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Analysis of genetic mosaicism using X-inactivation visualization mouse resource and development of model mouse for X-linked genetic disease

Research Project

Project/Area Number 26250025
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Abe Kuniya  国立研究開発法人理化学研究所, バイオリソースセンター, チームリーダー (40240915)

Co-Investigator(Kenkyū-buntansha) 横田 秀夫  国立研究開発法人理化学研究所, 光量子工学研究領域, チームリーダー (00261206)
久保田 健夫  山梨大学, 総合研究部, 教授 (70293511)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000)
Fiscal Year 2017: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2015: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2014: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
KeywordsX染色体不活性化 / 遺伝モザイシズム / イメージング / RNA-FISH / Xist / X染色体不活性化 / エピジェネティクス / 遺伝的モザイク / X連鎖遺伝病モデル / X連鎖遺伝病 / X連鎖遺伝病モデル / 病態モデル
Outline of Final Research Achievements

In mammalian females one of two X chromosomes is inactivated for gene dosage compensation, and this phenomenon is called X chromosome inactivation or XCI. Timing of X chromosome reactivation and inactivation during embryonic development remains elusive. In this study, we developed 3D whole-mount RNA-FISH method as well as Xvis mouse strain, in which XCI status can be visualized, and applied these techniques to XCI studies. Using these novel method and resources, we succeeded to determine timing of XCI reversal and initiation of random XCI during peri-implantation development for the first time. Also, by conducting image analyses of tissues/organs of Xvis mice, we could clearly demonstrate the presence of genetic mosaicism in mammalian females.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (58 results)

All 2018 2017 2016 2015 2014

All Journal Article (23 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 23 results,  Open Access: 15 results,  Acknowledgement Compliant: 7 results) Presentation (28 results) (of which Int'l Joint Research: 9 results,  Invited: 5 results) Book (5 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Cell Type-Specific Survey of Epigenetic Modifications by Tandem Chromatin Immunoprecipitation Sequencing2018

    • Author(s)
      Mito Mari、Kadota Mitsutaka、Tanaka Kaori、Furuta Yasuhide、Abe Kuniya、Iwasaki Shintaro、Nakagawa Shinichi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1143-1143

    • DOI

      10.1038/s41598-018-19494-9

    • NAID

      120006398777

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A simplified and efficient protocol for derivation and maintenance of high-quality mouse primed pluripotent stem cells using Wnt inhibition.2018

    • Author(s)
      Kondo M, Sugimoto M, Abe K
    • Journal Title

      Current Protocol Protocols in Stem Cell Biology

      Volume: in press

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide DNA methylation sequencing revealed that miR-663a is a novel epimutation candidate in CIMP- high endometrial cancer.2017

    • Author(s)
      Megumi Yanokura, Kouji Banno, Masataka Adachi, Daisuke Aoki, Kuniya Abe
    • Journal Title

      International Journal of Oncology

      Volume: - Issue: 6 Pages: 1934-1946

    • DOI

      10.3892/ijo.2017.3966

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SCPortalen: human and mouse single-cell centric database2017

    • Author(s)
      Abugessaisa Imad、Noguchi Shuhei、Bottcher Michael、Hasegawa Akira、Kouno Tsukasa、Kato Sachi、Tada Yuhki、Ura Hiroki、Abe Kuniya、Shin Jay W、Plessy Charles、Carninci Piero、Kasukawa Takeya
    • Journal Title

      Nucleic Acids Research

      Volume: 46 Issue: D1 Pages: D781-D787

    • DOI

      10.1093/nar/gkx949

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context2017

    • Author(s)
      Wagatsuma Akiko、Okuyama Teruhiro、Sun Chen、Smith Lillian M.、Abe Kuniya、Tonegawa Susumu
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115 Issue: 2 Pages: 2-2

    • DOI

      10.1073/pnas.1714082115

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Automated Detection and Tracking of Cell Clusters in Time-Lapse Fluorescence Microscopy Images2017

    • Author(s)
      Yuan-Hsiang Chang, Hideo Yokota, Kuniya Abe, Chia-Tong, TangMing-Dar Tasi
    • Journal Title

