Control and Analysis of Cells by Synthetic Small Molecules

• Project/Area Number: 26220206
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Chemical biology
• Research Institution: Kyoto University
• Principal Investigator: Uesugi Motonari 京都大学, 化学研究所, 教授 (10402926)
• Co-Investigator(Kenkyū-buntansha): 西川 元也 東京理科大学, 薬学部薬学科, 教授 (40273437)
• Project Period (FY): 2014-05-30 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥195,000,000 (Direct Cost: ¥150,000,000、Indirect Cost: ¥45,000,000); Fiscal Year 2018: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000); Fiscal Year 2017: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000); Fiscal Year 2016: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000); Fiscal Year 2015: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000); Fiscal Year 2014: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000)
• Keywords: ケミカルバイオロジー / 化学プローブ / 細胞治療

Outline of Final Research Achievements

This research project proposed a new way of using synthetic small molecules, in which small chemical compounds serve as tools for improving the efficacy and productivity of cell therapy by manipulating and detecting fundamental biological processes in human cells. The proposed research included proof-of-concept experiments that developed and used small molecule tools both for basic cell biology and cell therapy.

Academic Significance and Societal Importance of the Research Achievements

●テクノロジーブレークスルー 　細胞治療の分野に化合物ツールを活かすという新しいコンセプトを提案した。実際、本基盤研究で開発したアノイキス阻害剤は国内化学大手に、KP-1は国内試薬会社に、KY02111は国内ベンチャー企業にライセンスアウトされた。
●サイエンスブレークスルー　本研究で開発した化合物はいずれも、基礎細胞生物学のツールとなる可能性がある。実際、KP-1やKY02111は試薬として販売され、さまざまな研究者の研究に利用されている。アノイキス阻害剤やTRPA1アゴニストは細胞研究者に個別に分与し、活用されている。

Assessment Rating

Verification Result (Rating)

A

Research Products

• [Journal Article] Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment (2019)
  • Author(s): Takashima Ippei、Kusamori Kosuke、Hakariya Hayase、Takashima Megumi、Vu Thi Hue、Mizukami Yuya、Noda Naotaka、Takayama Yukiya、Katsuda Yousuke、Sato Shin-ichi、Takakura Yoshinobu、Nishikawa Makiya、Uesugi Motonari
  • Journal Title: ACS Chemical Biology Volume: 14 Issue: 4 Pages: 775-783
  • DOI: 10.1021/acschembio.9b00109
  • Peer Reviewed
• [Journal Article] Concise synthesis of 23-hydroxylated vitamin D ₃ metabolites (2019)
  • Author(s): Kawagoe Fumihiro、Sugiyama Toru、Yasuda Kaori、Uesugi Motonari、Sakaki Toshiyuki、Kittaka Atsushi
  • Journal Title: The Journal of Steroid Biochemistry and Molecular Biology Volume: 186 Pages: 161
  • DOI: 10.1016/j.jsbmb.2018.10.010
  • Peer Reviewed
• [Journal Article] Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis (2019)
  • Author(s): Nishikawa Y、Kodama Y、Shiokawa M、Matsumori T、Marui S、Kuriyama K、Kuwada T、Sogabe Y、Kakiuchi N、Tomono T、Mima A、Morita T、Ueda T、Tsuda M、Yamauchi Y、Sakuma Y、Ota Y、Maruno T、Uza N、Uesugi M、Kageyama R、Chiba T、Seno H
  • Journal Title: Oncogene Volume: in press Issue: 22 Pages: 4283-4296
  • DOI: 10.1038/s41388-019-0718-5
  • Peer Reviewed / Open Access
• [Journal Article] Click Chemistry as a Tool for Cell Engineering and Drug Delivery (2019)
  • Author(s): Yukiya Takayama, Kosuke Kusamori, Makiya Nishikawa
  • Journal Title: Molecules Volume: 24 Issue: 1 Pages: 1-20
  • DOI: 10.3390/molecules24010172
  • Peer Reviewed / Open Access
• [Journal Article] Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity (2018)
  • Author(s): Ohkanda Junko,Kusumoto Atsushi,Punzalan Louvy,Masuda Ryoma,Wang Chenyu,Parvatkar Prakash,Akase Dai,Aida Misako,Uesugi Motonari,Higuchi Yusuke,Kato Nobuo
  • Journal Title: Chemistry - A European Journal Volume: 24 Issue: 60 Pages: 16066-16071
  • DOI: 10.1002/chem.201804428
  • Peer Reviewed
• [Journal Article] Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array (2018)
  • Author(s): Mashimo, Y., Yoshioka, M., Tokunaga, Y., Fockenberg, C., Terada, S., Koyama, Y., Shibata-Seki, T., Yoshimoto, K., Sakai, R., Hakariya, H., Liu, L., Akaike, T., Kobatake, E., How, SE., Uesugi, M., Chen, Y., Kamei, KI.
