlag and menstrual symptoms among female university students. (2019)
  • Author(s): Komada Yoko、Ikeda Yuko、Sato Makoto、Kami Azusa、Masuda Chika、Shibata Shigenobu
  • Journal Title: Choronobiology International Volume: 36 Pages: 258-264
  • DOI: 10.1080/07420528.2018.1533561
  • Peer Reviewed
• [Journal Article] Day-Night Oscillation of Atrogin1 and Timing-Dependent Preventive Effect of Weight-Bearing on Muscle Atrophy. (2018)
  • Author(s): Aoyama Shinya、Kojima Shuichi、Sasaki Keisuke、Ishikawa Ryosuke、Tanaka Mizuho、Shimoda Takeru、Hattori Yuta、Aoki Natsumi、Takahashi Kengo、Hirooka Rina、Takizawa Miku、Haraguchi Atsushi、Shibata Shigenobu
  • Journal Title: EBioMedicine. Volume: 37 Pages: 30480-30488
  • DOI: 10.1016/j.ebiom.2018.10.057
  • Peer Reviewed / Open Access
• [Journal Article] Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington's Disease. (2018)
  • Author(s): Whittaker DS, Loh DH, Wang HB, Tahara Y, Kuljis D, Cutler T, Ghiani CA, Shibata S, Block GD, Colwell CS.
  • Journal Title: Journal Biologucal Rhythms Volume: 33(5). Pages: 535-554
  • DOI: 10.1177/0748730418790401
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chronotype and social jetlag influence human circadian clock gene expression. (2018)
  • Author(s): Takahashi M, Tahara Y, Tsubosaka M, Fukazawa M, Ozaki M, Iwakami T, Nakaoka T, Shibata S.
  • Journal Title: Scientific Reports Volume: 8(1): Pages: 10152-10152
  • DOI: 10.1038/s41598-018-28616-2
  • Peer Reviewed / Open Access
• [Journal Article] A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock. (2018)
  • Author(s): Fukuda T, Haraguchi A, Takahashi M, Nakaoka T, Fukazawa M, Okubo J, Ozaki M, Kanatome A, Ohya R, Miura Y, Obara K, Shibata S.
  • Journal Title: Chronobiol Int. Volume: 35(10). Pages: 1-11
  • DOI: 10.1080/07420528.2018.1490315
  • Peer Reviewed / Open Access
• [Journal Article] Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function (2018)
  • Author(s): Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S.
  • Journal Title: Sci Rep. Volume: 8(1) Pages: 9072-9072
  • DOI: 10.1038/s41598-018-27280-w
  • Peer Reviewed / Open Access
• [Journal Article] Circadian clock-dependent increase in salivary IgA secretion modulated by sympathetic receptor activation in mice (2017)
  • Author(s): Wada M, Orihara K, Kamagata M, Hama K, Sasaki H, Haraguchi A, Miyakawa H, Nakao A, Shibata S.
  • Journal Title: Scientific Reports Volume: ７ Pages: 8802-8802
  • DOI: 10.1038/s41598-017-09438-0
  • Peer Reviewed / Open Access
• [Journal Article] Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. (2017)
  • Author(s): Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H.
  • Journal Title: Scientific reports Volume: 7 Pages: 7348-7348
  • DOI: 10.1038/s41598-017-07845-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Polyporus and Bupleuri radix effectively alter peripheral circadian clock phase acutely in male mice (2017)
  • Author(s): Motohashi H, Sukigara H, Tahara Y, Saito K, Yamazaki M, Shiraishi T, Kikuchi Y, Haraguchi A, Shibata S.
  • Journal Title: Nutrition Research Volume: 43 Pages: 16-24
  • DOI: 10.1016/j.nutres.2017.05.001
  • Peer Reviewed
• [Journal Article] Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation. (2017)
  • Author(s): Tahara Y, Takatsu Y, Shiraishi T, Kikuchi Y, Yamazaki M, Motohashi H, Muto A, Sasaki H, Haraguchi A, Kuriki D, Nakamura TJ, Shibata S
  • Journal Title: Npj Aging and Mechanisms of Disease Volume: 3 Pages: 16030-16030
  • DOI: 10.1038/npjamd.2016.30
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Potent synchronization of peripheral circadian clocks by glucocorticoid injections in PER2::LUC-Clock/Clock mice. (2017)
  • Author(s): Kamagata M, Ikeda Y, Sasaki H, Hattori Y, Yasuda S, Iwami S, Tsubosaka M, Ishikawa R, Todoh A, Tamura K, Tahara Y, Shibata S.
  • Journal Title: Chronobiology International Volume: 13 Pages: 1-16
  • DOI: 10.1080/07420528.2017.1338716
  • Peer Reviewed
• [Journal Article] The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise. (2017)
  • Author(s): Aoyama S, Shibata S.
  • Journal Title: Frontier Neuroscience Volume: 11 Pages: 63-63
  • DOI: 10.3389/fnins.2017.00063
  • Peer Reviewed / Open Access
• [Journal Article] Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response. (2017)
  • Author(s): Kawauchi T, Ishimaru K, Nakamura Y, Nakano N, Hara M, Ogawa H, Okumura K, Shibata S, Nakao A.
  • Journal Title: Allergol Int. Volume: in press
  • NAID: 130005858846
  • Peer Reviewed / Open Access
• [Journal Article] The Role of Circadian Rhythms in Muscular and Osseous Physiology aPotent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts.nd Their Regulation by Nutrition and Exercise. (2017)
  • Author(s): Shinozaki A, Misawa K, Ikeda Y, Haraguchi A, Kamagata M, Tahara Y, Shibata S.
