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Synthetic Studies on Complex Alkaloids base on Development of Creative Construction of Complex Skeleton and Oxidative Transformations

Research Project

Project/Area Number 26253001
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionTohoku University

Principal Investigator

Tokuyama Hidetoshi  東北大学, 薬学研究科, 教授 (00282608)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2016: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2015: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2014: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Keywordsアルカロイド / 全合成 / 骨格構築 / 酸化反応 / ベンザイン / 不斉合成 / Friedel-Crafts反応 / 有機化学 / 薬学 / 生物活性天然物 / 二量体 / 多環性骨格 / 化学修飾法 / 多環性高次構造 / 構造修飾法
Outline of Final Research Achievements

Synthetic studies on pharmacologically important and structurally complex natural products were conducted based on development of novel oxidative transformations and constructions of the unique skeletons. As results, we established synthetic route of the number of synthetically challenging alkaloids such as MPC1001 B, asteroxepin, historionicotoxin, lepadiformine A, indolactam V, CC-1065, isoschizogamine, haplophytine, leuconoxine and its congeners. We also developed the synthetic method for tetracyclic core skeleton of aconitine alkaloid.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(175 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (7 results) Journal Article (36 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 35 results,  Open Access: 5 results,  Acknowledgement Compliant: 25 results) Presentation (128 results) (of which Int'l Joint Research: 28 results,  Invited: 22 results) Book (3 results) Remarks (1 results)

  • [Int'l Joint Research] Seoul National University(韓国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] BIOTEC(Thailand)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] BIOTEC, NSTDA(Thailand)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Nanyang Technological University(Singapore)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Max Planck Institute(Germany)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of East Anglia(United Kingdom)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] BIOTEC, NSTDA(タイ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Synthesis of 9,10-Diarylanthracenes via Mg(TMP)2_2LiCl-Mediated Benzyne Generation/[4+2] Cycloaddition and Deoxygenation of 9,10-Epoxyanthracene Intermediates2018

    • Author(s)
      Miyamoto, N.; Nakazawa, Y.; Nakamura, T.; Okano, K.; Sato, S.; Sun, Z.; Isobe, H.; Tokuyama, H.
    • Journal Title

      Synlett

      Volume: 29 Pages: 513-518

    • DOI

      10.1055/s-0036-1591510

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cordybislactone, a Stereoisomer of the 14-Membered Bislactone Clonostachydiol, from the Hopper Pathogenic Fungus Cordyceps sp. BCC 49294: Revision of the Absolute Configuration of Clonostachydiol2018

    • Author(s)
      K. Ojima, A. Yangchum, P. Laksanacharoen, K. Tasanathai, D. Thanakitpipattana, H. Tokuyama, M. Isaka
    • Journal Title

      Journal of Antibiotics

      Volume: 71 Pages: 351-358

    • DOI

      10.1038/s41429-017-0008-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] AgNTf2-Mediated Arylation of Bromopyrroloindolines2017

    • Author(s)
      Sato Soichiro、Hirayama Azusa、Adachi Touma、Kawauchi Daichi、Ueda Hirofumi、Tokuyama Hidetoshi
    • Journal Title

      Heterocycles

      Volume: 94 Pages: 1940-1957

    • DOI

      10.3987/com-17-13777

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of Actinophyllic Acid2017

    • Author(s)
      Yoshii Yu、Tokuyama Hidetoshi、Chen David Y.-K.
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 56 Pages: 12277-12281

    • DOI

      10.1002/anie.201706312

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] AgNTf2-Mediated Allylation with Allylsilanes at C3a-Position of Hexahydropyrroloindoles: Application to Total Syntheses of Amauromine Alkaloids2017

    • Author(s)
      Hakamata Hiroyuki、Sato Soichiro、Ueda Hirofumi、Tokuyama Hidetoshi
    • Journal Title

      Organic Letters

      Volume: 19 Pages: 5308-5311

    • DOI

      10.1021/acs.orglett.7b02602

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Syntheses of (+)-T988 B and C via AgNTf2-Mediated Coupling of Bromopyrroloindoline with Indole2017

    • Author(s)
      S. Sato, A. Hirayama, H. Ueda, H. Tokuyama
    • Journal Title

      Asian Journal of Organic Chemistry

      Volume: 6 Pages: 54-58

    • DOI

      10.1002/ajoc.201600474

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An obtuse-angled corner unit for fluctuating carbon nanohoops2017

    • Author(s)
      Z. Sun, N. Miyamoto, S. Sato, H. Tokuyama, H. Isobe
    • Journal Title

      Chem. Asian J.

      Volume: 12 Pages: 271-275

    • DOI

      10.1002/asia.201601614

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural determination of (-)-SCH 64874 and hirsutellomycin by semi-synthesis2017

    • Author(s)
      H. Tokuyama, K. Yamada, H. Fujiwara, J. Sakata, K. Okano, M. Sappan, M. Isaka
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 82 Pages: 353-371

    • DOI

      10.1021/acs.joc.6b02452

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Total Synthesis of (-)-Histrionicotoxin through a Stereoselective Radical Translocation-Cyclization Reaction2017

    • Author(s)
      M. Sato, H. Azuma, A. Daigaku, S. Sato, K. Takasu, K. Okano, H. Tokuyama
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 56 Pages: 1087-1091

    • DOI

      10.1002/anie.201609941

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Conversion of Vindoline into 11-Mesyloxytabersonine2016

    • Author(s)
      Y. Han-ya, T. Inui, S. Yokoshima, H. Tokuyama, T. Fukuyama
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 64 Issue: 7 Pages: 800-804

    • DOI

      10.1248/cpb.c16-00175

    • NAID

      130005160073

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Convergent Synthesis of 2-Aryl-Substituted Quinolines by Gold-Catalyzed Cascade Reaction2016

    • Author(s)
      H. Ueda, M. Yamaguchi, H. Tokuyama
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 64 Issue: 7 Pages: 824-829

    • DOI

      10.1248/cpb.c16-00193

    • NAID

      130005160037

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O2016

    • Author(s)
      A. Umehara, H. Ueda, H. Tokuyama
    • Journal Title

      Journal of Organic Chemistry

      Volume: 81 Pages: 11444-11453

    • DOI

      10.1021/acs.joc.6b02097

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bioinspired Total Synthesis of the Dimeric Indole Alkaloid (+)-Haplophytine by Direct Coupling and Late-Stage Oxidative Rearrangement2016

    • Author(s)
      H. Satoh, K. Ojima, H. Ueda, H. Tokuyama
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 55 Pages: 15157-15161

    • DOI

      10.1002/anie.201609285

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Total Synthesis of (+)-MPC1001B2016

    • Author(s)
      T. Kurogi, S. Okaya, H. Fujiwara, K. Okano, H. Tokuyama
    • Journal Title

      Angew. Chem. Int. Ed. Engl.

