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Neural control mechanisms during gaze and posture in health and disease

Research Project

Project/Area Number 26242041
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionOsaka University

Principal Investigator

Nomura Taishin  大阪大学, 基礎工学研究科, 教授 (50283734)

Co-Investigator(Kenkyū-buntansha) 佐古田 三郎  独立行政法人国立病院機構刀根山病院(臨床研究部), その他部局等, 病院長 (00178625)
望月 秀樹  大阪大学, 医学(系)研究科(研究院), 教授 (90230044)
小林 康  大阪大学, 生命機能研究科, 准教授 (60311198)
清野 健  大阪大学, 基礎工学研究科, 准教授 (40434071)
鈴木 康之  大阪大学, 基礎工学研究科, 助教 (30631874)
Project Period (FY) 2014-06-27 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2016: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2015: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2014: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Keywords運動制御 / 計算論的神経科学 / 姿勢制御 / 歩行 / 眼球運動 / 非線形制御 / ゆらぎ / パーキンソン病 / 生体医工学 / 生体生命情報学 / 生体シミュレーション / 生体運動制御 / 非線形システム / 生物・生体工学 / 生体計測 / システム生理学 / 間欠制御 / 姿勢動揺 / 固視微動 / 非ガウス性 / 拡散解析 / 臨界現象 / 生体ゆらぎ / 歩行リズム
Outline of Final Research Achievements

In this study, we aimed at elucidating neural mechanisms for stabilizing quiet stance, bipedal walking, and gaze fixation, as well as dynamical pathomechanism of destabilization of those postural control in patients with Parkinson's disease. To this end, we analyzed postural sway, gait stride variability, and fixational eye movement, and showed that these fluctuations can be characterized by long-range correlation and non-Gaussianity. Moreover, we proposed dynamical system models that could simulate such movement variabilities. Based on those analysis, we suggested that the central nervous system stabilize those steady states by intermittent controllers that exploit unstable dynamics of body and eye ball, and loss of intermittency in the control signals could be one of major causes of postural instability in patients with Parkinson's disease.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(44 results)

All 2016 2015 2014 Other

All Int'l Joint Research Journal Article Presentation Book Funded Workshop

  • [Int'l Joint Research] Italian Institute of Technology(Italy)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Italian Institute of Technology/University of Genoa(Italy)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] North Carolina State University(United States of America)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Dynamic determinants of the uncontrolled manifold during human quiet stance2016

    • Author(s)
      Yasuyuki Suzuki, Hiroki Morimoto, Ken Kiyono, Pietro G Morasso, Taishin Nomura
    • Journal Title

      frontiers in Human Neuroscience

      Volume: 10 Pages: 618-618

    • DOI

      10.3389/fnhum.2016.00618

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Reinforcement learning for stabilizing an inverted pendulum naturally leads to intermittent feedback control as in human quiet standing2016

    • Author(s)
      Kenjiro Michimoto, Yasuyuki Suzuki, Ken Kiyono, Yasushi Kobayashi, Pietro Morasso, Taishin Nomura
    • Journal Title

      Engineering in Medicine and Biology Society (EMBC), 2016 IEEE 38th Annual International Conference

      Volume: - Pages: 37-40

    • DOI

      10.1109/embc.2016.7590634

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Postural flexibility during quiet standing in healthy elderly and patients with Parkinson's disease2016

    • Author(s)
      Kazuyuki Matsuda, Yasuyuki Suzuki, Naoya Yoshikawa, Tomohisa Yamamoto, Ken Kiyono, Takao Tanahashi, Takuyuki Endo, Kei Fukada, Kunihiko Nomura, Saburo Sakoda, Taishin Nomura
    • Journal Title

      Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2016

      Volume: - Pages: 29-32

    • DOI

      10.1109/embc.2016.7590632

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The brain can mix different control strategies in a task-oriented and multi-referential manner: A simulation study2016

    • Author(s)
      Pietro Morasso, Taishin Nomura, Yasuyuki Suzuki, Jacopo Zenzeri
    • Journal Title

      Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2016

      Volume: - Pages: 9-12

    • DOI

      10.1109/embc.2016.7590627

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Pedunculopontine Tegmental Nucleus as a Motor and Cognitive Interface between the Cerebellum and Basal Ganglia2016

