Establishment of utilized predictive biomarkers of chemo sensitivity for ovarian cancer patients
Project/Area Number |
26253080
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Kyoto University |
Principal Investigator |
Konishi Ikuo 京都大学, 医学研究科, 名誉教授 (90192062)
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Co-Investigator(Kenkyū-buntansha) |
森 誠一 公益財団法人がん研究会, その他部局等, 研究員 (10334814)
岡本 愛光 東京慈恵会医科大学, 医学部, 教授 (20204026)
山口 建 京都大学, 医学(系)研究科(研究院), 助教 (20378772)
松村 謙臣 京都大学, 医学(系)研究科(研究院), 准教授 (20452336)
安彦 郁 京都大学, 医学(系)研究科(研究院), 助教 (20508246)
松田 文彦 京都大学, 医学(系)研究科(研究院), 教授 (50212220)
山田 亮 京都大学, 医学(系)研究科(研究院), 教授 (50301106)
馬場 長 京都大学, 医学(系)研究科(研究院), 講師 (60508240)
濱西 潤三 京都大学, 医学(系)研究科(研究院), 助教 (80378736)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥41,730,000 (Direct Cost: ¥32,100,000、Indirect Cost: ¥9,630,000)
Fiscal Year 2016: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2015: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2014: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
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Keywords | 卵巣癌 / 化学療法予測 / 個別化治療 / タキサン / 個別化 / 卵巣漿液性癌 / 卵巣明細胞癌 / 腫瘍免疫 / 上皮間葉転換 / 癌 / ゲノム / 卵巣明細胞腺癌 / バイオマーカー / 抗腫瘍免疫 / 分子標的療法 / 化学療法感受性 / アノイキス抵抗性 |
Outline of Final Research Achievements |
Prognoses of ovarian cancer have improved with the paclitaxel-carboplatin regimen. However, it remains unclear which cases exhibit a genuine benefit from taxane or from platinum. We aimed to predict taxane and platinum sensitivity via gene expression. Recently, The Cancer Genome Atlas data revealed four molecular subtypes of high-grade serous ovarian carcinoma (HGSOC) exhibiting distinct prognoses. We developed four novel HGSOC histopathological subtypes by focusing on tumor microenvironment and unraveled its mechanism. We discovered that the Mesenchymal Transition type which represents the “Mesenchymal” gene expression subtype could respond better to a dose dense taxane combined with carboplatin (ddTC) rather than a conventional taxane and carboplatin (TC) treatment. This new pathological classification reflecting HGSOC gene expression subtypes leads to individualization of chemotherapy treatments.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Comprehensive assessment of the expression of the SWI/SNF complex defines two distinct prognostic subtypes of ovarian clear cell carcinoma.2016
Author(s)
Abou-Taleb H, Yamaguchi K, Matsumura N, Murakami R, Nakai H, Higasa K, Amano Y, Abiko K, Yoshioka Y, Hamanishi J, Koshiyama M, Baba T, Yamada R, Matsuda F, Konishi I, Mandai M.
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Journal Title
Oncotarget.
Volume: Aug 23;7(34)
Pages: 54758-54770
DOI
Related Report
Peer Reviewed
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[Journal Article] Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer.2016
Author(s)
Yamanoi K, Matsumura N, Murphy SK, Baba T, Abiko K, Hamanishi J, Yamaguchi K, Koshiyama M, Konishi I, Mandai M.
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Journal Title
Oncotarget.
Volume: Jul 26;7(30)
Pages: 47620-47636
DOI
Related Report
Peer Reviewed
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[Journal Article] Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes.2016
Author(s)
Murakami R, Matsumura N, Mandai M, Yoshihara K, Tanabe H, Nakai H, Yamanoi K, Abiko K, Yoshioka Y, Hamanishi J, Yamaguchi K, Baba T, Koshiyama M, Enomoto T, Okamoto A, Murphy SK, Mori S, Mikami Y, Minamiguchi S, Konishi I.
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Journal Title
Am J Pathol.
Volume: 186(5)
Pages: 1103-13.
DOI
Related Report
Peer Reviewed
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[Journal Article] Prediction of taxane and platinum sensitivity in ovarian cancer based on gene expression profiles.2016
Author(s)
Murakami R, Matsumura N, Brown JB, Wang Z, Yamaguchi K, Abiko K, Yoshioka Y, Hamanishi J, Baba T, Koshiyama M, Mandai M, Yamada R, Konishi I.
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Journal Title
Gynecol Oncol.
Volume: 141
Pages: 49-56
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical efficacy of neoadjuvant chemotherapy with irinotecan (CPT-11) and nedaplatin followed by radical hysterectomy for locally advanced cervical cancer.2016
Author(s)
Abou-Taleb HA, Koshiyama M, Matsumura N, Baba T, Yamaguchi K, Hamanishi J, Abiko K, Yamanoi K, Murakami R, Horikawa N, Taha AA, Kitamura S, Konishi I.