  • Journal Title: Journal of Visualized Experiments Volume: - Issue: 139
  • DOI: 10.3791/57377
  • Peer Reviewed
• [Journal Article] A robust split-luciferase-based cell fusion screening for discovering myogenesis-promoting molecules (2018)
  • Author(s): Li, Q., Yoshimura, H., Komiya, M., Tajiri, K., Uesugi, M., Hata, Y., Ozawa, T.
  • Journal Title: The Analyst Volume: 143 Issue: 14 Pages: 3472-3480
  • DOI: 10.1039/c8an00285a
  • Peer Reviewed
• [Journal Article] Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics (2018)
  • Author(s): Yatsuzuka Kenji、Sato Shin-ichi、Pe Kathleen Beverly、Katsuda Yousuke、Takashima Ippei、Watanabe Mizuki、Uesugi Motonari
  • Journal Title: Chemical Communications Volume: 54 Issue: 52 Pages: 7151-7154
  • DOI: 10.1039/c8cc03805h
  • Peer Reviewed
• [Journal Article] Stable Surface Modification of Mesenchymal Stem Cells Using the Avidin-Biotin Complex Technique (2018)
  • Author(s): Kosuke Kusamori, Yukiya Takayama, Makiya Nishikawa
  • Journal Title: Current Protocols in Stem Cell Biology Volume: 47 Issue: 1 Pages: 1-11
  • DOI: 10.1002/cpsc.66
  • Peer Reviewed
• [Journal Article] Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. (2018)
  • Author(s): Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M.
  • Journal Title: J Biol Chem. Volume: 印刷中 Issue: 21 Pages: 8285-8294
  • DOI: 10.1074/jbc.ra118.002316
  • Peer Reviewed
• [Journal Article] Chemical decontamination of iPS cell-derived neural cell mixtures (2018)
  • Author(s): Mao Di、Chung Xie Khim Watson、Andoh-Noda Tomoko、Qin Ying、Sato Shin-ichi、Takemoto Yasushi、Akamatsu Wado、Okano Hideyuki、Uesugi Motonari
  • Journal Title: Chem Commun (Camb). 1355 Volume: 54 Issue: 11 Pages: 1355-1358
  • DOI: 10.1039/c7cc08686e
  • Peer Reviewed
• [Journal Article] Vitamin D metabolite, 25-Hydroxyvitamin D, regulates lipid metabolism by inducing degradation of SREBP/SCAP. (2017)
  • Author(s): Asano, L., Watanabe, M., Ryoden, Y., Usuda, K., Yamaguchi, T., Khambu, B., Takashima, M., Sato, S., Sakai, J., Nagasawa, K., Uesugi, M.
  • Journal Title: Cell Chem Biol. Volume: 24 Issue: 2 Pages: 207-217
  • DOI: 10.1016/j.chembiol.2016.12.017
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A synthetic hybrid molecule for the selective removal of human pluripotent stem cells from cell mixtures. (2017)
  • Author(s): Mao, D., Ando, S., Sato, S., Qin, Y., Hirata, N., Katsuda, Y., Kawase, E., Kuo, T.F., Minami, I., Shiba, Y., Ueda, K., Nakatsuji, N., Uesugi, M.
  • Journal Title: Angew. Chem. Int. Ed. Volume: 56 Issue: 7 Pages: 1765-1770
  • DOI: 10.1002/anie.201610284
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A small molecule that represses translation of G-quadruplex-containing mRNA. (2016)
  • Author(s): Katsuda, Y., Sato, S., Asano, L., Morimura, Y., Furuta, T., Sugiyama, H., Hagihara, M., Uesugi, M.
  • Journal Title: J. Am. Chem. Soc. Volume: 138 Issue: 29 Pages: 9037-9040
  • DOI: 10.1021/jacs.6b04506
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A potent and site-selective agonist of TRPA1. (2015)
  • Author(s): Takaya, J., Mio, K., Shiraishi, T., Kurokawa, T., Otsuka, S., Mori, Y., Uesugi, M.
  • Journal Title: J. Am. Chem. Soc. Volume: 137 Issue: 50 Pages: 15859-15864
  • DOI: 10.1021/jacs.5b10162
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intracellular generation of a diterpene-peptide conjugate that inhibits 14-3-3-mediated interactions. (2015)
  • Author(s): Parvatkar P., Kato N., Uesugi M., Sato S., Ohkanda J.
  • Journal Title: J. Am. Chem. Soc. Volume: 137 Issue: 50 Pages: 15624-15627
  • DOI: 10.1021/jacs.5b09817
  • Peer Reviewed
• [Journal Article] Live-cell Imaging of Endogenous mRNAs with a Small Molecule (2015)
  • Author(s): Sato, S.*, Watanabe, M., Katsuda, Y., Murata, A., Wang, D. O., Uesugi M.
