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Design and synthesis of tumor cell adherent blood compatible materials

Research Project

Project/Area Number 26282134
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionKyushu University

Principal Investigator

Tanaka Masaru  九州大学, 先導物質化学研究所, 教授 (00322850)

Research Collaborator KOBAYASHI SHINGO  九州大学, 先導物質化学研究所, 特任准教授 (70625110)
HOSHIBA TAKASHI  山形大学, 有機材料システム研究推進本部 (00469769)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords血液適合性 / がん細胞 / 血球細胞 / 水和構造 / 中間水 / 表面 / 癌細胞 / バイオ界面 / 細胞接着 / 癌細胞接着 / 生体適合性
Outline of Final Research Achievements

To decrease the victims of cancer death, the diagnosis of cancer as well as the therapy is important. Circulating tumor cells (CTCs) have received attention for cancer diagnosis and decisions on chemotherapeutic courses. For these purposes, the isolation of CTCs has been expected. In this study, we examined the possibility of capturing CTCs via an adhesion-based method using new poly(2-methoxyethyl acrylate)(PMEA) analogous polymers by controlling the chemical structure, surface properties and intermediate water structure through precision polymer synthesis. Tumor cells can adhere blood compatible PMEA analogous polymers via integrin-dependent and independent mechanism after 30 min and 1 h of incubation, suggesting that these blood compatible polymers possess the ability to capture CTCs from peripheral blood and inform decisions on chemotherapeutic courses.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (46 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (6 results) Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Acknowledgement Compliant: 12 results,  Open Access: 1 results) Presentation (20 results) (of which Int'l Joint Research: 8 results,  Invited: 13 results) Book (1 results) Remarks (3 results) Patent(Industrial Property Rights) (3 results)

  • [Int'l Joint Research] カリフォルニア大学バークレー校/テキサス大学/ワシントン大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] デンマーク工科大学(デンマーク)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ケンブリッジ大学/グラスゴー大学/エディンバラ大学(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] スロバキア高分子研究所(スロバキア)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] マックスプランク研究所/ハイデルベルク大学/ロイトリンゲン大学(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Blood compatible poly(2-methoxyethyl acrylate) (PMEA) for the adhesion and proliferation of lung cancer cells toward the isolation and analysis of circulating tumor cells2016

    • Author(s)
      T. Hoshiba, M. Nikaido, S.Yagi, I. Konno, A. Yoshihiro, M. Tanaka
    • Journal Title

      Journal of Bioactive and Compatible Polymers

      Volume: 31 Pages: 361-372

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ring-Opening Metathesis Polymerization of 3-Substituted Cyclooctenes with Ether Side-Chains2016

    • Author(s)
      S. Kobayashi, K. Fukuda, M. Kataoka, M. Tanaka
    • Journal Title

      Macromolecules

      Volume: 49 Pages: 2493-2501

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Adhesion-Based Simple Capture and Recovery of Circulating Tumor Cells Using a Blood-Compatible and Thermo-Responsive Polymer-Coated Substrate2016

    • Author(s)
      T. Hoshiba, T. Orui, C. Endo, K. Sato, A. Yoshihiro, Y. Minagawa, M.Tanaka
    • Journal Title

      RSC Advances

      Volume: 6 Pages: 89103-89112

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of Sequence-Specific Polymers with Amide Side-chains via Regio-/stereoselective Ring-opening Metathesis Polymerization of 3-Substituted cis-Cycloocte2016

    • Author(s)
      K. Osawa, S. Kobayashi, M. Tanaka
    • Journal Title

      Macromolecules

      Volume: 49 Pages: 8154-8161

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Promotion of adipogenesis of 3T3-L1 cells on protein adsorption-suppressing poly (2-methoxyethyl acrylate) analogous polymers2016

    • Author(s)
      T. Hoshiba, E. Nemoto, K. Sato, H. Maruyama, C. Endo, M. Tanaka
    • Journal Title

      Biomacromolecules

      Volume: 17 Pages: 3808-3815

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The relationship between water structure and blood compatibility in poly(2-methoxyethyl acrylate) (PMEA) analogues2015

    • Author(s)
      K. Sato, S. Kobayashi, M. Kusakari, S. Watahiki, M. Oikawa, T. Hoshiba, M. Tanaka
    • Journal Title

      Macromol. Biosci.

      Volume: 15 Pages: 1296-1303

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Evaluation of factors to determine platelet compatibility by using self-assembled monolayers with a chemical gradient2015

    • Author(s)
      T. Sekine, Y. Tanaka, C. Sato, M. Tanaka, T. Hayashi
    • Journal Title

      Langmuir

      Volume: 31 Pages: 7100-7105

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Blood compatible polymer for hepatocyte culture with high hepatocyte-specific functions toward bioartificial liver development2015

    • Author(s)
      T. Hoshiba, T. Otaki, E. Nemoto, H. Maruyama, M. Tanaka
    • Journal Title

      ACS Appl. Mater. Interfaces

      Volume: 7 Pages: 18096-18103

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Regulation of the contribution of integrin to cell attachment on poly(2-methoxyethyl acrylate) (PMEA) analogous polymers for attachment-based cell enrichment.2015

