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Basic and applied studies of chrononutrition based on development of functional foods and nutrients

Research Project

Project/Area Number 26220201
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Eating habits
Research InstitutionWaseda University

Principal Investigator

shibata shigenobu  早稲田大学, 理工学術院, 教授 (10162629)

Co-Investigator(Kenkyū-buntansha) 高橋 将記  早稲田大学, 重点領域研究機構, 次席研究員(研究院講師) (30711189)
折原 芳波  早稲田大学, 理工学術院, 講師(任期付) (60450623)
田原 優  早稲田大学, 高等研究所, 助教 (80707399)
Project Period (FY) 2014-05-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥116,870,000 (Direct Cost: ¥89,900,000、Indirect Cost: ¥26,970,000)
Fiscal Year 2018: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2017: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2016: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2015: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2014: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Keywords体内時計 / 時間栄養学 / 時間運動学 / 機能性食品 / メタボリックシンドローム / 腸内細菌 / 健康科学 / 介入試験 / 肥満 / 人介入試験 / マウス試験 / 農林水産物 / メタボリック / 腸内細菌多様性 / 栄養素 / 食事パターン / サルコペニア / ヒト介入試験 / 食品 / 生理学 / 食品科学 / 栄養 / 概日時計 / 概日リズム / 代謝 / 骨格筋 / 抗肥満 / 運動
Outline of Final Research Achievements

We could identify nobiletin, ornithine, cypress and Chinese medicine that affect the phase of the peripheral clock. The intellectual property of the functional food mentioned above acquired the joint patents. In addition to the insulin system, we have discovered the IGF-1 system, which runs on a protein diet. Coupled with the above finding, protein intake for breakfast rather than dinner is more important for skeletal muscle retention.
In addition, intake of Jerusalem artichoke and inulin at breakfast was effective for 24-hour blood glucose control, intestinal bacteria and constipation. The chrorno-nutrition research has been carried out until the publication of recipe cards and books. We have set up a society called “Chrorno-nutrition Science Study Group” and made a social contribution. Also, the research results were press-announced twice at Waseda University, the significance of protein for breakfast was also taken up three times in NHK programs.

Academic Significance and Societal Importance of the Research Achievements

先に述べた機能性食品の知財は共同特許を出願できた。期間中に体内時計がノーベル医学・生理学賞になったことと、時間栄養科学研究会という学会を立ち上げれたことから、時間栄養学の考え方の浸透が進み社会的貢献を行えた。また、研究成果は早稲田大学で2回プレス発表を行い、Nature review誌の依頼寄稿も受けることができた。朝食におけるタンパク質の意義については、NHKの番組でも3度取り上げられた。また、朝食タンパクの有用性としては、「毎朝これ1本」という、魚由来タンパク質製品の発売に貢献した。ヒトを対象としたイヌリン・菊芋の時間栄養学的研究は、レシピカードや書籍の出版を含め研究成果の普及中である。

Assessment Rating
Verification Result (Rating)

A-

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(10 results)
  • 2019 Research Progress Assessment (Verification Result) ( PDF )
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Abstract ( PDF )   Annual Research Report
  • Research Products

    (145 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (5 results) Journal Article (40 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 40 results,  Open Access: 25 results,  Acknowledgement Compliant: 4 results) Presentation (95 results) (of which Int'l Joint Research: 4 results,  Invited: 48 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] UCLA(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 南洋工科大学(シンガポール)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] UCLA(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] SP(Singapore)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] UCLA(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Phase resetting of circadian peripheral clocks using human and rodent diets in mouse models of type 2 diabetes and chronic kidney disease.2019

    • Author(s)
      Yasuda S, Iwami S, Tamura K, Ikeda Y, Kamagata M, Sasaki H, Haraguchi A, Miyamatsu M, Hanashi S, Takato Y, Shibata S.
    • Journal Title

      Chronobiology International

      Volume: 未定 Pages: 1-19

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation among clock gene expression rhythms, sleep quality, and meal conditions in delayed sleep-wake phase disorder and night eating syndrome.2019

    • Author(s)
      Haraguchi A, Komada Y, Inoue Y, Shibata S.
    • Journal Title

      Choronobiology International

      Volume: 未定 Issue: 6 Pages: 1-14

    • DOI

      10.1080/07420528.2019.1585366

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effect of night shift work on the expression of clock genes in beard hair follicle cells.2019

    • Author(s)
      Hattammaru M, Tahara Y, Kikuchi T, Okajima K, Konishi K, Nakajima S, Sato K, Otsuka K, Sakura H, Shibata S, Nakaoka T.
    • Journal Title

      Sleep Medicine

      Volume: 未定 Pages: 164-170

    • DOI

      10.1016/j.sleep.2019.01.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Systemic oscillator-driven and nutrient-responsive hormonal regulation of daily expression rhythms for gluconeogenic enzyme genes in the mouse liver.2019

    • Author(s)
      Taira A, Arita E, Matsumoto E, Oohira A, Iwase K, Hiwasa T, Yokote K, Shibata S, Takiguchi M.
    • Journal Title

      Chronobiology International

      Volume: 36(5). Issue: 5 Pages: 591-615

    • DOI

      10.1080/07420528.2019.1570246

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A low-protein diet eliminates the circadian rhythm of serum insulin and hepatic lipid metabolism in mice.2019