  • Journal Title: PLOS ONE Volume: 12
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Abnormal tuning of the hepatic circadian metabolic rhythms in lung cancer. (2017)
  • Author(s): Tahara Y, Shibata S.
  • Journal Title: Hepatology Volume: 65 Pages: 1061-1064
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] l-Ornithine affects peripheral clock gene expression in mice. (2016)
  • Author(s): Fukuda T, Haraguchi A, Kuwahara M, Nakamura K, Hamaguchi Y, Ikeda Y, Ishida Y, Wang G, Shirakawa C, Tanihata Y, Ohara K, Shibata S.
  • Journal Title: Scientific Reports Volume: 6 Pages: 34665-34665
  • Peer Reviewed / Open Access
• [Journal Article] Circadian rhythms of liver physiology and disease: experimental and clinical evidence. (2016)
  • Author(s): Tahara Y, Shibata S.
  • Journal Title: Nat Rev Gastroenterol Hepatol. Volume: 13 Pages: 217-26
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Inhibition of IgE-mediated allergic reaction by pharmacologically targeting the circadian clock. (2016)
  • Author(s): Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagki S, Ogawa H, Okumura K, Shibata S, Nakao A
  • Journal Title: Journal of allergy and clinical Immunology Volume: 137(4) Pages: 1226-1235
  • DOI: 10.1016/j.jaci.2015.08.052
  • NAID: 40020962856
  • Peer Reviewed / Open Access
• [Journal Article] Phase-delay in the light-dark cycle impairs clock gene expression and levels of serotonin, norepinephrine, and their metabolites in the mouse hippocampus and amygdala. (2015)
  • Author(s): Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S.
  • Journal Title: Sleep Med Volume: 16 Pages: 1352-9
  • DOI: 10.1016/j.sleep.2015.06.020
  • Peer Reviewed
• [Journal Article] Impairment of Circadian Rhythms in Peripheral Clocks by Constant Light Is Partially Reversed by Scheduled Feeding or Exercise. (2015)
  • Author(s): Hamaguchi Y, Tahara Y, Hitosugi M, Shibata S
  • Journal Title: J Biol Rhythms Volume: 30 Pages: 533-42
  • DOI: 10.1177/0748730415609727
  • Peer Reviewed
• [Journal Article] Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model. (2015)
  • Author(s): Tanabe K, Kitagawa E, Wada M, Haraguchi A, Orihara K, Tahara Y, Nakao A, Shibata S.
  • Journal Title: Sci Rep Volume: 5 Pages: 14424-14424
  • DOI: 10.1038/srep14424
  • Peer Reviewed / Open Access
• [Journal Article] Entrainment of mouse peripheral circadian clocks to <24&#8201;h feeding/fasting cycles under 24&#8201;h light/dark conditions. (2015)
  • Author(s): Hamaguchi Y, Tahara Y, Kuroda H, Haraguchi A, Shibata S
  • Journal Title: Sci Rep Volume: 23 Pages: 14207-14207
  • DOI: 10.1038/srep14207
  • Peer Reviewed / Open Access
• [Journal Article] The circadian clock controls fluctuations of colonic cell proliferation during the light/dark cycle via feeding behavior in mice. (2015)
  • Author(s): Yoshida D, Aoki N, Tanaka M, Aoyama S, Shibata S.
  • Journal Title: Chronobiol Int. Volume: 32 Pages: 1145-55
  • DOI: 10.3109/07420528.2015.1065415
  • Peer Reviewed
• [Journal Article] Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice. (2015)
  • Author(s): Ando N, Nakamura Y, Aoki R, Ishimaru K, Ogawa H, Okumura K, Shibata S, Shimada S, Nakao A
  • Journal Title: Journal of Investigative Dermatology Volume: 135 Pages: 3001-3008
  • DOI: 10.1038/jid.2015.316
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120. (2015)
  • Author(s): Furutani A, Ikeda Y, Itokawa M, Nagahama H, Ohtsu T, Furutani N, Kamagata M, Yang ZH, Hirasawa A, Tahara Y, Shibata S.
  • Journal Title: PLoS One Volume: 10
  • DOI: 10.1371/journal.pone.0132472
  • NAID: 120005763406
  • Peer Reviewed
• [Journal Article] Entrainment of the mouse circadian clock by sub-acute physical and psychological stress. (2015)
  • Author(s): Tahara Y, Shiraishi T, Kikuchi Y, Haraguchi A, Kuriki D, Sasaki H, Motohashi H, Sakai T, Shibata S.
  • Journal Title: Sci Rep. Volume: 15 Pages: 11417-11417
  • DOI: 10.1038/srep11417
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Eating meals before wheel-running exercise attenuate high fat diet-driven obesity in mice under two meals per day schedule. (2015)
  • Author(s): Sasaki H, Hattori Y, Ikeda Y, Kamagata M, Shibata S.
  • Journal Title: Chronobiol Int. Volume: 32 Pages: 677-86
  • DOI: 10.3109/07420528.2015.1035439
  • Peer Reviewed
• [Journal Article] Housing under abnormal light-dark cycles attenuates day/night expression rhythms of the clock genes Per1, Per2, and Bmal1 in the amygdala and hippocampus of mice. (2015)
  • Author(s): Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S.
