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Dynamics of neural circuit and its impariment studied by optical imaging

Research Project

Project/Area Number 26250014
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionThe University of Tokyo

Principal Investigator

Okabe Shigeo  東京大学, 大学院医学系研究科(医学部), 教授 (60204012)

Co-Investigator(Kenkyū-buntansha) 原田 彰宏  大阪大学, 医学系研究科, 教授 (40251441)
Co-Investigator(Renkei-kenkyūsha) IWASAKI Hirohide  東京大学, 大学院医学系研究科(医学部), 講師 (30342752)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥39,780,000 (Direct Cost: ¥30,600,000、Indirect Cost: ¥9,180,000)
Fiscal Year 2016: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2015: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2014: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Keywordsシナプス / イメージング / 超解像顕微鏡 / 自閉症モデル動物
Outline of Final Research Achievements

This study aimed at understanding biological mechanism of synaptic dynamics by cutting-edge imaging technologies. To achieve this goal, we analyzed morphology and function of excitatory and inhibitory synapses in the neocortex, maturation steps of individual synapses imaged in vivo by two-photon microscopy, and defects in synaptic functions and dynamics in mouse models of psychiatric disorders. From these experiments, we conclude that synaptic dynamics in the developing neural circuits show circuit-specific regulation mechanisms. Furthermore, we showed that early impairments in synaptic dynamics cause dysfunction of neural circuits in later stages of development.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (73 results)

All 2017 2016 2015 2014 Other

All Journal Article (11 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 11 results,  Acknowledgement Compliant: 5 results,  Open Access: 3 results) Presentation (59 results) (of which Int'l Joint Research: 14 results,  Invited: 30 results) Remarks (3 results)

  • [Journal Article] AMPA glutamate receptors are required for sensory-organ formation and morphogenesis in the basal chordate.2017

    • Author(s)
      Shinobu Hirai, Kohji Hotta, Yoshihiro Kubo, Atsuo Nishino, Shigeo Okabe, Yasushi Okamura, Haruo Okado
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A.

      Volume: - Issue: 15 Pages: 3939-3944

    • DOI

      10.1073/pnas.1612943114

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High affinity receptor labeling based on basic leucine zipper domain peptides conjugated with pH-sensitive fluorescent dye: visualization of AMPA type glutamate receptor endocytosis in living neurons.2016

    • Author(s)
      Hayashi, A., Asanuma, D., Kamiya, M., Urano, U. and S. Okabe.
    • Journal Title

      Neuropharmacology

      Volume: 100 Pages: 66-75

    • DOI

      10.1016/j.neuropharm.2015.07.026

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Temporal changes in the response of SVZ neural stem cells to intraventricular administration of growth factors2016

    • Author(s)
      Ochi, T., Nakatomi, H., Ito, A., Okabe, S. and N. Saito.
    • Journal Title

      Brain Research

      Volume: 1636 Pages: 118

    • DOI

      10.1016/j.brainres.2016.01.046

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fast 3D visualization of endogenous brain signals with high-sensitivity laser scanning photothermal microscopy2016

    • Author(s)
      J. Miyazaki, T.Iida, S. Tanaka, A. Hayashi-Takagi, H. Kasai, S. Okabe, and T. Kobayashi
    • Journal Title

      Biomed. Opt. Express

      Volume: 7 Issue: 5 Pages: 1702-1710

    • DOI

      10.1364/boe.7.001702

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Insights into age-old questions of new dendritic spines: From form to function.2016

    • Author(s)
      Parajuli, L. K., Tanaka, S., and S. Okabe
    • Journal Title

      Brain Research Bulletin.

      Volume: 129 Pages: 3-11

    • DOI

      10.1016/j.brainresbull.2016.07.014

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Up-regulation of HP1γ expression during neuronalmaturation promotes axonal and dendritic development inmouse embryonic neocortex.2015

    • Author(s)
      Oshiro H, Hirabayashi Y, Furuta Y, Okabe S, and Gotoh Y
    • Journal Title

      Genes Cells.