  • Journal Title: Angew. Chem. Int. Ed. Volume: 54 Issue: 6 Pages: 1855-1858
  • DOI: 10.1002/anie.201410339
  • NAID: 120005619801
  • Peer Reviewed
• [Journal Article] A chemical probe that labels human pluripotent stem cells (2014)
  • Author(s): Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M
  • Journal Title: Cell reports Volume: 6 Issue: 6 Pages: 1165-74
  • DOI: 10.1016/j.celrep.2014.02.006
  • NAID: 120005466668
  • Peer Reviewed / Open Access
• [Journal Article] Selective elimination of human pluripotent stem cells by a marine natural product derivative. (2014)
  • Author(s): Ting-Fang Kuo, Di Mao, Nao Hirata, Bilon Khambu, Yasuhisa Kimura, Eihachiro Kawase, Hiroki Shimogawa, Makoto Ojika, Norio Nakatsuji, Kazumitsu Ueda, and Motonari Uesugi
  • Journal Title: J Am Chem Soc Volume: 136 Issue: 28 Pages: 9798-9801
  • DOI: 10.1021/ja501795c
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Synthetic Molecules That Protect Cells from Anoikis and Their Use in Cell Transplantation (2014)
  • Author(s): Frisco-Cabanos, H.L., Watanabe, M., Okumura, N., Kusamori, K., Takemoto, N., Takaya, J., Sato, S., Yamazoe, S., Takakura, Y., Kinoshita, S., Nishikawa, M., Koizumi, M., Uesugi, M
  • Journal Title: Angew. Chem. Int. Ed. Volume: 53 Issue: 42 Pages: 11208-11213
  • DOI: 10.1002/anie.201405829
  • Peer Reviewed
• [Journal Article] Affinity-Based Isolation of Molecular Targets of Clinically Used Drugs (2014)
  • Author(s): Sato, S., Uesugi, M.
  • Journal Title: Concepts and Case Studies in Chemical Biology Volume: 15 Pages: 221-230
  • DOI: 10.1002/9783527687503.ch15
  • Peer Reviewed
• [Presentation] Small Molecules That Control Energy Metabolism (2019)
  • Author(s): Motonari Uesugi
  • Organizer: 2019 Queenstown Molecular Biology (QMB) Meetings in Shanghai
  • Int'l Joint Research / Invited
• [Presentation] 生理活性合成化合物の新しい世界 (2019)
  • Author(s): 上杉 志成
  • Organizer: 第42回白金シンポジウム
  • Invited
• [Presentation] 自己集合性生理活性化合物 (2019)
  • Author(s): 上杉 志成
  • Organizer: 有機合成2月セミナー「有機合成のニュートレンド2019」
  • Invited
• [Presentation] Synthetic Molecules That Control Energy Metabolism (2019)
  • Author(s): Motonari Uesugi
  • Organizer: 2nd SPIRITS Symposium
  • Int'l Joint Research / Invited
• [Presentation] Self-Assembling Bioactive Molecules (2019)
  • Author(s): Motonari Uesugi
  • Organizer: The Chinese University of Hong Kong, Department Seminar
  • Int'l Joint Research / Invited
• [Presentation] Small-Molecule Discovery by Library Profiling (2019)
  • Author(s): Motonari Uesugi
  • Organizer: ACBI 2019 Yangon Meeting
  • Int'l Joint Research / Invited
• [Presentation] Small Molecules That Control Energy Metabolism (2019)
  • Author(s): Motonari Uesugi
  • Organizer: The 1st International Symposium on the Chemical Communications (ISCC2019)
  • Int'l Joint Research / Invited
• [Presentation] 静脈内投与した間葉系幹細胞の肺移行回避を目的とした細胞表面へのPEG修飾 (2019)
  • Author(s): 髙山 幸也, 草森 浩輔, 西川 元也
  • Organizer: 日本薬学会第139年会
• [Presentation] Small Molecules That Control Energy Metabolism (2018)
  • Author(s): Motonari Uesugi
  • Organizer: Special Seminar, Nanjing University
  • Invited
• [Presentation] Nutrient-Oriented Peptide Library as a Source of Energy Metabolism Modulators (2018)
  • Author(s): Motonari Uesugi
  • Organizer: 10th International Peptide Symposium
  • Int'l Joint Research / Invited
• [Presentation] 生理活性合成化合物の新しい世界 (2018)
  • Author(s): 上杉 志成
  • Organizer: 「理研セミナー・ケミカルバイオロジーチュートリアル」平成30年度 第3回 特別講演
  • Invited
• [Presentation] Small Molecules That Control Energy Metabolism (2018)
  • Author(s): Motonari Uesugi
  • Organizer: A3 Lecture, Zhejiang University
  • Invited
• [Presentation] Natural Product Derivatives for Controlling Stem Cells (2018)
  • Author(s): Motonari Uesugi
  • Organizer: 6th International Symposium on Marine Drugs in the Yangtze River Delta
  • Int'l Joint Research / Invited
• [Presentation] Self-Assembling Bioactive Molecules (2018)
  • Author(s): Motonari Uesugi
  • Organizer: The 3rd A3 Roundtable Meeting on Chemical Probe Research Hub
  • Int'l Joint Research / Invited
• [Presentation] エネルギー代謝を制御する小分子化合物 (2018)
  • Author(s): 上杉 志成