  • Journal Title: Neurosci Res. Volume: 99 Pages: 16-21
  • DOI: 10.1016/j.neures.2015.05.005
  • Peer Reviewed
• [Journal Article] Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene. (2015)
  • Author(s): Hamada T, Miyakawa K, Kushige H, Shibata S, Kurachi S.
  • Journal Title: J Physiol Sci. Volume: 65 Pages: 349-57
  • DOI: 10.1007/s12576-015-0373-8
  • Peer Reviewed
• [Journal Article] The circadian clock functions as a potent regulator of allergic reaction. (2015)
  • Author(s): Nakao A, Nakamura Y, Shibata S
  • Journal Title: Allergy. 2015 Volume: 70(5) Pages: 467-473
  • DOI: 10.1111/all.12596
  • Peer Reviewed / Open Access
• [Journal Article] Feeding and adrenal entrainment stimuli are both necessary for normal circadian oscillation of peripheral clocks in mice housed under different photoperiods. (2015)
  • Author(s): Ikeda Y, Sasaki H, Ohtsu T, Shiraishi T, Tahara Y, Shibata S.
  • Journal Title: Chronobiology International Volume: 32 Pages: 195-210
  • DOI: 10.3109/07420528.2014.962655
  • Peer Reviewed / Open Access
• [Journal Article] Controlling access time to a high-fat diet during the inactive period protects against obesity in mice. (2014)
  • Author(s): Haraguchi A, Aoki N, Ohtsu T, Ikeda Y, Tahara Y, Shibata S.
  • Journal Title: Chronobiology International Volume: 31 Pages: 959-975
  • DOI: 10.3109/07420528.2014.931413
  • Peer Reviewed
• [Journal Article] Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice. (2014)
  • Author(s): Narishige S, Kuwahara M, Shinozaki A, Okada S, Ikeda Y, Kamagata M, Tahara Y, Shibata S.
  • Journal Title: Br J Pharmacol Volume: 171 Pages: 5858-5869
  • DOI: 10.1111/bph.12890
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα) activity underlies circadian expression of intestinal peptide absorption transporter PepT1/Slc15a1. (2014)
  • Author(s): Okamura A, Koyanagi S, Dilxiat A, Kusunose N, Chen JJ, Matsunaga N, Shibata S, Ohdo S.
  • Journal Title: The Journal of Biological Chemistry Volume: 289(36) Pages: 25296-2505
  • DOI: 10.1074/jbc.m114.577023
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Combination of meal and exercise timing with a high-fat diet influences energy expenditure and obesity in mice. (2014)
  • Author(s): Sasaki H, Ohtsu T, Ikeda Y, Tsubosaka M, Shibata S.
  • Journal Title: Chronobiology International Volume: 31 Pages: 959-975
  • DOI: 10.3109/07420528.2014.935785
  • Peer Reviewed
• [Presentation] 「時間栄養学を活用した栄養指導～体内時計と食生活～」 (2019)
  • Author(s): 柴田重信
  • Organizer: 鳥取県 平成30年度栄養指導推進研修会
  • Invited
• [Presentation] 「時間栄養学の視点からの内分泌学・代謝学」 (2019)
  • Author(s): 柴田重信
  • Organizer: 第41回小児成長研究会
  • Invited
• [Presentation] 「時間軸のリズム現象で健康科学を捉える」 (2019)
  • Author(s): 柴田重信
  • Organizer: 平成30年度 発酵と代謝研究会
  • Invited
• [Presentation] 「体内時計と生活習慣病（糖尿病）」 (2018)
  • Author(s): 柴田重信
  • Organizer: 岩手栄養改善学会
  • Invited
• [Presentation] 「高齢者の生活リズムと健康―時間栄養・運動学からの提言―」 (2018)
  • Author(s): 柴田重信
  • Organizer: 第6回日本介護予防・健康づくり学会
  • Invited
• [Presentation] 「いつ食べよう？体内時計と相談だ！」 (2018)
  • Author(s): 柴田重信
  • Organizer: 第7回信州の食を育む県民大会
  • Invited
• [Presentation] 「時間栄養学～マウスから人の健康まで～」 (2018)
  • Author(s): 柴田重信
  • Organizer: 第25回日本時間生物学会学術大会
  • Invited
• [Presentation] 「時間栄養学」 (2018)
  • Author(s): 柴田重信
  • Organizer: 一般社団法人日本臨床栄養学会 2018年度 認定臨床栄養医研修会
  • Invited
• [Presentation] 「Protein rich breakfast is important for peripheral clock and muscle function」 (2018)
  • Author(s): Shigenobu Shibata
  • Organizer: ASIAN FORUM ON CHRONOBIOLOGY
  • Int'l Joint Research / Invited
• [Presentation] 「体内時計の視点から時間について考える」 (2018)
  • Author(s): 柴田重信
  • Organizer: 第36回日本生理心理学会大会
  • Invited
• [Presentation] 「食事の時間栄養学」 (2018)
  • Author(s): 柴田重信
  • Organizer: 第61回日本糖尿病学会年次学術集会
  • Invited
• [Presentation] 時間栄養学と食品機能性 (2017)