    • Author(s)
      Fumika Mori, Ken-ichi Okada, Taishin Nomura, Yasushi Kobayashi
    • Journal Title

      Frontiers in Neuroanatomy

      Volume: 10 Pages: 1-10

    • DOI

      10.3389/fnana.2016.00109

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intermittent feedback-control strategy for stabilizing inverted pendulum on manually controlled cart as analogy to human stick balancing2016

    • Author(s)
      Naoya Yoshikawa, Yasuyuki Suzuki, Ken Kiyono, Taishin Nomura
    • Journal Title

      frontiers in Computational Neuroscience

      Volume: 10 Pages: 3389-3389

    • DOI

      10.3389/fncom.2016.00034

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Stability and Flexibility During Human Motor Control2016

    • Author(s)
      Taishin Nomura, Yasuyuki Suzuki, Chunjiang Fu, Naoya Yoshikawa, Ken Kiyono, Maura Casadio, Pietro Morasso
    • Journal Title

      Advances in Cognitive Neurodynamics (V)

      Volume: 5 Pages: 67-73

    • DOI

      10.1007/978-981-10-0207-6_11

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A Model of Gait Cycle Variability During Human Walking2016

    • Author(s)
      Chunjiang Fu, Yasuyuki Suzuki, Ken Kiyono, Taishin Nomura
    • Journal Title

      Advances in Cognitive Neurodynamics (V)

      Volume: 5 Pages: 79084-79084

    • DOI

      10.1007/978-981-10-0207-6_13

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Universal and individual characteristics of postural sway during quiet standing in healthy young adults2015

    • Author(s)
      Tomohisa Yamamoto, Charles E. Smith, Yasuyuki Suzuki, Ken Kiyono, Takao Tanahashi, Saburo Sakoda, Pietro Morasso, Taishin Nomura
    • Journal Title

      Physiological Reports

      Volume: 3

    • DOI

      10.14814/phy2.12329

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Non-actively controlled double-inverted-pendulum-like dynamics can minimize center of mass acceleration during human quiet standing2015

    • Author(s)
      Y Suzuki, H Morimoto, K Kiyono, P Morasso, T Nomura
    • Journal Title

      37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

      Volume: 0 Pages: 1432-1435

    • DOI

      10.1109/embc.2015.7318638

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Intermittent appearances of saddle-type hyperbolic dynamics during human stick balancing on a manually controlled cart2015

    • Author(s)
      N Yoshikawa, Y Suzuki, K Kiyono, T Nomura
    • Journal Title

      37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

      Volume: 0 Pages: 3500-3053

    • DOI

      10.1109/embc.2015.7319147

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Gap Effect Abnormalities during a Visually Guided Pro-Saccade Task in Children with Attention Deficit Hyperactivity Disorder2015

    • Author(s)
      Matsuo Y, Watanabe M, Taniike M, Mohri I, Kobashi S, Tachibana M, Kobayashi Y, Kitamura Y.
    • Journal Title

      Plos ONE

      Volume: 10 Pages: 110-110

    • DOI

      10.1371/journal.pone.0125573

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Rhythmic Firing of Pedunculopontine Tegmental Nucleus Neurons in Monkeys during Eye Movement Task2015

    • Author(s)
      Okada KI, Kobayashi Y.
    • Journal Title

      PLoS ONE

      Volume: 10(6):e0128147 Pages: 110-110

    • DOI

      10.1371/journal.pone.0128147

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 安定かつ柔軟なヒト直立姿勢の神経制御仮説2015

    • Author(s)
      野村泰伸,鈴木康之,清野健,付春江,吉川直也,佐古田三郎
    • Journal Title

      バイオメカニズム学会誌

      Volume: 39 Pages: 185-195

    • NAID

      130005145371

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An intermittent control model of flexible human gait using a stable manifold of saddle-type unstable limit cycle dynamics2014

    • Author(s)
      Chunjiang Fu, Yasuyuki Suzuki, Ken Kiyono, Pietro Morasso, Taishin Nomura
    • Journal Title

