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Study on molecular machinery of suppression of neurodegeneration by autophagy and drug discovery research

Research Project

Project/Area Number 26251020
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Cell biology
Research InstitutionOsaka University

Principal Investigator

Yoshimori Tamotsu  大阪大学, 生命機能研究科, 教授 (60191649)

Project Period (FY) 2014-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥39,520,000 (Direct Cost: ¥30,400,000、Indirect Cost: ¥9,120,000)
Fiscal Year 2018: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Keywordsオートファジー / 神経変性疾患 / Rubicon / パーキンソン病 / 低分子化合物 / 脳神経疾患 / たんぱく質分解 / KOマウス
Outline of Final Research Achievements

The intracellular degradation system, autophagy is known to degrade aggregate-prone proteins causing neurodegeneration including Parkinson disease. We found that suppression of Rubicon, a negative regulator of autophagy enhances these proteins. In addition, we identified several Low molecular weight compounds, which are candidates for activating autophagy thereby promote degradation of the proteins.

Academic Significance and Societal Importance of the Research Achievements

アルツハイマー病やパーキンソン病等の神経変性疾患は、超高齢社会を迎える我が国の重要課題です。それを抑える細胞の仕組みの一端を明らかにできたことと、そしてその結果治療の標的となりうるタンパク質が判ったことは学術的にも社会的にも大きな意義があります。さらにこの研究で発見したオートファジーを促進する化合物は、将来これらの病気の治療薬の開発に結びつくことが期待されます。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(67 results)

All 2019 2018 2016 2015 2014 Other

All Journal Article (13 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 13 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (50 results) (of which Int'l Joint Research: 20 results,  Invited: 50 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics2019

    • Author(s)
      Chang C, Young LN, Morris KL, von Buelow S, Schoeneberg J, Yamamoto-Imoto H, Oe Y, Yamamoto K, Nakamura S, Stjepanovic G, Hummer G, Yoshimori T, Hurley JH
    • Journal Title

      Mol. Cell

      Volume: 73 Pages: 339-353

    • DOI

      10.1016/j.molcel.2018.10.035

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Suppression of autophagic activity by Rubicon is a signature of aging.2019

    • Author(s)
      Nakamura S, Oba M, Suzuki M, Takahashi A, Yamamuro T, Fujiwara M, Ikenaka K, Minami S, Tabata N, Yamamoto K, Kubo S, Tokumura A, Akamatsu K, Miyazaki Y, Kawabata T, Hamasaki M, Fukui K, Sango K, Watanabe Y, Takabatake Y, Kitajima T, Okada Y, Mochizuki H, Isaka Y, Antebi A, Yoshimori T.
    • Journal Title

      Nature communications

      Volume: 10 Pages: 847-847

    • DOI

      10.1038/s41467-019-08729-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes2019

    • Author(s)
      Lystad AH*, Carlsson SR*, de la Ballina LR, Kauffman KJ, Nag S, Yoshimori T, Melia TJ, Simonsen A
    • Journal Title

      Nat. Cell. Biol.

      Volume: 21 Pages: 372-383

    • DOI

      10.1038/s41556-019-0274-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A brain-enriched Drp1 isoform associates with lysosomes, late endosomes and the plasma membrane2018

    • Author(s)
      Itoh K, Adachi Y, Yamada T, Suzuki TL, Otomo T, McBride HM, Yoshimori T, Iijima M, Sesaki H
    • Journal Title

      J. Biol. Chem.

      Volume: 293 Pages: 11809-11822

    • DOI

      10.1074/jbc.ra117.001253

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension2018

    • Author(s)
      Aoki A, Nakashima A, Kusabiraki T, Ono Y, Yoshino O, Muto M, Kumasawa K, Yoshimori T, Ikawa M, Saito S
    • Journal Title

      Am J Pathol.

