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Elucidation of molecular structure of wheat protein causing severe allergic symptoms

Research Project

Project/Area Number 26282018
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Eating habits
Research InstitutionKyoto University

Principal Investigator

MARUYAMA NOBUYUKI  京都大学, (連合)農学研究科(研究院), 准教授 (90303908)

Co-Investigator(Renkei-kenkyūsha) MIKAMI BUNZO  京都大学, 大学院農学研究科, 教授 (40135611)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywordsアレルゲン / 小麦 / エピトープ / 食品 / アレルギー / 食物 / 植物 / 種子
Outline of Final Research Achievements

Plant seeds are widely consumed as food. However, seed proteins are often the causative substances of food allergy. Wheat is an important part of the daily diet, but it is also one of the three major allergenic food. In this study, comparative analysis of wheat allergens using recombinant proteins indicated that α-gliadin is the major allergen among wheat proteins. Furthermore, its allergenicity is attributed to characteristic structural factors.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (10 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (5 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] バイオテクノロジーの進歩と抗原学2017

    • Author(s)
      丸山 伸之
    • Journal Title

      アレルギー・免疫

      Volume: 1 Pages: 21-27

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Recent advances in component resolved diagnsis in food allergy2016

    • Author(s)
      Borrs, MP., Maruyama N., Sato S., Ebisawa M.
    • Journal Title

      Allegology International

      Volume: 65 Issue: 4 Pages: 378-387

    • DOI

      10.1016/j.alit.2016.07.002

    • NAID

      130005431302

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 食物アレルゲン解析の進歩2014

    • Author(s)
      丸山 伸之
    • Journal Title

      小児科診療

      Volume: 77 Pages: 1249-1253

    • Related Report
      2014 Annual Research Report
  • [Journal Article] アレルゲンとコンポーネントの研究の進歩2014

    • Author(s)
      丸山 伸之
    • Journal Title

      医学の歩み

      Volume: 252 Pages: 927-930

    • Related Report
      2014 Annual Research Report
  • [Presentation] Seed storage proteins in crops: biosynthesis and accumulation2016

    • Author(s)
      Maruyama, N.
    • Organizer
      The second Kasetsert University and the Graduate School of Agriculture, Kyoto University Bilateral Symposium on Food, Environment, and Life for the Next Generation
    • Place of Presentation
      Kyoto University (Kyoto, Kyoto)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 小麦運動誘発性アナフィラキシーの感作アレルゲンコンポーネント2016

    • Author(s)
      福田 啓伸, 吉原 重美, 中山 元子, 加藤 正也, 安藤 祐輔, 宮本 学, 有阪 治, 丸山 伸之
    • Organizer
      日本小児アレルギー学会
    • Place of Presentation
      ベイシア文化ホール (群馬県・前橋市)
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] 食物アレルギーにおけるアレルゲンコンポーネント2016

    • Author(s)
      丸山 伸之
    • Organizer
      愛知免疫アレルギーを語る会
    • Place of Presentation
      名古屋国際ホテル(愛知県・名古屋市)
    • Year and Date
      2016-08-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 小麦ω-5グリアジン陰性症例におけるアレルゲンコンポーネントの臨床性能の解析2016

    • Author(s)
      丸山 伸之, 佐藤 さくら, 田中 昭, 海老澤 元宏
    • Organizer
      第65回日本アレルギー学会学術大会 ミニシンポジウム
    • Place of Presentation
      東京国際フォーラム(東京都・千代田区)
    • Year and Date
      2016-06-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 植物性食物アレルギーにおけるコンポーネント2015

    • Author(s)
      丸山 伸之
    • Organizer
      第2回日本アレルギー学会総合アレルギー講習会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] 食物アレルゲン2016

    • Author(s)
      丸山 伸之
    • Publisher
      診断と治療社
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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