  • Author(s): 柴田重信
  • Organizer: 第６回シンポジウム「次世代の食品機能性と自然免疫」
  • Place of Presentation: 東京
  • Year and Date: 2017-03-24
  • Invited
• [Presentation] Chrono-nutrition and n-3 fatty acids (2017)
  • Author(s): Shigenobu Shibata
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-15
  • Invited
• [Presentation] chrono-nutrition (2017)
  • Author(s): Shigenobu Shibata
  • Organizer: IUNS Workshop on Capacity and Leadership Development in Nutritional Science 2017
  • Place of Presentation: 東京
  • Year and Date: 2017-03-07
  • Int'l Joint Research / Invited
• [Presentation] 脳や末梢臓器の時計遺伝子をターゲットにした時間栄養学的研究 (2017)
  • Author(s): 柴田重信
  • Organizer: 第99回日本栄養・食糧学会関東支部シンポジューム
  • Place of Presentation: 東京
  • Year and Date: 2017-03-04
  • Invited
• [Presentation] 時間栄養学 臨床的観点など (2017)
  • Author(s): 柴田重信
  • Organizer: 第20回日本病態栄養学会年次学術集会
  • Place of Presentation: 京都
  • Year and Date: 2017-01-14
  • Invited
• [Presentation] 時間栄養学～基礎から臨床まで～ (2017)
  • Author(s): 柴田重信
  • Organizer: 益社団法人日本メディカル給食協会 第３回関東信越支部連絡会
  • Invited
• [Presentation] 体内時計と健康―臓器から皮膚まで (2017)
  • Author(s): 柴田重信
  • Organizer: 日本化粧品技術者会大阪支部 第２０７回講演会
  • Invited
• [Presentation] Chrono-nutrition and -exercise studies from mice to human (2017)
  • Author(s): Shigenobu Shibata
  • Organizer: The6th Annual ⅢS Symposium in Tsukuba
  • Int'l Joint Research / Invited
• [Presentation] 時間栄養学の視点からみたフロボノイドの作用 (2017)
  • Author(s): 柴田重信
  • Organizer: ノビレチン研究会 第１回学術集会
  • Invited
• [Presentation] 時間栄養学の魅力 (2017)
  • Author(s): 柴田重信
  • Organizer: 第4回日本薬膳学会学術総会
  • Invited
• [Presentation] 糖尿病治療と時間栄養学の可能性 (2017)
  • Author(s): 柴田重信
  • Organizer: 第２回ＫＦＳmeeting
  • Invited
• [Presentation] 腎疾患指導に携わるスタッフのための時間栄養学 (2017)
  • Author(s): 柴田重信
  • Organizer: 第4回腎と栄養研究会
  • Invited
• [Presentation] 時間栄養学 (2017)
  • Author(s): 柴田重信
  • Organizer: 日本機能性食品医用学会 教育セミナー2017
  • Invited
• [Presentation] Chrono－nutrition and chrono-exereise approaches to obesity and locomotive syndromes (2017)
  • Author(s): Shigenobu Shibata
  • Organizer: ２nd CHRONOBIOLOGY FORUM and 2017 conference of Chinese Society for Biological Rhythms
  • Int'l Joint Research / Invited
• [Presentation] 時間栄養学を視点とした機能性食品の開発と適用 (2016)
  • Author(s): 柴田重信
  • Organizer: 第14回日本機能性食品医用学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-12-10
  • Invited
• [Presentation] 時間栄養学と体内時計 (2016)
  • Author(s): 柴田重信
  • Organizer: 第5回ブルーライト研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-10-30
  • Invited
• [Presentation] Chrono-nutrition and chrono-exercise in mouse circadian rhythm (2016)
  • Author(s): S Shibata
  • Organizer: The 29th Conference of the International Society for Chronobiology
  • Place of Presentation: China
  • Year and Date: 2016-10-24
  • Invited
• [Presentation] 栄養学を広く考えよう：時間、運動そして睡眠との関係 (2016)
  • Author(s): 柴田重信
  • Organizer: 第38回日本臨床栄養学会総会、及び第37回日本臨床栄養協会総会
  • Place of Presentation: 大阪
  • Year and Date: 2016-10-07
  • Invited
• [Presentation] CIRCADIAN CLOCKS AND METABOLIC HEALTH (2016)
  • Author(s): S Shibata
  • Organizer: Chrono-nutrition Symposium
  • Place of Presentation: France
  • Year and Date: 2016-06-23
  • Invited
• [Presentation] 食事と時刻（時間栄養学）の視点～食品開発にからめて～ (2016)
  • Author(s): 柴田重信
  • Organizer: 招待講演、第22回日本調理食品研究会年次大会
  • Place of Presentation: 大阪
  • Year and Date: 2016-05-27
  • Invited
• [Presentation] 時間栄養学の基礎からヒトへの応用展開 (2016)
  • Author(s): 柴田重信
  • Organizer: 第70回日本栄養・食糧学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-17
  • Invited
• [Presentation] 時間栄養学～栄養管理と食指導への活用～ (2016)
  • Author(s): 柴田重信
  • Organizer: 松戸健康福祉センター特定給食施設従事者研修会
  • Place of Presentation: 千葉県東葛合同庁舎、千葉
  • Year and Date: 2016-02-29
• [Presentation] 基礎研究としての体内時計と食・運動の相互作用 (2016)
  • Author(s): 柴田重信
  • Organizer: 第30回日本体力医学会近畿地方会
  • Place of Presentation: 大阪市立大学医学部、大阪
