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Elucidation of mechanisms of the development of auditory and balance disorders associated with aging and establishment of the treatment strategy against them

Research Project

Project/Area Number 26253081
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionThe University of Tokyo

Principal Investigator

Yamasoba Tatsuya  東京大学, 医学部附属病院, 教授 (60251302)

Co-Investigator(Kenkyū-buntansha) 岩崎 真一  東京大学, 医学部附属病院, 准教授 (10359606)
樫尾 明憲  東京大学, 医学部附属病院, 助教 (20451809)
柿木 章伸  東京大学, 医学部附属病院, 准教授 (60243820)
藤本 千里  東京大学, 医学部附属病院, 助教 (60581882)
松本 有  東京大学, 医学部附属病院, 助教 (80548553)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2016: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2015: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2014: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Keywords神経科学 / 老化 / 難聴 / 酸化ストレス / ミトコンドリア / アポトーシス / 平衡障害 / 加齢
Outline of Final Research Achievements

When endogenous antioxidant MnSOD was reduced to half, oxidation stress of the cochlea was exacerbated by aging and acoustic trauma aggravated it. When GeO2 was given to mice, cochlear tissue showed marked degeneration with decrease of mitochondrial function. This damage was ameliorated by antioxidant. When gentamycin was injected into the middle ear, hair cell(HC) in semicircular canal showed marked degeneration and showed partial recovery due to regeneration via cell division of the sopporting cells. When TrkB agonist was given, HC showed significant recovery and synapse and afferent fibers were better preserved. When immortalized inner ear cells were exposed to oxidation stress, mitochondria were degenerated, mitochondrial membrane potential decreased, mitochondrial fusion/fission was impaired, and respiratory capacity was affected. We found that the cochlear HC, possess autophagy functoion. When Atg5 was knock out in the cochlear HC, these cells exhibited progressive degeneration.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(43 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (21 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Acknowledgement Compliant: 11 results,  Open Access: 5 results) Presentation (20 results) (of which Int'l Joint Research: 3 results,  Invited: 13 results)

  • [Int'l Joint Research] University of Florida(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] フロリダ大学(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Rational design of reversible fluorescent probes for live-cell imaging and quantification of fast glutathione dynamics.2017

    • Author(s)
      Umezawa K, Yoshida M, Kamiya M, Yamasoba T, Urano Y
    • Journal Title

      nature chemistry

      Volume: 9 Pages: 217-286

    • DOI

      10.1038/nchem.2648

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Manganese superoxide dismutase influences the extent of noise-induced hearing loss in mice.2017

    • Author(s)
      Tuerdi A, Kinoshita M, Kamogashira T, Fujimoto C, Iwasaki S, Shimizu T, Yamasoba T
    • Journal Title

      Neurosci. Lett.

      Volume: 642 Pages: 123-128

    • DOI

      10.1016/j.neulet.2017.02.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress.2017

    • Author(s)
      Kamogashira T, Hayashi K, Fujimoto C, Iwasaki S, Yamasoba T
    • Journal Title

      npj Aging and Mechanisms of Disease

      Volume: 3 Pages: 2-2

    • DOI

      10.1038/s41514-017-0002-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Age-related morphological changes in the basement membrane in the stria vascularis of C57BL/6 mice.2016

    • Author(s)
      Suzuki M, Sakamoto T, Kashio A, Yamasoba T.
    • Journal Title

      European Archives of Oto-Rhino-Laryngology and Head & Neck

      Volume: 273 Pages: 57-62

    • DOI

      10.1007/s00405-014-3478-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Reactive Oxygen Species, Apoptosis, and Mitochondrial Dysfunction in Hearing Loss2015

    • Author(s)
      T Kamogashira, C Fujimoto, T Yamasoba
    • Journal Title

      BioMed research international

      Volume: 617207 Pages: 1-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dizziness and imbalance in the elderly: Age-related decline in the vestibular system.2015

    • Author(s)
      Iwasaki S, Yamasoba T.
    • Journal Title

      Aging and disease

      Volume: 6 Pages: 38-47

    • DOI

      10.14336/ad.2014.0128

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The effect of center-of-pressure power spectrum in foam posturography.2015

    • Author(s)
      Fujimoto C, Egami N, Demura S, Yamasoba T, Iwasaki S.
    • Journal Title