      Journal of Medical and Biological Engineering

      Volume: 37,1 Issue: 1 Pages: 18-25

    • DOI

      10.1007/s40846-016-0216-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Conserved role of Ovo in germline development in mouse and Drosophila.2017

    • Author(s)
      Hayashi, M., Shinozuka, Y., Shigenobu, S., Sato, M., Sugimoto, M., Ito, S., Abe, K., Kobayashi, S.
    • Journal Title

      Scientific Report

      Volume: 6 Issue: 1 Pages: 40056-40056

    • DOI

      10.1038/srep40056

    • NAID

      120007135169

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene2017

    • Author(s)
      Michiko Hirose, Ayumi Hasegawa, Keiji Mochida, Shogo Matoba, Yuki Hatanaka, Kimiko Inoue, Tatsuhiko Goto, Hideki Kaneda, Ikuko Yamada, Tamio Furuse, Kuniya Abe, Yoshihisa Uenoyama, Hiroko Tsukamura, Shigeharu Wakana, Arata Honda, and Atsuo Ogura
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 42476-42476

    • DOI

      10.1038/srep42476

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A simplified and efficient protocol for derivation and maintenance of high-quality mouse primed pluripotent stem cells using Wnt inhibition.2017

    • Author(s)
      Kondo M, Sugimoto M, Abe K
    • Journal Title

      Current Protocol Protocols in Stem Cell Biology

      Volume: -

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular dynamics of mouse trophoblast stem cells: Identification of a persistent stem cell type.2016

    • Author(s)
      Motomura K, Oikawa M, Hirose M, Honda A, Togayachi S, Miyoshi H, Ohinata Y, Sugimoto M, Abe K, Inoue K, Ogura A.
    • Journal Title

      Biology of Reproduction

      Volume: 94 Issue: 6 Pages: 122-122

    • DOI

      10.1095/biolreprod.115.137125

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection and Localization of Mouse Induced Pluripotent Stem Cell Formation using Time-Lapse Fluorescence Microscopy Images.2016

    • Author(s)
      Yuan-Hsiang Chang, Hideo Yokota, Kuniya Abe, Jung Hsien Liu, Ming-Dar Tsai
    • Journal Title

      Accepted as a contributed paper for the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

      Volume: - Pages: 3914-3917

    • DOI

      10.1109/embc.2016.7591583

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fluorescence Microscopy Image Processing and Visualization for Analyzing Cell Kinematics, Proliferation and Attachment in Mouse Embryonic Stem Cell Culture.2016

    • Author(s)
      Yuan-Hsiang Chang, Hideo Yokota, Kuniya Abe, Chih-Cheng Li, Ming-Dar Tsai
    • Journal Title

      Accepted as a contributed paper for 2016 IEEE 16th International Conference on Bioinformatics and Bioengineering (BIBE)

      Volume: - Pages: 222-229

    • DOI

      10.1109/bibe.2016.44

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cellular dynamics of mouse trophoblast stem cells: Identification of a persistent stem cell type.2016

    • Author(s)
      Motomura K, Oikawa M, Ohinata Y, Sugimoto M, Abe K, Inoue K and Ogura A.
    • Journal Title

      Biology of Reproduction

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pluripotent stem cells derived from mouse primordial germ cells by small molecule compounds.2015

    • Author(s)
      Kimura T et al.
    • Journal Title

      Stem Cells

      Volume: 33 Issue: 1 Pages: 45-55

    • DOI

      10.1002/stem.1838

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Generation of cloned mice from adult neurons by direct nuclear transfer.2015

    • Author(s)
      Mizutani E, Oikawa M, Kassai H, Inoue K, Shiura H, Hirasawa R, Kamimura S, Matoba S, Ogonuki N, Nagatomo H, Abe K, Wakayama T, Aiba A, Ogura A
    • Journal Title

      Biology of Reproduction

      Volume: 92 Issue: 3 Pages: 1-11

    • DOI

      10.1095/biolreprod.114.123455

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Simple and Robust Method for Establishing Homogeneous Mouse Epiblast Stem Cell Lines by Wnt Inhibition2015

    • Author(s)
      Sugimoto M, Kondo M, Koga Y, Shiura H, Ikeda R, Hirose M, Ogura A, Murakami A, Yoshiki A, Chuva de Sousa Lopes SM, Abe K
    • Journal Title