      Volume: 55 Pages: 283-287

    • DOI

      10.1002/anie.201507830

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthetic Studies on Acochlearine: Construction of A/B/C/E/F Ring System2016

    • Author(s)
      K. Fujioka, N. Miyamoto, H. Toya, K. Okano, H. Tokuyama
    • Journal Title

      Synlett

      Volume: 27 Pages: 621-625

    • DOI

      10.1055/s-0035-1560384

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of Substituted Quinolizidines via a Gold-Catalyzed Double Cyclization Cascade2016

    • Author(s)
      S. Nonaka, K. Sugimoto, H. Ueda, H. Tokuyama
    • Journal Title

      Advanced Synthesis & Catalysis

      Volume: 358 Pages: 380-385

    • DOI

      10.1002/adsc.201500907

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] DIBALH-Mediated Reductive Ring-Expansion Reaction of Cyclic Ketoxime2016

    • Author(s)
      T. Imaizumi, K. Okano, H. Tokuyama
    • Journal Title

      Organic Syntheses

      Volume: 93 Pages: 1-13

    • DOI

      10.15227/orgsyn.093.0001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total syntheses of codonopsinine and 4-epi-codonopsinine via gold-mediated tandem catalyzed pyrrole synthesis2016

    • Author(s)
      M. Yamaguchi, D. Itagaki, H. Ueda, H. Tokuyama
    • Journal Title

      The Journal of Antibiotics

      Volume: 印刷中

    • DOI

      10.1038/ja.2016.13

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Structural and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase.2016

    • Author(s)
      Morita J, Kano K, Kato K, Takita H, Skagami H, Yamamoto Y, Mihara E, Ueda H, Sato T, Tokuyama H, Arai H, Asou H, Takagi J, Ishitani R, Nishimasu H, Nureki O, Aoki J
    • Journal Title

      Sci. Rep.

      Volume: 6 Pages: 1-14

    • DOI

      10.1038/srep20995

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Trichloroboron-Promoted Deprotection of Phenolic Benzyl Ether using Pentamethylbenzene as a Non Lewis-Basic Cation Scavenger2016

    • Author(s)
      S. Okaya, K. Okuyama, K. Okano, H. Tokuyama
    • Journal Title

      Organic Syntheses

      Volume: 93 Pages: 63-74

    • DOI

      10.15227/orgsyn.093.0063

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Concise Total Synthesis of (-)-Indolactam V2015

    • Author(s)
      T. Noji, K. Okano, H. Tokuyama
    • Journal Title

      Tetrahedron

      Volume: 71 Pages: 3833-3837

    • DOI

      10.1016/j.tet.2015.04.015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Total Synthesis of (-)-Isoschizogamine2015

    • Author(s)
      A. Takada, H. Fujiwara, K. Sugimoto, H. Ueda, H. Tokuyama
    • Journal Title

      Chemistry - A European Journal

      Volume: 21 Pages: 16400-16403

    • DOI

      10.1002/chem.201503606

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The Total Synthesis of Biosynthetically Related Monoterpene Indole Alkaloids2015

    • Author(s)
      H. Tokuyama
    • Journal Title

      J. Syn. Org. Chem., Jpn.

      Volume: 73 Issue: 11 Pages: 1120-1129

    • DOI

      10.5059/yukigoseikyokaishi.73.1120

    • NAID

      130005113520

    • ISSN
      0037-9980, 1883-6526
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereochemistry of Vinylogous Rubottom Oxidation of Proline-fused Cyclohexadienol Silyl Ether2015

    • Author(s)
      K. Okano, S. Okaya, T. Kurogi, H. Fujiwara, H. Tokuyama
    • Journal Title

      Heterocycles

      Volume: 90 Pages: 1299-1308

    • DOI

      10.3987/com-14-s(k)62

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthetic studies toward penitrem E: enantiocontrolled construction of B-E rings2015

    • Author(s)
      Yu Yoshii, Takanori Otsu, Norihiko Hosokawa, Kiyosei Takasu, Kentaro Okano, and Hidetoshi Tokuyama
    • Journal Title

      Chem. Commun.

      Volume: 51巻 Pages: 1070-1073

    • DOI

      10.1039/c4cc08505a

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Total Synthesis of (-)-Rhazinilam Using 1,3-Dipolar Cycloaddition of Optically Active Munchnone Intermediate2015

    • Author(s)
      K. Sugimoto, Y. Miyakawa, H. Tokuyama
    • Journal Title

      Tetrahedron

      Volume: 71

    • DOI

      10.1016/j.tet.2014.12.018

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of a Human Urate Transporter-1 Inhibitor, an Arginine Vasopressin Antagonist, and a 17β-Hydroxysteroid Dehydrogenase Type-3 Inhibitor, Using Ring-Expansion of Cyclic Ketoximes with DIBALH2014

    • Author(s)
      H. Cho, Y. Iwama, K. Okano, H. Tokuyama
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 62 Issue: 4 Pages: 354-363

    • DOI

      10.1248/cpb.c13-00961

    • NAID

      130003390785

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Sy ntheses of Leuconoxine, Leuconodine B, a nd Melodinine E by Oxidative Cyclic Am inal Formation and Diastereoselective Ring -Closing Metathesis2014

    • Author(s)
      梅原厚志、植田浩史、徳山英利
    • Journal Title

      Organic Letters

      Volume: 16巻 Pages: 2526-2529

    • DOI

      10.1021/ol500903e

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Acetic Acid-Promoted Metal-Free Aerobic Carbon-Carbon Bond Forming Reactions at α-Position of Tertiary Amines2014

    • Author(s)
      H. Ueda, K. Yoshida, H. Tokuyama
    • Journal Title

      Organic Letters

      Volume: 16 Pages: 4194-4197

    • DOI

      10.1021/ol5018883

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stereocontrolled Total Synthesis and Biological Evaluation of (-)- and (+)-Petrosin, and Its Derivatives2014