      Volume: 188 Pages: 2474-2486

    • DOI

      10.1016/j.ajpath.2018.07.021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo2018

    • Author(s)
      Lee JH, Rao MV, Yang DS, Stavrides P, Im E, Pensalfini A, Huo C, Sarkar P, Yoshimori T, Nixon RA
    • Journal Title

      Autophagy

      Volume: 15 Pages: 543-557

    • DOI

      10.1080/15548627.2018.1528812

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Induction of selective autophagy in cells replicating hepatitis C virus genome2018

    • Author(s)
      Mori Hiroyuki、Fukuhara Takasuke、Ono Chikako、Tamura Tomokazu、Sato Asuka、Fauzyah Yuzy、Wada Masami、Okamoto Toru、Noda Takeshi、Yoshimori Tamotsu、Matsuura Yoshiharu
    • Journal Title

      J. Gen. Virol.

      Volume: 99 Pages: 1643-1657

    • DOI

      10.1099/jgv.0.001161

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread2018

    • Author(s)
      Tan JM, Mellouk N, Osborne SE, Ammendolia DA, Dyer DN, Li R, Brunen D, van Rijn JM, Huang J, Czuczman MA, Cemma MA, Won AM, Yip CM, Xavier RJ, MacDuff DA, Reggiori F, Debnath J, Yoshimori T, Kim PK, Fairn GD, Coyaud E, Raught B, Muise AM, Higgins DE, Brumell JH
    • Journal Title

      Nat. Microbiol.

      Volume: 3 Pages: 1472-1485

    • DOI

      10.1038/s41564-018-0293-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity.2016

    • Author(s)
      Hao F, Itoh T, Morita E, Shirahama-Noda K, Yoshimori T, Noda T.
    • Journal Title

      FEBS Letters

      Volume: 509 Pages: 161-173

    • DOI

      10.1002/1873-3468.12048

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.2015

    • Author(s)
      Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T, Miyatsuka T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H.
    • Journal Title

      J. Clin. Invest.

      Volume: 124 Pages: 3634-3644

    • DOI

      10.1172/jci69866

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reciprocal conversion of Gtr1 and Gtr2 nucleotide- binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy.2014

    • Author(s)
      Kira S, Tabata K, Shirahama-Noda K, Nozoe A, Yoshimori T, Noda T.
    • Journal Title

      autophagy

      Volume: 10 Pages: 54-67

    • DOI

      10.4161/auto.29397

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy.2014

    • Author(s)
      Choi J, Park S, Biering SB, Selleck E, Liu CY, Zhang X, Fujita N, Saitoh T, Akira S, Yoshimori T, Sibley LD, Hwang S, Virgin HW.
    • Journal Title

      Immunity

      Volume: 40 Pages: 1-12

    • DOI

      10.1016/j.immuni.2014.05.006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy induced by calcium phosphate precipitates targets damaged endosomes.2014

    • Author(s)
      Chen X, Khambu B, Zhang H, Gao W, Li M, Chen X, Yoshimori T, Yin XM.
    • Journal Title

      J Biol Chem.

      Volume: 289 Pages: 11162-74

    • DOI

      10.1074/jbc.m113.531855

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] オートファジー:疾患に対抗し寿命を延ばす細胞の守護者2019

    • Author(s)
      吉森保
    • Organizer
      第1回 医学系研究科-産業科学研究所懇話会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Autophagy: Its molecular machinery and implications in diseases2019

    • Author(s)
      吉森保
    • Organizer
      The 1st OIST-OU Joint Symposium “Cell Biology and Immunology”,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Suppression of Autophagy by Rubicon Is Signature of Aging.2019

    • Author(s)
      吉森保
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology "Autophagy: From Model Systems to Therapeutic Opportunities"
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dissection of Molecular Mechanisms in Lysophagy2018

    • Author(s)
      吉森保
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology "Selective Autophagy"
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オートファジー:感染症などの疾患に対抗する細胞の守護者2018