    • Author(s)
      Yokota SI, Nakamura K, Ando M, Haraguchi A, Omori K, Shibata S.
    • Journal Title

      Journal nutrition Biochemistry

      Volume: 63 Pages: 177-185

    • DOI

      10.1016/j.jnutbio.2018.10.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Social jetlag and menstrual symptoms among female university students2018

    • Author(s)
      Komada Yoko、Ikeda Yuko、Sato Makoto、Kami Azusa、Masuda Chika、Shibata Shigenobu
    • Journal Title

      Chronobiology International

      Volume: 36 Issue: 2 Pages: 258-264

    • DOI

      10.1080/07420528.2018.1533561

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Day-Night Oscillation of Atrogin1 and Timing-Dependent Preventive Effect of Weight-Bearing on Muscle Atrophy2018

    • Author(s)
      Aoyama Shinya、Kojima Shuichi、Sasaki Keisuke、Ishikawa Ryosuke、Tanaka Mizuho、Shimoda Takeru、Hattori Yuta、Aoki Natsumi、Takahashi Kengo、Hirooka Rina、Takizawa Miku、Haraguchi Atsushi、Shibata Shigenobu
    • Journal Title

      EBioMedicine

      Volume: 37 Pages: 499-508

    • DOI

      10.1016/j.ebiom.2018.10.057

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington's Disease.2018

    • Author(s)
      Whittaker DS, Loh DH, Wang HB, Tahara Y, Kuljis D, Cutler T, Ghiani CA, Shibata S, Block GD, Colwell CS.
    • Journal Title

      Journal Biologucal Rhythms

      Volume: 33(5). Issue: 5 Pages: 535-554

    • DOI

      10.1177/0748730418790401

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chronotype and social jetlag influence human circadian clock gene expression.2018

    • Author(s)
      Takahashi M, Tahara Y, Tsubosaka M, Fukazawa M, Ozaki M, Iwakami T, Nakaoka T, Shibata S.
    • Journal Title

      Scientific Reports

      Volume: 8(1): Issue: 1 Pages: 10152-10152

    • DOI

      10.1038/s41598-018-28616-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fukuda T, Haraguchi A, Takahashi M, Nakaoka T, Fukazawa M, Okubo J, Ozaki M, Kanatome A, Ohya R, Miura Y, Obara K, Shibata S.2018

    • Author(s)
      Fukuda T, Haraguchi A, Takahashi M, Nakaoka T, Fukazawa M, Okubo J, Ozaki M, Kanatome A, Ohya R, Miura Y, Obara K, Shibata S.
    • Journal Title

      Chronobiology International

      Volume: 35(10). Issue: 10 Pages: 1445-1455

    • DOI

      10.1080/07420528.2018.1490315

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function.2018

    • Author(s)
      Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S.
    • Journal Title

      Scientific Reports

      Volume: 8(1) Issue: 1 Pages: 9072-9072

    • DOI

      10.1038/s41598-018-27280-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circadian clock-dependent increase in salivary IgA secretion modulated by sympathetic receptor activation in mice.2017

    • Author(s)
      Wada M, Orihara K, Kamagata M, Hama K, Sasaki H, Haraguchi A, Miyakawa H, Nakao A, Shibata S.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 8802-8802

    • DOI

      10.1038/s41598-017-09438-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK72017

    • Author(s)
      Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H.
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 7348-7348

    • DOI

      10.1038/s41598-017-07845-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polyporus and Bupleuri radix effectively alter peripheral circadian clock phase acutely in male mice.2017

    • Author(s)
      Motohashi H, Sukigara H, Tahara Y, Saito K, Yamazaki M, Shiraishi T, Kikuchi Y, Haraguchi A, Shibata S.
    • Journal Title

      Nutrition Research

      Volume: 43 Pages: 16-24

    • DOI

      10.1016/j.nutres.2017.05.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation2017

    • Author(s)
      Tahara Y, Takatsu Y, Shiraishi T, Kikuchi Y, Yamazaki M, Motohashi H, Muto A, Sasaki H, Haraguchi A, Kuriki D, Nakamura TJ, Shibata S
    • Journal Title

      npj Aging and Mechanisms and Disease

      Volume: 3 Issue: 1 Pages: 16030-16030

    • DOI

      10.1038/npjamd.2016.30

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Potent synchronization of peripheral circadian clocks by glucocorticoid injections in PER2::LUC-Clock/Clock mice.2017

    • Author(s)
      Kamagata M, Ikeda Y, Sasaki H, Hattori Y, Yasuda S, Iwami S, Tsubosaka M, Ishikawa R, Todoh A, Tamura K, Tahara Y, Shibata S.
    • Journal Title

      Chronobiology International

      Volume: 13 Issue: 8 Pages: 1-16

    • DOI

      10.1080/07420528.2017.1338716

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise.2017

    • Author(s)
      Aoyama S, Shibata S.
    • Journal Title

      Frontier Neuroscience

      Volume: 11 Pages: 63-63

    • DOI

      10.3389/fnins.2017.00063

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response.2017

    • Author(s)
      Kawauchi T, Ishimaru K, Nakamura Y, Nakano N, Hara M, Ogawa H, Okumura K, Shibata S, Nakao A.
    • Journal Title

      Allergol Int.