    • Author(s)
      H. Toya, T. Satoh, K. Okano, K. Takasu, M. Ihara, A. Takahashi, H. Tanaka, H. Tokuyama
    • Journal Title

      Tetrahedron

      Volume: 70 Pages: 8129-8141

    • DOI

      10.1016/j.tet.2014.08.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Autotandem Catalysis: Synthesis of Pyrroles by Gold-Catalyzed Cascade Reaction2014

    • Author(s)
      H. Ueda, M. Yamaguchi, H. Kameya, K. Sugimoto, H. Tokuyama
    • Journal Title

      Organic Letters

      Volume: 16 Pages: 4948-4951

    • DOI

      10.1021/ol5024695

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Generation of Aryl Grignard Reagent from Arene Chromium Tricarbonyl Complex by Mg(TMP)2・2LiCl and Its Application to Murahashi Coupling2014

    • Author(s)
      Y. Momoi, K. Okuyama, H. Tokuyama
    • Journal Title

      Synlett

      Volume: 24 Pages: 2503-2507

    • DOI

      10.1055/s-0034-1379205

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Total Synthesis of (-)-Haouamine B Pentaacetate and Structural Revision of Haouamine B2014

    • Author(s)
      Y. Momoi, K. Okuyama, H. Toya, K. Sugimoto, K. Okano, H. Tokuyama
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 53 Pages: 13215-13219

    • DOI

      10.1002/anie.201407686

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Copper-mediated aromatic amination reaction and its application to the total synthesis of natural products2014

    • Author(s)
      K. Okano, H. Tokuyama, T. Fukuyama
    • Journal Title

      Chemical Communications

      Volume: 50 Pages: 13650-13663

    • DOI

      10.1039/c4cc03895a

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthetic studies on lycopodine: construction of hexahydrojulolidine core by intramolecular Mannich reaction2014

    • Author(s)
      T. Sato, H. Ueda, H. Tokuyama
    • Journal Title

      Tetrahedron Letters

      Volume: 55 Pages: 7177-7180

    • DOI

      10.1016/j.tetlet.2014.10.150

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 不安定な七員環をいかにつくるか?ーアセチルアラノチンの全合成2014

    • Author(s)
      徳山英利, 岡野健太郎
    • Journal Title

      化学

      Volume: 69 Pages: 68-69

    • Related Report
      2014 Annual Research Report
  • [Presentation] Total Synthesis of (+)-Haplophytine2018

    • Author(s)
      Hirofumi Ueda, Hitoshi Satoh, Kenichi Ojima, Hidetoshi Tokuyama
    • Organizer
      International Symposium on Pure & Applied Chemistry 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Total Synthesis of (-)-Lepadiformine A via Diastereoselective Radical Translocation-Cyclization Reaction2018

    • Author(s)
      Masashi Shimomura, Manabu Sato, Juri Sakata, Hidetoshi Tokuyama
    • Organizer
      International Symposium on Pure & Applied Chemistry 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 官能基の化学選択的活性化を基盤とする高次構造アルカロイドの全合成2018

    • Author(s)
      植田浩史
    • Organizer
      本薬学会第138年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 金触媒による連続環化反応を用いたpyrrolopyrimidine骨格構築法の開発とTetraponerine類合成への応用2018

    • Author(s)
      丸茂和哉、板垣大地、亀谷紘、植田浩史、徳山英利
    • Organizer
      本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 不斉誘起型ラジカル転位環化反応を用いた(-)-Lepadiformine Aの全合成2018

    • Author(s)
      下村誠志、佐藤学、坂田樹理、徳山英利
    • Organizer
      本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ベンゾシクロブテノンオキシムスルホナートのBeckmann開裂を利用する新規ベンゾニトリル合成法の開発2018

    • Author(s)
      清水瑛大、坂田樹理、徳山英利
    • Organizer
      本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アミドのワンポット還元的アリル化反応の開発とアルカロイド合成への応用2018

    • Author(s)
      坂田樹理、板橋優、徳山英利
    • Organizer
      本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酸素をバルク酸化剤とするカテコール類酸化反応の開発とインドリン骨格構築法への応用2018

    • Author(s)
      川上亮英、 岡田康佑、 植田浩史、 徳山英利
    • Organizer
      本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エポキシアントラセンを経由した新規シクロパラフェニレン合成法の開発2017

    • Author(s)
      宮本尚也,孫哲,佐藤宗太, 徳山英利, 磯部寛之
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Discorhabdin Vの合成研究2017

    • Author(s)
      野呂尭広, 坂田樹理, 徳山英利
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 海産アルカロイドPlakinidine Dの合成研究2017

    • Author(s)
      安達陶磨,佐藤喬仁, 坂田樹理,岡野健太郎,徳山英利
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] チタニウムヒドリドとジアリル亜鉛を組み合わせたアミドの還元的アリル化反応の開発2017

    • Author(s)
      板橋優,佐藤学,坂田樹理,徳山英利
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 金触媒を用いた三成分連結反応による多置換アニリンの合成2017

    • Author(s)
      山本稜太, 山口 南実, 植田 浩史, 徳山 英利
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 金触媒による連続環化反応を鍵とするBatzelladine類の合成研究2017

    • Author(s)
      板垣大地, 丸茂和哉, 植田浩史, 徳山英利
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 二量体型インドールアルカロイド (+)-haplophytine 類縁化合物の合成研究2017

    • Author(s)
      小島健一,植田浩史,徳山英利
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規非対称ケトン合成法を用いた (+)-cylindricine C の全合成2017

    • Author(s)
      山田香織, 黒木太一, 岡野健太郎, 坂田樹理, 徳山英利
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] ボアカンジミンAの合成研究2017

    • Author(s)
      吉田慶, 植田浩史, 徳山英利
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Neostenineの合成研究2017

    • Author(s)
      飯村健太郎,佐藤敬直,植田浩史,徳山英利
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 4位にスピロ環状構造を有するテトラヒドロキノリン骨格の新規構築法2017

    • Author(s)
      若原裕子,野呂尭広,坂田樹理,植田浩史,徳山英利
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 鉄触媒を用いたN-メチルアニリンの酸化的脱メチル化反応の開発2017