    • Author(s)
      吉森保
    • Organizer
      第92回日本感染症学会学術講演会・第66回日本化学療法学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] オートファジーによる疾患抑制の分子機構2018

    • Author(s)
      吉森保
    • Organizer
      千里ライフサイエンスセミナーM2:オートファジーと疾患
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 疾患と老化に対抗するオートファジー2018

    • Author(s)
      吉森保
    • Organizer
      新潟大学教育研究特別シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] オートファジー:疾患に対抗し寿命を延長する細胞内分解システム2018

    • Author(s)
      吉森保
    • Organizer
      第34回創薬セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] オートファジー:疾患と老化に対抗する細胞の恒常性維持機構2018

    • Author(s)
      吉森保
    • Organizer
      第2回Aging Forum
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Autophagy and its Relevance to Movement Disorders2018

    • Author(s)
      吉森保
    • Organizer
      MDS Basic Science Summer School
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 22 Years of Autophagy: towards Understanding the Cellular Self-Degradation System Fighting against Diseases and Aging2018

    • Author(s)
      吉森保
    • Organizer
      Keynote lecture in 2nd Nordic Autophagy Society Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞の守護者オートファジー:疾患と老化に対抗する細胞恒常性維持機構2018

    • Author(s)
      吉森保
    • Organizer
      第16回高付加価値食品開発のためのフォーラム(シーズとニーズの新たな出会い)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 21 Years of Autophagy: towards Understanding the Intracellular Degradation System Fighting against Diseases and Aging2018

    • Author(s)
      吉森保
    • Organizer
      26th Conference of the European Cell Death Organization “Cell death in disease: from small molecules to translational medicine”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A E3 Ligase in Lysophagy and Xenophagy in Endothelial Cells2018

    • Author(s)
      吉森保
    • Organizer
      HFSP meeting 2018 in Osaka~The physical basis of autophagosome biogenesis~
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オートファジーによる疾患制御の分子機構2018

    • Author(s)
      吉森保
    • Organizer
      第40回北海等大学獣医学学術交流基金群講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 組織によってオートファジーの能力や役割は異なる2018

    • Author(s)
      吉森保
    • Organizer
      第11回オートファジー研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] オートファジーとは何か:ノーベル賞の大隅先生と挑んだ21年2018

    • Author(s)
      吉森保
    • Organizer
      安田記念医学財団創立30周年記念講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Selective Autophagy and Diseases2016

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      Keynote Session in The Gordon Research Conference on Autophagy in Stress, Development & Disease
    • Place of Presentation
      Ventura Beach Marriott, Ventura, USA
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 20 years of Autophagy: towards Understanding the Intracellular Self-Degradation System Fighting against Diseases2016

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      2016 International A3 Foresight Symposium on Autophagy
    • Place of Presentation
      Chungnam National University, Daejeon, Korea
    • Year and Date
      2016-02-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanistic Insights into Membrane Dynamics in Autophagy2016

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      FRIAS Black Forrest Winter Conference on Autophagic Membrane Trafficking and Dynamics in Ageing and Disease
    • Place of Presentation
      Hotel Saigerhoeh, Freiburg, Germany
    • Year and Date
      2016-01-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Autophagy: The Intracellular Self-Degradation System Fighting against Disease.2016

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      The5th NIF Winter School on Advanced Immunology
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Awaji Island, Japan
    • Year and Date
      2016-01-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞の守護者オートファジー:疾患に対抗する細胞内自己分解システム2015

    • Author(s)
      吉森 保
    • Organizer
      第5回 MD研究者養成コース四大学コンソーシアムリトリート
    • Place of Presentation
      ザ・パレスサイドホテル, 京都
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] オートファジー:疾患に対抗する細胞内大規模分解系2015

    • Author(s)
      吉森 保
    • Organizer
      第452回日本皮膚科学会大阪地方会・第22回小林浩記念講演
    • Place of Presentation
      大阪科学技術センター, 大阪
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] オートファジーによる病態抑制のメカニズム2015

