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Reconstitution of thee-dimensional kidney structures from stem cells

Research Project

Project/Area Number 26253051
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionKumamoto University

Principal Investigator

Nishinakamura Ryuichi  熊本大学, 発生医学研究所, 教授 (70291309)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2016: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2015: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2014: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Keywords腎臓発生 / ネフロン / iPS細胞 / 糸球体 / 再生医学 / 細胞・組織 / 間質
Outline of Final Research Achievements

The kidney develops through mutual interactions between three precursor tissues: namely nephron progenitors, ureteric buds, and the stroma.The purpose of this project is to induce the three lineages from pluripotent stem cells and reconstitute the three-dimensional kidney structures. We identified genes expressed during the ureteric bud development in mice, and established a method to re-aggregate the three lineages to form the kidney structures. In addition, we transplanted the human iPS cell-derived nephron progenitors into the mice, and found that human glomeruli were connected with the host vasculature.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(15 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (9 results) (of which Int'l Joint Research: 5 results,  Invited: 7 results) Remarks (2 results)

  • [Int'l Joint Research] National Institutes of Health(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Human induced pluripotent stem cell-derived podocytes mature into vascularized glomeruli upon experimental transplantation.2017

    • Author(s)
      Sharmin S, Taguchi A, Kaku Y, Yoshimura Y, Ohmori T, Sakuma T, Mukoyama M, Yamamoto T, Kurihara H, Nishinakamura R
    • Journal Title

      J Am Soc Nephrol

      Volume: 27 Pages: 1778-1791

    • DOI

      10.1681/asn.2015010096

    • Description
      印刷中
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Selective In Vitro Propagation of Nephron Progenitors Derived from Embryos and Pluripotent Stem Cells.2016

    • Author(s)
      Tanigawa S, Taguchi A, Sharma N, Perantoni AO and Nishinakamura R
    • Journal Title

      Cell Reports

      Volume: 15 Pages: 801-813

    • DOI

      10.1016/j.celrep.2016.03.076

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Sall1 in renal stromal progenitors non-cell autonomously restricts the excessive expansion of nephron progenitors.2015

    • Author(s)
      Ohmori T, Tanigawa S, Kaku Y, Fujimura S, and Nishinakamura R
    • Journal Title

      Scientific Reports

      Volume: 5 Pages: 15676-15676

    • DOI

      10.1038/srep15676

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Complex 3D Kidney Structures from Pluripotent Stem Cells2016

    • Author(s)
      Nishinakamura R
    • Organizer
      Kidney Week 2016 (American Society of Nephrology)
    • Place of Presentation
      Chicago (米国)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Creating the kidney based on its developmental origin2016

    • Author(s)
      Nishinakamura R
    • Organizer
      EMBO/EMBL symposium
    • Place of Presentation
      Heidelberg(ドイツ)
    • Year and Date
      2016-10-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Recreating the kidney2016

    • Author(s)
      Nishinakamura R
    • Organizer
      Santa Cruz Developmental Biology Meeting
    • Place of Presentation
      Santa Cruz (米国)
    • Year and Date
      2016-08-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Programming stem cells toward the kidney.2016

    • Author(s)
      Nishinakamura R
    • Organizer
      CiRA/ISSCR 2016 International Symposia
    • Place of Presentation
      京都大学(京都府京都市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Kidney progenitor expansion and generation of vascularized glomeruli from stem cells.2015

    • Author(s)
      Nishinakamura R
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Programming stem cells toward the kidney.2015

    • Author(s)
      Nishinakamura R
    • Organizer
      The 13th International Workshop on Developmental Nephrology
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Creating the kidney in vitro.2015

    • Author(s)
      Nishinakamura R and Taguchi A.
    • Organizer
      第48回日本発生生物学会
    • Place of Presentation
      つくば国際会議場(茨城県筑波市)
    • Year and Date
      2015-06-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Programming stem cells toward the kidney2014

    • Author(s)
      西中村隆一、太口敦博
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 多能性幹細胞からの3次元腎臓組織の誘導2014

    • Author(s)
      西中村隆一、太口敦博
    • Organizer
      第87回日本生化学会
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
  • [Remarks] 熊本大学 発生医学研究所 腎臓発生分野

    • URL

      http://www.imeg.kumamoto-u.ac.jp/bunya_top/kidney_development/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 熊本大学発生医学研究所 腎臓発生分野

    • URL

      http://www.imeg.kumamoto-u.ac.jp/bunya_top/kidney_development/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report

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Published: 2014-04-04   Modified: 2022-01-28  

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