      Volume: 20 Issue: 2 Pages: 108-120

    • DOI

      10.1111/gtc.12205

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fluorescent ratiometric pH indicator SypHer2: applications in neuroscience and regenerative biology.2015

    • Author(s)
      Matlashov M. V., Bogdanova Y. A., Mishina N. M., Ermakova Y. G., Nikitin E. S., Balaban P. M., Okabe S., Lukyanov S., Enikolopov G., Zaraisky A. G., and Belousov VV.
    • Journal Title

      BBA-General Subjects

      Volume: 1850 Issue: 11 Pages: 2318-2328

    • DOI

      10.1016/j.bbagen.2015.08.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enhanced synapse remodeling as a common phenotype in mouse models of autism.2014

    • Author(s)
      Isshiki, M., Tanaka, S., Kuriu, T., Tabuchi, K., Takumi, T. and Okabe, S.
    • Journal Title

      Nat. Commun.

      Volume: 5 Issue: 1 Pages: 4742-4742

    • DOI

      10.1038/ncomms5742

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural dynamics of dendritic spines: molecular composition, geometry and functional regulation.2014

    • Author(s)
      Ebrahimi, S., and S. Okabe.
    • Journal Title

      BBA-Biomembranes

      Volume: 1838 Issue: 10 Pages: 2391-2398

    • DOI

      10.1016/j.bbamem.2014.06.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The role of Cbln1 on Purkinje cell synapse formation2014

    • Author(s)
      Ito-Ishida, A., Okabe, S. and M. Yuzaki
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 64-68

    • DOI

      10.1016/j.neures.2014.01.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cbln1 down-regulates the formation and function of inhibitory synapses in mouse cerebellar Purkinje cells2014

    • Author(s)
      Ito-Ishida, A., Kakegawa, W., Kohda, K., Miura, E., Okabe, S. and M. Yuzaki
    • Journal Title

      European Journal of Neuroscience

      Volume: 39 Issue: 8 Pages: 1268-80

    • DOI

      10.1111/ejn.12487

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Abnormal synapse dynamics in mouse models for autism spectrum disorders2017

    • Author(s)
      Shinji Tanaka, Masaaki Isshiki, Risa Iguchi, Shinji Urata, Shunsuke Mizutani, Toshihiko Kuriu, Katsuhiko Tabuchi, Toru Takumi, Shigeo Okabe
    • Organizer
      第122回日本解剖学会総会・学術集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Molecular mobility inside dendritic spines of cultured hippocampal neurons2017

    • Author(s)
      Kazuki Obashi, Yasuhiro Inoue, Shigeo Okabe
    • Organizer
      第122回日本解剖学会総会・学術集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Analysis of postsynaptic function of ACF7, an actin-microtubule crosslinking protein2017

    • Author(s)
      Yutaro Kashiwagi, Shigeo Okabe
    • Organizer
      第122回日本解剖学会総会・学術集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Three-dimensional analysis of microglia and synapses in developing cerebral cortex2017

    • Author(s)
      Tadatsune Iida, Shinji Tanaka, Shigeo Okabe
    • Organizer
      第122回日本解剖学会総会・学術集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] The effects of noise-induced hearing loss on the cochlea revealed by the new optical clearing method2017

    • Author(s)
      Shinji Urata, Tadatsune Iida, Yu Mizushima, Chisato Fujimoto, Yu Matsumoto, Tatsuya Yamasoba, Shigeo Okabe
    • Organizer
      第122回日本解剖学会総会・学術集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] イメージングによる神経回路発達の理解2017

    • Author(s)
      岡部繁男
    • Organizer
      第66回日本小児神経学会関東地方会
    • Place of Presentation
      日本医科大学(東京都文京区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] High resolution imaging of synaptic structure and molecules.2016

    • Author(s)
      岡部繁男
    • Organizer
      The 4th International Anatomical Sciences & Cell Biology Conference
    • Place of Presentation
      Hong Kong (China)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Imaging synapses in vivo; physiology and pathology of synapses and neural circuits2016

    • Author(s)
      岡部繁男
    • Organizer
      The 4th International Anatomical Sciences & Cell Biology Conference
    • Place of Presentation
      Hong Kong (China)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Developmental Defects in cortical synapse remodeling associated with autism spectrum disorders.2016

    • Author(s)
      岡部繁男
    • Organizer
      NSF-AMED Workshop: Comparative Principles of Brain Architecture and Functions.
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Maturation-dependent regulation of synaptic density and dynamics.2016