  • Year and Date: 2016-02-20
• [Presentation] 時間栄養学について (2016)
  • Author(s): 柴田重信
  • Organizer: 第29回岡山県栄養改善学会、
  • Place of Presentation: おかやま西川原プラザ、岡山、
  • Year and Date: 2016-02-20
• [Presentation] 時間栄養学とは (2015)
  • Author(s): 柴田重信
  • Organizer: 社会福祉法人恩賜財団母子愛育会研修事業「地域栄養活動～妊産婦から子ども～」
  • Place of Presentation: 社会福祉法人恩賜財団母子愛育会総合母子保健センター研修室、東京
  • Year and Date: 2015-12-03
• [Presentation] Diurnal oscillation of gut microbiota and an influence of immobilization stress on microbial rhythmicity (2015)
  • Author(s): 星野友梨、高見澤菜穂子、丸山徹、細川正人、柴田重信、矢澤一良、竹山春子
  • Organizer: 第22回日本時間生物学会学術大会
  • Place of Presentation: 東京大学 伊藤国際学術研究センター、東京
  • Year and Date: 2015-11-22
• [Presentation] Renal circadian clock system in mice with adenine-induced tubulointerstitial nephropathy (2015)
  • Author(s): 本橋弘章、 田原優、山崎まゆ、菊池耀介、白石卓也、酒井智子、柴田重信
  • Organizer: 第22回日本時間生物学会学術大会
  • Place of Presentation: 東京大学 伊藤国際学術研究センター、東京
  • Year and Date: 2015-11-22
• [Presentation] Dosing time-dependent change in the beneficial effect of sesamin on high fat-induced hyperlipidemia in rat (2015)
  • Author(s): 立石法史、青山晋也、田中瑞穂、小島修一、櫓木智裕、伊地智節、柴田浩志、柴田重信
  • Organizer: 第22回日本時間生物学会学術大会
  • Place of Presentation: 東京大学 伊藤国際学術研究センター、東京
  • Year and Date: 2015-11-22
• [Presentation] Characteristic of circadian rhythm of brain monoamine levels from a model mouse with night eating syndrome (2015)
  • Author(s): 福澤雅、原口敦嗣、西村裕太郎、岩見志保、本橋弘章、安田晋之介、柴田重信
  • Organizer: 第22回日本時間生物学会学術大会
  • Place of Presentation: 東京大学 伊藤国際学術研究センター、東京
  • Year and Date: 2015-11-22
• [Presentation] Characters of entrainment by intraperitoneal administration of DEX in peripheral clocks of Clock mutant mice (2015)
  • Author(s): 鎌形真世、池田祐子、佐々木裕之、服部雄太、石川亮祐、安田晋之介、岩見志保、坪坂美来、柴田重信
  • Organizer: 第22回日本時間生物学会学術大会
  • Place of Presentation: 東京大学 伊藤国際学術研究センター、東京
  • Year and Date: 2015-11-22
• [Presentation] Effect of changes in the serotonin system on clock gene expression in mice (2015)
  • Author(s): 田中瑞穂、青木菜摘、青山晋也、小島修一、柴田重信
  • Organizer: 第22回日本時間生物学会学術大会
  • Place of Presentation: 東京大学 伊藤国際学術研究センター、東京
  • Year and Date: 2015-11-22
• [Presentation] Effects of macronutrients of mouse diet and human foods on circadian entrainment (2015)
  • Author(s): 池田祐子、柴田重信
  • Organizer: 第22回日本時間生物学会学術大会
  • Place of Presentation: 京大学 情報学環・福武ホール、東京
  • Year and Date: 2015-11-22
• [Presentation] Inhibition of IgE-mediated allergic reaction by pharmacologically targeting the circadian clock (2015)
  • Author(s): 中村勇規、中尾篤人、柴田重信
  • Organizer: 第22回日本時間生物学会学術大会
  • Place of Presentation: 東京大学 伊藤国際学術研究センター、東京
  • Year and Date: 2015-11-21
• [Presentation] A relation between circadian clock and bleomycin-induced interstitial pneumonia mouse model (2015)
  • Author(s): 北川絵理、和田美咲、柴田重信
  • Organizer: 第22回日本時間生物学会学術大会
  • Place of Presentation: 東京大学 伊藤国際学術研究センター、東京
  • Year and Date: 2015-11-21
• [Presentation] Study of Chrono-exercise and Chrono-nutritional effect on the bone in mice (2015)
  • Author(s): 服部雄太、佐々木裕之、岩見志保、安田晋之介、池田祐子、鎌形真世、青山晋也、柴田重信
  • Organizer: 第22回日本時間生物学会学術大会
  • Place of Presentation: 東京大学 伊藤国際学術研究センター、東京
  • Year and Date: 2015-11-21
• [Presentation] Circadian rhythm of the mucosal immune system of the mouse oral cavity is evaluated by salivary IgA secretion (2015)
  • Author(s): 和田美咲、北川絵理、柴田重信
  • Organizer: 第22回日本時間生物学会学術大会
  • Place of Presentation: 東京大学 伊藤国際学術研究センター、東京
  • Year and Date: 2015-11-21
• [Presentation] Effects of acid milk on entrainment of mice peripheral clocks (2015)
  • Author(s): 安田晋之介、池田祐子、服部雄太、岩見志保、佐々木裕之、鎌形真世、東誠一郎、野間晃幸、伊藤裕之、柴田重信
  • Organizer: 第22回日本時間生物学会学術大会
  • Place of Presentation: 東京大学 伊藤国際学術研究センター、東京
  • Year and Date: 2015-11-21
• [Presentation] Effect of period of exercise, exercise type and span of exercise to entrainment on mouse peripheral clock (2015)
