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Molecular basis and therapeutic target for autoimmune arthritis

Research Project

Project/Area Number 26253030
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionOsaka University

Principal Investigator

Sakaguchi Shimon  大阪大学, 免疫学フロンティア研究センター, 教授 (30280770)

Co-Investigator(Kenkyū-buntansha) 廣田 圭司  京都大学, 再生医科学研究所, 准教授 (90631250)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥40,430,000 (Direct Cost: ¥31,100,000、Indirect Cost: ¥9,330,000)
Fiscal Year 2016: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2015: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2014: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
KeywordsSKG / 自己免疫性関節炎 / 関節リウマチ / ZAP-70 / 自己抗原
Outline of Final Research Achievements

In this study, we have developed a new mouse model system with different ZAP-70 functions to understand the development and autoimmune function of T helper cells and identified a particular range of ZAP-70 function associated with the developmental arrest of T cells in the thymus and generation of arthritogenic T helper cells. We have also established a novel retrogenic mouse system to identify auto-antigens recognized by arthritogenic T cells isolated from inflamed joints of SKG mice and demonstrated that T cells specific for the auto-antigen RPL23A induced psoriasis-like skin disease and arthritis. Anti-RPL23A auto-antibody was specific to patients with rheumatoid arthritis, indicating that this screening system for auto-antigens is useful for identifying novel therapeutic targets and new biomarkers for rheumatoid arthritis.

Report

(3 results)
  • 2016 Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (53 results)

All 2016 2015 2014

All Journal Article (22 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 22 results,  Open Access: 21 results,  Acknowledgement Compliant: 20 results) Presentation (31 results) (of which Invited: 23 results)

  • [Journal Article] Advertisement Hypomethylation of the Treg-specific demethylated region in FOXP3 is a hallmark of the regulatory T-cell subtype in adult T-cell leukemia2016

    • Author(s)
      Shimazu Y, Shimazu Y, Hishizawa M, Hamaguchi M, Nagai Y, Sugino N, Fujii S, Kawahara M, Kadowaki N, Nishikawa H, Sakaguchi S, Takaori-Kondo A.
    • Journal Title

      Cancer Immunol Res.

      Volume: 4 Pages: 136-145

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans.2015

    • Author(s)
      Miyara M, Chader D, Sage E, Sugiyama D, Nishikawa H, Bouvry D, Claër L, Hingorani R, Balderas R, Rohrer J, Warner N, Chapelier A, Valeyre D, Kannagi K, Sakaguchi S, Amoura Z, Gorochov G.
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 112 Pages: 7225-7230

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Transcriptional and epigenetic control of regulatory T cell development.2015

    • Author(s)
      Kitagawa Y, Wing JB, Sakaguchi S.
    • Journal Title

      Prog Mol Biol Transl Sci.

      Volume: 136 Pages: 1-33

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The microbiota regulates type 2 immunity through RORt+ T cells.2015

    • Author(s)
      Ohnmacht C, Park J, Cording S, Wing JB, Atarashi K, Obata Y, Gaboriau-Routhiau V, Marques R, Dulauroy S, Fedoseeva M, Busslinger M, Cerf-Bensussan N, Boneca IG, Voehringer D, Hase K, Honda K, Sakaguchi S, Eberl G.
    • Journal Title

      Science.

      Volume: 349 Pages: 989-993

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals2014

    • Author(s)
      Maeda Y, Nishikawa H, Sugiyama D, Ha D, Hamaguchi M, Saito T, Nishioka M, Wing JB, Adeegbe D, Katayama I, Sakaguchi S.
    • Journal Title

      Science

      Volume: 346 Pages: 1536-1540

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Detection of T-cell responses to a ubiquitous cellular protein in autoimmune disease2014

    • Author(s)
      Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S.
    • Journal Title

      Science

      Volume: 346 Pages: 363-368

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulatory T-cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-42014

    • Author(s)
      Wing JB, Ise W, Kurosaki T, Sakaguchi S.
    • Journal Title

      Immunity

      Volume: 41 Pages: 1013-1025

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Interleukin-10- Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation2014

    • Author(s)
      Matsumoto M, Baba A, Yokota T, Nishikawa H, Ohkawa Y, Kayama H, Kallies A, Nutt SL, Sakaguchi S, Takeda K, Kurosaki T, and Baba Y.
    • Journal Title

