• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of analysis method of accurate mass data for monitoring chemicals in environment

Research Project

Project/Area Number 26241026
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental risk control and evaluation
Research InstitutionNational Institute for Environmental Studies

Principal Investigator

HASHIMOTO Shunji  国立研究開発法人国立環境研究所, 環境計測研究センター, 室長 (80321719)

Co-Investigator(Kenkyū-buntansha) 大塚 宜寿  埼玉県環境科学国際センター, 化学物質担当, 研究員 (30415393)
山本 敦史  大阪市立環境科学研究所, 調査研究課, 研究員 (40332449)
高澤 嘉一  国立研究開発法人国立環境研究所, 環境計測研究センター, 主任研究員 (40391122)
柏木 宣久  統計数理研究所, 大学共同利用機関等の部局等, 教授 (50150032)
田邊 潔  国立研究開発法人国立環境研究所, 環境計測研究センター, フェロー (60150174)
頭士 泰之  国立研究開発法人産業技術総合研究所, 排出暴露解析グループ, 研究員 (80611780)
Co-Investigator(Renkei-kenkyūsha) ANAZAKI Katsunori  北海道立総合研究機構, 環境・地質研究本部・環境科学研究センター・環境保全部, 研究主任 (20442634)
OOHARA Toshihiko  広島県立総合技術研究所, 保健環境センター・環境研究部, 研究部長 (20419930)
Research Collaborator HANNO Katsumasa  千葉県環境研究センター, 水質環境研究室, 室長
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥30,680,000 (Direct Cost: ¥23,600,000、Indirect Cost: ¥7,080,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2014: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Keywords環境モニタリング / 精密質量 / ノンターゲット分析 / 網羅分析 / 迅速分析 / 未知物質 / インフォマティクス / データ解析 / 多次元分離技術 / ノンターゲット / 異常の検出 / 次世代モニタリング / 精密質量分析 / 早期警戒 / 網羅的モニタリング
Outline of Final Research Achievements

Air or water samples collected onto solid phase sampler were directly introduced into an instrument by thermal desorption due to achieve rapid and non-targeted analysis. A comprehensive gas chromatography-high resolution time-of-flight mass spectrometry (GC×GC-HRToFMS) was effective for precious separation of huge number of chemicals in samples. Exact mass measurement made it possible to select chemicals by post data processing such as mass defect filtration that was especially effective to remove hydrocarbons from a data. And reliable estimation of unknown chemicals required above 30,000 of mass resolution. Non-negative matrix factorization (NMF) was applied to detection of data difference and compensation method of retention times of each two-dimensional chromatograms from GC×GC-HRToFMS, which was essential to data comparison, was also developed in this study. Consequently, rapid and informative non-targeted environmental monitoring method was developed based on GC-HRTofMS.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (21 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 6 results,  Open Access: 4 results) Presentation (15 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Revaluation of stockpile amount of PFOS-containing aqueous film-forming foam in Japan: gaps and pitfalls in the stockpile survey2017

    • Author(s)
      Zushi, Y., Yamamoto, A., Tsunemi, K., Masunaga, S.
    • Journal Title

      Environ. Sci. Pollut. Res.

      Volume: 24 Issue: 7 Pages: 6736-6745

    • DOI

      10.1007/s11356-017-8374-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nontarget approach for environmental monitoring by GC x GC-HRTOMFS in the Tokyo Bay basin2016

    • Author(s)
      Zushi, Y., Hashimoto, S., Tanabe, K
    • Journal Title

      Chemosphere

      Volume: 156 Pages: 398-406

    • DOI

      10.1016/j.chemosphere.2016.04.131

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification of Anthropogenic Compounds in Urban Environments and Evaluation of Automated Methods for Reading Fragmentation2016

    • Author(s)
      Yamamoto, A., Matsumoto, N., Kawasaki, H., Arakawa, R.
    • Journal Title

      Mass Spectrometry

      Volume: 5 Issue: 1 Pages: A0045-A0045

    • DOI

      10.5702/massspectrometry.A0045

    • NAID

      130005155909

    • ISSN
      2186-5116, 2187-137X
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Selective and comprehensive analysis of organohalogen compounds by GC×GC-HRTofMS and MS/MS2015

    • Author(s)
      Hashimoto S., Zushi Y., Takazawa Y., IEDA T., Fushimi A., Tanabe K., Shibata Y.
    • Journal Title

      Environmental Science and Pollution Research

      Volume: open Issue: 8 Pages: 1-12

    • DOI

      10.1007/s11356-015-5059-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Global Spectral Deconvolution Based on Non-Negative Matrix Factorization in GC x GC-HRTOFMS2015

    • Author(s)
      Zushi Y., Hashimoto S., Tanabe K.
    • Journal Title

      Analytical Chemistry

      Volume: 87 Pages: 1829-1838

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Use of high-resolution mass spectrometry to identify precursors and biodegradation products of perfluorinated and polyfluorinated compounds in end-user products2014

    • Author(s)
      Yamamoto, Atsushi; Hisatomi, Hirotaka; Ando, Tomoshige; Takemine, Shusuke; Terao, Tomoko; Tojo, Toshiki; Yagi, Masahiro; Ono, Daisuke; Kawasaki, Hideya; Arakawa, Ryuichi
    • Journal Title

      Anal. Bioanal. Chem.

