Research Project
Grant-in-Aid for Scientific Research (A)
The roles and modes of action of nectins in heterotypic cell-cell adhesions were investigated. We identified a novel cell adhesion apparatus formed by the heterophilic trans-interaction between nectin-4 and nectin-1, which were expressed in the luminal and basal cells in the mammary gland, respectively. Nectin-4 in this apparatus enhanced the prolactin receptor signaling. Moreover, we showed that nectin-2 and nectin-3 expressed in olfactory and supporting cells, respectively, interacted in trans and recruited cadherin to the heterotypic cell junctions, resulting in the formation of the mosaic pattern in the olfactory epithelium. Further, we showed that nectin-2δ was localized on the plasma membranes of astrocytic perivascular endfoot processes facing the basement membrane of blood vessels in the brain. Genetic ablation of nectin-2 caused degeneration of the astrocytic perivascular endfoot processes and neurons, indicating that nectin- 2 is required to maintain the brain structures.
All 2017 2016 2015 2014
All Journal Article (27 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 27 results, Open Access: 15 results, Acknowledgement Compliant: 18 results) Presentation (12 results) (of which Invited: 2 results) Patent(Industrial Property Rights) (1 results)
J. Biol. Chem.
Volume: 292 Pages: 6895-6909
10.1074/jbc.m116.769091
Molecular and Cellular Neuroscience
Volume: 79 Pages: 34-44
10.1016/j.mcn.2016.12.007
Genes Cells
Volume: 印刷中 Pages: 472-484
10.1111/gtc.12489
J Comp Neurol
Volume: 印刷中
European Journal of Physiology
Volume: 44 Pages: 2272-2284
10.1111/ejn.13331
Brain Research
Volume: 1649 Pages: 90-101
10.1016/j.brainres.2016.08.023
Biochem J
Volume: 473 Pages: 2691-2715
10.1042/bcj20160235
Volume: 21 Pages: 88-98
10.1111/gtc.12322
J.Cell Biology
Volume: 212 Pages: 561-571
10.1083/jcb.201509020
120005766825
Volume: 291 Pages: 5817-5831
10.1074/jbc.m115.685917
Mol Cell Neurosci
Volume: 71 Pages: 25-33
10.1016/j.mcn.2015.12.005
Volume: 68 Pages: 143-150
10.1016/j.mcn.2015.07.003
Volume: 523 Pages: 1824-1839
10.1002/cne.23762
Brain Res.
Volume: 43 Pages: 139-152
10.1016/j.brainres.2015.05.012
PLoS One
Volume: 10
10.1371/journal.pone.0130032
PLoS ONE.
10.1371/journal.pone.0124259
J Comp Neurol.
PLoS Pathog.
Volume: 16
10.1371/journal.ppat.1004721
Curr Top Dev Biol.
Volume: 112 Pages: 197-231
10.1016/bs.ctdb.2014.11.019
Protein Science
Volume: 24 Pages: 376-385
10.1002/pro.2628
J Histochem Cytochem
Volume: 63 Pages: 99-113
10.1369/0022155414562045
120005593935
Volume: 9
10.1371/journal.pone.0110549
Genes Cells.
Volume: 19 Pages: 842-52
10.1111/gtc.12184
Genes to Cells
Volume: 19 Pages: 853-63
10.1111/gtc.12185
J Clin Invest
Volume: 124 Pages: 4503-16
10.1172/jci71245
J Clin Invest.
Volume: 124 Pages: 4517-28
10.1172/jci75572
Volume: 19 Pages: 667-675
10.1111/gtc.12166