    • Author(s)
      岡部繁男
    • Organizer
      The 47th NIPS International Symposium “Decoding Synapses”
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] High resolution imaging analysis of postsynaptic structure2016

    • Author(s)
      岡部繁男
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 自閉スペクトラム症の病態理解に向けて―モデル動物イメージングからのアプローチ2016

    • Author(s)
      岡部繁男
    • Organizer
      第46回日本神経精神薬理学会
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Maturation-dependent regulation of synaptic density and the role of CaMKIIα.2016

    • Author(s)
      岡部繁男
    • Organizer
      US-Japan Brain Research Cooperative Program Current trends and future directions of synaptic plasticity research.
    • Place of Presentation
      Baltimore (USA)
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Imaging technologies for the understanding of synapse development and dysfunction.2016

    • Author(s)
      岡部繁男
    • Organizer
      US-Japan Brain Workshop
    • Place of Presentation
      AMED本部 (東京都千代田区)
    • Year and Date
      2016-03-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of spine structure and stability by two-photon in vivo imaging2016

    • Author(s)
      田中 慎二、岡部 繁男
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビックパレット福島(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Raster image correlation spectroscopy inside dendritic spines of cultured hippocampal neuron2016

    • Author(s)
      小橋 一喜、岡部 繁男
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビックパレット福島(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Molecular characterization of ACF7,an actin-microtubule crosslinking protein, in excitatory synapses2016

    • Author(s)
      柏木 有太郎、岡部 繁男
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビックパレット福島(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Three-dimensional immunostaining of glia in transparent brain2016

    • Author(s)
      飯田 忠恒、田中 慎二、岡部 繁男
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビックパレット福島(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Three-dimensional imaging of the whole intact cochlear by optical clearing methods2016

    • Author(s)
      浦田 真次、飯田 忠恒、田中 慎二、藤本 千里、樫尾 明憲、松本 有、吉川 弥生、岩崎 広英、山岨 達也、岡部 繁男
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビックパレット福島(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of techniques for correlated imaging of in vivo two-photon microscopy and electron microscopy2016

    • Author(s)
      岩崎 広英、田中 慎二、岡部 繁男
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビックパレット福島(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脳神経回路の網羅的解析:現状とその将来について2016

    • Author(s)
      岡部繁男
    • Organizer
      第11回日本統合失調症学会
    • Place of Presentation
      ベイシア文化ホール(群馬県前橋市)
    • Year and Date
      2016-03-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Imaging synapse remodeling in vitro and in vivo.2016

    • Author(s)
      岡部繁男
    • Organizer
      IMA conference on neural imaging in neuroscience.
    • Place of Presentation
      Cambridge (U.K.)
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Imaging synapse dynamics by cutting edge imaging technologies.2016

    • Author(s)
      岡部繁男
    • Organizer
      7th APICA (Asian-Pacific International Congress of Anatomists)
    • Place of Presentation
      Kent Ridge (Singapore)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳の機能理解を目指したシナプス計測技術の開発2016

    • Author(s)
      岡部繁男
    • Organizer
      自然科学研究機構シンポジウム「次ステージ機能生命科学の展望」
    • Place of Presentation
      岡崎カンファランスセンター(愛知県岡崎市)
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] In vivo imaging of synapse dynamics applied to psychiatric disorders.2015

    • Author(s)
      岡部繁男
    • Organizer
      Symposium “Advanced molecular imaging of synapses in health and disease”, Neuroscience 2015
    • Place of Presentation
      Chicago (U.S.A.)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Imaging synapse dynamics in vivo; its application in the analysis of neurodevelopmental disorders.2015

    • Author(s)
      岡部繁男
    • Organizer
      25th Neuropharmacology Conference 2015, “Synaptopathy – From biology to therapy”
    • Place of Presentation
      Chicago (U.S.A.)
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 興奮性シナプスの発達過程におけるACF7の分子イメージング2015

    • Author(s)
      柏木 有太郎、岡部 繁男
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス大脳皮質におけるスパイン安定性の解析2015

    • Author(s)
      田中 慎二、岩崎 広英、岡部 繁男
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] シナプス形成・維持過程におけるBMP4の役割2015

    • Author(s)
      東 誉人、田中 慎二、大城 洋明、岡部 繁男
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 広範囲の光学再構築法を用いたミクログリアとシナプスの3次元解析2015

