|Budget Amount *help
¥39,260,000 (Direct Cost: ¥30,200,000、Indirect Cost: ¥9,060,000)
Fiscal Year 2017: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2016: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2015: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2014: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
|Outline of Final Research Achievements
Bovine leukemia virus (BLV) is highly endemic in many countries including Japan. In this study, we evaluated the risk for BLV transmission among the infected animals to establish the guideline for effective eradication of EBL. We found that BLV-infected cattle with persistent lymphocytosis (PL) or high proviral load or EBL are considered major sources of both horizontal and vertical BLV transmission. Furthermore, maternal proviral load is closely correlated with the frequency of vertical transmission to calves. However, no direct evidence of intrauterine BLV infection has been confirmed in infected cattle. We confirmed intrauterine BLV infection in two pregnant dams with high viral load by cesarean delivery, and BLV was detected in the newborns. In the study, we presented a direct evidence of intrauterine BLV transmission in pregnant dam with a high proviral load. These results could aid the development of BLV control measures targeting viral load.