      Volume: in press

    • NAID

      130005858846

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Role of Circadian Rhythms in Muscular and Osseous Physiology aPotent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts.nd Their Regulation by Nutrition and Exercise.2017

    • Author(s)
      Shinozaki A, Misawa K, Ikeda Y, Haraguchi A, Kamagata M, Tahara Y, Shibata S.
    • Journal Title

      PLOS ONE

      Volume: 12

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Abnormal tuning of the hepatic circadian metabolic rhythms in lung cancer.2017

    • Author(s)
      Tahara Y, Shibata S.
    • Journal Title

      Hepatology

      Volume: 65 Pages: 1061-1064

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] l-Ornithine affects peripheral clock gene expression in mice.2016

    • Author(s)
      Fukuda T, Haraguchi A, Kuwahara M, Nakamura K, Hamaguchi Y, Ikeda Y, Ishida Y, Wang G, Shirakawa C, Tanihata Y, Ohara K, Shibata S.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 34665-34665

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circadian rhythms of liver physiology and disease: experimental and clinical evidence.2016

    • Author(s)
      Tahara Y, Shibata S.
    • Journal Title

      Nat Rev Gastroenterol Hepatol.

      Volume: 13 Pages: 217-26

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock.2015

    • Author(s)
      Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagki S, Ogawa H, Okumura K, Shibata S, Nakao A
    • Journal Title

      The Journal of allergy and clinical immunology

      Volume: 137(4) Issue: 4 Pages: 1226-1235

    • DOI

      10.1016/j.jaci.2015.08.052

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase-delay in the light-dark cycle impairs clock gene expression and levels of serotonin, norepinephrine, and their metabolites in the mouse hippocampus and amygdala.2015

    • Author(s)
      Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S.
    • Journal Title

      Sleep Med

      Volume: 16 Issue: 11 Pages: 1352-9

    • DOI

      10.1016/j.sleep.2015.06.020

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of Circadian Rhythms in Peripheral Clocks by Constant Light Is Partially Reversed by Scheduled Feeding or Exercise.2015

    • Author(s)
      Hamaguchi Y, Tahara Y, Hitosugi M, Shibata S
    • Journal Title

      J Biol Rhythms

      Volume: 30 Issue: 6 Pages: 533-42

    • DOI

      10.1177/0748730415609727

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model.2015

    • Author(s)
      Tanabe K, Kitagawa E, Wada M, Haraguchi A, Orihara K, Tahara Y, Nakao A, Shibata S.
    • Journal Title

      Sci Rep.

      Volume: 5 Issue: 1 Pages: 14424-14424

    • DOI

      10.1038/srep14424

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Entrainment of mouse peripheral circadian clocks to <24&#8201;h feeding/fasting cycles under 24&#8201;h light/dark conditions.2015

    • Author(s)
      Hamaguchi Y, Tahara Y, Kuroda H, Haraguchi A, Shibata S
    • Journal Title

      Sci Rep

      Volume: 23 Issue: 1 Pages: 14207-14207

    • DOI

      10.1038/srep14207

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The circadian clock controls fluctuations of colonic cell proliferation during the light/dark cycle via feeding behavior in mice.2015

    • Author(s)
      Yoshida D, Aoki N, Tanaka M, Aoyama S, Shibata S.
    • Journal Title

      Chronobiol Int.

      Volume: 32 Issue: 8 Pages: 1145-55

    • DOI

      10.3109/07420528.2015.1065415

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice.2015

    • Author(s)
      Ando N, Nakamura Y, Aoki R, Ishimaru K, Ogawa H, Okumura K, Shibata S, Shimada S, Nakao A
    • Journal Title

      J Invest Dermatol

      Volume: 135 Issue: 12 Pages: 3001-3008

    • DOI

      10.1038/jid.2015.316

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120.2015

    • Author(s)
      Furutani A, Ikeda Y, Itokawa M, Nagahama H, Ohtsu T, Furutani N, Kamagata M, Yang ZH, Hirasawa A, Tahara Y, Shibata S.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 7 Pages: e0132472-e0132472

    • DOI

      10.1371/journal.pone.0132472

    • NAID

      120005763406

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Entrainment of the mouse circadian clock by sub-acute physical and psychological stress.2015

    • Author(s)
      Tahara Y, Shiraishi T, Kikuchi Y, Haraguchi A, Kuriki D, Sasaki H, Motohashi H, Sakai T, Shibata S.
    • Journal Title

      Sci Rep

      Volume: 15 Issue: 1 Pages: 11417-11417

    • DOI

      10.1038/srep11417

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eating meals before wheel-running exercise attenuate high fat diet-driven obesity in mice under two meals per day schedule.2015

    • Author(s)
      Sasaki H, Hattori Y, Ikeda Y, Kamagata M, Shibata S.
    • Journal Title

      Chronobiol Int.

      Volume: 32 Issue: 5 Pages: 677-86

    • DOI

      10.3109/07420528.2015.1035439

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Housing under abnormal light-dark cycles attenuates day/night expression rhythms of the clock genes Per1, Per2, and Bmal1 in the amygdala and hippocampus of mice.2015

    • Author(s)
      Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S.
    • Journal Title

      Neurosci Res.