  • Organizer: 第4回Neo Vitamin D Workshop
  • Invited
• [Presentation] Synthetic Molecules for Detecting and Eliminating Human Pluripotent Stem Cells (2018)
  • Author(s): Motonari Uesugi
  • Organizer: IBS Conference on Molecular Recognition & Imaging in Complex System
  • Int'l Joint Research / Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2018)
  • Author(s): Motonari Uesugi
  • Organizer: BOSS XVI - 16th Belgian Organic Synthesis Symposium
  • Int'l Joint Research / Invited
• [Presentation] Self-Assembling Bioactive Molecules (2018)
  • Author(s): Motonari Uesugi
  • Organizer: 日本ケミカルバイオロジー学会 第13回年会
  • Int'l Joint Research / Invited
• [Presentation] Small Molecules That Control Lipid Homeostasis (2018)
  • Author(s): Motonari Uesugi
  • Organizer: The 24th IUBMB and 15th FAOBMB Congress
  • Int'l Joint Research / Invited
• [Presentation] 25‐hydroxyvitamin D and Lipid Metabolism (2018)
  • Author(s): Motonari Uesugi
  • Organizer: The 21st Workshop on Vitamin D
  • Int'l Joint Research / Invited
• [Presentation] 脂質代謝ケミカルバイオロジー (2018)
  • Author(s): 上杉 志成
  • Organizer: 第91回 日本内分泌学会学術総会
  • Invited
• [Presentation] New Opportunities of Synthetic Bioactive Molecules (2018)
  • Author(s): Motonari Uesugi
  • Organizer: POSTECH Seminar
  • Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2018)
  • Author(s): Motonari Uesugi
  • Organizer: UNIST Seminar
  • Invited
• [Presentation] Functionalization of mesenchymal stem cells with an anticancer agent using the avidin-biotin complex method (2018)
  • Author(s): Yukiya Takayama, Kosuke Kusamori, Makiya Nishikawa
  • Organizer: International Symposium of Tokyo University of Science, Translational Research (TR) Center
  • Int'l Joint Research
• [Presentation] Development of mesenchymal stem cells modified with doxorubicin-loaded liposomes for cancer therapy (2018)
  • Author(s): Yukiya Takayama, Kosuke Kusamori, Makiya Nishikawa
  • Organizer: Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress 2018
  • Int'l Joint Research
• [Presentation] ドキソルビシン封入リポソーム修飾間葉系幹細胞の抗腫瘍効果 (2018)
  • Author(s): 高山 幸也、草森 浩輔、勝見 英正、坂根 稔康、山本 昌、西川 元也
  • Organizer: 第34回日本DDS学会学術集会
• [Presentation] Development of doxorubicin-loaded liposome-modified mesenchymal stem cells for cancer therapy (2018)
  • Author(s): Yukiya Takayama, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto, Makiya Nishikawa
  • Organizer: 第41回日本基礎老化学会大会・日韓老化学会合同シンポジウムおよび第9回東京理科大学総合研究院TRシンポジウム
  • Int'l Joint Research
• [Presentation] 生理活性合成化合物の新しい世界 (2018)
  • Author(s): 上杉 志成
  • Organizer: 平成29年度クラスター・概算合同シンポジウム
  • Invited
• [Presentation] 脂質合成を遮断する小分子化合物 (2018)
  • Author(s): 上杉 志成
  • Organizer: 日本農芸化学会大会2018
  • Invited
• [Presentation] 「おもしろい」の３法則 (2018)
  • Author(s): 上杉 志成
  • Organizer: 平成29年度PRIME会議「画期的医薬品等の創出をめざす脂質の生理活性と機能の解明」研究開発領域
  • Invited
• [Presentation] 細胞を操る合成化合物 (2018)
  • Author(s): 上杉 志成
  • Organizer: 第5回 Medical Frontier Consortium beyond the Organcentric Dogma
  • Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2017)
  • Author(s): Uesugi, M.
  • Organizer: Special Seminar, Institut de Recherche Servier
  • Place of Presentation: Crossiy (France)
  • Year and Date: 2017-01-31
  • Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2017)
  • Author(s): Uesugi, M.
  • Organizer: Department Seminar, University of Oxford
  • Place of Presentation: Oxford (UK)
  • Year and Date: 2017-01-30
  • Invited
• [Presentation] RNA G-Quadruplex Stabilizer (2017)
  • Author(s): Uesugi, M.
  • Organizer: Asian Chemical Biology Initiative 2017 Ho Chi Minh Meeting
  • Place of Presentation: Ho Chi Minh City (Vietnam)
  • Year and Date: 2017-01-20
  • Int'l Joint Research / Invited
• [Presentation] Synthetic Small-Molecule Tools for Cell Biology (2017)
  • Author(s): Uesugi, M.
  • Organizer: RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 6th Symposium
  • Int'l Joint Research / Invited
• [Presentation] 細胞を操る合成化合物 (2017)
  • Author(s): 上杉 志成
  • Organizer: 第27回 万有福岡シンポジウム 革新的新薬・新物質の創製 今こそ有機化学の力を結集せよ
  • Invited
• [Presentation] Chemical Biology Research: Basics and Examples (2017)
  • Author(s): Uesugi, M.