      Neuroscience letters

      Volume: 585 Pages: 92-7

    • DOI

      10.1016/j.neulet.2014.11.033

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Current Concepts of the Mechanisms in Age-Related Hearing Loss2015

    • Author(s)
      T Sakamoto, T Yamasoba
    • Journal Title

      J Clin Exp Pathol

      Volume: 5 Pages: 1-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fujimoto C, Yamasoba T, Iwasaki S. Idiopathic latent vestibulopathy: a clinical entity as a cause of chronic postural instability.2015

    • Author(s)
      Fujimoto C, Yamasoba T, Iwasaki S.
    • Journal Title

      European Archives of Oto-Rhino-Laryngology

      Volume: 272 Pages: 43-49

    • DOI

      10.1007/s00405-013-2834-0

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Interventions to Prevent Age-Related Hearing Loss2015

    • Author(s)
      Tatsuya Yamasoba
    • Journal Title

      Springer International Publishing

      Volume: VI Pages: 335-349

    • DOI

      10.1007/978-3-319-13473-4_16

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 感覚器領域の機能評価と加齢変化に対するサプリメントの効果2015

    • Author(s)
      山岨達也
    • Journal Title

      FOOD STYLE 21

      Volume: 222 Pages: 48-51

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 老人性難聴:疫学。病態、治療戦略2015

    • Author(s)
      山岨達也
    • Journal Title

      都耳鼻会報

      Volume: 146 Pages: 34-38

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Age-related morphological changes in the basement membrane in the stria vascularis of C57BL/6 mice2015

    • Author(s)
      Suzuki M, Sakamoto T, Kashio A, Yamasoba T.
    • Journal Title

      European Archives of Oto-Rhino-Laryngology

      Volume: Epub ahead of print

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Reactive Oxygen Species, Apoptosis and Mitochondrial Dysfunction in Hearing Loss2015

    • Author(s)
      Kamogashira T, Fujimoto C, Yamasoba T
    • Journal Title

      BioMed Research International

      Volume: 617207

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Developmental changes in the protective effect of exogenous brain-derived neurotrophic factor and neurotrophin-3 against ototoxic drugs in cultured rat vestibular ganglion.2014

    • Author(s)
      Inoue A, Iwasaki S, Fujimoto C, Nakajima T, Yamasoba T
    • Journal Title

      Cell and Tissue Research

      Volume: 356 Pages: 299-308

    • DOI

      10.1007/s00441-014-1813-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Oxidative stresses and mitochondrial dysfunction in age-related hearing loss.2014

    • Author(s)
      Fujimoto C, Yamasoba T.
    • Journal Title

      Oxidative Medicine and Cellular Longevity Volume

      Volume: 2014 Pages: 582849-582849

    • DOI

      10.1155/2014/582849

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 加齢に伴う聴覚障害2014

    • Author(s)
      山岨達也
    • Journal Title

      Audiology Japan

      Volume: 57 Pages: 52-62

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 耳鼻咽喉科のアンチエイジング. 老人性難聴の予防2014

    • Author(s)
      山岨達也
    • Journal Title

      Therapeutic Research

      Volume: 35 Pages: 808-810

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 聴覚のアンチエンジング. 女性の聴覚を保つには2014

    • Author(s)
      山岨達也
    • Journal Title

      Modern Physician

      Volume: 34 Pages: 1287-1290

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 難聴の基礎と臨床2014

    • Author(s)
      山岨達也
    • Journal Title

      Anti-aging medicine

      Volume: 10 Pages: 916-924

    • NAID

      40020329452

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 老人性難聴2014

    • Author(s)
      山岨達也
    • Journal Title

      ENT compass

      Volume: なし Pages: 194-196

    • Related Report
      2014 Annual Research Report
  • [Presentation] 加齢に伴う聴覚障害と機序・予防・治療戦略2016

    • Author(s)
      山岨達也
    • Organizer
      抗加齢医学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Age-Related Hearing Loss: Epidemiology, Possible Mechanistic Pathways, and Interventions2016

    • Author(s)
      Tatsuya Yamasoba
    • Organizer
      The 100th Scientific Congress of the Taiwan Otolaryngological Society
    • Place of Presentation
      Kaohsiung, Taiwan
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 老人性難聴の疫学・病態・対応2016

    • Author(s)
      山岨達也
    • Organizer
      静岡県耳鼻咽喉科医会学術講演会
    • Place of Presentation
      静岡
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 老人性難聴の特徴と予防・治療2016

