Tubular- glomerular interaction nd metabolic kidney disease
| Project/Area Number |
26253053
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
Itoh Hiroshi 慶應義塾大学, 医学部(信濃町), 教授 (40252457)
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| Co-Investigator(Kenkyū-buntansha) |
長谷川 一宏 慶應義塾大学, 医学部, 助教 (30424162)
脇野 修 慶應義塾大学, 医学部, 准教授 (50265823)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
Fiscal Year 2016: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2015: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2014: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
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| Keywords | 慢性腎臓病 / 糖尿病性腎症 / 肥満関連腎症 / 近位尿細管 / 糸球体 / 臨床 / 糖尿病 / 微生物 / Sirt1 / TGFbeta / 線維化 / iNAMPT / NMN / SGLT2 / ニコチン酸代謝 / Sirtuin / Rhoキナーゼ / 腎臓肥大 / 肥満 |
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| Outline of Final Research Achievements |
We defined chronic kidney disease based on the diabetes, obesity, and hypertension as metabolic kidney disease and found the molecular mechanism. We delineated the pathological relevance of iNAMPT of proximal tubular cells. The expression of iNAMPT was reduced by TGFb in diabetic kidney disease. We also analyzed regulatory mechanism for the promoter activity of iNMPT genes. In diabetic kidney disease, iNAMPT expression was downregulated which contributed to the tissue fibrotic changes through the reduced expressions of Sirt6. We also investigated the role of NMMT in the pathogenesis of tissue fibrotic changes of both kidney and liver. NMMT-overexpressing mice exhibited prominent liver fibrosis but not renal fibrosis. Liver fibrosis was demonstrated to result from the decreased turnover of methionine metabolism, which lead to methyl-donor deficiency and epigenetic induction of CTGF gene in the liver.
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Report
(3 results)
Research Products
(15 results)
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[Presentation] 肥満関連腎症 組織学的変化の新たな知見2014
Author(s)
内藤 真規子, 徳山 博文, 林 晃一, 脇野 修, 伊藤 裕
Organizer
日本糖尿病合併症学会
Place of Presentation
都市センターホテル/シェーンバッハ・サボー（東京千代田区）
Year and Date
2014-10-03 – 2014-10-04
Related Report
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[Presentation] 肥満関連腎症 組織学的変化の新たな知見2014
Author(s)
徳山 博文、脇野 修, 橋口 明典, 小西 孝之助, 林 晃一, 伊藤 裕
Organizer
日本腎臓学会
Place of Presentation
パシフィコ横浜会議センター（神奈川県横浜市）
Year and Date
2014-07-04 – 2014-07-06
Related Report
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