      Immunity

      Volume: 41 Pages: 1040-1051

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Schmidt-Supprian M. Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool2014

    • Author(s)
      Vahl JC, Drees C, Heger K, Heink S, Fischer JC, Nedjic J, Ohkura N, Morikawa H, Poeck H, Schallenberg S, RieB D, Hein MY, Buch T, Polic B, Schonle A, Zeiser R, Schmitt-Graff A, Kretschmer K, Klein L, Korn T, Sakaguchi S
    • Journal Title

      Immunity

      Volume: 41 Pages: 722-736

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Homeostasis of Thymus-Derived Foxp3+ Regulatory T Cells Is Controlled by Ultraviolet B Exposure in the Skin.2014

    • Author(s)
      Yamazaki S, Nishioka A, Kasuya S, Ohkura N, Hemmi H, Kaisho T, Taguchi O, Sakaguchi S, Morita A.
    • Journal Title

      J Immunol

      Volume: 193 Pages: 5488-5497

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Epigenetic control of thymic Treg-cell development.2014

    • Author(s)
      Kitagawa Y, Ohkura N, Sakaguchi S.
    • Journal Title

      Eur. J. Immunol

      Volume: 45 Pages: 11-16

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] FRT - Fondation Rene Touraine: Pour La Dermatologie.2014

    • Author(s)
      Sakaguchi S, Sallusto F, Gebhardt T, Stingl G, Clark RA, Santamaria-Babí LF, Guttman-Yassky E, Schuler G, Koenen HJ.
    • Journal Title

      Exp Dermatol

      Volume: 23 Pages: 772-785

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation.2014

    • Author(s)
      Morikawa H, Ohkura N, Vandenbon A, Itoh M, Nago-Sato S, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest A, Standley D, Date D, Sakaguchi S, and the FANTOM consortium.
    • Journal Title

      PNAS

      Volume: 111 Pages: 5289-5294

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer.2014

    • Author(s)
      Pastille E, Bardini K, Fleissner D, Adamczyk A, Frede A, Wadwa M, von Smolinski D, Kasper S, Sparwasser T, Gruber AD, Schuler M, Sakaguchi S, Roers A, Miiller W, Hansen W, Buer J, Westendorf AM.
    • Journal Title

      Cancer Res.

      Volume: 74 Pages: 4258-4269

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comprehensive exploration of autoantibody in Behçet's disease: A novel autoantibody to claudin-1, an essential protein for tight junctions, is identified.2014

    • Author(s)
      Morishima A, Hirano T, Nishikawa H, Nakai K, Sakaguchi S, Kumanogoh A.
    • Journal Title

      Joint Bone Spine.

      Volume: 81 Pages: 546-548

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CD28 signals the differential control of regulatory T cells and effector T cells.2014

    • Author(s)
      Mikami N, Sakaguchi S.
    • Journal Title

      Eur J Immunol

      Volume: 44 Pages: 955-957

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TREG-cell therapies for autoimmune rheumatic diseases.2014

    • Author(s)
      Miyara M, Ito Y, Sakaguchi S.
    • Journal Title

      Nat Rev Rheumatol.

      Volume: 10 Pages: 543-551

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genetic and epigenetic basis of Treg cell development and function: From a FoxP3-centered view to an epigenome-defined view of natural Treg cells2014

    • Author(s)
      Morikawa H, Sakaguchi S.
    • Journal Title

      Immunol. Rev

      Volume: 259 Pages: 192-205

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A promoter level mammalian expression atlas.2014

    • Author(s)
      Forrest A, ..., Morikawa H., ..., Hamaguchi M., ..., Ohkura N., ...,Sakaguchi S., ...,Hayashizaki Y, et al.,
    • Journal Title

      Nature

      Volume: 507 Pages: 462-470

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Foxp3+ Treg cells in humoral immunity.2014

    • Author(s)
      Wing JB, Sakaguchi S.
    • Journal Title

      Int Immunol.