  • Author(s): 佐々木裕之、池田祐子、服部雄太、鎌形真世、岩見志保、安田晋之介、柴田重信
  • Organizer: 第22回日本時間生物学会学術大会
  • Place of Presentation: 東京大学 伊藤国際学術研究センター、東京
  • Year and Date: 2015-11-21
• [Presentation] 体内時計と食 (2015)
  • Author(s): 柴田重信
  • Organizer: 第81回一般社団法人日本栄養評議会勉強会
  • Place of Presentation: ホテルグランドヒル市ヶ谷、東京
  • Year and Date: 2015-11-19
• [Presentation] 体内時計と脂質栄養学 (2015)
  • Author(s): 柴田重信
  • Organizer: 第17回公開講演会『生理活性物質としてのDHA・EPAの機能と動態』
  • Place of Presentation: アイビーホール青学会館、東京
  • Year and Date: 2015-10-23
• [Presentation] 時間栄養学の視点による食品開発 (2015)
  • Author(s): 柴田重信
  • Organizer: 東京都立食品技術センター成果発表会・第2回講演会
  • Place of Presentation: 東京都産業労働局秋葉原庁舎、東京
  • Year and Date: 2015-10-20
• [Presentation] Interaction between circadian rhythm and exercise (2015)
  • Author(s): Shigenobu Shibata
  • Organizer: 3D Lab Exchange Symposium,NUS
  • Place of Presentation: Singapore
  • Year and Date: 2015-09-09
• [Presentation] Effect of changes in the serotonin system on clock gene expression in mice (2015)
  • Author(s): Mizuho Tanaka
  • Organizer: 3D Lab Exchange Symposium,NUS
  • Place of Presentation: Singapore
  • Year and Date: 2015-09-07
• [Presentation] The effect of microbiota-produced short&#8211;chain fatty acids (SCFAs) on the circadian clock in host peripheral tissues (2015)
  • Author(s): Mayu Yamazaki
  • Organizer: 3D Lab Exchange Symposium,NUS
  • Place of Presentation: Singapore
  • Year and Date: 2015-09-07
• [Presentation] 時間栄養学的観点からの、マウスのカフェインの脂質代謝への影響 (2015)
  • Author(s): 三澤憲一郎
  • Organizer: 第2回時間栄養科学研究会
  • Place of Presentation: 早稲田大学国際会議場、東京
  • Year and Date: 2015-09-02
• [Presentation] ポリフェノール・フラボノイド系化合物の体内時計への作用インビトロ評価 (2015)
  • Author(s): 篠崎綾子、原口敦嗣、池田祐子、鎌形真世、三澤憲一郎、田原優、柴田重信
  • Organizer: 第2回時間栄養科学研究会
  • Place of Presentation: 早稲田大学国際会議場、東京
  • Year and Date: 2015-09-02
• [Presentation] 体内時計に作用する生薬の探索 (2015)
  • Author(s): 本橋弘章、鋤柄春奈、田原優、柴田重信
  • Organizer: 第2回時間栄養科学研究会
  • Place of Presentation: 早稲田大学国際会議場、東京
  • Year and Date: 2015-09-02
• [Presentation] 腸内細菌の代謝産物が末梢時計に及ぼす影響 (2015)
  • Author(s): 山崎まゆ、田原優、鋤柄春奈、本橋弘章、柴田重信
  • Organizer: 第2回時間栄養科学研究会
  • Place of Presentation: 早稲田大学国際会議場、東京
  • Year and Date: 2015-09-02
• [Presentation] 正常食もしくはトリプトファンやチロシン添加食下の運動タイミングがマウス脳内モノアミン含量に与える影響 (2015)
  • Author(s): 岩見志保、安田晋之介、服部雄太、鎌形真世、佐々木裕之、池田祐子、本橋弘章、柴田重信
  • Organizer: 第2回時間栄養科学研究会
  • Place of Presentation: 早稲田大学国際会議場、東京
  • Year and Date: 2015-09-02
• [Presentation] 人の糖尿病、腎臓病の治療食がマウスの体内時計に与える影響 (2015)
  • Author(s): 安田晋之介、岩見志保、池田祐子、佐々木裕之、鎌形真世、服部雄太、宮松雅子、葉梨静香、高戸良之、田口素子、柴田重信
  • Organizer: 第2回時間栄養科学研究会
  • Place of Presentation: 早稲田大学国際会議場、東京
  • Year and Date: 2015-09-02
• [Presentation] 明暗や給餌時間シフトによる社会的時差ぼけモデルマウスの作製とその評価 (2015)
  • Author(s): 西村裕太郎、原口敦嗣、福澤雅、柴田重信
  • Organizer: 第2回時間栄養科学研究会
  • Place of Presentation: 早稲田大学国際会議場、東
  • Year and Date: 2015-09-02
• [Presentation] 時間栄養学～体内時計と栄養・食の関係 (2015)
  • Author(s): 柴田重信
  • Organizer: 平成27年度食育推進リーダー養成講習会
  • Place of Presentation: 西九州大学佐賀キャンパス、佐賀
  • Year and Date: 2015-08-27
• [Presentation] モデルマウスを用いた社会的時差ボケが体内時計や行動リズムに与える影響に関する検証 (2015)
  • Author(s): 原口敦嗣、西村裕太郎、高橋将記、柴田重信
  • Organizer: 第26回霧島神経薬理フォーラム
  • Place of Presentation: 霧島国際ホテル、鹿児島
  • Year and Date: 2015-08-17
• [Presentation] カテキン類摂取が糖代謝機能に及ぼす影響‐摂取時刻および摂取量に着目して (2015)
  • Author(s): 高橋将記、原口敦嗣、池田祐子、柴田重信
  • Organizer: 第26回霧島神経薬理フォーラム
  • Place of Presentation: 霧島国際ホテル、鹿児島
  • Year and Date: 2015-08-17
• [Presentation] 時間栄養学による機能性食品開発 (2015)
  • Author(s): 田原優、柴田重信
  • Organizer: 第42回日本毒性学会学術年会
  • Place of Presentation: ポルテ金沢 金沢市アートホール、石川
  • Year and Date: 2015-06-29
• [Presentation] 睡眠と食と時間栄養学 (2015)
  • Author(s): 柴田重信
  • Organizer: 睡眠と食と健康セミナー(第20回国際食品素材／添加物展・会議、第13回 ヘルスフードエキスポ)
  • Place of Presentation: 東京ビッグサイト
  • Year and Date: 2015-05-22