      Volume: 99 Pages: 16-21

    • DOI

      10.1016/j.neures.2015.05.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene.2015

    • Author(s)
      Hamada T, Miyakawa K, Kushige H, Shibata S, Kurachi S.
    • Journal Title

      J Physiol Sci.

      Volume: 65 Issue: 4 Pages: 349-57

    • DOI

      10.1007/s12576-015-0373-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Cricadian Clock Functions As A Potent Regulator of Allergic Reaction. [Review]2015

    • Author(s)
      Nakao A, Nakamura Y, Shibata S
    • Journal Title

      Allergy

      Volume: 70(5) Issue: 5 Pages: 467-473

    • DOI

      10.1111/all.12596

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feeding and adrenal entrainment stimuli are both necessary for normal circadian oscillation of peripheral clocks in mice housed under different photoperiods.2015

    • Author(s)
      Ikeda Y, Sasaki H, Ohtsu T, Shiraishi T, Tahara Y, Shibata S.
    • Journal Title

      Chronobiol Int.

      Volume: 32 Issue: 2 Pages: 195-210

    • DOI

      10.3109/07420528.2014.962655

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Controlling access time to a high-fat diet during the inactive period protects against obesity in mice.2014

    • Author(s)
      Haraguchi A, Aoki N, Ohtsu T, Ikeda Y, Tahara Y, Shibata S.
    • Journal Title

      Chronobiology International

      Volume: 31 Issue: 8 Pages: 959-975

    • DOI

      10.3109/07420528.2014.931413

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice.2014

    • Author(s)
      Narishige S, Kuwahara M, Shinozaki A, Okada S, Ikeda Y, Kamagata M, Tahara Y, Shibata S.
    • Journal Title

      Br J Pharmacol.

      Volume: 171 Issue: 24 Pages: 5858-69

    • DOI

      10.1111/bph.12890

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα) activity underlies circadian expression of intestinal peptide absorption transporter PepT1/Slc15a1.2014

    • Author(s)
      Okamura A, Koyanagi S, Dilxiat A, Kusunose N, Chen JJ, Matsunaga N, Shibata S, Ohdo S.
    • Journal Title

      J Biol Chem.

      Volume: 289(36) Issue: 36 Pages: 25296-25305

    • DOI

      10.1074/jbc.m114.577023

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combination of meal and exercise timing with a high-fat diet influences energy expenditure and obesity in mice.2014

    • Author(s)
      Sasaki H, Ohtsu T, Ikeda Y, Tsubosaka M, Shibata S.
    • Journal Title

      Chronobiology International

      Volume: 31 Issue: 9 Pages: 959-975

    • DOI

      10.3109/07420528.2014.935785

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 「時間栄養学を活用した栄養指導~体内時計と食生活~」2019

    • Author(s)
      柴田重信
    • Organizer
      鳥取県 平成30年度栄養指導推進研修会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 「時間栄養学の視点からの内分泌学・代謝学」2019

    • Author(s)
      柴田重信
    • Organizer
      第41回小児成長研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 「時間軸のリズム現象で健康科学を捉える」2019

    • Author(s)
      柴田重信
    • Organizer
      平成30年度 発酵と代謝研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 「体内時計と生活習慣病(糖尿病)」2018

    • Author(s)
      柴田重信
    • Organizer
      岩手栄養改善学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 「高齢者の生活リズムと健康―時間栄養・運動学からの提言―」2018

    • Author(s)
      柴田重信
    • Organizer
      第6回日本介護予防・健康づくり学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 「いつ食べよう?体内時計と相談だ!」2018

    • Author(s)
      柴田重信
    • Organizer
      第7回信州の食を育む県民大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 「時間栄養学~マウスから人の健康まで~」2018

    • Author(s)
      柴田重信
    • Organizer
      第25回日本時間生物学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 「時間栄養学」2018

    • Author(s)
      柴田重信
    • Organizer
      一般社団法人日本臨床栄養学会 2018年度 認定臨床栄養医研修会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 「Protein rich breakfast is important for peripheral clock and muscle function」2018

    • Author(s)
      Shigenobu Shibata
    • Organizer
      ASIAN FORUM ON CHRONOBIOLOGY
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「体内時計の視点から時間について考える」2018

    • Author(s)
      柴田重信
    • Organizer
      第36回日本生理心理学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 「食事の時間栄養学」2018

    • Author(s)
      柴田重信
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学と食品機能性2017

    • Author(s)
      柴田重信
    • Organizer
      第6回シンポジウム「次世代の食品機能性と自然免疫」
    • Place of Presentation
      東京
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Chrono-nutrition and n-3 fatty acids2017

    • Author(s)
      Shigenobu Shibata
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] chrono-nutrition2017

    • Author(s)
      Shigenobu Shibata
    • Organizer
      IUNS Workshop on Capacity and Leadership Development in Nutritional Science 2017
    • Place of Presentation
      東京
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳や末梢臓器の時計遺伝子をターゲットにした時間栄養学的研究2017

    • Author(s)
      柴田重信
    • Organizer
      第99回日本栄養・食糧学会関東支部シンポジューム
    • Place of Presentation
      東京
    • Year and Date
      2017-03-04
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学 臨床的観点など2017