  • Organizer: Amgen Scholars Program Seminar
  • Invited
• [Presentation] ケミカルバイオロジーが拓く研究と教育の世界 (2017)
  • Author(s): 上杉 志成
  • Organizer: 長野県科学教育研究大会
  • Invited
• [Presentation] ビタミンＤによる脂質代謝調節 (2017)
  • Author(s): 上杉 志成
  • Organizer: 第６４回日本栄養改善学会学術集会 日本栄養改善学会・日本ビタミン学会合同シンポジウム 「ビタミン・ミネラル研究の最前線」
  • Invited
• [Presentation] Chemical Biology Research: Basics and Examples (2017)
  • Author(s): Uesugi, M.
  • Organizer: Special Lecture, UST Biochemistry
  • Int'l Joint Research / Invited
• [Presentation] Chemical Biology Research: Basics and Examples (2017)
  • Author(s): Uesugi, M.
  • Organizer: Special Lecture, University of the Philippines, Diliman
  • Int'l Joint Research / Invited
• [Presentation] 面白いの法則 (2017)
  • Author(s): 上杉 志成
  • Organizer: 早稲田大学講演
  • Int'l Joint Research / Invited
• [Presentation] 細胞を操る合成化合物 (2017)
  • Author(s): 上杉 志成
  • Organizer: 平成29年度秋季（後期）有機合成化学講習会
  • Invited
• [Presentation] Synthetic Small-Molecule Tools for Cell Biology and Cell Therapy (2017)
  • Author(s): Uesugi, M.
  • Organizer: AFPS2017 Integration, Improvement and Innovation toward Targeted Drug Discovery
  • Int'l Joint Research / Invited
• [Presentation] Synthetic Small-Molecule Tools for Cell Biology (2017)
  • Author(s): Uesugi, M.
  • Organizer: The Second A3 Roundtable Meeting on Asia Chemical Probe Research Hub
  • Int'l Joint Research / Invited
• [Presentation] Synthetic Molecules for Detecting and Eliminating Human Pluripotent Stem Cells (2017)
  • Author(s): 上杉 志成
  • Organizer: 日本薬物動態学会第32回年会
  • Invited
• [Presentation] 細胞を操る合成化合物 (2016)
  • Author(s): 上杉 志成
  • Organizer: 第39回日本分子生物学会年会 最先端の化学と生物学のミックス
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-11-30
  • Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2016)
  • Author(s): Uesugi, M.
  • Organizer: Special Seminar, Department of Chemistry, Tsinghua University
  • Place of Presentation: Beijing (China)
  • Year and Date: 2016-11-18
  • Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2016)
  • Author(s): Uesugi, M.
  • Organizer: Research Seminar, College of Chemistry and School of Pharmaceutical Science, Peking University
  • Place of Presentation: Beijing (China)
  • Year and Date: 2016-11-17
  • Invited
• [Presentation] Chemical Biology Research: Basics and Examples (2016)
  • Author(s): Uesugi, M.
  • Organizer: Tutorial Seminar, Peking-Tsinghua Center for Life Sciences (CLS)
  • Place of Presentation: Beijing (China)
  • Year and Date: 2016-11-16
  • Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2016)
  • Author(s): Uesugi, M.
  • Organizer: Research Seminar, Peking-Tsinghua Center for Life Sciences (CLS)
  • Place of Presentation: Beijing (China)
  • Year and Date: 2016-11-16
  • Invited
• [Presentation] Chemical Biology Research: Basics and Examples (2016)
  • Author(s): Uesugi, M.
  • Organizer: 京都府立医科大学医薬品化学特別講演会
  • Place of Presentation: 京都府立医科大学(京都府・京都市)
  • Year and Date: 2016-11-04
  • Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2016)
  • Author(s): Uesugi, M.
  • Organizer: Special Seminar, Department of Chemistry, Sookmyung Women's University
  • Place of Presentation: Seoul (South Korea)
  • Year and Date: 2016-11-01
  • Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2016)
  • Author(s): Uesugi, M.
  • Organizer: Special Seminar, Department of Chemistry, Seoul National University
  • Place of Presentation: Seoul (South Korea)
  • Year and Date: 2016-10-31
  • Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2016)
  • Author(s): Uesugi, M.
  • Organizer: Nano/Bioscience International Symposium
  • Place of Presentation: 同志社大学京田辺キャンパス(京都府・京田辺市)
  • Year and Date: 2016-10-07
  • Int'l Joint Research / Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2016)
  • Author(s): Uesugi, M.
  • Organizer: Asian 3 Roundtable on Nucleic Acids and Chemical Probe Research Hub, Fukuoka 2016 (A3 RONA & CPRH)
  • Place of Presentation: レオパレスホテル博多(福岡県・福岡市)
  • Year and Date: 2016-09-22
  • Int'l Joint Research / Invited
• [Presentation] Chemical Biology Research: Basics and Examples (2016)
  • Author(s): Uesugi, M.