    • Author(s)
      伊東由夏,植田浩史,徳山英利
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Teleocidin Bの合成研究2017

    • Author(s)
      下村誠志、坂田樹理、徳山英利
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] オキシムスルホナートの環拡大反応を用いたインドール合成法の開発と(+)-CC-1065の全合成2017

    • Author(s)
      坂田樹理,今泉 拓,山下有美,岡野健太郎,徳山英利
    • Organizer
      第15回次世代を担う有機化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Concise Synthesis of Anthracene Embedded Cycloparaphenylenes from Epoxide Precursor2017

    • Author(s)
      aoya Miyamoto, Zhe Sun, Sota Sato, Hidetoshi Tokuyama, Hiroyuki Isobe
    • Organizer
      International Symposium on Pure & Applied Chemistry 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] AgNTf2を用いたピロロインドール3a位の修飾法の開発と天然物合成への応用2017

    • Author(s)
      袴田容章、佐藤壮一郎、清水瑛大、植田浩史、徳山英利
    • Organizer
      第28回万有仙台シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] AgNTf2を用いたピロロインドール3a位の修飾法の開発と天然物合成への応用2017

    • Author(s)
      袴田容章
    • Organizer
      万有札幌シンポジウム,「3地区交流院生ミニシンポジウム」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] AgNTf2を用いたピロロインドール3a位の修飾法の開発と天然物合成への応用2017

    • Author(s)
      袴田容章、佐藤壮一郎、清水瑛大、植田浩史、徳山英利
    • Organizer
      第29回万有札幌シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Oxidative Derivatization of N-Aryl Amino Acid and Peptide Derivatives Using Iron Phthalocyanine Complex2017

    • Author(s)
      Kei Yoshida, Hirofumi Ueda, Hidetoshi Tokuyama
    • Organizer
      第3回野依フォーラム若手育成塾
    • Related Report
      2017 Annual Research Report
  • [Presentation] 二量体型中分子アルカロイド(+)-pestalazine Bの合成研究2017

    • Author(s)
      植田浩史
    • Organizer
      第4回新学術領域「反応集積化が導く中分子戦略:高次生物機能分子の創製」若手シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] AgNTf2を用いたピロロインドール3a位の修飾法の開発と天然物合成への応用2017

    • Author(s)
      袴田容章
    • Organizer
      第4回新学術領域「反応集積化が導く中分子戦略:高次生物機能分子の創製」若手シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Concise Synthesis of Large Ring Size of Cycloparaphenylenes from Epoxide Precursor2017

    • Author(s)
      Naoya Miyamoto, Zhe Sun, Sota Sato, Hidetoshi Tokuyama, Hiroyuki Isobe
    • Organizer
      Tohoku University's Chemistry Summer School 2017 10th anniversary
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthetic Studies on Plakinidines2017

    • Author(s)
      Touma Adachi, Takahito Sato, Kentaro okano, Juri, Sakata, Hidetoshi Tokuyama
    • Organizer
      Tohoku University's Chemistry Summer School 2017 10th anniversary
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Indole Synthesis by Ring Expansion of Oxime Sulfonate2017

    • Author(s)
      Yumi Yamashita, Taku Imaizumi, Juri Sakata, Hidetoshi Tokuyama
    • Organizer
      平成29年度化学系学協会東北大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Gold-Catalized Nucleophilic Addition of Terminal Acetylenes to Acetals2017

    • Author(s)
      Kyoko Sugiyama, Minami Yamaguchi, Hirofumi ueda, Hidetoshi Tokuyama
    • Organizer
      平成29年度化学系学協会東北大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Synthetic Studies on Epidithiodiketopiperazine Alkaloid Asteroxepin2017

    • Author(s)
      Kanato Umeki, Taichi Kurogi, Juri Sakata, Hidetoshi Tokuyama
    • Organizer
      平成29年度化学系学協会東北大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Total Syntheses of Dimeric Indole Alkaloids2017

    • Author(s)
      Hirofumi Ueda, Hitoshi Satoh, Kenichi Ojima, Soichiro Sato, Azusa Hirayama, Hidetoshi Tokuyama
    • Organizer
      平成29年度化学系学協会東北大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Total Syntheses of (-)-Histrionicotoxin and (-)-Histrionicotoxin 235A via Radical Translocation Cyclization Cascade2017

    • Author(s)
      Manabu Sato, Hiroki Azuma, Akihiro Daigaku, Souta Sato, Kiyosei Takasu, Kentaro Okano, Hidetoshi Tokuyama
    • Organizer
      26th International Society of Heterocyclic Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ジケトピペラジンの立体制御に基づく(+)-Gliocladin C および T988 類の効率的全合成2017

    • Author(s)
      植田浩史、佐藤壮一郎、平山 梓、徳山英利
    • Organizer
      第59回天然有機化合物討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 銅触媒を用いたタンデム触媒反応によるオレフィンの官能基化反応2017

    • Author(s)
      河内大知、植田浩史、徳山英利
    • Organizer
      第56回日本薬学会東北支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] プラキニジンDの全合成2017

    • Author(s)
      安達陶磨,佐藤喬仁、岡野健太郎、坂田樹理,徳山英利
    • Organizer
      第56回日本薬学会東北支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ベンゾシクロブテノンオキシムスルホナートの環拡大反応を活用したインドールの新規合成法2017

    • Author(s)
      坂田樹理、今泉拓、山下有美、徳山英利
    • Organizer
      第56回日本薬学会東北支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] スピロ環状構造を有するテトラヒドロキノリン骨格の新規構築法の開発とその応用2017

    • Author(s)
      若原裕子,野呂尭広,坂田樹理,植田浩史,徳山英利
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 金触媒による連続環化反応を鍵とするBatzelladine類の合成研究2017

    • Author(s)
      板垣大地,丸茂和哉,植田浩史,徳山英利
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] AgNTf2-Mediated Functionalization of Pyrroloindoles and Application to Synthesis of Natural Products2017

    • Author(s)
      H. Hakamata, S. Sato, H. Ueda, H. Tokuyama
    • Organizer
      The 11th International Symposium on Integrated Synthesis (ISONIS-11) and The 3rd International Symposium on Middle Molecular Strategy (ISMMS-3)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Discorhabdin Vの全合成研究2017