    • Author(s)
      柴田重信
    • Organizer
      第20回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2017-01-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学~基礎から臨床まで~2017

    • Author(s)
      柴田重信
    • Organizer
      益社団法人日本メディカル給食協会 第3回関東信越支部連絡会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 体内時計と健康―臓器から皮膚まで2017

    • Author(s)
      柴田重信
    • Organizer
      日本化粧品技術者会大阪支部 第207回講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Chrono-nutrition and -exercise studies from mice to human2017

    • Author(s)
      Shigenobu Shibata
    • Organizer
      The6th Annual ⅢS Symposium in Tsukuba
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 時間栄養学の視点からみたフロボノイドの作用2017

    • Author(s)
      柴田重信
    • Organizer
      ノビレチン研究会 第1回学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学の魅力2017

    • Author(s)
      柴田重信
    • Organizer
      第4回日本薬膳学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 糖尿病治療と時間栄養学の可能性2017

    • Author(s)
      柴田重信
    • Organizer
      第2回KFSmeeting
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 腎疾患指導に携わるスタッフのための時間栄養学2017

    • Author(s)
      柴田重信
    • Organizer
      第4回腎と栄養研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学2017

    • Author(s)
      柴田重信
    • Organizer
      日本機能性食品医用学会 教育セミナー2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Chrono-nutrition and chrono-exereise approaches to obesity and locomotive syndromes2017

    • Author(s)
      Shigenobu Shibata
    • Organizer
      2nd CHRONOBIOLOGY FORUM and 2017 conference of Chinese Society for Biological Rhythms
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 時間栄養学を視点とした機能性食品の開発と適用2016

    • Author(s)
      柴田重信
    • Organizer
      第14回日本機能性食品医用学会総会
    • Place of Presentation
      東京
    • Year and Date
      2016-12-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学と体内時計2016

    • Author(s)
      柴田重信
    • Organizer
      第5回ブルーライト研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-10-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Chrono-nutrition and chrono-exercise in mouse circadian rhythm2016

    • Author(s)
      S Shibata
    • Organizer
      The 29th Conference of the International Society for Chronobiology
    • Place of Presentation
      China
    • Year and Date
      2016-10-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 栄養学を広く考えよう:時間、運動そして睡眠との関係2016

    • Author(s)
      柴田重信
    • Organizer
      第38回日本臨床栄養学会総会、及び第37回日本臨床栄養協会総会
    • Place of Presentation
      大阪
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] CIRCADIAN CLOCKS AND METABOLIC HEALTH2016

    • Author(s)
      S Shibata
    • Organizer
      Chrono-nutrition Symposium
    • Place of Presentation
      France
    • Year and Date
      2016-06-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 食事と時刻(時間栄養学)の視点~食品開発にからめて~2016

    • Author(s)
      柴田重信
    • Organizer
      招待講演、第22回日本調理食品研究会年次大会
    • Place of Presentation
      大阪
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学の基礎からヒトへの応用展開2016

    • Author(s)
      柴田重信
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学~栄養管理と食指導への活用~2016

    • Author(s)
      柴田重信
    • Organizer
      松戸健康福祉センター特定給食施設従事者研修会
    • Place of Presentation
      千葉県東葛合同庁舎、千葉
    • Year and Date
      2016-02-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 基礎研究としての体内時計と食・運動の相互作用2016

    • Author(s)
      柴田重信
    • Organizer
      第30回日本体力医学会近畿地方会
    • Place of Presentation
      大阪市立大学医学部、大阪
    • Year and Date
      2016-02-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 時間栄養学について2016

    • Author(s)
      柴田重信
    • Organizer
      第29回岡山県栄養改善学会、
    • Place of Presentation
      おかやま西川原プラザ、岡山、
    • Year and Date
      2016-02-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 時間栄養学とは2015

    • Author(s)
      柴田重信
    • Organizer
      社会福祉法人恩賜財団母子愛育会研修事業「地域栄養活動~妊産婦から子ども~」
    • Place of Presentation
      社会福祉法人恩賜財団母子愛育会総合母子保健センター研修室、東京
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Diurnal oscillation of gut microbiota and an influence of immobilization stress on microbial rhythmicity2015

    • Author(s)
      星野友梨、高見澤菜穂子、丸山徹、細川正人、柴田重信、矢澤一良、竹山春子
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター、東京
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Renal circadian clock system in mice with adenine-induced tubulointerstitial nephropathy2015

    • Author(s)
      本橋弘章、 田原優、山崎まゆ、菊池耀介、白石卓也、酒井智子、柴田重信
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター、東京
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dosing time-dependent change in the beneficial effect of sesamin on high fat-induced hyperlipidemia in rat2015

    • Author(s)
      立石法史、青山晋也、田中瑞穂、小島修一、櫓木智裕、伊地智節、柴田浩志、柴田重信
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター、東京
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Characteristic of circadian rhythm of brain monoamine levels from a model mouse with night eating syndrome2015

    • Author(s)
      福澤雅、原口敦嗣、西村裕太郎、岩見志保、本橋弘章、安田晋之介、柴田重信
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター、東京
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Characters of entrainment by intraperitoneal administration of DEX in peripheral clocks of Clock mutant mice2015