  • Organizer: Special Seminar, Institute of Chemistry and Chemical Technology, Mongolian Academy of Science
  • Place of Presentation: Ulaanbaatar (Mongolia)
  • Year and Date: 2016-09-19
  • Invited
• [Presentation] 生物活性化合物の新しい世界 (2016)
  • Author(s): 上杉 志成
  • Organizer: 第2回 Neo Vitamin D Workshop学術集会
  • Place of Presentation: TKPガーデンシティ品川(東京都・品川区)
  • Year and Date: 2016-08-26
  • Invited
• [Presentation] 生物活性化合物の新しい世界 (2016)
  • Author(s): 上杉 志成
  • Organizer: 京都市成長産業創造センターフォーラム
  • Place of Presentation: 京都市成長産業創造センター(京都府・京都市)
  • Year and Date: 2016-08-04
  • Invited
• [Presentation] Chemical Biology Research: Basics and Examples (2016)
  • Author(s): Uesugi, M.
  • Organizer: Special Lecture, University of Science, VNU-HCM City
  • Place of Presentation: Ho Chi Minh City (Vietnam)
  • Year and Date: 2016-06-13
  • Invited
• [Presentation] Synthetic Molecules for Cell Therapy (2016)
  • Author(s): Uesugi, M.
  • Organizer: 2016 Queenstown Molecular Biology Meetings in Shanghai
  • Place of Presentation: Shanghai (China)
  • Year and Date: 2016-03-17
  • Int'l Joint Research / Invited
• [Presentation] Synthetic Molecules for Detecting and Eliminating Human Pluripotent Stem Cells (2016)
  • Author(s): Uesugi, M.
  • Organizer: ABC2016 - 6th Special Meeting on ABC Proteins
  • Place of Presentation: Innsbruck (Austria)
  • Year and Date: 2016-03-05
  • Int'l Joint Research / Invited
• [Presentation] 生理活性化合物の新しい世界 (2016)
  • Author(s): 上杉 志成
  • Organizer: 第108回分子科学フォーラム 市民公開講座
  • Place of Presentation: 岡崎コンファレンスセンター（愛知県岡崎市)
  • Year and Date: 2016-02-05
  • Invited
• [Presentation] Synthetic Molecules for Eliminating Human Pluripotent Stem Cells (2016)
  • Author(s): Uesugi, M.
  • Organizer: ACBI 2016 Jakarta Meeting
  • Place of Presentation: Jakarta (Indonesia)
  • Year and Date: 2016-01-29
  • Int'l Joint Research / Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2016)
  • Author(s): Uesugi, M.
  • Organizer: The 8th Takeda Science Foundation Symposium on PharmaSciences
  • Place of Presentation: 武田薬品研修所（大阪府吹田市）
  • Year and Date: 2016-01-21
  • Int'l Joint Research / Invited
• [Presentation] Small Molecule Tools for Cell Biology and Cell Therapy (2015)
  • Author(s): Uesugi, M.
  • Organizer: Pacifichem 2015 Natural Product-based Drug Discovery
  • Place of Presentation: Honolulu (USA)
  • Year and Date: 2015-12-15
  • Int'l Joint Research / Invited
• [Presentation] Small Molecules That Modulate Protein Assemblies (2015)
  • Author(s): Uesugi, M.
  • Organizer: Pacifichem 2015 Synthetic Modulators of Protein-Protein Interactions
  • Place of Presentation: Honolulu (USA)
  • Year and Date: 2015-12-15
  • Int'l Joint Research / Invited
• [Presentation] 細胞を操る合成化合物 (2015)
  • Author(s): 上杉 志成
  • Organizer: 岡崎統合バイオサイエンスセンター 生命時空間設計研究領域 心循環シグナル研究部門公開セミナー
  • Place of Presentation: 岡崎統合バイオサイエンスセンター(愛知県岡崎市)
  • Year and Date: 2015-12-12
  • Invited
• [Presentation] 嫌いなものにチャンスがある！：ケミカルバイオロジーとは？ (2015)
  • Author(s): 上杉 志成
  • Organizer: BMB2015市民公開講座
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-12-04
  • Invited
• [Presentation] Synthetic Molecules for Detecting and Eliminating Human Pluripotent Stem Cells (2015)
  • Author(s): Uesugi, M.
  • Organizer: NEA & ASIAHORCs Joint Symposium - Chemical Biology - in Okinawa
  • Place of Presentation: 沖縄科学技術大学院大学(沖縄県国頭郡)
  • Year and Date: 2015-11-08
  • Int'l Joint Research / Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2015)
  • Author(s): Uesugi, M.
  • Organizer: XVII NOST-Organic Chemistry Conference
  • Place of Presentation: Jaipur (India)
  • Year and Date: 2015-10-27
  • Int'l Joint Research / Invited
• [Presentation] Small Molecule Tools for Cell Biology and Cell Therapy (2015)
  • Author(s): Uesugi, M.
  • Organizer: 2015 Fall Annual Convention of Pharmaceutical Society of Korea
  • Place of Presentation: Daegu (Korea)
  • Year and Date: 2015-10-22
  • Int'l Joint Research / Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2015)
  • Author(s): Uesugi, M.