      Journal of The Royal Society Interface

      Volume: 11 Pages: 20140958-20140958

    • DOI

      10.1098/rsif.2014.0958

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Stabilization strategies for unstable dynamics2014

    • Author(s)
      Pietro Morasso, Maura Casadio, Dalia De Santis, Taishin Nomura, Francesco Rea, Jacopo Zenzeri
    • Journal Title

      Journal of Electromyography and Kinesiology

      Volume: 24 Pages: 803-814

    • DOI

      10.1016/j.jelekin.2014.10.006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] ヒト立位姿勢・歩行・スティックバランス制御系の運動揺らぎに見られる臨界的挙動の数理モデル化2016

    • Author(s)
      野村泰伸
    • Organizer
      計測自動制御学会ライフエンジニアリング部門シンポジウム2016
    • Place of Presentation
      大阪国際交流センター(大阪府・大阪市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] An intermittent feedback controller for stabilizing human upright posture can be acquired through reinforcement learning2016

    • Author(s)
      Kenjiro Michimoto, Yasuyuki Suzuki, Ken Kiyono, Taishin Nomura
    • Organizer
      計測自動制御学会ライフエンジニアリング部門シンポジウム2016
    • Place of Presentation
      大阪国際交流センター(大阪府・大阪市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Intermittency and loss of intermittency during human motor control in health and disease2016

    • Author(s)
      Taishin Nomura, Yasuyuki Suzuki, Fu Chunjiang, Ken Kiyono
    • Organizer
      8th International Workshop on Biosignal Interpretation
    • Place of Presentation
      大阪国際交流センター(大阪府・大阪市)
    • Year and Date
      2016-11-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Skin motion artifact in motion capturing of human bipedal gait: Characterization and influence on joint torque estimation2016

    • Author(s)
      Takuya Inoue, Yasuyuki Suzuki, Ken Kiyono, Taishin Nomura
    • Organizer
      8th International Workshop on Biosignal Interpretation
    • Place of Presentation
      大阪国際交流センター(大阪府・大阪市)
    • Year and Date
      2016-11-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel characterization of fixational eye movements2016

    • Author(s)
      Hajime Tanaka, Yasuyuki Suzuki, Ken Kiyono, Taishin Nomura
    • Organizer
      生体医工学シンポジウム2016
    • Place of Presentation
      旭川市大雪クリスタルホール国際会議場(北海道・旭川市)
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Reinforcement learning for stabilizing an inverted pendulum naturally leads to intermittent feedback control as in human quiet standing2016

    • Author(s)
      Kenjiro Michimoto, Yasuyuki Suzuki, Ken Kiyono, Yasushi Kobayashi, Pietro Morasso, Taishin Nomura
    • Organizer
      38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
    • Place of Presentation
      Disney's Contemporary Resort (Orlando, USA)
    • Year and Date
      2016-08-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Postural flexibility during quiet standing in healthy elderly and patients with Parkinson's disease2016

    • Author(s)
      Kazuyuki Matsuda, Yasuyuki Suzuki, Naoya Yoshikawa, Tomohisa Yamamoto, Ken Kiyono, Takao Tanahashi, Takuyuki Endo, Kei Fukada, Kunihiko Nomura, Saburo Sakoda, Taishin Nomura
    • Organizer
      38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
    • Place of Presentation
      Disney's Contemporary Resort (Orlando, USA)
    • Year and Date
      2016-08-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modeling long-range correlated movement variability during bipedal standing and walking using an intermittent delayed feedback controller2015

    • Author(s)
      Taishin Nomura
    • Organizer
      数学協働プログラム ゆらぎと遅れを含む力学の数理と応用2
    • Place of Presentation
      名古屋大学大学院多元数理科学研究科(名古屋市)
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 立位歩行運動におけるoptimal motor variability2015

    • Author(s)
      野村泰伸
    • Organizer
      日本めまい平衡医学会総会・学術講演会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Analysis of eye movements after repetitive transcranial magnetic stimulation on behaving monkeys2015

    • Author(s)
      Kenichi Okada, Yasushi Kobayashi
    • Organizer
      Society for Neuroscience 45th Annual meeting
    • Place of Presentation
      Hyatt Regency Chicago, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト静止立位と二足歩行の運動揺らぎと間欠制御モデル2015