    • Author(s)
      鎌形真世、池田祐子、佐々木裕之、服部雄太、石川亮祐、安田晋之介、岩見志保、坪坂美来、柴田重信
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター、東京
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effect of changes in the serotonin system on clock gene expression in mice2015

    • Author(s)
      田中瑞穂、青木菜摘、青山晋也、小島修一、柴田重信
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター、東京
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of macronutrients of mouse diet and human foods on circadian entrainment2015

    • Author(s)
      池田祐子、柴田重信
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      京大学 情報学環・福武ホール、東京
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Inhibition of IgE-mediated allergic reaction by pharmacologically targeting the circadian clock2015

    • Author(s)
      中村勇規、中尾篤人、柴田重信
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター、東京
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] A relation between circadian clock and bleomycin-induced interstitial pneumonia mouse model2015

    • Author(s)
      北川絵理、和田美咲、柴田重信
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター、東京
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Study of Chrono-exercise and Chrono-nutritional effect on the bone in mice2015

    • Author(s)
      服部雄太、佐々木裕之、岩見志保、安田晋之介、池田祐子、鎌形真世、青山晋也、柴田重信
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター、東京
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Circadian rhythm of the mucosal immune system of the mouse oral cavity is evaluated by salivary IgA secretion2015

    • Author(s)
      和田美咲、北川絵理、柴田重信
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター、東京
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of acid milk on entrainment of mice peripheral clocks2015

    • Author(s)
      安田晋之介、池田祐子、服部雄太、岩見志保、佐々木裕之、鎌形真世、東誠一郎、野間晃幸、伊藤裕之、柴田重信
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター、東京
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effect of period of exercise, exercise type and span of exercise to entrainment on mouse peripheral clock2015

    • Author(s)
      佐々木裕之、池田祐子、服部雄太、鎌形真世、岩見志保、安田晋之介、柴田重信
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター、東京
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 体内時計と食2015

    • Author(s)
      柴田重信
    • Organizer
      第81回一般社団法人日本栄養評議会勉強会
    • Place of Presentation
      ホテルグランドヒル市ヶ谷、東京
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 体内時計と脂質栄養学2015

    • Author(s)
      柴田重信
    • Organizer
      第17回公開講演会『生理活性物質としてのDHA・EPAの機能と動態』
    • Place of Presentation
      アイビーホール青学会館、東京
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 時間栄養学の視点による食品開発2015

    • Author(s)
      柴田重信
    • Organizer
      東京都立食品技術センター成果発表会・第2回講演会
    • Place of Presentation
      東京都産業労働局秋葉原庁舎、東京
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Interaction between circadian rhythm and exercise2015

    • Author(s)
      Shigenobu Shibata
    • Organizer
      3D Lab Exchange Symposium,NUS
    • Place of Presentation
      Singapore
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effect of changes in the serotonin system on clock gene expression in mice2015

    • Author(s)
      Mizuho Tanaka
    • Organizer
      3D Lab Exchange Symposium,NUS
    • Place of Presentation
      Singapore
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] The effect of microbiota-produced short&#8211;chain fatty acids (SCFAs) on the circadian clock in host peripheral tissues2015

    • Author(s)
      Mayu Yamazaki
    • Organizer
      3D Lab Exchange Symposium,NUS
    • Place of Presentation
      Singapore
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 時間栄養学的観点からの、マウスのカフェインの脂質代謝への影響2015

    • Author(s)
      三澤憲一郎
    • Organizer
      第2回時間栄養科学研究会
    • Place of Presentation
      早稲田大学国際会議場、東京
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] ポリフェノール・フラボノイド系化合物の体内時計への作用インビトロ評価2015

    • Author(s)
      篠崎綾子、原口敦嗣、池田祐子、鎌形真世、三澤憲一郎、田原優、柴田重信
    • Organizer
      第2回時間栄養科学研究会
    • Place of Presentation
      早稲田大学国際会議場、東京
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 体内時計に作用する生薬の探索2015

    • Author(s)
      本橋弘章、鋤柄春奈、田原優、柴田重信
    • Organizer
      第2回時間栄養科学研究会
    • Place of Presentation
      早稲田大学国際会議場、東京
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腸内細菌の代謝産物が末梢時計に及ぼす影響2015

    • Author(s)
      山崎まゆ、田原優、鋤柄春奈、本橋弘章、柴田重信
    • Organizer
      第2回時間栄養科学研究会
    • Place of Presentation
      早稲田大学国際会議場、東京
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 正常食もしくはトリプトファンやチロシン添加食下の運動タイミングがマウス脳内モノアミン含量に与える影響2015

    • Author(s)
      岩見志保、安田晋之介、服部雄太、鎌形真世、佐々木裕之、池田祐子、本橋弘章、柴田重信
    • Organizer
      第2回時間栄養科学研究会
    • Place of Presentation
      早稲田大学国際会議場、東京
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 人の糖尿病、腎臓病の治療食がマウスの体内時計に与える影響2015

    • Author(s)
      安田晋之介、岩見志保、池田祐子、佐々木裕之、鎌形真世、服部雄太、宮松雅子、葉梨静香、高戸良之、田口素子、柴田重信
    • Organizer
      第2回時間栄養科学研究会
    • Place of Presentation
      早稲田大学国際会議場、東京
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 明暗や給餌時間シフトによる社会的時差ぼけモデルマウスの作製とその評価2015

