Reconstitution of thee-dimensional kidney structures from stem cells
| Project/Area Number |
26253051
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2016: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2015: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2014: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
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| Keywords | 腎臓発生 / ネフロン / iPS細胞 / 糸球体 / 再生医学 / 細胞・組織 / 間質 |
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| Outline of Final Research Achievements |
The kidney develops through mutual interactions between three precursor tissues: namely nephron progenitors, ureteric buds, and the stroma.The purpose of this project is to induce the three lineages from pluripotent stem cells and reconstitute the three-dimensional kidney structures. We identified genes expressed during the ureteric bud development in mice, and established a method to re-aggregate the three lineages to form the kidney structures. In addition, we transplanted the human iPS cell-derived nephron progenitors into the mice, and found that human glomeruli were connected with the host vasculature.
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Report
(4 results)
Research Products
(15 results)
