Pathophysiological roles of adipokines in the regulation of gut microbiota in life-style related diseases
| Project/Area Number |
26253058
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IWABU Masato 東京大学, 医学部附属病院, 特任准教授 (30557236)
IWABU Miki 東京大学, 医学部附属病院, 特任講師 (70392529)
KADOWAKI Takashi 東京大学, 医学部附属病院, 教授 (30185889)
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| Project Period (FY) |
2014-06-27 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2015: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2014: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
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| Keywords | 糖尿病 / 細菌 / シグナル伝達 / 脂質 / 食品 |
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| Outline of Final Research Achievements |
We tried to clarify the mechanisms by which high-fat diet results in life-style related diseases, especially we studied interactions between immune cells and metabolism cells as well as gut microbiota and enteral metabolites. We analyzed the effects of high-fat diet, reduction in adiponectin/AdipoR actions, AdipoR activation, and transplantation of gut microbiota from AdipoR deficient mice into germfree mice. Our results raised the possibility that reduction in AdipoR actions could result in increased inflammation and oxidative stress and so on, leading to dysregulation of gut microbiota and enteral metabolites, which could worsen fatty liver, NASH, atherosclerosis, conversely AdipoR activation could ameliorate them.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Crystal structures of the human adiponectin receptors.2015
Author(s)
Tanabe H, Fujii Y, Okada-Iwabu M, Iwabu M, Nakamura Y, Hosaka T, Motoyama K. Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hato M, …, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T, Yokoyama S
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Journal Title
Nature
Volume: 520
Pages: 312-316
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A novel peroxisome proliferator-activated receptor (PPAR) α agonist and PPAR γ antagonist, Z-551, ameliorates high-fat diet-induced obesity and metabolic disorders in mice.2015
Author(s)
Shiomi Y, Yamauchi T, Iwabu M, Okada-Iwabu M, Nakayama R, Orikawa Y, Yoshioka Y, Tanaka K, Ueki K, Kadowaki T
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Journal Title
J. Biol. Chem.
Volume: 290
Pages: 14567-14581
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from γδ-T cells.2015
Author(s)
Shibata S, Tada Y, Hau C, Mitsui A, Kamata M, Asano Y, Sugaya M, Kadono T, Masamoto Y, Kurokawa M, Yamauchi T, Kubota N, Kadowaki T, and Sato S.
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Journal Title
Nat Commun
Volume: 6
Pages: 1-14
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.2015
Author(s)
Hwang JY, Sim X, Wu Y, Liang J, Tabara Y, Hu C, Hara K, Tam CH, Cai Q, Zhao Q, Jee S, …, Kadowaki T, Jia W, Miki T : Qi L, Tai ES, Mohlke KL, Han BG, Cho YS, Kim BJ
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Journal Title
Diabetes
Volume: 64
Pages: 291-298
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoR1 and AdipoR2.2015
Author(s)
Tanabe H,..., Iwata S, Okada-Iwabu M, Iwabu M,..., Yamauchi T, Kadowaki T, and Yokoyama S
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Journal Title
J Struct Funct Genomics.
Volume: 16
Pages: 11-23
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 糖尿病と肥満症2014
Author(s)
山内 敏正
Organizer
第29回日本糖尿病合併症学会
Place of Presentation
シェーンバッハ・サボー
Year and Date
2014-10-04
Related Report
Invited
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[Book] 細胞2014
Author(s)
山内 敏正
Total Pages
3
Publisher
北隆館
Related Report
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