  • Organizer: AIMECS 2015 (10th AFMC International Medicinal Chemistry Symposium in 2015)
  • Place of Presentation: Jeju (Korea)
  • Year and Date: 2015-10-18
  • Int'l Joint Research / Invited
• [Presentation] 生理活性合成化合物のケミカルバイオロジーが開く新しい世界 (2015)
  • Author(s): 上杉 志成
  • Organizer: 日本化学会秋季事業- 第5回CSJ化学フェスタ2015
  • Place of Presentation: タワーホール船堀(東京都江戸川区)
  • Year and Date: 2015-10-15
  • Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2015)
  • Author(s): Uesugi, M.
  • Organizer: IUPAC2015
  • Place of Presentation: Busan (Korea)
  • Year and Date: 2015-08-10
  • Int'l Joint Research / Invited
• [Presentation] くすりの形 (2015)
  • Author(s): 上杉 志成
  • Organizer: 京都大学化学研究所 第18回高校生のための化学
  • Place of Presentation: 京都大学宇治キャンパス（京都府宇治市)
  • Year and Date: 2015-07-25
  • Invited
• [Presentation] 細胞治療を助ける合成化合物 (2015)
  • Author(s): 上杉 志成
  • Organizer: 第52回薬剤学懇談会研究討論会
  • Place of Presentation: 瑠璃光(石川県加賀市)
  • Year and Date: 2015-07-17
  • Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2015)
  • Author(s): Uesugi, M.
  • Organizer: The 51th International Conference on Medicinal Chemistry (RICT 2015) - "Drug Discovery and Selection - Understanding Targets and Mechanisms
  • Place of Presentation: Avignon (France)
  • Year and Date: 2015-07-01
  • Int'l Joint Research / Invited
• [Presentation] 細胞を操作する合成化合物 (2015)
  • Author(s): 上杉 志成
  • Organizer: 第10回理研シンポジウム：第10回有機合成化学のフロンティア
  • Place of Presentation: 理化学研究所和光事業所(埼玉県和光市)
  • Year and Date: 2015-06-26
  • Invited
• [Presentation] Introduction of Chemical Biology (2015)
  • Author(s): Motonari Uesugi
  • Organizer: Cell Biology, Developmental Biology, and Systems Biology Course Meeting
  • Place of Presentation: 京都大学(京都市)
  • Year and Date: 2015-02-13
  • Invited
• [Presentation] 細胞を操作・検出する合成小分子化合物 (2015)
  • Author(s): 上杉 志成
  • Organizer: 近畿化学協会機能性色素部会 第88回例会「未来をつくる機能性色素･･･その技術と応用･･･」
  • Place of Presentation: 大阪科学技術センター(大阪市)
  • Year and Date: 2015-01-12
  • Invited
• [Presentation] Introuction to Chemical Biology (2014)
  • Author(s): Motonari Uesugi
  • Organizer: Asian Chemical Biology Initiative 2014 Kota Kinabalu Meeting: Open Tutorial Lectures
  • Place of Presentation: Kota Kinabalu (Malaysia)
  • Year and Date: 2014-12-19
  • Invited
• [Presentation] Small Molecule Tools for Cell Biology and Cell Therapy (2014)
  • Author(s): Motonari Uesugi
  • Organizer: Institute of Molecular and Cell Biology (IMCB) Seminar
  • Place of Presentation: Singapore
  • Year and Date: 2014-12-17
  • Invited
• [Presentation] Small molecule tools for cell therapy (2014)
  • Author(s): Motonari Uesugi
  • Organizer: The 3rd Asian Chemical Biology Conference
  • Place of Presentation: Singapore
  • Year and Date: 2014-12-15 – 2014-12-17
  • Invited
• [Presentation] Small Molecule Tools for Cell Biology and Cell Therapy (2014)
  • Author(s): Motonari Uesugi
  • Organizer: Nanjing University School of Life Sciences Seminar
  • Place of Presentation: Nanjing (China)
  • Year and Date: 2014-11-26
  • Invited
• [Presentation] Small Molecule Tools for Cell Biology and Cell Therapy (2014)
  • Author(s): Motonari Uesugi
  • Organizer: Asian Chemical Biology Initiative 2014 Hangzhou Meeting
  • Place of Presentation: Hangzhou (China)
  • Year and Date: 2014-11-22 – 2014-11-25
  • Invited
• [Presentation] Small molecule tools for cell biology and cell therapy (2014)
  • Author(s): Motonari Uesugi
  • Organizer: Chinese National Compound Library 2014 Seminar Series
  • Place of Presentation: Shanghai (China)
  • Year and Date: 2014-11-21
  • Invited
• [Presentation] New Functions of Endogenous Lipid Molecules and Their Modulation (2014)
  • Author(s): Motonari Uesugi
  • Organizer: The 3rd International Symposium on Chemical Biology of Natural Products
  • Place of Presentation: 千里ライフサイエンスセンター(吹田市)