      Stem Cell Reports

      Volume: 4 Issue: 4 Pages: 744-757

    • DOI

      10.1016/j.stemcr.2015.02.014

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer.2015

    • Author(s)
      Inoue K, Oikawa M, Kamimura S, Ogonuki N, Nakamura T, Nakano T, Abe K, Ogura A.
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 10127-10127

    • DOI

      10.1038/srep10127

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a general-purpose method for cell purification using Cre/loxP-mediated recombination.2015

    • Author(s)
      Kuroki S, Akiyoshi M, Ideguchi K, Kitano S, Miyachi H, Hirose M, Mise N, Abe K, Ogura A, Tachibana M.
    • Journal Title

      Genesis.

      Volume: 53(6) Issue: 6 Pages: 387-93

    • DOI

      10.1002/dvg.22863

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer2015

    • Author(s)
      Inoue K, Oikawa M, Kamimura S, Ogonuki N, Nakamura T, Nakano T, Abe K, Ogura A
    • Journal Title

      Scientific Reports

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Understanding the X chromosome inactivation cycle in mice: A comprehensive view provided by nuclear transfer.2014

    • Author(s)
      Oikawa M, Inoue K, Shiura H, Matoba S, Kamimura S, Hirose M, Mekada K, Yoshiki A, Tanaka A, Abe K, Ishino F, Ogura A.
    • Journal Title

      Epigenetics

      Volume: 9 Issue: 2 Pages: 204-211

    • DOI

      10.4161/epi.26939

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide analysis of the chromatin composition of histone H2A and H3 variants in mouse embryonic stem cells.2014

    • Author(s)
      Yukawa, M. et al.
    • Journal Title

      PLOS One

      Volume: 9 Issue: 3 Pages: e92689-e92689

    • DOI

      10.1371/journal.pone.0092689

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prdm9 Polymorphism Unveils Mouse Evolutionary Tracks2014

    • Author(s)
      Kono H, Tamura M, Osada N, Suzuki H, Abe K, Moriwaki K, Ohta K, Shiroishi T
    • Journal Title

      DNA Research

      Volume: - Issue: 3 Pages: 315-326

    • DOI

      10.1093/dnares/dst059

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Whole-mount MeFISH : A novel technique for simultaneous visualization of specific DNA methylation and protein/RNA expression2014

    • Author(s)
      Shiura, H. ; Okamoto, A. ; Sasaki, H. ; Abe, K.
    • Journal Title

      PLoS ONE

      Volume: 9-4 Issue: 4 Pages: e95750-e95750

    • DOI

      10.1371/journal.pone.0095750

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Technology development for gene function analysis by CRISPR/Cas9 system2017

    • Author(s)
      Shinnosuke Suzuki and Kuniya Abe
    • Organizer
      4th World Congress of Reproductive Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comprehensive single-cell analyses on developmental transitions in mouse pluripotent stem cells.2017

    • Author(s)
      Bottcher M, Ura H, Tada Y, Suzuki S, Carninci P, Abe K
    • Organizer
      Single Cell Genomics 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Study on Epigenetic Barrier Formation in Mammalian Stem Cells2017

    • Author(s)
      阿部訓也
    • Organizer
      RIKEN・MARC・KMPC Mouse Workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2つの異なる多能性幹細胞状態を分けるエピジェネティックバリアー形成における新規DNAメチル化の役割2017

    • Author(s)
      浦大樹、阿部訓也
    • Organizer
      第11回日本エピジェネティクス研究会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2つの多能性状態であるナイーブ状態とプライム状態を分けるエピジェネティックバリアーにおけるDNAメチル化の役割2017

    • Author(s)
      浦大樹、鈴木伸之介、田夛祐喜、阿部訓也
    • Organizer
      日本遺伝学会第89回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生殖系列細胞の発生サイクルにおける減数分裂プログラムの獲得メカニズム2017

    • Author(s)
      細川美穂子、刀谷在美、林瑛理、望月綾子、沼田興治、阿部訓也、末盛博文、中辻憲夫、中馬新一郎
    • Organizer
      日本遺伝学会第89回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ナイーブ型とプライム型多能性幹細胞をわけるエピジェネティックバリアー形成におけるDNAメチル化の役割2017