    • Author(s)
      飯田 忠恒、田中 慎二、岩崎 広英、市川 和典、岡部 繁男
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Imaging mircoglia and synapses with an optical clearing tehcnique2015

    • Author(s)
      岡部繁男
    • Organizer
      XII European meeting on glial cells in health and disease
    • Place of Presentation
      Bilbao (Spain)
    • Year and Date
      2015-07-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Imaging microglia and synapses with an optical clearing technique.2015

    • Author(s)
      岡部繁男
    • Organizer
      “Novel insights into glia function & dysfunction” Cold Spring Harbor Conferences Asia
    • Place of Presentation
      Suzhou (China)
    • Year and Date
      2015-06-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synapse development and remodeling studied by imaging technologies.2015

    • Author(s)
      岡部繁男
    • Organizer
      “International Brain Projects” Cold Spring Harbor Conferences Asia
    • Place of Presentation
      Suzhou (China)
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] シナプス構造と動態のイメージング2015

    • Author(s)
      岡部繁男
    • Organizer
      日本顕微鏡学会第71回学術講演会
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 「光学顕微鏡技術と電子顕微鏡技術の融合的手法によるスパイン形成解析」2015

    • Author(s)
      岩崎広英、一色真明、石田綾、柏木有太郎、岡部繁男
    • Organizer
      第120回日本解剖学会総会・全国学術集会、第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 「マウス大脳皮質におけるシナプスナノ構造と安定性の関連」2015

    • Author(s)
      田中慎二、飯田忠恒、岩崎広英、岡部繁男
    • Organizer
      第120回日本解剖学会総会・全国学術集会、第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 「神経細胞の発達に伴ったACF7の動的な局在変化」2015

    • Author(s)
      柏木有太郎、岡部繁男
    • Organizer
      第120回日本解剖学会総会・全国学術集会、第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 「二光子励起蛍光相関分光法を用いた神経細胞内分子構造解析」2015

    • Author(s)
      小橋一喜、岡部繁男
    • Organizer
      第120回日本解剖学会総会・全国学術集会、第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 「ニューロン成熟に伴うHP1の発現増加とマウス胎仔大脳新皮質における軸索・樹状突起発達促進」2015

    • Author(s)
      大城洋明、平林祐介、古田泰秀、岡部繁男、後藤由季子
    • Organizer
      第120回日本解剖学会総会・全国学術集会、第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 「シナプス形成・維持過程におけるBMP4シグナルの役割」2015

    • Author(s)
      東誉人、田中慎二、大城洋明、岡部繁男
    • Organizer
      第120回日本解剖学会総会・全国学術集会、第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 「タイムラプスイメージングを用いた軸索の形態変化とミトコンドリア動態の定量的解析」2015

    • Author(s)
      清水夕貴、小橋一喜、岡部繁男
    • Organizer
      第120回日本解剖学会総会・全国学術集会、第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 「脳組織における広範囲かつ単一シナプスレベルの解像度での光学再構築法」2015

    • Author(s)
      飯田忠恒、田中慎二、岡部繁男
    • Organizer
      第120回日本解剖学会総会・全国学術集会、第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] “Visualization of assembly and remodeling of synaptic molecules.”2015

    • Author(s)
      岡部繁男
    • Organizer
      “Dendrites: Molecules, Structure & Functions”
    • Place of Presentation
      Gordon Research Conference(Ventura, CA、USA)
    • Year and Date
      2015-03-15 – 2015-03-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Molecular Dynamics in synapse formation and remodeling.”2015

    • Author(s)
      岡部繁男
    • Organizer
      “The 18th iCeMS International Symposium, The 15th International Membrane Research Forum”iCeMS
    • Place of Presentation
      京都大学(京都府・京都市)
    • Year and Date
      2015-03-02 – 2015-03-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Structural analysis of dendritic spine by two-photon and electron microscopy.”2015

    • Author(s)
      岩崎広英、田中慎二、岡部繁男
    • Organizer
      “The 18th iCeMS International Symposium, The 15th International Membrane Research Forum”iCeMS
    • Place of Presentation
      京都大学(京都府・京都市)
    • Year and Date
      2015-03-02 – 2015-03-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] “Investigation of the cellular structures inside neuronal compartments by two-photon fluorescent correlation spectroscopy.”2015