    • Author(s)
      西村裕太郎、原口敦嗣、福澤雅、柴田重信
    • Organizer
      第2回時間栄養科学研究会
    • Place of Presentation
      早稲田大学国際会議場、東
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 時間栄養学~体内時計と栄養・食の関係2015

    • Author(s)
      柴田重信
    • Organizer
      平成27年度食育推進リーダー養成講習会
    • Place of Presentation
      西九州大学佐賀キャンパス、佐賀
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] モデルマウスを用いた社会的時差ボケが体内時計や行動リズムに与える影響に関する検証2015

    • Author(s)
      原口敦嗣、西村裕太郎、高橋将記、柴田重信
    • Organizer
      第26回霧島神経薬理フォーラム
    • Place of Presentation
      霧島国際ホテル、鹿児島
    • Year and Date
      2015-08-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] カテキン類摂取が糖代謝機能に及ぼす影響‐摂取時刻および摂取量に着目して2015

    • Author(s)
      高橋将記、原口敦嗣、池田祐子、柴田重信
    • Organizer
      第26回霧島神経薬理フォーラム
    • Place of Presentation
      霧島国際ホテル、鹿児島
    • Year and Date
      2015-08-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 時間栄養学による機能性食品開発2015

    • Author(s)
      田原優、柴田重信
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      ポルテ金沢 金沢市アートホール、石川
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 睡眠と食と時間栄養学2015

    • Author(s)
      柴田重信
    • Organizer
      睡眠と食と健康セミナー(第20回国際食品素材/添加物展・会議、第13回 ヘルスフードエキスポ)
    • Place of Presentation
      東京ビッグサイト
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Chrono-nutritional effect of a-CD on serum triglyceride and glucose after injection at different circadian times in mice,2015

    • Author(s)
      Yuta Hattori, Mayo Kamagata, Yuko Ikeda, Sasaki Hiroyuki, Miku Tsubosaka, Mizuho Hirao, Shigenobu Shibata
    • Organizer
      第69回日本栄養・食糧学会大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Flavonoids affect circadian rhythm in PER2::LUC mouse embryonic fibroblast cells2015

    • Author(s)
      Ayako Shinozaki, Aya Yokota, Atsushi Haraguchi, Mari Kuwahara, Yu Tahara, Shigenobu Shibata
    • Organizer
      第69回日本栄養・食糧学会大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Interaction between circadian rhythm and chocolate intake in mice2015

    • Author(s)
      Yuko Ikeda, Hiroyuki Sasaki, Yuta Hattori, Mayo Kamagata, Shigenobu Shibata
    • Organizer
      第69回日本栄養・食糧学会大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effect of caffeine, capsaicin, and several amino acids on the lipid metabolism from chrono-nutritional view2015

    • Author(s)
      Kenichiro Misawa, Yuko Ikeda, Shigenobu Shibata
    • Organizer
      第69回日本栄養・食糧学会大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Interactions between circadian clock system and food/nutrition/exercise2015

    • Author(s)
      Shigenobu Shibata
    • Organizer
      Waseda University and Singapore Polytechnic work shop
    • Place of Presentation
      Singapore
    • Year and Date
      2015-02-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 体内時計における食と運動の相互作用2015

    • Author(s)
      柴田 重信
    • Organizer
      第1回時間栄養科学研究会
    • Place of Presentation
      早稲田大学 先端生命医科学センター
    • Year and Date
      2015-02-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Interactions between circadian system and exercise2015

    • Author(s)
      Shigenobu Shibata
    • Organizer
      The 16th Joint Symposium between the University of Bonn and Waseda University
    • Place of Presentation
      早稲田大学 先端生命医科学センター
    • Year and Date
      2015-02-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Interaction between Circadian Rhythm and Food/Nutrition in Mice2015

    • Author(s)
      Shigenobu Shibata
    • Organizer
      KAUST-WASEDA University Joint Workshop/Meeting
    • Place of Presentation
      Saudi Arabia
    • Year and Date
      2015-01-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学からみた食事の重要性2014

    • Author(s)
      柴田重信
    • Organizer
      第126回日本体力医学会関東地方会
    • Place of Presentation
      早稲田大学 東伏見キャンパス
    • Year and Date
      2014-12-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 時計遺伝子と食事のリズム2014

    • Author(s)
      柴田重信
    • Organizer
      港北福祉保健センター食育講演会
    • Place of Presentation
      菊名ウォータープラザ
    • Year and Date
      2014-12-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ワークライフスタイルと時間健康科学2014

    • Author(s)
      柴田重信
    • Organizer
      子供の早起きをすすめる会シンポジウム
    • Place of Presentation
      国立オリンピック記念青少年総合センター
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 食と体内時計のサイエンス2014

    • Author(s)
      柴田重信
    • Organizer
      第6回慶應義塾生命科学シンポジウム
    • Place of Presentation
      慶應義塾大学三田キャンパス北館ホール
    • Year and Date
      2014-12-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 体内時計を基盤にした動物実験の実施について2014

    • Author(s)
      柴田重信
    • Organizer
      (公社)日本実験動物学会維持会員懇談会
    • Place of Presentation
      中央大学駿河記念館
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学と機能性食品について2014