    • Author(s)
      浦大樹、阿部訓也
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] シングルセルRNA-Seqを用いたナイーブ型 -プライム型多能性幹細胞変換過程におけるモノアレル遺伝子発現解析2017

    • Author(s)
      田夛祐喜、阿部訓也
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Xist/Tsix expression dynamics during mouse peri-implantation development revealed by whole-mout 3D RNA-FISH2016

    • Author(s)
      Hirosuke Shiura and Kunia Abe
    • Organizer
      X-Chromosome inactivation: a tribute to Mary Lyon
    • Place of Presentation
      London and Oxford, UK
    • Year and Date
      2016-10-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Robust induction of primed pluripotency in mammals: Wnt inhibition is critical for derivation and maintenance of mouse epiblast stem cells.2016

    • Author(s)
      Abe K, Kondo M, Sugimoto M
    • Organizer
      INASCON (International Scientific Conference) 2016
    • Place of Presentation
      Universiti Sains Malaysia, Health Campus
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Studies on mouse peri-implantation development using developmental mutant and stem cells.2016

    • Author(s)
      阿部訓也
    • Organizer
      熊本大学リエゾンラボ研究会/HIGOプログラム最先端研究セミナー
    • Place of Presentation
      熊本大学
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Robust induction of primed pluripotency in mammals: Wnt inhibition is critical for derivation and maintenance of mouse epiblast stem cells.2016

    • Author(s)
      Kuniya Abe
    • Organizer
      Tsukuba Global Science Week 2016
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Visualization tools for epigenomics2016

    • Author(s)
      阿部訓也
    • Organizer
      The 5th BRC-MARC Mouse Resource Workshop
    • Place of Presentation
      理化学研究所バイオリソースセンター
    • Related Report
      2016 Annual Research Report
  • [Presentation] Comprehensive study on naive-to-primed stem cell conversion process by integration of single-cell transcriptomics and epigenomic analysis2016

    • Author(s)
      Hiroki Ura, Michael Bottcher, Shinnosuke Suzuki, Piero Carninci, Kuniya Abe
    • Organizer
      QBiC Symposium 2016 「Decording Organisms by Quantitative Cell Profiling」
    • Place of Presentation
      理化学研究所生命システム研究センター
    • Related Report
      2016 Annual Research Report
  • [Presentation] Germline Stem (GS)細胞における複数遺伝子の高効率機能解析技術の開発2016

    • Author(s)
      鈴木伸之介、阿部訓也
    • Organizer
      第109回日本繁殖生物学会大会
    • Place of Presentation
      麻布大学
    • Related Report
      2016 Annual Research Report
  • [Presentation] Xist / Tsix expression dynamics during mouse peri-implantation development revealed by whole-mount 3D RNA-FISH2015

    • Author(s)
      Hirosuke Shiura, Kuniya Abe
    • Organizer
      29th International Mammalian Genome Conference
    • Place of Presentation
      横浜市開港記念会館(神奈川県横浜市)
    • Year and Date
      2015-11-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] WNT inhibition facilitates the establishment of stable and homogeneous EpiSCs2015

    • Author(s)
      Michihiko Sugimoto, Kuniya Abe
    • Organizer
      29th International Mammalian Genome Conference
    • Place of Presentation
      横浜市開港記念会館(神奈川県横浜市)
    • Year and Date
      2015-11-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ナイーブ型とプライム型を分けるエピジェネティックバリアーにおけるDNAメチル化の役割2015

    • Author(s)
      浦大樹、阿部訓也、丹羽仁史
    • Organizer
      日本遺伝学会第87回大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県仙台市)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Germline Stem (GS)細胞の精子形成能獲得に必要な遺伝子の探索2015

    • Author(s)
      鈴木伸之介、池田理恵子、浦大樹、佐藤卓也、小川毅彦、阿部訓也
    • Organizer
      第108回日本繁殖生物学会大会
    • Place of Presentation
      宮崎大学木花キャンパス(宮崎県宮崎市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] A Simple and Robust Method for Establishing Homogeneous Mouse Epiblast Stem Cell Lines by WNT Inhibition2015