    • Author(s)
      吉森 保
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会 (BMB2015) オリンパス(株)ランチョンセミナー
    • Place of Presentation
      神戸国際会議場, 神戸
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] New Insights into Autophagy in Disease2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会 (BMB2015) 1S14:科学研究費補助金 新学術領域研究「オートファジーの集学的研究:分子基盤から疾患まで」共催シンポジウム Autophagy
    • Place of Presentation
      神戸国際会議場, 神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オートファジーの膜動態:分子機構と疾患との関わり2015

    • Author(s)
      吉森 保
    • Organizer
      第9回オートファジー研究会・新学術領域研究「オートファジーの集学的研究:分子基盤から疾患まで」第3回班会議, セッション6 (分子機構・膜動態)
    • Place of Presentation
      淡路夢舞台国際会議場, 淡路
    • Year and Date
      2015-11-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Autophagy: Molecular Machinery and Role in Suppression of Diseases2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      The 14th CRG symposium: Cellular Machineries
    • Place of Presentation
      PRBB auditorium CRG, Bercelona, Spain
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New Insights into Membrane Biogenesis and Targeting in Autophagy2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      EMBO Conference on Autophagy: Autophagy signaling and progression in health and disease
    • Place of Presentation
      Chia Laguna Resort, Chia, Italy
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 疾患に対抗する細胞内大規模分解システム・オートファジー2015

    • Author(s)
      吉森 保
    • Organizer
      第2回GSK皮膚免疫カンファレンス
    • Place of Presentation
      大津プリンスホテル, 滋賀
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Autophagy: The Intracellular Self-Degradation System Fighting against Diseases2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      The 21st Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Osaka International Convention Center, Osaka
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Insights into Membrane Dynamics in Autophagy2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      The Gordon Research Conference on Molecular Membrane Biology
    • Place of Presentation
      Proctor Academy, Andover, NH, USA
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞の守護者オートファジー:疾患に対抗する細胞内自己分解システム2015

    • Author(s)
      吉森 保
    • Organizer
      第24回日本Cell Death学会学術集会
    • Place of Presentation
      大阪大学会館, 大阪
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Autophagy: the cellular Guardian Sustaining Life2015

    • Author(s)
      吉森 保
    • Organizer
      第67回日本細胞生物学会大会 大会長企画シンポジウム
    • Place of Presentation
      タワーホール船堀, 東京
    • Year and Date
      2015-07-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New Insights into Membrane Dynamics and Role of Autophagy2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology “Autophagy (E6)”
    • Place of Presentation
      Beaver Run Resort, Breckenridge, Colorado, USA
    • Year and Date
      2015-06-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞の守護者オートファジー:分子機構と病態生理2015

    • Author(s)
      吉森 保
    • Organizer
      第118回日本小児科学会学術集会
    • Place of Presentation
      大阪国際会議場, 大阪
    • Year and Date
      2015-04-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Autophagy: Its Membrane Dynamics and Role in Suppression of Diseases2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      British Society for Cell Biology & British Society for Developmental Biology Joint Spring Meeting
    • Place of Presentation
      University of Warwick, Coventry, UK
    • Year and Date
      2015-04-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New Insights into Membrane Biogenesis and Targeting in Autophagy2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      The 7th International Symposium on Autophagy
    • Place of Presentation
      Smoky Willow Resort, Anhui, China
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Lysophagy: Damaged Lysosomes Are Selectively Eliminated by Autophagy2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      Gordon Research Conference on Lysosomal Diseases
    • Place of Presentation
      Hotel Galvez, Galveston, USA
    • Year and Date
      2015-03-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Autophagy: The Intracellular Self-Degradation System Fighting against Diseases2015

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      Lorne Infection & Immunity Conference 2015
    • Place of Presentation
      Mantra Erskine Beach Resort, Lorne, Australia
    • Year and Date
      2015-02-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] New Insights into Membrane Biogenesis and Targeting in Autophagy2014

