Understanding the mechanism of how central action of amino acids suppresses hepatic glucose production
Project/Area Number |
26282022
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Eating habits
|
Research Institution | Kanazawa University |
Principal Investigator |
Inoue Hiroshi 金沢大学, 新学術創成研究機構, 教授 (50397832)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
Keywords | アミノ酸 / 糖産生 / 中枢神経 / 迷走神経 / 肝臓 / 食品 / 糖 |
Outline of Final Research Achievements |
We have reported that histidine administration reduced blood glucose levels in mice, by suppressing hepatic glucose production via central histamine action. Although histidine is expected to be a candidate for blood glucose-lowering nutrient, the precise mechanism of how central histidine suppresses hepatic glucose production remains unclear. Here, we found that central action of histidine and histamine decreased hepatic gluconeogenic genes by activating hepatic STAT3 signaling via the vagus nerve. Moreover, we found that the vagus nerve suppressed hepatic IL-6/STAT3 signaling via the α7-nicotinic acetylcholine receptors, and that central insulin action activated hepatic IL-6/STAT3 signaling by suppressing vagal activity.
|
Report
(4 results)
Research Products
(27 results)
-
[Journal Article] Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease.2017
Author(s)
Watanabe H, Inaba Y, Kimura K, Asahara SI, Kido Y, Matsumoto M, Motoyama T, Tachibana N, Kaneko S, Kohno M, Inoue H*.
-
Journal Title
J Nutr.
Volume: 147
Pages: 52-60
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch.2016
Author(s)
Sakai M, Tujimura-Hayakawa T, Yagi T, Yano H, Mitsushima M, Unoki-Kubota H, Kaburagi Y, Inoue H, Kido Y, Kasuga M, Matsumoto M.
-
Journal Title
Nat Commun.
Volume: 7
Pages: 13147
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor.2016
Author(s)
Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H.
-
Journal Title
Cell Rep
Volume: 14
Pages: 2362-74
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Hepatocyte β-Klotho regulates lipid homeostasis but not body weight in mice.2016
Author(s)
Kobayashi K, Tanaka T, Okada S, Morimoto Y, Matsumura S, Manio MC, Inoue K, Kimura K, Yagi T, Saito Y, Fushiki T, Inoue H, Matsumoto M, Nabeshima Y.
-
Journal Title
FASEB J.
Volume: 30
Pages: 849-62
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
[Journal Article] Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c.2015
Author(s)
Asahara S, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, Kawada Y, Bartolome A, Hashimoto N, Matsuda T, Koyanagi-Kimura M, Kanno A, Hirota Y, Hosooka T, Nagashima K, Nishimura W, Inoue H, Matsumoto M, Higgins MJ, Yasuda K, Inagaki N, Seino S, Kasuga M, Kido Y.
-
Journal Title
Proc Natl Acad Sci U S A.
Volume: 112
Pages: 8332-7
DOI
Related Report
Peer Reviewed
-
[Journal Article] Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice.2015
Author(s)
Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Matsumoto M, Yamamoto Y, Harada K, Kaneko S, Oyadomari S, Ozaki M, Kasuga M, Inoue H.
-
Journal Title
Hepatology
Volume: 61
Pages: 1343-56
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Gadd34 regulates liver regeneration in hepatic steatosis.2015
Author(s)
Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Matsumoto M, Yamamoto Y, Harada K, Kaneko S, Oyadomari S, Ozaki M, Kasuga M, Inoue H.
-
Journal Title
Hepatology
Volume: 61
Pages: 1343-56
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice.2014
Author(s)
Tsuneki H, Tokai E, Nakamura Y, Takahashi K, Fujita M, Asaoka T, Kon K, Anzawa Y, Wada T, Takasaki I, Kimura K, Inoue H, Yanagisawa M, Sakurai T, Sasaoka T.
-
Journal Title
Diabetes
Volume: 64
Pages: 459-470
DOI
Related Report
Peer Reviewed
-
[Journal Article] p62/SQSTM1 Plays a Protective Role in Oxidative Injury of Steatotic Liver in a Mouse Hepatectomy Model.2014
Author(s)
Haga S, Ozawa T, Yamada Y, Morita N, Nagashima I, Inoue H, Inaba Y, Noda N, Abe R, Umezawa K, Ozaki M.
-
Journal Title
Antioxid Redox Signal.
Volume: 21
Pages: 2515-2530
DOI
Related Report
Peer Reviewed
-
[Journal Article] Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis.2014
Author(s)
Tanaka M, Ikeda K, Suganami T, Komiya C, Ochi K, Shirakawa I, Hamaguchi M, Nishimura S, Manabe I, Matsuda T, Kimura K, Inoue H, Inagaki Y, Aoe S, Yamasaki S, Ogawa Y.
-
Journal Title
Nat Commun.
Volume: 5
Pages: 4982
DOI
Related Report
Peer Reviewed
-
[Journal Article] Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis.2014
Author(s)
Harada K, Kakuda Y, Sato Y, Ikeda H, Shimoda S, Yamamoto Y, Inoue H, Ohta H, Kasashima S, Kawashima A, Nakanuma Y.
-
Journal Title
J Clin Pathol.
Volume: 67
Pages: 396-402
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-