    • Author(s)
      野村泰伸
    • Organizer
      共同利用・共同研究拠点 MIMS 現象数理学拠点 共同研究集会
    • Place of Presentation
      明治大学(東京都)
    • Year and Date
      2015-10-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Non-actively controlled double-inverted-pendulum-like dynamics can minimize center of mass acceleration during human quiet standing2015

    • Author(s)
      Y Suzuki, H Morimoto, K Kiyono, P Morasso, T Nomura
    • Organizer
      37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Milano Conference Center, Milan, Italy
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] サル繰り返し経頭蓋磁気刺激の眼球運動への影響2015

    • Author(s)
      小林康,岡田研一
    • Organizer
      日本神経科学学会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 多発性硬化症患者における注視時微小眼球運動の解析2015

    • Author(s)
      船本万里,浜咲雄太,浅原舜平,田中文哲,岡田研一,小林康,Alla Sridhar,MacAskill Michael,Mason Deborah,Anderson Tim,渡邊雅之
    • Organizer
      日本神経科学学会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] パーキンソン病患者における注視時微小眼球運動の解析2015

    • Author(s)
      浜咲雄太,船本万里,浅原舜平,田中文哲,岡田研一,小林康,Michael MacAskill,Leslie Livingston,Tim Anderson,渡邊 雅之
    • Organizer
      日本神経科学学会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Stability vs variability of human bipedal standing and walking2015

    • Author(s)
      Taishin Nomura
    • Organizer
      24th Annual Computational Neuroscience Meeting
    • Place of Presentation
      University of Economics, Prague, Czech Republic
    • Year and Date
      2015-07-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Stability and Flexibility During Human Motor Control2015

    • Author(s)
      Taishin Nomura
    • Organizer
      5th International Conference on Cognitive Neurodynamics
    • Place of Presentation
      The hotel The Palm Beach Resort & Spa, Sanya, Hainan Province, China
    • Year and Date
      2015-06-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Stability versus flexibility in the human motor control2014

    • Author(s)
      Taishin Nomura
    • Organizer
      The Eleventh Neural Coding Workshop
    • Place of Presentation
      Research Centre of the National Institute for Agricultural Research (Institut National de la Recherche Agronomique)
    • Year and Date
      2014-10-06 – 2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] An intermittent control model during human stance and gait2014

    • Author(s)
      野村泰伸
    • Organizer
      計測自動制御学会ライフエンジニアリング部門シンポジウム2014
    • Place of Presentation
      金沢大鶴間キャンパス
    • Year and Date
      2014-09-17 – 2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 静止立位時における足関節と股関節の協調運動とUCMの関係2014

    • Author(s)
      森本大樹,鈴木康之,清野健,野村泰伸
    • Organizer
      モーターコントロール研究会
    • Place of Presentation
      筑波大学
    • Year and Date
      2014-08-07 – 2014-08-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] スティックバランス課題の運動スキル評価2014

    • Author(s)
      吉川直也,鈴木康之,清野健,野村泰伸
    • Organizer
      モーターコントロール研究会
    • Place of Presentation
      筑波大学
    • Year and Date
      2014-08-07 – 2014-08-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 若年健常者の静止立位時重心動揺の普遍性と個人特異性2014

    • Author(s)
      山本智久,C.E. Smith,鈴木康之,清野健,野村泰伸
    • Organizer
      モーターコントロール研究会
    • Place of Presentation
      筑波大学
    • Year and Date
      2014-08-07 – 2014-08-09
    • Related Report
      2014 Annual Research Report
  • [Book] スポーツと脳: 脳を知る・創る・守る・育む162015

    • Author(s)
      津本忠治, 室伏広治, 森 郁恵, 野村泰伸, 水澤英洋, 下郡智美, 宮下保司
    • Total Pages
      170
    • Publisher
      クバプロ
    • Related Report
      2015 Annual Research Report
  • [Funded Workshop] 8th International Workshop on Biosignal Interpretation2016

    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2016-11-01
    • Related Report
      2016 Annual Research Report

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Published: 2014-11-20   Modified: 2018-03-22  

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