      Volume: 26 Pages: 61-69

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CD8+ tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma2014

    • Author(s)
      Fujii H, Arakawa A, Utsumi D, Sumiyoshi S, Yamamoto Y, Kitoh A, Ono M, Matsumura Y, Kato M, Konishi K, Shiga T, Sano S, Sakaguchi S, Miyagawa-Hayashino A, Takahashi K, Uezato H, Miyachi Y, Tanioka M.
    • Journal Title

      Int J Cancer

      Volume: 134 Pages: 2393-2402

    • NAID

      120005458273

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulatory T cells in cancer immunotherapy.2014

    • Author(s)
      Nishikawa H, Sakaguchi S.
    • Journal Title

      Curr Opin Immunol.

      Volume: 27 Pages: 1-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Role of glucocorticoid-induced TNFR-related protein (GITR) ligand in effector function and Treg-mediated suppression2015

    • Author(s)
      Yasuda Keiko, Nishioka Tomohisa, Hirota Keiji, Takeda Kiyoshi, Akira Shizuo, Sakaguchi Shimon
    • Organizer
      第44回 日本免疫学会学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Regulation of immune responses by sCTLA-4 produced by Treg cells2015

    • Author(s)
      Osaki Motonao, Sakaguchi Shimon
    • Organizer
      第44回 日本免疫学会学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Establishment of regulatory T cell-specific super-enhancers2015

    • Author(s)
      Kitagawa Yohko, Ohkura Naganari, Sakaguchi Shimon
    • Organizer
      第44回 日本免疫学会学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Specific characteristics of tumor infiltrating regulatory T cells2015

    • Author(s)
      Kidani Yujiro, Sakaguchi Shimon, Ohkura Naganari
    • Organizer
      第44回 日本免疫学会学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Rheumatoid arthritis patients-derived gut microbiota induce Th17-mediated arthritis in SKG Mice2015

    • Author(s)
      Maeda Yuichi, Umemoto Eiji, Matsushita Masato, Saeki Yukihiko, Ito Yoshinaga, Hirota Keiji, Sakaguchi Noriko, Kumanogo Atushi, Sakaguchi Shimon, Takeda Kiyoshi
    • Organizer
      第44回 日本免疫学会学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Control of Immune Responses by Regulatory T cells2015

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      KEYSTONE SYMPOSIA T Cells: Regulation and Effector Function
    • Place of Presentation
      Utah(USA)
    • Year and Date
      2015-03-29 – 2015-04-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] APC and T Regs2015

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      KEYSTONE SYMPOSIA Dendritic Cells and Macrophages Reunited
    • Place of Presentation
      Montreal(Canada)
    • Year and Date
      2015-03-08 – 2015-03-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Control of immune responses by regulatory T cells.2015

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      The 4th NIF Winter School on Advanced Immunology
    • Place of Presentation
      Singapore
    • Year and Date
      2015-01-18 – 2015-01-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Regulatory T Cells and Immune Tolerance.2015

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      Sushruta Lecture Transplantation Update-2015
    • Place of Presentation
      Ahmedabad(India)
    • Year and Date
      2015-01-09 – 2015-01-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Control of autoimmunity and tumor immunity by regulatory T cells2014

    • Author(s)
      坂口志文
    • Organizer
      日本研究皮膚科学会第39回年次学術大会・総会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪)
    • Year and Date
      2014-12-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The soluble form of CTLA-4 in regulatory T cells-mediated suppression2014

    • Author(s)
      Osaki Motonao, Sakaguchi Shimon
    • Organizer
      第43回日本免疫学会総会・学術総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] The genome organizer Satb1 differentially controls thymic and peripheral development of regulatory T cells.2014

    • Author(s)
      4.Kitagawa Yohko, Ohkura Naganari, Hirota Keiji, Adeegbe Olakunle, Yasada Keiko, Kondo Motonari, Taniuchi Ichiro, Kohwi-ShigematuTerumi, Sakaguchi Shimon
    • Organizer
      第43回日本免疫学会総会・学術総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Regulatory T cells2014

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      development, maintenance and function in normal and disease states 22nd FRT –Fondation Rene Touraine Annual Scientific Meeting
    • Place of Presentation
      Paris(France)
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Keynote Address Immune Regulation for Cancer Immunotherapy The 45th International Symposium of The Princess Takamatsu Cancer Research Fund2014

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      Recent Advances in Cancer Immunotherapy
    • Place of Presentation
      パレスホテル東京(東京)
    • Year and Date
      2014-11-18 – 2014-11-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 制御性T細胞と自己免疫・癌2014