    • Author(s)
      小橋一喜、岡部繁男
    • Organizer
      “The 18th iCeMS International Symposium, The 15th International Membrane Research Forum”iCeMS
    • Place of Presentation
      京都大学(京都府・京都市)
    • Year and Date
      2015-03-02 – 2015-03-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 「シナプス可視化による脳の機能解明―新しい光学顕微鏡と電子顕微鏡技術」2015

    • Author(s)
      岡部繁男
    • Organizer
      超解像イメージングセミナー
    • Place of Presentation
      東北大学医学系研究科(宮城県・仙台市)
    • Year and Date
      2015-02-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「シナプス可視化による脳の機能解明―新しい光学顕微鏡と電子顕微鏡技術」2015

    • Author(s)
      岡部繁男
    • Organizer
      超解像イメージングセミナー
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2015-01-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「精神疾患研究とマウスMRI:その意義と期すること」2015

    • Author(s)
      岡部繁男
    • Organizer
      マウス精神疾患モデルMRI研究会
    • Place of Presentation
      慶応大学信濃町キャンパス(東京都・新宿区)
    • Year and Date
      2015-01-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「グリアアセンブリによる脳機能発現の制御と動態」2014

    • Author(s)
      岡部繁男
    • Organizer
      第19回 グリア研究会 ランチョンセミナー
    • Place of Presentation
      東京商工会議所(東京都・新宿区)
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Light microscopic imaging of live tissues and cells”2014

    • Author(s)
      岡部繁男
    • Organizer
      総合画像研究支援 (IIRS) 創立十周年記念学術講演会
    • Place of Presentation
      東京大学伊藤国際学術研究センター(東京都・文京区)
    • Year and Date
      2014-11-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「個体イメージングで探る自閉症モデル動物の神経回路病態」2014

    • Author(s)
      岡部繁男
    • Organizer
      第30回Wakoワークショップ 神経回路の生理と病態―精神疾患の病態基盤の解明を目指して
    • Place of Presentation
      東京コンファレンスセンター・品川(東京都・品川区)
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「シナプス発達のイメージングによる脳の機能と病態の解明」2014

    • Author(s)
      岡部繁男
    • Organizer
      第44回東京女子医科大学 神経懇話会
    • Place of Presentation
      東京女子医科大学(東京都・新宿区)
    • Year and Date
      2014-07-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「神経回路のイメージングによる脳の生理と病態の理解」2014

    • Author(s)
      岡部繁男
    • Organizer
      第48回広島神経医科学研究会
    • Place of Presentation
      広島大学(広島県・東広島市)
    • Year and Date
      2014-07-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「最先端脳科学セミナー」2014

    • Author(s)
      岡部繁男
    • Organizer
      第110回日本精神神経学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-06-26 – 2014-06-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「シナプスイメージング:動態から機能を考える」2014

    • Author(s)
      岡部繁男
    • Organizer
      脳末梢科学研究センターシンポジウム「脳と末梢の最先端研究」
    • Place of Presentation
      埼玉大学(埼玉県・さいたま市)
    • Year and Date
      2014-06-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「シナプス研究の最前線」2014

    • Author(s)
      岡部繁男
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Imaging structural remodeling of synapses in vitro and in vivo.2014

    • Author(s)
      岡部繁男
    • Organizer
      “Collaborations in Neuroscience Symposium”
    • Place of Presentation
      Max-Planck Florida Institute for Neuroscience (Jupiter, Florida,USA)
    • Year and Date
      2014-05-09 – 2014-05-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Imaging dynamics of postsynaptic molecules and its application in the analysis of neurodevelopmental disorders.2014

    • Author(s)
      岡部繁男
    • Organizer
      “Imaging synapse structure and function in the vertebrate brain”
    • Place of Presentation
      Janelia Farm (Ashburn, VA,USA)
    • Year and Date
      2014-04-01 – 2014-04-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Remarks] 東京大学 大学院医学系研究科 神経細胞生物学分野 岡部研究室

    • URL

      http://synapse.m.u-tokyo.ac.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京大学医学系研究科岡部研究室webページ

    • URL

      http://synapse.m.u-tokyo.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科神経細胞生物学 岡部研究室ホームページURL

    • URL

      http://synapse.m.u-tokyo.ac.jp/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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