Dynamics of neural circuit and its impariment studied by optical imaging
| Project/Area Number |
26250014
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Okabe Shigeo 東京大学, 大学院医学系研究科(医学部), 教授 (60204012)
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| Co-Investigator(Kenkyū-buntansha) |
原田 彰宏 大阪大学, 医学系研究科, 教授 (40251441)
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| Co-Investigator(Renkei-kenkyūsha) |
IWASAKI Hirohide 東京大学, 大学院医学系研究科(医学部), 講師 (30342752)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥39,780,000 (Direct Cost: ¥30,600,000、Indirect Cost: ¥9,180,000)
Fiscal Year 2016: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2015: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2014: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
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| Keywords | シナプス / イメージング / 超解像顕微鏡 / 自閉症モデル動物 |
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| Outline of Final Research Achievements |
This study aimed at understanding biological mechanism of synaptic dynamics by cutting-edge imaging technologies. To achieve this goal, we analyzed morphology and function of excitatory and inhibitory synapses in the neocortex, maturation steps of individual synapses imaged in vivo by two-photon microscopy, and defects in synaptic functions and dynamics in mouse models of psychiatric disorders. From these experiments, we conclude that synaptic dynamics in the developing neural circuits show circuit-specific regulation mechanisms. Furthermore, we showed that early impairments in synaptic dynamics cause dysfunction of neural circuits in later stages of development.
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] Enhanced synapse remodeling as a common phenotype in mouse models of autism.2015
Author(s)
Isshiki, M., Tanaka, S., Kuriu, T., Tabuchi, K., Takumi, T. and Okabe, S.
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Journal Title
Brain Research
Volume: 5
Pages: 4742-4742
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Fluorescent ratiometric pH indicator SypHer2: applications in neuroscience and regenerative biology.2015
Author(s)
Matlashov M. V., Bogdanova Y. A., Mishina N. M., Ermakova Y. G., Nikitin E. S., Balaban P. M., Okabe S., Lukyanov S., Enikolopov G., Zaraisky A. G., and Belousov VV.
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Journal Title
BBA-General Subjects
Volume: 1850
Pages: 2318-2328
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 「最先端脳科学セミナー」2014
Author(s)
岡部繁男
Organizer
第１１０回日本精神神経学会学術集会
Place of Presentation
パシフィコ横浜（神奈川県・横浜市）
Year and Date
2014-06-26 – 2014-06-28
Related Report
Invited
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[Presentation] 「シナプス研究の最前線」2014
Author(s)
岡部繁男
Organizer
第５５回日本神経学会学術大会
Place of Presentation
福岡国際会議場(福岡県・福岡市）
Year and Date
2014-05-21 – 2014-05-24
Related Report
Invited
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