    • Author(s)
      坂口志文
    • Organizer
      第57回日本甲状腺学会学術集会
    • Place of Presentation
      ナレッジキャピタル コングレコンベンションセンター(大阪)
    • Year and Date
      2014-11-13 – 2014-11-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Control of immune responses by regulatory T cells2014

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      BK seminar Integrative Biosciences and Biotechnology
    • Place of Presentation
      Pohan(Korea)
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Genetic and epigenetic basis of Treg cell development and function.2014

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      Academy of Immunology and Microbiology Workshop on Immunology 2014
    • Place of Presentation
      Pohan(Korea)
    • Year and Date
      2014-11-09 – 2014-11-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Regulatory T Cells2014

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      Development, Maintenance and Function in Normal and Disease States The 2014 Fall Conference of Korean Association of Immunologists
    • Place of Presentation
      Seoul(Korea)
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Treg-mediated control of the cell fate of autoimmune T cells2014

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      The Fourth International Conference on Regulatory T Cells and T Helper Cell Subsets and Clinical Application in Human Diseases
    • Place of Presentation
      Shanghai(China)
    • Year and Date
      2014-11-01 – 2014-11-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 制御性T細胞による免疫応答制御2014

    • Author(s)
      坂口志文
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Control of Treg cells for immune tolerance2014

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      Novo nordisk innovation summit Tokyo
    • Place of Presentation
      東京大学医科学研究所(東京)
    • Year and Date
      2014-10-01 – 2014-10-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 制御性T細胞による免疫応答制御2014

    • Author(s)
      坂口志文
    • Organizer
      第51回補体シンポジウム
    • Place of Presentation
      神戸常盤大学(神戸)
    • Year and Date
      2014-08-22 – 2014-08-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Control of Tumor Immunity by Regulatory T Cells.2014

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      IAAO(International Academy for Advanced Oncology) Convergence for Breakthroughs in Oncology Therapy
    • Place of Presentation
      六本木ヒルズ(東京)
    • Year and Date
      2014-08-01 – 2014-08-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 制御性T細胞による免疫応答制御2014

    • Author(s)
      坂口志文
    • Organizer
      第33回分子病理学研究会
    • Place of Presentation
      宮城蔵王ロイヤルホテル(蔵王)
    • Year and Date
      2014-07-25 – 2014-07-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 制御性T細胞による免疫応答制御2014

    • Author(s)
      坂口志文
    • Organizer
      第51回日本消化器免疫学会総会
    • Place of Presentation
      京都大学医学部 芝蘭会館(京都)
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Control of autoimmunity and tumor immunity by regulatory T cells.2014

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      RJKEN IMS-JSI International Symposium on Immunology 2014 Decoding Immune Complexity Bench to Bedside
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2014-06-26 – 2014-06-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 制御性T細胞による免疫応答制御2014

    • Author(s)
      坂口志文
    • Organizer
      第38回日本リンパ学会総会東京
    • Place of Presentation
      北里大学白金キャンパス薬学部コンベンションホール(東京)
    • Year and Date
      2014-06-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Regulatory T cells in autoimmunity and tumor immunity2014

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      The 1st joint symposium of Karolinska Institute and Osaka University 2014 Immunology and Infection biology
    • Place of Presentation
      Stockholm(Sweden)
    • Year and Date
      2014-06-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Epigenetic changes and Treg cell development.2014

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      European Academy of Allergy and Clinical Immunology Congress 2014
    • Place of Presentation
      Copenhagen(Denmark)
    • Year and Date
      2014-06-07 – 2014-06-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 胸腺と末梢の制御性T細胞発生におけるSATB1の役割2014

    • Author(s)
      北川瑤子、大倉永也、廣田圭司、安田佳子、谷内一郎、近藤元就、重松照美、坂口志文
    • Organizer
      第24回Kyoto T Cell Conference
    • Place of Presentation
      京都平安ホテル(京都)
    • Year and Date
      2014-05-16 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Genetic and epigenetic basis of Treg cell development and function.2014

    • Author(s)
      Shimon Sakaguchi
    • Organizer
      2014 Beijing-Shanghai Immunology Joint Symposium
    • Place of Presentation
      Hangzhou(China)
    • Year and Date
      2014-04-12
    • Related Report
      2014 Annual Research Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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