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      2014 Northeastern Asian Symposium on Autophagy
    • Place of Presentation
      Westin Chosun Hotel, Busan, Korea
    • Year and Date
      2014-12-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞の守護者オートファジー:分子機構と疾患との関わり2014

    • Author(s)
      吉森 保
    • Organizer
      脳心血管抗加齢研究会2014 併催:第4回 運動器抗加齢医学研究会/アンチエイジングフェスタ2014
    • Place of Presentation
      梅田スカイビル、大阪
    • Year and Date
      2014-12-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞の守護者オートファジー:分子機構と疾患との関わり2014

    • Author(s)
      吉森 保
    • Organizer
      第41回日本臓器保存生物医学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター、大阪
    • Year and Date
      2014-11-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] オートファジーの膜動態:分子機構と疾患との関わり2014

    • Author(s)
      吉森 保
    • Organizer
      第8回 オートファジー研究会、セッション5:分子機構と膜動態 (5) 生理・病態
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ、札幌
    • Year and Date
      2014-11-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] オートファジーの膜動態の分子機構とその破綻による病態の解明2014

    • Author(s)
      吉森 保
    • Organizer
      第87回 日本生化学会大会 平成26年度 第9回柿内三郎記念賞受賞講演
    • Place of Presentation
      国立京都国際会館、京都
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞の守護者オートファジー:分子機構と疾患との関わり2014

    • Author(s)
      吉森 保
    • Organizer
      第3回 川島腎カンファレンス
    • Place of Presentation
      内藤記念くすり博物館、岐阜
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Insights into membrane dynamics and role of mammalian autophagy2014

    • Author(s)
      Tamotsu Yoshimori
    • Organizer
      The 38th Naito Conference on Molecule-based biological systems
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ、札幌
    • Year and Date
      2014-10-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞の守護者オートファジー:分子機構と疾患との関わり2014

    • Author(s)
      吉森 保
    • Organizer
      第5回 Molecular Cardiovascular Conference Ⅱ キーノートレクチャー
    • Place of Presentation
      神戸ベイシェラトンホテル&タワーズ、神戸
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞の守護者オートファジー:分子機構と疾患との関わり2014

    • Author(s)
      吉森 保
    • Organizer
      平成26年度 がん若手研究者ワークショップ
    • Place of Presentation
      蓼科グランドホテル滝の湯、長野
    • Year and Date
      2014-09-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] オートファジーと疾患2014

    • Author(s)
      吉森 保
    • Organizer
      第19回 日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター、大阪
    • Year and Date
      2014-08-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 18 years of Autophagy: 生命を支える細胞内大規模分解系の理解を目指して2014

    • Author(s)
      吉森 保
    • Organizer
      第10回近畿先天代謝異常症研究会
    • Place of Presentation
      ホテルグランヴィア大阪、大阪
    • Year and Date
      2014-07-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] Encyclopedia of Cell Biology, 1st Edition (Section editor for Volume 2: Organizational Cell Biology)2015

    • Author(s)
      Yoshimori Tamotsu 他
    • Total Pages
      852
    • Publisher
      Academic Press
    • Related Report
      2015 Annual Research Report
  • [Book] プログレッシブ 生命科学(第1版)2014

    • Author(s)
      吉森 保、岡正啓、米田悦啓、田中亀代次、西條將文、岩井一宏、菊池章、松本真司、岡村康司、山本浩靖、木原進士、松岡達、高木都、犬束歩、山中章弘、金井好克、磯谷綾子、伊川正人、古川貴久、戸田達史、他
    • Total Pages
      312
    • Publisher
      南山堂
    • Related Report
      2014 Annual Research Report
  • [Remarks] 研究室HP

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/yoshimori/

    • Related Report
      2017 Annual Research Report 2015 Annual Research Report
  • [Remarks] 研究室HP

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/yoshimori/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2020-03-30  

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