Elucidation of mechanisms of the development of auditory and balance disorders associated with aging and establishment of the treatment strategy against them
| Project/Area Number |
26253081
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岩崎 真一 東京大学, 医学部附属病院, 准教授 (10359606)
樫尾 明憲 東京大学, 医学部附属病院, 助教 (20451809)
柿木 章伸 東京大学, 医学部附属病院, 准教授 (60243820)
藤本 千里 東京大学, 医学部附属病院, 助教 (60581882)
松本 有 東京大学, 医学部附属病院, 助教 (80548553)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2016: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2015: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2014: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
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| Keywords | 神経科学 / 老化 / 難聴 / 酸化ストレス / ミトコンドリア / アポトーシス / 平衡障害 / 加齢 |
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| Outline of Final Research Achievements |
When endogenous antioxidant MnSOD was reduced to half, oxidation stress of the cochlea was exacerbated by aging and acoustic trauma aggravated it. When GeO2 was given to mice, cochlear tissue showed marked degeneration with decrease of mitochondrial function. This damage was ameliorated by antioxidant. When gentamycin was injected into the middle ear, hair cell(HC) in semicircular canal showed marked degeneration and showed partial recovery due to regeneration via cell division of the sopporting cells. When TrkB agonist was given, HC showed significant recovery and synapse and afferent fibers were better preserved. When immortalized inner ear cells were exposed to oxidation stress, mitochondria were degenerated, mitochondrial membrane potential decreased, mitochondrial fusion/fission was impaired, and respiratory capacity was affected. We found that the cochlear HC, possess autophagy functoion. When Atg5 was knock out in the cochlear HC, these cells exhibited progressive degeneration.
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Report
(4 results)
Research Products
(42 results)
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[Presentation] 加齢に伴う聴覚障害2014
Author(s)
山岨達也
Organizer
日本聴覚医学会総会・学術講演会
Place of Presentation
下関
Year and Date
2014-11-27 – 2014-11-28
Related Report
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