    • Author(s)
      柴田重信
    • Organizer
      持続型食・農・バイオ研究所主催シンポジウム
    • Place of Presentation
      早稲田大学コレド日本橋ホール
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Circadian rhythm and lipid metabolism in mice2014

    • Author(s)
      Shigenobu Shibata
    • Organizer
      第15回応用動物科学セミナー
    • Place of Presentation
      東京大学農学部FS棟中島董一郎記念ホール
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学について2014

    • Author(s)
      柴田重信
    • Organizer
      第2回地域保健関係職員等研修会
    • Place of Presentation
      いわき市総合保健福祉センター
    • Year and Date
      2014-10-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脂質代謝と時間栄養学2014

    • Author(s)
      柴田重信
    • Organizer
      日本油脂学会第53回年会プログラム
    • Place of Presentation
      ホテルロイトン札幌
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Multiple factors for entrainment of peripheral circadian clock2014

    • Author(s)
      Shigenobu Shibata
    • Organizer
      Waseda University Research Consortium
    • Place of Presentation
      UCLA
    • Year and Date
      2014-09-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂質の時間栄養学2014

    • Author(s)
      柴田重信
    • Organizer
      日本脂質栄養学会第23回大会
    • Place of Presentation
      東京国際交流館プラザ平成会議施設
    • Year and Date
      2014-08-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学に根ざした健康保持2014

    • Author(s)
      柴田重信
    • Organizer
      第34回KSS健康フォーラム
    • Place of Presentation
      東京都中小企業振興公社3F第4会議室
    • Year and Date
      2014-07-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Physical and psychological stress as potent synchronizers of mouse peripheral circadian clocks2014

    • Author(s)
      Tahara Y,Shiraishi T,Kikuchi Y,Haraguchi A,Kuriki D,Shibata S
    • Organizer
      The 30th Anniversary Meeting Sapporo Symposium on Biological Rhythm
    • Place of Presentation
      Keio Plaza Hotel Sapporo
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Unique effects of flavonoids on circadian rhythm in vitro MEF from PER2::LUC mouse2014

    • Author(s)
      Shinozaki A,Yokota A,Kuwahara M,Haraguchi A,Tahara Y,Shibata S
    • Organizer
      The 30th Anniversary Meeting Sapporo Symposium on Biological Rhythm
    • Place of Presentation
      Keio Plaza Hotel Sapporo
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] The mouse circadian rhythm of the mucosal immune system of the oral cavity is evaluated by salivary IgA secretion2014

    • Author(s)
      Wada M,Kitagawa E,Tanabe K,Shibata S
    • Organizer
      The 30th Anniversary Meeting Sapporo Symposium on Biological Rhythm
    • Place of Presentation
      Keio Plaza Hotel Sapporo
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of restraint stress on clock gene expression and serotonin levels in the brain and intestine using PCPA, serotonin synthesis inhibitor2014

    • Author(s)
      Tanaka M,Aoki N,Ishikawa R,Thara Y,Shibata S
    • Organizer
      The 30th Anniversary Meeting Sapporo Symposium on Biological Rhythm
    • Place of Presentation
      Keio Plaza Hotel Sapporo
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Chrono-nutritional effect of α-CD on serum triglyceride and glucose after injection at different circadian times in mice2014

    • Author(s)
      Hattori Y,Kamagata M,Ikeda Y,Sasaki H,Tsubosaka M,Shibata S
    • Organizer
      The 30th Anniversary Meeting Sapporo Symposium on Biological Rhythm
    • Place of Presentation
      Keio Plaza Hotel Sapporo
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Chrono-nutrition and chrono-exercise2014

    • Author(s)
      Shibata S
    • Organizer
      The 30th Anniversary Meeting Sapporo Symposium on Biological Rhythm
    • Place of Presentation
      Keio Plaza Hotel Sapporo
    • Year and Date
      2014-07-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 健康科学としての時間栄養学と時間運動学2014

    • Author(s)
      柴田重信
    • Organizer
      第五回関西血糖変動研究会
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 子どもの夜型化を食い止めるために~多角的提言~2014

    • Author(s)
      柴田重信
    • Organizer
      日本睡眠学会第39回定期学術集会
    • Place of Presentation
      ホテルクレメント徳島
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] ブルーライトテキストブック2016

    • Author(s)
      柴田重信
    • Total Pages
      211
    • Publisher
      金原出版
    • Related Report
      2016 Annual Research Report
  • [Book] 睡眠科学2016

    • Author(s)
      柴田重信
    • Total Pages
      350
    • Publisher
      化学同人
    • Related Report
      2016 Annual Research Report
  • [Book] Mechanism of circadian systems in animals and their clinical relevance (Circadian rhythm and food/nutrition)2015

    • Author(s)
      Tahara Y and Shibata S(Aguilar-Roblero 編集)
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Remarks] 柴田研究室

    • URL

      https://www.waseda-shibatas.com/

    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 概日リズム変調及びそれに起因する症状の予防又は改善用の内服剤並びに飲食品組成物2018

    • Inventor(s)
      柴田重信、草野崇一
    • Industrial Property Rights Holder
      柴田重信、草野崇一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-153937
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2014-06-05   Modified: 2022-04-28  

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