    • Author(s)
      山岨達也
    • Organizer
      東京都港区医師会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] アンチエイジングに関する最新の話題2015

    • Author(s)
      山岨達也
    • Organizer
      第5回アンチエイジングセミナー
    • Place of Presentation
      順天堂大学(東京都文京区)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The effect of mitochondrial damage on hearing loss2015

    • Author(s)
      Tatsuya Yamasoba
    • Organizer
      Gwangju Otology & Neurotology Symposium
    • Place of Presentation
      Gwaungju( Korea)
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Prevention of cochlear damage due to GeO2-induced mitochondrial dysfunction by antioxidants2015

    • Author(s)
      Tatsuya Yamasoba, Akinori Kashio, Chikako Yamada, Teru Kamogashira, Chisato Fujimoto, Shinichi Someya
    • Organizer
      CORLAS annual meeting
    • Place of Presentation
      San Francisco(USA)
    • Year and Date
      2015-08-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 老人性難聴 ~臨床所見、疫学、発症機序、対策~2015

    • Author(s)
      山岨達也
    • Organizer
      千葉市医師会学術講演会
    • Place of Presentation
      千葉市総合保健医療センター(千葉県千葉市)
    • Year and Date
      2015-06-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 老人性難聴:聴覚所見、発症機序、予防と治療2014

    • Author(s)
      山岨達也
    • Organizer
      日耳鼻茨城県地方部会研修会
    • Place of Presentation
      筑波
    • Year and Date
      2014-12-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 加齢に伴う聴覚障害2014

    • Author(s)
      山岨達也
    • Organizer
      日本聴覚医学会総会・学術講演会
    • Place of Presentation
      下関
    • Year and Date
      2014-11-27 – 2014-11-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 内耳有毛細胞におけるオートファジーの役割2014

    • Author(s)
      藤本千里、岩﨑真一、鴨頭輝、木下淳、水島昇、山岨達也
    • Organizer
      第8回オートファジー研究会・第2回「オートファジー」班会議
    • Place of Presentation
      札幌
    • Year and Date
      2014-11-09 – 2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 特発性両側性末梢前庭機能低下症の臨床経過と障害部位に関する検討2014

    • Author(s)
      藤本千里、木下淳、鴨頭輝、江上直也、牛尾宗貴、菅澤恵子、山岨達也、岩崎真一
    • Organizer
      第73回日本めまい平衡医学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 加振器を使用したマウス前庭機能検査システムの構築2014

    • Author(s)
      鴨頭 輝, 岩崎 真, 木下 淳, 藤本 千, 松本 有, 狩野 章, 山岨 達也
    • Organizer
      第73回日本めまい平衡医学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 老人性難聴の疫学、病態、予防戦略2014

    • Author(s)
      山岨達也
    • Organizer
      東京都耳鼻咽喉科医会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 経皮的ノイズ前庭電気刺激が前庭誘発眼筋電位(oVEMP)に及ぼす影響2014

    • Author(s)
      岩﨑真一、狩野章太郎、鴨頭輝、木下淳、藤本千里、山岨達也
    • Organizer
      第24回日本耳科学会
    • Place of Presentation
      新潟
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高齢者のめまい:診断と治療2014

    • Author(s)
      岩﨑真一
    • Organizer
      長崎めまい講演会2014
    • Place of Presentation
      長崎
    • Year and Date
      2014-07-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 耳鼻咽喉科領域のアンチエイジングについて2014

    • Author(s)
      山岨達也
    • Organizer
      日本抗加齢医学会マスメディア向けエデュケーショナルセミナー
    • Place of Presentation
      東京
    • Year and Date
      2014-07-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 高齢者のめまいとその対策2014

    • Author(s)
      岩﨑真一
    • Organizer
      第16回 山形めまい研究会
    • Place of Presentation
      山形
    • Year and Date
      2014-06-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 高齢者の聴力障害の特徴と治療2014

    • Author(s)
      山岨達也
    • Organizer
      東大医師会市民公開講座
    • Place of Presentation
      東京
    • Year and Date
      2014-06-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 末梢前庭障害患者におけるラバー負荷重心動揺検査のパワースペクトル解析2014

    • Author(s)
      藤本千里、岩崎真一、鴨頭輝、木下淳、江上直也、菅澤恵子、山岨達也
    • Organizer
      第115回日本耳鼻咽喉科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-14 – 2014-05-17
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2022-02-02  

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