• [Presentation] Chrono-nutritional effect of a-CD on serum triglyceride and glucose after injection at different circadian times in mice, (2015)
  • Author(s): Yuta Hattori, Mayo Kamagata, Yuko Ikeda, Sasaki Hiroyuki, Miku Tsubosaka, Mizuho Hirao, Shigenobu Shibata
  • Organizer: 第69回日本栄養・食糧学会大会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2015-05-15
• [Presentation] Flavonoids affect circadian rhythm in PER2::LUC mouse embryonic fibroblast cells (2015)
  • Author(s): Ayako Shinozaki, Aya Yokota, Atsushi Haraguchi, Mari Kuwahara, Yu Tahara, Shigenobu Shibata
  • Organizer: 第69回日本栄養・食糧学会大会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2015-05-15
• [Presentation] Interaction between circadian rhythm and chocolate intake in mice (2015)
  • Author(s): Yuko Ikeda, Hiroyuki Sasaki, Yuta Hattori, Mayo Kamagata, Shigenobu Shibata
  • Organizer: 第69回日本栄養・食糧学会大会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2015-05-15
• [Presentation] Effect of caffeine, capsaicin, and several amino acids on the lipid metabolism from chrono-nutritional view (2015)
  • Author(s): Kenichiro Misawa, Yuko Ikeda, Shigenobu Shibata
  • Organizer: 第69回日本栄養・食糧学会大会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2015-05-15
• [Presentation] Interactions between circadian clock system and food/nutrition/exercise (2015)
  • Author(s): Shigenobu Shibata
  • Organizer: Waseda University and Singapore Polytechnic work shop
  • Place of Presentation: Singapore
  • Year and Date: 2015-02-23
  • Invited
• [Presentation] 体内時計における食と運動の相互作用 (2015)
  • Author(s): 柴田 重信
  • Organizer: 第1回時間栄養科学研究会
  • Place of Presentation: 早稲田大学 先端生命医科学センター
  • Year and Date: 2015-02-14
  • Invited
• [Presentation] Interactions between circadian system and exercise (2015)
  • Author(s): Shigenobu Shibata
  • Organizer: The 16th Joint Symposium between the University of Bonn and Waseda University
  • Place of Presentation: 早稲田大学 先端生命医科学センター
  • Year and Date: 2015-02-02
• [Presentation] Interaction between Circadian Rhythm and Food/Nutrition in Mice (2015)
  • Author(s): Shigenobu Shibata
  • Organizer: KAUST-WASEDA University Joint Workshop/Meeting
  • Place of Presentation: Saudi Arabia
  • Year and Date: 2015-01-12
  • Invited
• [Presentation] 時間栄養学からみた食事の重要性 (2014)
  • Author(s): 柴田重信
  • Organizer: 第126回日本体力医学会関東地方会
  • Place of Presentation: 早稲田大学 東伏見キャンパス
  • Year and Date: 2014-12-20
  • Invited
• [Presentation] 時計遺伝子と食事のリズム (2014)
  • Author(s): 柴田重信
  • Organizer: 港北福祉保健センター食育講演会
  • Place of Presentation: 菊名ウォータープラザ
  • Year and Date: 2014-12-08
  • Invited
• [Presentation] ワークライフスタイルと時間健康科学 (2014)
  • Author(s): 柴田重信
  • Organizer: 子供の早起きをすすめる会シンポジウム
  • Place of Presentation: 国立オリンピック記念青少年総合センター
  • Year and Date: 2014-12-06
  • Invited
• [Presentation] 食と体内時計のサイエンス (2014)
  • Author(s): 柴田重信
  • Organizer: 第6回慶應義塾生命科学シンポジウム
  • Place of Presentation: 慶應義塾大学三田キャンパス北館ホール
  • Year and Date: 2014-12-03
  • Invited
• [Presentation] 体内時計を基盤にした動物実験の実施について (2014)
  • Author(s): 柴田重信
  • Organizer: （公社）日本実験動物学会維持会員懇談会
  • Place of Presentation: 中央大学駿河記念館
  • Year and Date: 2014-11-21
  • Invited
• [Presentation] 時間栄養学と機能性食品について (2014)
  • Author(s): 柴田重信
  • Organizer: 持続型食・農・バイオ研究所主催シンポジウム
  • Place of Presentation: 早稲田大学コレド日本橋ホール
  • Year and Date: 2014-11-06
• [Presentation] Circadian rhythm and lipid metabolism in mice (2014)
  • Author(s): Shigenobu Shibata
  • Organizer: 第15回応用動物科学セミナー
  • Place of Presentation: 東京大学農学部FS棟中島董一郎記念ホール
  • Year and Date: 2014-10-11
  • Invited
• [Presentation] 時間栄養学について (2014)
  • Author(s): 柴田重信
  • Organizer: 第2回地域保健関係職員等研修会
  • Place of Presentation: いわき市総合保健福祉センター
  • Year and Date: 2014-10-09
  • Invited
• [Presentation] 脂質代謝と時間栄養学 (2014)
  • Author(s): 柴田重信
  • Organizer: 日本油脂学会第53回年会プログラム
  • Place of Presentation: ホテルロイトン札幌