  • Year and Date: 2014-10-28 – 2014-10-29
  • Invited
• [Presentation] Small Molecules That Detect and Remove Human Pluripotent Stem Cells (2014)
  • Author(s): Motonari Uesugi
  • Organizer: Sino-Japan Workshop on Chemical Biology
  • Place of Presentation: Beijing (China)
  • Year and Date: 2014-10-10 – 2014-10-13
  • Invited
• [Presentation] Small Molecule Tools That Detect and Remove Human Pluripotent Stem Cells (2014)
  • Author(s): Motonari Uesugi
  • Organizer: 11th China-Japan Joint Seminar on Histochemistry and Cytochemistry
  • Place of Presentation: 松本市中央公民館(松本市)
  • Year and Date: 2014-09-28 – 2014-09-29
  • Invited
• [Presentation] Small Molecule Tools for Cell Therapy (2014)
  • Author(s): Motonari Uesugi
  • Organizer: Forth Norman Bethune International Forum on Medical Sciences
  • Place of Presentation: Jilin (China)
  • Year and Date: 2014-09-20 – 2014-09-22
  • Invited
• [Presentation] 生理活性合成化合物の新しい世界 (2014)
  • Author(s): 上杉 志成
  • Organizer: 第31回有機合成化学セミナー
  • Place of Presentation: 休暇村志賀島(福岡市)
  • Year and Date: 2014-09-17 – 2014-09-19
  • Invited
• [Presentation] 細胞を操作・検出する合成小分子化合物 (2014)
  • Author(s): 上杉 志成
  • Organizer: 東京農工大学工学府講演会
  • Place of Presentation: 東京農工大学(小金井市)
  • Year and Date: 2014-07-25
  • Invited
• [Presentation] 細胞治療を助ける合成化合物 (2014)
  • Author(s): 上杉 志成
  • Organizer: 創薬科学研究センターシンポジウム2014有機合成によるアンメット・メディカルニーズに応える医薬品開発
  • Place of Presentation: 立命館大学(草津市)
  • Year and Date: 2014-07-11
  • Invited
• [Presentation] Introduction of Chemical Biology, Small-Molecule Tools for Cell Biology and Cell Therapy (2014)
  • Author(s): Motonari Uesugi
  • Organizer: Asian Chemical Biology Initiative-Sponsored Lectures
  • Place of Presentation: Hanoi (Vietnam)
  • Year and Date: 2014-07-01
  • Invited
• [Presentation] Small Molecule Tools for Cell Biology and Cell Therapy (2014)
  • Author(s): Motonari Uesugi
  • Organizer: 東京大学大学院理学系化学専攻第1527回雑誌会セミナー
  • Place of Presentation: 東京大学(東京都文京区)
  • Year and Date: 2014-06-20
  • Invited
• [Presentation] 脂質合成を遮断する小分子化合物 (2014)
  • Author(s): 上杉 志成
  • Organizer: 小野医学研究財団 第25回研究成果発表会
  • Place of Presentation: 千里ライフサイエンスセンター(豊中市)
  • Year and Date: 2014-06-07
  • Invited
• [Book] ビオチン化体を利用した生化学的標的タンパク質精製法 (2015)
  • Author(s): 佐藤慎一、勝田陽介、上杉志成
  • Total Pages: 5
  • Publisher: 化学同人
• [Remarks] 京都大学化学研究所上杉研究室
  • URL: https://www.scl.kyoto-u.ac.jp/~uesugi/ja/index.php
• [Remarks] 東京理科大学薬学部生物薬剤学
  • URL: http://www.rs.tus.ac.jp/nishikawa_lab/
• [Remarks] 京都大学化学研究所・iCeMS 上杉研究室
  • URL: http://www.scl.kyoto-u.ac.jp/~uesugi/
• [Remarks] 東京理科大学薬学部生物薬剤学 西川研究室
  • URL: http://www.rs.tus.ac.jp/nishikawa_lab/
• [Remarks] 京都大学物質－細胞統合システム拠点・化学研究所 上杉研究室
  • URL: http://www.scl.kyoto-u.ac.jp/~uesugi/
• [Remarks] 京都大学iCeMS・化学研究所 上杉研究室
  • URL: http://www.scl.kyoto-u.ac.jp/~uesugi/
• [Patent(Industrial Property Rights)] 細胞移植を効率化する化合物 (2019)
  • Inventor(s): 上杉志成、高嶋一平、西川元也
  • Industrial Property Rights Holder: 国立大学法人京都大学、学校法人東京理科大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
  • Overseas
• [Patent(Industrial Property Rights)] Cell Cycle Progression Inhibitor (2019)
  • Inventor(s): 上杉志成、ペロンアメリ、児玉裕三
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
  • Overseas
• [Patent(Industrial Property Rights)] 免疫を賦活化する自己集合体 (2018)
  • Inventor(s): 上杉志成、フエ・ティ・ブー、吉田大樹、山崎晶、島根徹
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-161582
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] Nutrient Conjugates (2018)
  • Inventor(s): 上杉志成、古田智行、西川元也
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2019-007537
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] 細胞移植を効率化する化合物 (2018)
  • Inventor(s): 上杉志成、高嶋一平、西川元也
  • Industrial Property Rights Holder: 上杉志成、高嶋一平、西川元也
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-053515
  • Filing Date: 2018