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Journal Title
J Int Med Res.
Volume: 44
Pages: 346-356
DOI
Related Report
Peer Reviewed
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[Journal Article] The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-a potential therapeutic target.2016
Author(s)
Peng J, Yoshioka Y, Mandai M, Matsumura N, Baba T, Yamaguchi K, Hamanishi J, Kharma B, Murakami R, Abiko K, Murphy SK, Konishi I.
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Journal Title
Mol Carcinog.
Volume: 55
Pages: 335-345
DOI
Related Report
Peer Reviewed
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[Journal Article] Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer.2015
Author(s)
Peng J, Hamanishi J, Matsumura N, Abiko K, Murat K, Baba T, Yamaguchi K, Horikawa N, Hosoe Y, Murphy SK, Konishi I, Mandai M.
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Journal Title
Cancer Res.
Volume: 75
Pages: 5034-5045
DOI
Related Report
Peer Reviewed
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[Journal Article] Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer.2015
Author(s)
Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Murayama T, Kanai M, Mori Y, Matsumoto S, Chikuma S, Matsumura N, Abiko K, Baba T, Yamaguchi K, Ueda A, Hosoe Y, Morita S, Yokode M, Shimizu A, Honjo T, Konishi I.
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Journal Title
J Clin Oncol.
Volume: 33
Pages: 4015-4022
DOI
Related Report
Peer Reviewed
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[Journal Article] Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma.2015
Author(s)
Okamoto T, Mandai M, Matsumura N, Yamaguchi K, Kondoh H, Amano Y, Baba T, Hamanishi J, Abiko K, Kosaka K, Murphy SK, Mori S, Konishi I.
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Journal Title
Mol Carcinog.
Volume: 54
Pages: 35-49
DOI
Related Report
Peer Reviewed
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[Journal Article] Invasion of uterine cervical squamous cell carcinoma cells is facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta.2015
Author(s)
Nagura M, Matsumura N, Baba T, Murakami R, Kharma B, Hamanishi J, Yamaguchi K, Abiko K, Koshiyama M, Mandai M, Murata T, Murphy SK, Konishi I.
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Journal Title
Gynecol Oncol.
Volume: 136
Pages: 104-111
DOI
Related Report
Peer Reviewed
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[Journal Article] STAT1 drives tumor progression in serous papillary endometrial cancer.2014
Author(s)
Kharma B, Baba T, Matsumura N, Kang HS, Hamanishi J, Murakami R, McConechy MM, Leung S, Yamaguchi K, Hosoe Y, Yoshioka Y, Murphy SK, Mandai M, Huntsman DG, Konishi I.
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Journal Title
Cancer Res.
Volume: 74
Pages: 6519-6530
DOI
Related Report
Peer Reviewed
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[Presentation] The investigation for overcSachiko Kitamura, Ken Yamaguchi, Ryusuke Murakami, Kaoru Abiko, Junzo Hamanishi, Tsukasa Baba, Noriomi Matsumuraoming platinum resistance of Ovarian Clear Cell Carcinoma with chromosome 17q amplification2016
Author(s)
Sachiko Kitamura, Ken Yamaguchi, Ryusuke Murakami, Kaoru Abiko, Junzo Hamanishi, Tsukasa Baba, Noriomi Matsumura
Organizer
がんプロ 5大学連携 香港合同教育セミンター
Place of Presentation
Chinese University HongKong
Year and Date
2016-10-28
Related Report
Int'l Joint Research
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[Presentation] Specific Gene Signatures and Oligo Clonal Expansion of B cell Repertoire with Responders of Anti-PD-1 Antibody, Nivolumab for Ovarian Cancer; Novel Predictive Biomarkers.2016
Author(s)
Hamanishi J, Mandai M, Matsumura N, Abiko K, Baba T, Konishi I.Junzo Hamanishi, Ryusuke Murakami, Masaki Mandai, Noriomi Matsumura, Kaoru Abiko, Ken Yamaguchi, Tsukasa Baba, Ikuo Konishi;
Organizer
2016 ASCO Annual Meeting
Place of Presentation
USA, Chicago
Year and Date
2016-06-03 – 2016-06-07
Related Report
Int'l Joint Research
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[Presentation] 卵巣明細胞腺癌におけるSWI/SNF複合体の網羅的遺伝子変異解析2015
Author(s)
山口 建, Abou-Taleb Hisham, 松村 謙臣, 天野 泰彰, 山ノ井 康二, 村上 隆介, 安彦 郁, 吉岡 弓子, 濱西 潤三, 越山 雅文, 馬場 長, 小西 郁生
Organizer
第67回日本産科婦人科学会学術講演会
Place of Presentation
パシフィコ横浜
Year and Date
2015-04-09 – 2015-04-12
Related Report
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