  • Year and Date: 2014-09-11
  • Invited
• [Presentation] Multiple factors for entrainment of peripheral circadian clock (2014)
  • Author(s): Shigenobu Shibata
  • Organizer: Waseda University Research Consortium
  • Place of Presentation: UCLA
  • Year and Date: 2014-09-08
• [Presentation] 脂質の時間栄養学 (2014)
  • Author(s): 柴田重信
  • Organizer: 日本脂質栄養学会第23回大会
  • Place of Presentation: 東京国際交流館プラザ平成会議施設
  • Year and Date: 2014-08-30
  • Invited
• [Presentation] 時間栄養学に根ざした健康保持 (2014)
  • Author(s): 柴田重信
  • Organizer: 第34回KSS健康フォーラム
  • Place of Presentation: 東京都中小企業振興公社3Ｆ第4会議室
  • Year and Date: 2014-07-30
  • Invited
• [Presentation] Physical and psychological stress as potent synchronizers of mouse peripheral circadian clocks (2014)
  • Author(s): Ｔahara Y,Shiraishi T,Kikuchi Y,Haraguchi A,Kuriki D,Shibata S
  • Organizer: The 30th Anniversary Meeting Sapporo Symposium on Biological Rhythm
  • Place of Presentation: Keio Plaza Hotel Sapporo
  • Year and Date: 2014-07-26
• [Presentation] Unique effects of flavonoids on circadian rhythm in vitro MEF from PER2::LUC mouse (2014)
  • Author(s): Shinozaki A,Yokota A,Kuwahara M,Haraguchi A,Tahara Y,Shibata S
  • Organizer: The 30th Anniversary Meeting Sapporo Symposium on Biological Rhythm
  • Place of Presentation: Keio Plaza Hotel Sapporo
  • Year and Date: 2014-07-26
• [Presentation] The mouse circadian rhythm of the mucosal immune system of the oral cavity is evaluated by salivary IgA secretion (2014)
  • Author(s): Wada M,Kitagawa E,Tanabe K,Shibata S
  • Organizer: The 30th Anniversary Meeting Sapporo Symposium on Biological Rhythm
  • Place of Presentation: Keio Plaza Hotel Sapporo
  • Year and Date: 2014-07-26
• [Presentation] Effect of restraint stress on clock gene expression and serotonin levels in the brain and intestine using PCPA, serotonin synthesis inhibitor (2014)
  • Author(s): Tanaka M,Aoki N,Ishikawa R,Thara Y,Shibata S
  • Organizer: The 30th Anniversary Meeting Sapporo Symposium on Biological Rhythm
  • Place of Presentation: Keio Plaza Hotel Sapporo
  • Year and Date: 2014-07-26
• [Presentation] Chrono-nutritional effect of α-CD on serum triglyceride and glucose after injection at different circadian times in mice (2014)
  • Author(s): Hattori Y,Kamagata M,Ikeda Y,Sasaki H,Tsubosaka M,Shibata S
  • Organizer: The 30th Anniversary Meeting Sapporo Symposium on Biological Rhythm
  • Place of Presentation: Keio Plaza Hotel Sapporo
  • Year and Date: 2014-07-26
• [Presentation] Chrono-nutrition and chrono-exercise (2014)
  • Author(s): Shibata S
  • Organizer: The 30th Anniversary Meeting Sapporo Symposium on Biological Rhythm
  • Place of Presentation: Keio Plaza Hotel Sapporo
  • Year and Date: 2014-07-25
  • Invited
• [Presentation] 健康科学としての時間栄養学と時間運動学 (2014)
  • Author(s): 柴田重信
  • Organizer: 第五回関西血糖変動研究会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-11
  • Invited
• [Presentation] 子どもの夜型化を食い止めるために～多角的提言～ (2014)
  • Author(s): 柴田重信
  • Organizer: 日本睡眠学会第39回定期学術集会
  • Place of Presentation: ホテルクレメント徳島
  • Year and Date: 2014-07-04
  • Invited
• [Book] ブルーライトテキストブック (2016)
  • Author(s): 柴田重信
  • Total Pages: 211
  • Publisher: 金原出版
• [Book] 睡眠科学 (2016)
  • Author(s): 柴田重信
  • Total Pages: 350
  • Publisher: 化学同人
• [Book] Mechanism of circadian systems in animals and their clinical relevance (Circadian rhythm and food/nutrition) (2015)
  • Author(s): Ｔａｈａｒａ Y ａｎｄ Ｓｈｉｂａｔａ S（Ａｇｕｉｌａｒ－Ｒｏｂｌｅｒｏ 編集）
  • Publisher: Springer
• [Remarks] 柴田研究室
  • URL: https://www.waseda-shibatas.com/
• [Patent(Industrial Property Rights)] 概日リズム変調及びそれに起因する症状の予防又は改善用の内服剤並びに飲食品組成物 (2018)
  • Inventor(s): 柴田重信、草野崇一
  • Industrial Property Rights Holder: 柴田重信、草野崇一
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-153937
  • Filing Date: 2018