| Budget Amount *help |
¥40,430,000 (Direct Cost: ¥31,100,000、Indirect Cost: ¥9,330,000)
Fiscal Year 2016: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2015: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2014: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
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| Outline of Final Research Achievements |
In this study, we have developed a new mouse model system with different ZAP-70 functions to understand the development and autoimmune function of T helper cells and identified a particular range of ZAP-70 function associated with the developmental arrest of T cells in the thymus and generation of arthritogenic T helper cells. We have also established a novel retrogenic mouse system to identify auto-antigens recognized by arthritogenic T cells isolated from inflamed joints of SKG mice and demonstrated that T cells specific for the auto-antigen RPL23A induced psoriasis-like skin disease and arthritis. Anti-RPL23A auto-antibody was specific to patients with rheumatoid arthritis, indicating that this screening system for auto-antigens is useful for identifying novel therapeutic targets and new biomarkers for rheumatoid arthritis.
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