    • Author(s)
      Kuniya Abe, Michihiko Sugimoto, Masayo Kondo, Yumiko Koga, Hirosuke Shiura, Susana M. Chuva de Sousa Lopes
    • Organizer
      International Society for Stem Cell Research 2015 Annual Meeting
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] tw5 and mouse early embryogenesis: developmental genetics of t-complex2015

    • Author(s)
      Kuniya Abe, Karen Artzt, Michihiko Sugimoto
    • Organizer
      日本発生生物学会第48回年会 シンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ホールマウントRNA-FISHによるマウス着床期におけるXist/Tsix発現動態解析2015

    • Author(s)
      志浦寛相、阿部訓也
    • Organizer
      第9回日本エピジェネティクス研究会年会
    • Place of Presentation
      学術総合センター一橋講堂(東京都千代田区)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 分化能の異なる2つの多能性状態における転写因子とDNAメチル化の関係について2015

    • Author(s)
      浦大樹、阿部訓也
    • Organizer
      第9回日本エピジェネティクス研究会年会
    • Place of Presentation
      学術総合センター一橋講堂(東京都千代田区)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Xist/Tsix発現から見るマウス着床期におけるX不活性化ダイナミクス2014

    • Author(s)
      志浦寛相、阿部訓也
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Vps52および関連遺伝子のマウス胚発生における役割2014

    • Author(s)
      杉本道彦、田村勝、阿部訓也
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      長浜バイオ大学(滋賀県長浜市)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Xist/Tsix発現から見るマウス着床期におけるX不活性化ダイナミクス2014

    • Author(s)
      志浦寛相、阿部訓也
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      長浜バイオ大学(滋賀県長浜市)
    • Year and Date
      2014-09-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 哺乳類発生過程におけるエピゲノム動態解析2014

    • Author(s)
      阿部訓也
    • Organizer
      第28回環境ホルモン学会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2014-06-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Whole-mount MeFISH:特定DNA配列メチル化と遺伝子/タンパク発現の同時イメージング2014

    • Author(s)
      志浦 寛相、 岡本 晃充、佐々木 裕之、阿部 訓也
    • Organizer
      第8回日本エピジェネティクス研究会年会
    • Place of Presentation
      伊藤国際学術研究センター(東京都文京区)
    • Year and Date
      2014-05-26
    • Related Report
      2014 Annual Research Report
  • [Book] 遺伝単 遺伝学用語集 対訳付き 日本遺伝学会監修・編「生物の科学 遺伝」別冊2017

    • Author(s)
      日本遺伝学会監修・編
    • Total Pages
      371
    • Publisher
      エヌ・ティー・エス
    • ISBN
      9784860434991
    • Related Report
      2017 Annual Research Report
  • [Book] 遺伝単 遺伝学用語集 対訳付き 日本遺伝学会監修・編「生物の科学 遺伝」別冊2017

    • Author(s)
      阿部 訓也
    • Publisher
      NTS社
    • Related Report
      2016 Annual Research Report
  • [Book] 実験医学別冊 次世代シークエンス解析スタンダード2014

    • Author(s)
      池田理恵子、阿部訓也
    • Total Pages
      401
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Book] 実験医学別冊 次世代シークエンス解析スタンダード2014

    • Author(s)
      鈴木雅子、阿部訓也
    • Total Pages
      401
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Book] Advances in Intravital Microscopy: From Basic to Clinical Research2014

    • Author(s)
      Cao, L. and Abe, K.
    • Total Pages
      418
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] iPS細胞の白色光観察+機械学習判定2017

    • Inventor(s)
      張元翔, 横田秀夫, 阿部訓也, 蔡明達
    • Industrial Property Rights Holder
      張元翔, 横田秀夫, 阿部訓也, 蔡明達
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-026477
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] METHOD AND APPARATUS FOR DETECTING CELL REPROGRAMMING2017

    • Inventor(s)
      張 元翔, 横田 秀夫, 阿部 訓也, 蔡 明達
    • Industrial Property Rights Holder
      国立研究開発法人理化学研究所, 中原大學
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-026477
    • Filing Date
      2017-02-15
    • Related Report
      2016 Annual Research Report
    • Overseas

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Published: 2014-04-04   Modified: 2019-03-29  

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