    • Author(s)
      野呂尭広,坂田樹理,徳山英利
    • Organizer
      第112回有機合成シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Total Synthesis of (+)-CC-10652016

    • Author(s)
      Taku Imaizumi, Yuki Nakazawa, Kentaro Okano, Juri Sakata, Hidetoshi Tokuyama
    • Organizer
      The 16th Tateshina Conference on Organic Chemistry
    • Place of Presentation
      Tateshina, Nagano, Japan
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bio-inspired Total Synthesis of (+)-Haplophytine2016

    • Author(s)
      Hidetoshi Tokuyama, Hitoshi Satoh, Kenichi Ojima, Hirofumi Ueda
    • Organizer
      The 10th International Symposium on Integrated Synthesis (ISONIS-10)
    • Place of Presentation
      Awaji Island, Hyogo, Japan
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] (+)-Cylindricine Cの合成研究2016

    • Author(s)
      山田香織, 黒木太一, 岡野健太郎, 坂田樹理, 徳山英利
    • Organizer
      第110回有機合成シンポジウム
    • Place of Presentation
      早稲田大学国際会議場(東京、新宿区)
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] オキシムスルホナートの環拡大反応を用いる(+)-CC-1065の全合成2016

    • Author(s)
      今泉拓,中沢佑起,岡野健太郎,坂田樹理,徳山英利
    • Organizer
      第42回反応と合成の進歩シンポジウム
    • Place of Presentation
      静岡市清水文化会館マリナート(静岡、静岡)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Total Synthesis of Dimeric Indole Alkaloids2016

    • Author(s)
      Hirofumi Ueda, Hitoshi Satoh, Ken-ichi Ojima, Soichiro Sato, Azusa Hirayama, Hidetoshi Tokuyama
    • Organizer
      ACP-2016-Korea ICCEOCA-11/ARNCEOCA-2
    • Place of Presentation
      Daejeon, Korea
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthetic Studies on Architecturally Complex N-Heterocyclic Natural Produc2016

    • Author(s)
      Hidetoshi Tokuyama
    • Organizer
      大塚有機化学シンポジウム
    • Place of Presentation
      大塚製薬(徳島、徳島)
    • Year and Date
      2016-10-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生合成関連モノテルペンインドールアルカロイドの網羅的全合成2016

    • Author(s)
      梅原厚志,植田浩史,徳山英利
    • Organizer
      第7回 大津会議
    • Place of Presentation
      びわ湖大津プリンスホテル(滋賀、大津)
    • Year and Date
      2016-10-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 銀試薬を用いた新規タンデム型 N-アルキルインドール合成法の開発とその応用2016

    • Author(s)
      袴田容章, 植田浩史, 徳山英利
    • Organizer
      第46回複素環化学討論会
    • Place of Presentation
      金沢歌劇座(金沢、金沢)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生合成を模倣した (+)-Haplophytine の全合成2016

    • Author(s)
      佐藤均, 小島健一, 植田浩史, 徳山英利
    • Organizer
      第58回天然有機化合物討論会
    • Place of Presentation
      東北大学百周年記念会館 川内萩ホール(宮城、仙台)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthetic studies on Teleocidine B2016

    • Author(s)
      Masashi Shimomura, Toshiharu Noji, Kentaro Okano, Juri Sakata, Hidetoshi Tokuyama
    • Organizer
      平成28年度化学系学協会東北大会
    • Place of Presentation
      いわき明星大学(福島、いわき)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] A new synthetic method for construction of 4-spirocyclic tetrahydroquinoline derivatives2016

    • Author(s)
      Takahiro Noro, Yuko Wakahara, Juri Sakata, Hidetoshi Tokuyama
    • Organizer
      平成28年度化学系学協会東北大会
    • Place of Presentation
      いわき明星大学(福島、いわき)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of Pyrrolo[1,2-c]pyrimidine Synthesis by Gold Mediated Auto-Tandem Catalysis2016

    • Author(s)
      Daichi Itagaki, Kazuya Marumo, Hiroshi Kameya, Hirohumi Ueda, Hidetoshi Tokuyama
    • Organizer
      平成28年度化学系学協会東北大会
    • Place of Presentation
      いわき明星大学(福島、いわき)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] Total synthesis of (+)-CC-10652016

    • Author(s)
      Taku Imaizumi, Yuki Nakazawa, Kentaro Okano, Juri Sakata, Hidetoshi Tokuyama
    • Organizer
      平成28年度化学系学協会東北大会
    • Place of Presentation
      いわき明星大学(福島、いわき)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 含窒素芳香環構造の新規構築法の開発と アルカロイドの全合成への応用2016

    • Author(s)
      徳山英利
    • Organizer
      平成28年度化学系学協会東北大会 有機化学コロキウム
    • Place of Presentation
      いわき明星大学(福島、いわき)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Total Synthesis of Amauromine Alkaloids2016

    • Author(s)
      Hiroyuki Hakamata, Hirofumi Ueda, Hidetoshi Tokuyama
    • Organizer
      Tohoku University's Chemistry Summer School 2016
    • Place of Presentation
      Tohoku University, Sendai, Japan
    • Year and Date
      2016-08-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aerobic Oxidation of Amines with Grubbs Catalysts and Its Application2016

    • Author(s)
      Daichi Kawauchi, Yoshiyuki Komatsu, Kei Yoshida, Hirofumi Ueda, Hidetoshi Tokuyama
    • Organizer
      Tohoku University's Chemistry Summer School 2016
    • Place of Presentation
      Tohoku University, Sendai, Japan
    • Year and Date
      2016-08-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biomimetic Total Synthesis of (+)-Haplophytine2016

    • Author(s)
      Kenichi Ojima, Hitoshi Satoh, Hirofumi Ueda, Hidetoshi Tokuyama
    • Organizer
      Tohoku University's Chemistry Summer School 2016
    • Place of Presentation
      Tohoku University, Sendai, Japan
    • Year and Date
      2016-08-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Total Syntheses of Architecturally Complex N-Heterocyclic Natural Products2016

    • Author(s)
      Hidetoshi Tokuyama
    • Organizer
      International Symposium on Pure & Applied Chemistry (ISPAC) 2016
    • Place of Presentation
      Kutching, Sarawak, Malaysia
    • Year and Date
      2016-08-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthetic Studies toward N-Contained Heterocyclic Natural Products Using Benzyne Chemistry2016

    • Author(s)
      Takahiro Noro, Kentaro Okano, Juri Sakata, Hidetoshi Tokuyama
    • Organizer
      第2回野依フォーラム若手育成塾
    • Place of Presentation
      名古屋大学野依記念館(愛知、名古屋)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Synthesis of Substituted Nitrogen-containing Heterocyclic Compounds using Gold Catalyzed Cascade Reaction2016

    • Author(s)
      Shiori Nonaka, Minami Yamaguchi, Hiroshi Kameya, Daichi Itagaki, Kenji Sugimoto, Hirofumi Ueda, Hidetoshi Tokuyama
    • Organizer
      The International Symposium on Homogeneous Catalysis
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2016-07-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Total Synthesis of Biosynthetically Related Leuconoxine and Rhazinilam Type Monoterpene Indole Alkaloids2016

    • Author(s)
      Atsushi Umehara, Hirofumi Ueda, Hidetoshi Tokuyama
    • Organizer
      Gordon Research Conferences on Heterocyclic Compounds
    • Place of Presentation
      Newport, USA
    • Year and Date
      2016-06-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 金触媒を用いた新規含窒素複素環構築法の開発2016

    • Author(s)
      植田浩史,野中汐里,亀谷紘,板垣大地,杉本健士,徳山英利
    • Organizer
      第14回次世代を担う有機化学シンポジウム
    • Place of Presentation
      日本薬学会長井記念ホール(東京、渋谷区)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Boc2Oと有機アミン触媒を用いる新規アミド結合形成反応2016

    • Author(s)
      梅原厚志,植田浩史,徳山英利
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川,横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] (+)-Chetominの合成研究2016

    • Author(s)
      袴田容章,植田浩史,徳山英利
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川,横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Stenine類の合成研究2016

    • Author(s)
      佐藤敬直,飯村健太郎,植田浩史,徳山英利
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川,横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] オキシムスルホナートの新規環拡大反応の開発とその応用2016

    • Author(s)
      中沢佑起,今泉拓,岡野健太郎, 坂田樹理,徳山英利
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川,横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 金触媒のオートタンデム触媒機構を用いた Pyrrolo[1,2-c]pyrimidine 骨格構築法の開発2016

    • Author(s)
      亀谷紘, 板垣大地, 山口南実, 植田浩史, 徳山英利
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川,横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] チタニウムヒドリドと亜鉛アート錯体を組み合わせた2 級アミドの還元的アルキル化反応2016

    • Author(s)
      我妻弘基, 佐藤学, 板橋優, 岡野健太郎, 坂田樹理, 徳山英利
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川,横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生合成を模倣した(+)-Haplophytineの全合成2016

    • Author(s)
      小島健一、佐藤均、植田浩史、徳山英利
    • Organizer
      第27回万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Related Report
      2016 Annual Research Report
  • [Presentation] チタニウムヒドリドとジアリル亜鉛を組み合わせた第二級アミドの還元的アリル化反応2016

    • Author(s)
      板橋優、佐藤学、坂田樹理、徳山英利
    • Organizer
      第55回日本薬学会東北支部大会
    • Place of Presentation
      奥羽大学(福島、郡山)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 金触媒を用いた二重付加環化三成分連結反応によるビアリール誘導体の合成2016

    • Author(s)
      山本稜太、山口南実、植田浩史、徳山英利
    • Organizer
      第55回日本薬学会東北支部大会
    • Place of Presentation
      奥羽大学(福島、郡山)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Total Synthesis of Dimeric Indole Alkaloids via Late-Stage Chemoselective Oxidation2016

    • Author(s)
      Hidetoshi Tokuyama
    • Organizer
      万有生命科学振興国際交流財団 四半世紀記念万有シンポジウム
    • Place of Presentation
      東京大学伊東国際学術センター(本郷、東京)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Total Syntheses of T988 B and C2015

    • Author(s)
      Soichiro Sato, Azusa Hirayama, Hirofumi Ueda, and Hidetoshi Tokuyama
    • Organizer
      2015環太平洋国際化学会議
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Total Synthesis of (-)-Isoschizogamine2015

    • Author(s)
      Hirofumi Ueda, Akihiro Takada, Hiroaki Fujiwara, Kenji Sugimoto, and Hidetoshi Tokuyama
    • Organizer
      2015環太平洋国際化学会議
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Total Synthesis of Dihydrooxepine-containing Epidithiodiketopiperazine Natural Products2015

    • Author(s)
      Hidetoshi Tokuyama
    • Organizer
      2015環太平洋国際化学会議
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生合成を模倣した(+)-Haplophytineの全合成2015

    • Author(s)
      小島健一
    • Organizer
      第30回有機合成化学若手研究者の仙台セミナー
    • Place of Presentation
      東北大学(宮城、仙台)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] ラジカル転位環化反応を用いた(-)-Histrionicotoxinの全合成2015

    • Author(s)
      佐藤学,我妻弘基, 大学明広, 高須清誠, 岡野健太郎, 徳山英利
    • Organizer
      第45回複素環化学討論会
    • Place of Presentation
      早稲田大学国際会議場(東京)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Synthetic studies on pyranoindoles having inhibitory activity for HCV NS5B polymerase2015

    • Author(s)
      Takahiro Noro, Kentaro Okano, Hidetoshi Tokuyama
    • Organizer
      Pharmaceutical Science Symposium 2015 in Sendai
    • Place of Presentation
      東北大学(宮城、仙台)
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthetic studies on amauromine and its congeners2015

    • Author(s)
      Hiroyuki Hakamata, Hirofumi Ueda, Hidetoshi Tokuyama
    • Organizer
      Pharmaceutical Science Symposium 2015 in Sendai
    • Place of Presentation
      東北大学(宮城、仙台)
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Leuconoxine及び類縁天然物の全合成研究2015

    • Author(s)
      梅原厚志,植田浩史,徳山英利
    • Organizer
      第108回有機合成シンポジウム
    • Place of Presentation
      早稲田大学国際会議場(東京)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規合成方法論を基盤とした 多環性アルカロイドの全合成2015

    • Author(s)
      徳山英利
    • Organizer
      第108回有機合成シンポジウム
    • Place of Presentation
      早稲田大学国際会議場(東京)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] アコニチンアルカロイドの全合成研究2015

    • Author(s)
      藤岡孝佑,戸谷博希,宮本尚也,岡野健太郎,徳山英利
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      近畿大学11月ホール(大阪、東大阪)
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Boc2Oを用いるインドール及び二級アミドとカルボン酸との新規縮合反応の開発2015

    • Author(s)
      梅原厚志,植田浩史,徳山英利
    • Organizer
      第54回日本薬学会東北支部大会
    • Place of Presentation
      岩手医科大学 矢巾キャンパス(岩手)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 鉄フタロシアニン触媒を用いたジチオアセタールの酸化的脱保護法の開発2015

    • Author(s)
      植田浩史,佐藤綾,徳山 英利
    • Organizer
      第54回日本薬学会東北支部大会
    • Place of Presentation
      岩手医科大学 矢巾キャンパス(岩手)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 鉄フタロシアニン触媒を用いたN-アリールアミドの新規脱アリール化反応の開発2015

    • Author(s)
      植田浩史、川上亮英、徳山英利
    • Organizer
      第54回日本薬学会東北支部大会
    • Place of Presentation
      岩手医科大学 矢巾キャンパス(岩手)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 金触媒のオートタンデム触媒機構を用いたpyroro[1,2-c]pyrimidine骨格構築法の開発2015

    • Author(s)
      亀谷紘、板垣大地、山口南実、植田浩史、徳山英利
    • Organizer
      第54回日本薬学会東北支部大会
    • Place of Presentation
      岩手医科大学 矢巾キャンパス(岩手)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] (+)-MPC1001Bの全合成2015

    • Author(s)
      黒木太一,岡谷駿,岡野健太郎,徳山英利
    • Organizer
      第57回天然有機化合物討論会
    • Place of Presentation
      神奈川県民ホール(神奈川、横浜)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Total Synthesis of (-)-Histrionicotoxin by Radical Translocation-Cyclization Reaction2015

    • Author(s)
      Manabu Sato, Hiroki Azuma, Akihiro Daigaku, Kiyosei Takasu, Kentaro Okano, Hidetoshi Tokuyama
    • Organizer
      Tohoku University Campus Asia Summer School
    • Place of Presentation
      東北大学(宮城、仙台)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthetic Studies on Aconitine Alkaloids2015

    • Author(s)
      Kosuke Fujioka, Hiroki Toya, Kentaro Okano, Hidetoshi Tokuyama
    • Organizer
      Tohoku University Campus Asia Summer School
    • Place of Presentation
      東北大学(宮城、仙台)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Total Synthesis of (+)-MPC1001B2015

    • Author(s)
      Taichi Kurogi, Shun Okaya, Kentaro Okano, Hidetoshi Tokuyama
    • Organizer
      Tohoku University Campus Asia Summer School
    • Place of Presentation
      東北大学(宮城、仙台)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthetic Studies on N-Heterocyclic Natural Products2015

    • Author(s)
      Hidetoshi Tokuyama
    • Organizer
      The 25th International Society of Heterocyclic Chemistry Congress
    • Place of Presentation
      UCSB, Santa Barbara, USA
    • Year and Date
      2015-08-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アコニチンアルカロイドの全合成研究2015

    • Author(s)
      藤岡孝佑,戸谷博希,岡野健太郎、徳山英利
    • Organizer
      第26回万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター(宮城、仙台)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] Total Synthesis of Dihydrooxepine-containing Epidithiodiketopiperazine Natural Products2015

    • Author(s)
      Hidetoshi Tokuyama
    • Organizer
      Organic Chemistry Symposia-Sendai, Royal Society of Chemistry Road Show
    • Place of Presentation
      東北大学(宮城、仙台)
    • Year and Date
      2015-06-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 酢酸と酸素を用いたアミンの新規酸化的修飾法の開発2015

    • Author(s)
      吉田慶,植田浩史,徳山英利
    • Organizer
      第13回次世代を担う有機化学シンポジウム
    • Place of Presentation
      立命館大学びわこくさつキャンパス(滋賀、草津)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 金触媒を用いた新規多置換ピロール合成法の開発2015

    • Author(s)
      山口南実,亀谷紘,杉本健士,植田浩史,徳山英利
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Plakinidine Bの合成研究2015

    • Author(s)
      佐藤喬仁,安達陶磨,岡野健太郎,徳山英利
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] ベンザイン中間体を経由した9,10-ジアリールアントラセンの合成法とその応用2015

    • Author(s)
      中沢佑起,中村崇則,宮本尚也,岡野健太郎,徳山英利
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 金触媒を用いた多置換キノリジジン合成法の開発とその応用2015

    • Author(s)
      植田浩史,野中汐里,杉本健士,徳山英利
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Amauromine関連化合物の合成研究2015

    • Author(s)
      袴田容章,植田浩史,徳山英利
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] T988類の全合成2015

    • Author(s)
      佐藤壮一郎,平山梓,植田浩史,徳山英利
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] アコニチンアルカロイド類の全合成研究2015

    • Author(s)
      藤岡孝佑,戸谷博希,岡野健太郎,徳山英利
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規含窒素複素環構築法の開発 を基盤とする複雑なアルカロイドの全合成2015

    • Author(s)
      徳山英利
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 酸化反応を鍵とする多環性アルカロイドの合成研究2014

    • Author(s)
      徳山英利
    • Organizer
      第45回 中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      春日井市
    • Year and Date
      2014-11-29 – 2014-11-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Total Synthesis of Acetylaranotin and Structural Determination of Its Congener2014

    • Author(s)
      Hideto Fujiwara, Taichi Kurogi, Shun Okaya, Kaori Yamada, Malipan Sappan, Masahiko Isaka, Kentaro Okano, Hidetoshi Tokuyama
    • Organizer
      The 4th Junior International Conference on Cutting-Edge Organic Chemistry in Asia (JICCEOCA-4)
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2014-11-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Total Syntheses of T988 B and C2014

    • Author(s)
      Soichiro Sato, Azusa Hirayama, Hirofumi Ueda, Hidetoshi Tokuyama
    • Organizer
      The Fourth Joint Campus Asia Symposium
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Total Synthesis of Polycyclic Alkaloids based on New Synthetic Methodologies2014

    • Author(s)
      Hidetoshi Tokuyama
    • Organizer
      The 5th International Symposium of the Korean Society of Organic Synthesis
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2014-11-20 – 2014-11-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ラジカル転位環化反応を用いるアザスピロ環の不斉構築を基盤としたHistrionicotoxinの合成研究2014

    • Author(s)
      岡野健太郎,我妻弘基,佐藤 学,大学明広,高須清誠,徳山英利
    • Organizer
      第40回反応と合成の進歩シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-10 – 2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] アミン類の新規空気酸化反応および酸化的誘導体化法の開発2014

    • Author(s)
      吉田慶,河内大知,小松巧征,植田浩史,徳山英利
    • Organizer
      第106回有機合成シンポジウムシンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] (-)-Penitrem Eの合成研究2014

    • Author(s)
      大津隆則,吉井優,細川法彦,高須清誠,岡野健太郎,徳山英利
    • Organizer
      第56回天然有機化合物討論会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-15 – 2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 酸素を用いるアルキルアミンα位での酸化的カップリング反応2014

    • Author(s)
      植田浩史,吉田慶,徳山英利
    • Organizer
      第53回日本薬学会東北支部大会
    • Place of Presentation
      いわき
    • Year and Date
      2014-10-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Amauromine関連化合物の合成研究2014

    • Author(s)
      袴田容章,植田浩史,徳山英利
    • Organizer
      第53回日本薬学会東北支部大会
    • Place of Presentation
      いわき
    • Year and Date
      2014-10-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] アレーントリカルボニルクロム錯体の脱プロトンとクロスカップリングを経るビアリール化合物の合成2014

    • Author(s)
      百井雄一,岡野健太郎,徳山英利
    • Organizer
      第53回日本薬学会東北支部大会
    • Place of Presentation
      いわき
    • Year and Date
      2014-10-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] ピリジンおよびオキサゾリンを配向基とした銅塩を用いる芳香族C-Hアミノ化反応の開発2014

    • Author(s)
      安達陶磨,岡野健太郎,徳山英利
    • Organizer
      第53回日本薬学会東北支部大会
    • Place of Presentation
      いわき
    • Year and Date
      2014-10-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthetic Studies toward Indole Alkaloids (-)-Penitrem E and Actinophyllic Acid2014

    • Author(s)
      Yu Yoshii, Takanori Otsu, Norihiko Hosokawa, Kiyosei Takasu, Kentaro Okano, David Yu-Kai Chen, Hidetoshi Tokuyama
    • Organizer
      Tohoku University Campus Asia Summer School
    • Place of Presentation
      仙台
    • Year and Date
      2014-08-24 – 2014-08-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Total Syntheses of Gliocladin C and T988s by Divergent Strategy2014

    • Author(s)
      Soichiro Sato, Azusa Hirayama, Hirofumi Ueda, Hidetoshi Tokuyama
    • Organizer
      Tohoku University Campus Asia Summer School
    • Place of Presentation
      仙台
    • Year and Date
      2014-08-24 – 2014-08-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural Determination of SCH648742014

    • Author(s)
      Kaori Yamada, Hideto Fujiwara, Malipan Sappan, Masahiko Isaka, Kentaro Okano, Hidetoshi Tokuyama
    • Organizer
      Tohoku University Campus Asia Summer School
    • Place of Presentation
      仙台
    • Year and Date
      2014-08-24 – 2014-08-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Syntheses of Substituted Indolizines and Pyrroles using Gold Catalyzed Cascade Reaction2014

    • Author(s)
      Shiori Nonaka, Minami Yamaguchi, Hiroshi Kameya, Kenji Sugimoto, Hirofumi Ueda, Hidetoshi Tokuyama
    • Organizer
      XXVI International Conference on Organometallic Chemistry
    • Place of Presentation
      札幌
    • Year and Date
      2014-07-13 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Total syntheses of Rhazinilum, Lueconoxine, and Related Compounds using Gold-catalyzed Cascade Reaction and Diastereoselective Ring-closing Olefin Metathesis2014

    • Author(s)
      Hidetoshi Tokuyama, Kazuki Toyoshima, Atsushi Umehara, Kenji Sugimoto, Hirofumi Ueda
    • Organizer
      XXVI International Conference on Organometallic Chemistry
    • Place of Presentation
      札幌
    • Year and Date
      2014-07-13 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 酸化反応を鍵とする多環性アルカロイドの合成研究2014

    • Author(s)
      徳山英利
    • Organizer
      第26回万有札幌シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] (-)-Acetylaranotinの全合成2014

    • Author(s)
      黒木太一,藤原栄人,岡谷駿,中村崇則,岡野健太郎,徳山英利
    • Organizer
      第24回万有福岡シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞外コリン特異ホスホジエステラーゼNPP6 の機能解析2014

    • Author(s)
      滝田浩之,可野邦行,佐藤敬直,植田 浩史,徳山英利,青木淳賢
    • Organizer
      第56回日本脂質生化学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラジカル転位環化反応を用いたHistrionicotoxin類の合成研究2014

    • Author(s)
      我妻弘基,佐藤学,大学明広,高須清誠,岡野健太郎,徳山英利
    • Organizer
      モレキュラーキラリティー2014
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] SCH64874の構造決定2014

    • Author(s)
      山田香織,藤原栄人,Malipan Sappan,伊坂雅彦,岡野健太郎,徳山英利
    • Organizer
      モレキュラーキラリティー2014
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Leuconoxine及び類縁化合物の全合成2014

    • Author(s)
      梅原厚志,植田浩史,徳山英利
    • Organizer
      第12回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-05-23 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Book] 天然有機化合物の全合成2018

    • Author(s)
      日本化学会
    • Total Pages
      208
    • Publisher
      化学同人
    • ISBN
      9784759813876
    • Related Report
      2017 Annual Research Report
  • [Book] アルカロイドの科学2017

    • Author(s)
      高山 廣光
    • Total Pages
      560
    • Publisher
      化学同人
    • ISBN
      9784759814187
    • Related Report
      2017 Annual Research Report
  • [Book] スタンダード薬学シリーズII 化学系薬学 I. 化学物質の性質と反応2014

    • Author(s)
      日本薬学会編
    • Total Pages
      445
    • Publisher
      東京化学同人
    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学大学院薬学研究科医薬製造化学分野

    • URL

      http://www.pharm.tohoku.ac.jp/~seizou/index.html

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report 2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2022-04-28  

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