      Volume: 406 Issue: 19 Pages: 4745-4755

    • DOI

      10.1007/s00216-014-7862-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Data Processing Based on Exact Mass Spectra for Non-Target Monitoring by Using GCxGC/HRTofMS2016

    • Author(s)
      Hashimoto S., Ieda T., Takazawa Y., Tanabe K., Shibata Y., Zushi Y.
    • Organizer
      36th International Symposium on Halogenated Persistent Organic Pollutants
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2016-08-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comprehensive analysis of house dust using GC×GC-HRTOFMS and in-house software2016

    • Author(s)
      Ieda T., Hashimoto S., Takazawa Y., Tanabe K., Zushi Y., Shibata Y., Maekawa F., Sano K., Suzuki G., Nakayama S., Isobe T., Tin-Tin-Win-Shwe, Kawashima T.
    • Organizer
      36th International Symposium on Halogenated Persistent Organic Pollutants
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2016-08-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reading of accurate mass spectra to find anthropogenic substances in the environment2016

    • Author(s)
      Yamamoto, A., Matsumoto, N., Kawasaki, H., Arakawa, R.
    • Organizer
      21st International Mass Spectrometry Conference
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CxGC-HRTOFMSによるノンターゲットモニタリングのための差の解析法の検討2016

    • Author(s)
      橋本俊次, 高澤嘉一, 田邊潔, 柴田康行, 頭士泰之, 大塚宜寿
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      新潟コンベンションセンター(新潟)
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 複雑混合物のリスク評価のための手法提案2016

    • Author(s)
      頭士泰之, 山取由樹, 加茂将史, 恒見清孝
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      新潟コンベンションセンター(新潟)
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] ネオニコチノイド系殺虫剤の埼玉県からの流出量の推計2016

    • Author(s)
      大塚宜寿, 蓑毛康太郎, 茂木守, 野尻喜好, 堀井勇一
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      新潟コンベンションセンター(新潟)
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 埼玉県の野通川におけるネオニコチノイド系殺虫剤の季節変動2016

    • Author(s)
      埼玉県の野通川におけるネオニコチノイド系殺虫剤の季節変動大塚宜寿, 竹峰秀祐, 蓑毛康太郎, 野尻喜好, 茂木守, 堀井勇一
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      新潟コンベンションセンター(新潟)
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] GCxGC-HRTofMSによる環境ノンターゲット分析の試み2016

    • Author(s)
      橋本俊次, 家田曜世, 高澤嘉一, 田邊潔, 柴田康行, 頭士泰之
    • Organizer
      第64回質量分析総合討論会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Non-target analysis by GC × GC-HRTOFMS and its application to emission source analysis of the detected contaminants using GIS2015

    • Author(s)
      Yasuyuki ZUSHI, Shunji HASHIMOTO, Kiyoshi TANABE
    • Organizer
      SETAC North America 36th Annual Meeting
    • Place of Presentation
      Salt Palace Convention Center, Salt Lake City, USA
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Selective and Comprehensive Analysis of Organohalogens by GCxGC-HRTOFMS2015

    • Author(s)
      3.Hashimoto S., IEDA T., Takazawa Y., Tanabe K., Shibata Y., Zushi Y.
    • Organizer
      International Network of Environmental Foresics Conference (The INEF2015)
    • Place of Presentation
      Victoria College, Toronto, Canada
    • Year and Date
      2015-08-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 各種イオン化法とソフトウェアを用いたGCxGC-HRTOFMSによる環境試料中のハロゲン化合物検索の検討2015

    • Author(s)
      橋本俊次, 家田曜世, 高澤嘉一, 田邊潔, 柴田康行, 佐々木裕子, 頭士泰之
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] ノンターゲット分析とGISを組み合わせた環境中存在物質の排出源解析2015

    • Author(s)
      頭士泰之, 橋本俊次, 田邊潔
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 災害時における大気中有害化学物質の探索的・迅速サンプリング手法の予備的検討2015

    • Author(s)
      6.高澤嘉一, 家田曜世, 橋本俊次, 田邊潔, 柴田康行, 頭士泰之
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 災害時におけるGC×GC-HRTOF-MSを用いた多成分網羅分析手法の適用-基礎検討-2015

    • Author(s)
      家田曜世, 高澤嘉一, 橋本俊次, 田邊潔, 柴田康行
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of chemical structures of polyfluoroalkyl substances in fire extinguishing chemicals by using high resolution mass spectrometry2014

    • Author(s)
      Yamamoto, Atsushi; Kitai, Shiho; Zushi, Yasuyuki; Masunaga, Shigeki; Kawasaki, Hideya; Arakawa, Ryuichi
    • Organizer
      20th International Mass Spectrometry Conference
    • Place of Presentation
      Geneva, Swiss
    • Year and Date
      2014-08-24 – 2014-08-29
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi