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Multiple functional electron paramagnetic resonance imaging for quantitative cancer studies

Research Project

Project/Area Number 26249057
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Measurement engineering
Research InstitutionHokkaido University

Principal Investigator

Hirata Hiroshi  北海道大学, 情報科学研究科, 教授 (60250958)

Co-Investigator(Kenkyū-buntansha) 安井 博宣  北海道大学, アイソトープ総合センター, 准教授 (10570228)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥41,080,000 (Direct Cost: ¥31,600,000、Indirect Cost: ¥9,480,000)
Fiscal Year 2017: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2016: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2015: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2014: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Keywords電子スピン共鳴 / 酸素分圧 / pH / 腫瘍 / イメージング / 酸素 / 計測工学 / 癌 / 分析科学 / 放射線 / 可視化 / 電子常磁性共鳴 / 電子スピン共鳴イメージング / 画像再構成 / 緩和時間
Outline of Final Research Achievements

We developed the methods of continues-wave electron spin resonance (ESR) imaging for the visualization of oxygen partial pressure and pH of tumor tissues. Using accelerated four-dimensional spectral-spatial imaging, mapping of oxygen partial pressure and pH performed. ESR imaging recorded relaxation time T2* of oxygen-sensitive spin probes and ESR spectral lines of a pH-sensitive spin probe for oxygen mapping and pH mapping. Estimations of oxygen partial pressure and pH used those spectral parameters. Finally, we tested the developed methods with solution phantoms and tumor-bearing mice.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (29 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (5 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results) Presentation (19 results) (of which Int'l Joint Research: 6 results,  Invited: 3 results)

  • [Int'l Joint Research] West Virginia University(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Novosibirsk Inst. of Organic Chemistry(ロシア連邦)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Novosibirsk Inst. Organic Chemistry(ロシア連邦)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] West Virginia University/School of Medicine/Department of Biochemistry(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Impact of the characteristic impedance of coaxial lines on the sensitivity of a 750-MHz electronically tunable EPR resonator2018

    • Author(s)
      R. Nakaoka, D. A. Komarov, S. Matsumoto, H. Hirata
    • Journal Title

      Applied Magnetic Resonance

      Volume: 印刷中 Issue: 8 Pages: 853-867

    • DOI

      10.1007/s00723-018-1001-6

    • NAID

      120006709282

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A 750-MHz electronically tunable resonator using microstrip line couplers for electron paramagnetic resonance imaging of a mouse tumor-bearing leg2018

    • Author(s)
      T. Amida, R. Nakaoka, D. A. Komarov, K. Yamamoto, O. Inanami, S. Matsumoto, H. Hirata
    • Journal Title

      IEEE Transactions on Biomedical Engineering

      Volume: 65 Pages: 1124-1132

    • DOI

      10.1109/tbme.2017.2743232

    • NAID

      120006466513

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fast backprojection-based reconstruction of spectral-spatial EPR images from projections with the constant sweep of a magnetic field2017

    • Author(s)
      D. A. Komarov, H. Hirata
    • Journal Title

      Journal of Magnetic Resonance

      Volume: 281 Pages: 44-50

    • DOI

      10.1016/j.jmr.2017.05.005

    • NAID

      120006709274

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of in vivo three-dimensional T2* mapping using dicarboxy-PROXYL and CW-EPR-based single-point imaging2017

    • Author(s)
      H. Kubota, D. A. Komarov, H. Yasui, S. Matsumoto, O. Inanami, I. A. Kirilyuk, V. V. Khramtsov, and H. Hirata
    • Journal Title

      Magnetic Resonance Materials in Physics, Biology and Medicine

      Volume: 印刷中 Issue: 3 Pages: 291-298

    • DOI

      10.1007/s10334-016-0606-8

    • NAID

      120006470969

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Passive decoupling due to low Q-factors of four-channel coils in 300-MHz pulsed EPR imaging2015

    • Author(s)
      A. Enomoto, K. Saito, S. Subramanian, M. C. Krishna, H. Hirata, and N. Devasahayam
    • Journal Title

      Applied Magnetic Resonance

      Volume: - Issue: 6 Pages: 671-683

    • DOI

      10.1007/s00723-015-0671-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Three-dimensional oxygen mapping using a pair of isotopic nitroxyl radicals and CW-EPR-based single-point imaging2017

    • Author(s)
      H. Kubota, D. A. Komarov, S. Matsumoto, K. Yamamoto, H. Yasui, O. Inanami, I. A. Kirilyuk, V. V. Khramtsov, H. Hirata
    • Organizer
      EPR 2017: International Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Fast backprojection-based reconstruction of spectral-spatial EPR images from projections with the constant sweep of a magnetic field2017

    • Author(s)
      D. A. Komarov, H. Hirata
    • Organizer
      EPR 2017: International Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 窒素同位体標識ニトロキシルラジカルによる腫瘍モデルマウスの酸素分圧イメージング2017

    • Author(s)
      久保田晴江, 安井博宣, 松元慎吾, 稲波修, Igor A. Kirilyuk, Valery V. Khramtsov, 平田拓
    • Organizer
      第56回電子スピンサイエンス学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 電子常磁性共鳴分光による腫瘍組織のpHマッピング法の開発2017

    • Author(s)
      市川裕貴, Denis A. Komarov, 山本久美子, 稲波修, 松元慎吾, 平田拓
    • Organizer
      第56回電子スピンサイエンス学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 腫瘍モデルマウス用750MHzチューナブル共振器の最適設計2017

    • Author(s)
      中岡梨々子, 平田拓
    • Organizer
      第56回電子スピンサイエンス学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マイクロ波シミュレーションによる750 MHz EPR共振器の磁場発生効率の最適化2016

    • Author(s)
      編田竜也, 松元慎吾, 平田拓
    • Organizer
      第55回電子スピンサイエンス学会年会
    • Place of Presentation
      大阪市立大学
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高速EPRシングル・ポイント・イメージング法における部分k空間データ取得の緩和時間T2*マッピングへの影響評価2016

    • Author(s)
      長谷川昴平, 松元慎吾, 平田拓
    • Organizer
      第55回電子スピンサイエンス学会年会
    • Place of Presentation
      大阪市立大学
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] EPR分光によるpH推定アルゴリズムの開発2016

    • Author(s)
      市川裕貴, 平田拓
    • Organizer
      第55回電子スピンサイエンス学会年会
    • Place of Presentation
      大阪市立大学
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] CW-EPR法による酸素分圧及びプローブ濃度定量化計測の実現可能性検証2016

    • Author(s)
      安田雄介, 久保田晴江, 松元慎吾, 平田拓
    • Organizer
      第54回電子スピンサイエンス学会年会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)
    • Year and Date
      2016-11-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 部分k空間データ取得による高速EPRシングル・ポイント・イメージング法の実験2016

    • Author(s)
      長谷川昴平, 松元慎吾, 平田拓
    • Organizer
      第54回電子スピンサイエンス学会年会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)
    • Year and Date
      2016-11-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] マイクロストリップラインの結合を利用して共振周波数の調整を行う750MHz EPR共振器の開発2016

    • Author(s)
      編田竜也, 平田拓
    • Organizer
      第54回電子スピンサイエンス学会年会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)
    • Year and Date
      2016-11-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 酸素感受性同位体ニトロキシルラジカルの特性評価実験2016

    • Author(s)
      久保田晴江, 安井博宣, 松元慎吾, 三宅祐輔, 稲波修, I. A. Kirilyuk, V. V. Khramtsov, 平田拓
    • Organizer
      第54回電子スピンサイエンス学会年会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)
    • Year and Date
      2016-11-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] CW-EPR-based oxygen mapping technique using a pair of isotopic nitroxyl radicals2016

    • Author(s)
      H. Kubota, H. Yasui, S. Matsumoto, O. Inanami, I. A. Kirilyuk, V. V. Khramtsov, H. Hirata
    • Organizer
      Xth International Workshop on EPR in Biology and Medicine
    • Place of Presentation
      Krakow, Poland
    • Year and Date
      2016-10-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of a CW-EPR-based oxygen-mapping technique using a pair of isotopic nitroxyl radicals2016

    • Author(s)
      H. Hirata, H. Kubota, H. Yasui, S. Matsumoto, O. Inanami, I. A. Kirilyuk, and V. V. Khramtsov
    • Organizer
      Asia-Pacific EPR/ESR Symposium 2016
    • Place of Presentation
      Irkutsk, Russia
    • Year and Date
      2016-08-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Feasibility study of a CW-EPR-based oxygen mapping technique using a pair of isotopic nitroxyl radicals2016

    • Author(s)
      H. Hirata, H. Kubota, H. Yasui, S. Matsumoto, O. Inanami, I. A. Kirilyuk, and V. V. Khramtsov
    • Organizer
      58th Annual Rocky Mountain Conference on Magnetic Resonance (39th International EPR Symposium)
    • Place of Presentation
      Breckenridge, Colorado, USA
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characteristics of 14N- and 15N-labeled dicarboxy-PROXYLs as oxygen-sensitive probes for CW-EPR-based single-point imaging (SPI)2016

    • Author(s)
      H. Kubota, H. Yasui, S. Matsumoto, O. Inanami, I. A. Kirilyuk, V. V. Khramtsov, and H. Hirata
    • Organizer
      58th Annual Rocky Mountain Conference on Magnetic Resonance (39th International EPR Symposium)
    • Place of Presentation
      Breckenridge, Colorado, USA
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simulation of RF magnetic fields in crossed loop resonators for 300 MHz pulsed EPR2014

    • Author(s)
      T. Ishii and H. Hirata
    • Organizer
      Joint Conference of 9th Asia-Pacific EPR/ESR Symposium, 1st International EPR (ESR) Society Symposium, and 53rd SEST Annual Meeting (APES-IES-SEST 2014)
    • Place of Presentation
      Nara, Japan
    • Year and Date
      2014-11-12 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Artifact suppression in electron paramagnetic resonance imaging of 14N- and 15N-labeled nitroxyl radicals with asymmetric absorption spectra2014

    • Author(s)
      W. Takahashi, Y. Miyake, and H. Hirata
    • Organizer
      Joint Conference of 9th Asia-Pacific EPR/ESR Symposium, 1st International EPR (ESR) Society Symposium, and 53rd SEST Annual Meeting (APES-IES-SEST 2014)
    • Place of Presentation
      Nara, Japan
    • Year and Date
      2014-11-12 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Electron paramagnetic resonance spectroscopy for in vivo measurement of tumour extracellular pH- the effect of X-ray irradiation2014

    • Author(s)
      J. Goodwin, K. Yachi, M. Nagane, H. Yasui, Y. Miyake, O. Inanami, A. Bobko, V. Khramstov, H. Hirata
    • Organizer
      Joint Annual Meeting ISMRM-ESMRMB 2014
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2014-05-10 – 2014-05-16
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2022-02-28  

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