    • Author(s)
      T. Hoshiba, E. Nemoto, K. Sato, T. Orui, T. Otaki, A. Yoshihiro, M. T
    • Journal Title

      PLoS One

      Volume: 10

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Polymeric Biomaterials, their Processing and Fabrication: A Strategy for Tissue Engineering and Medical devices2015

    • Author(s)
      .F. Khan, M. Tanaka, S.R. Ahmad
    • Journal Title

      Journal of Materials Chemistry B

      Volume: 3 Pages: 8224-8249

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Design of biocompatible and biodegradable polymers based on intermediate water concept.2015

    • Author(s)
      Masaru Tanaka, Kazuhiro Sato, Erika Kitakami, Shingo Kobayashi, Takashi Hoshiba, Kazuki Fukushima.
    • Journal Title

      Polymer Journal

      Volume: 47 Issue: 2 Pages: 114-121

    • DOI

      10.1038/pj.2014.129

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of the mechanisms of attachment of tissue-derived cell lines to blood-compatible polymers2014

    • Author(s)
      T. Hoshiba, M. Nikaido, M. Tanaka,
    • Journal Title

      Adv. Healthcare Mater.

      Volume: 3 Pages: 775-784

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effect of Sodium Chloride on Hydration Structures of PMEA and P(MPC-r-BMA)2014

    • Author(s)
      5.S.Morita, M. Tanaka
    • Journal Title

      Langmuir

      Volume: 30 Pages: 10698-10703

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 健康・医療産業振興に必要な材料技術-基礎研究から製品化までの道のり-2017

    • Author(s)
      田中 賢
    • Organizer
      理研×九大×福岡市 イノベーションフォーラム
    • Place of Presentation
      福岡
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Design of biocompatible polymers based on the biomimetic intermediate water concept2016

    • Author(s)
      M. Tanaka
    • Organizer
      The European Materials Research Society (E-MRS)-2016 Fall Meeting
    • Place of Presentation
      ポーランド
    • Year and Date
      2016-09-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design Concept of the Dialyzer Biomaterials Based on the Water Structure2016

    • Author(s)
      M. Tanaka
    • Organizer
      International Society of Blood Purification 2016(ISBP2016)
    • Place of Presentation
      広島
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design of Biocompatible Polymers Based on the Biomimetic Intermediate Water Concept2016

    • Author(s)
      Masaru Tanaka, Daiki Murakami, Fumihiro Aratsu, Shingo Kobayashi
    • Organizer
      4th Japan-China Symposium on Nanomedicine
    • Place of Presentation
      北九州
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design and Synthesis of Soft-biocompatible Materials Based on the Intermediate Water Concept2016

    • Author(s)
      M. Tanaka
    • Organizer
      International Conference on Frontiers at the Chemistry- Allied Sciences Interface (FCASI-2016)
    • Place of Presentation
      University of Rajasthan, Jaipur, India
    • Year and Date
      2016-04-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体適合性材料設計の基礎と医療製品への応用2016

    • Author(s)
      田中 賢
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      京都
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Design and synthesis of 2D/3D biocompatible materials based on the intermediate water concept2016

    • Author(s)
      田中 賢
    • Organizer
      International Conference on Advancements in Engineering and Technology (ICAET-2016)
    • Place of Presentation
      インド
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design of biocompatible polymers based on the intermediate water concept2016

    • Author(s)
      田中 賢
    • Organizer
      International Conference on Materials Science&Technology(ICMTech-2016)
    • Place of Presentation
      インド
    • Year and Date
      2016-03-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中間水コンセプトによる生体適合性高分子の設計と合成2016

    • Author(s)
      田中 賢
    • Organizer
      機能性材料シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2016-02-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Synthesis of novel polymers having precisely placed tetrahydrofurfuryl side-chain branches via +C147:D150region/stereoselective ring-opening metathesis polymerization2016

    • Author(s)
      片岡真依子,小林慎吾,佐藤力哉,田中賢
    • Organizer
      IMCE International Symposium
    • Place of Presentation
      福岡
    • Year and Date
      2016-01-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がん診断用の生体親和性高分子の設計2016

    • Author(s)
      田中 賢
    • Organizer
      高分子学会九州支部フォーラム
    • Place of Presentation
      熊本
    • Year and Date
      2016-01-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 中間水コンセプトによる生体親和性ソフトマテリアルの設計と合成2015

    • Author(s)
      田中 賢
    • Organizer
      第25回日本MRS年次大会
    • Place of Presentation
      横浜
    • Year and Date
      2015-12-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 細胞とマテリアルの融合:健康長寿社会に貢献するバイオ化学工学をめざして2015

    • Author(s)
      田中 賢
    • Organizer
      日本化学会秋季事業 第5回CSJ化学フェスタ2015
    • Place of Presentation
      東京
    • Year and Date
      2015-10-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Design of biocompatible and biodegradable polymers based on intermediate water concept2015

    • Author(s)
      ,田中賢,佐藤一博,北上恵理香,小林慎吾,干場隆志,福島和樹
    • Organizer
      Symposium on Advanced Polymer Science
    • Place of Presentation
      福岡
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 側鎖間隔を制御した新規アミド基導入ポリマーの合成2014

    • Author(s)
      大澤康平,小林慎吾,田中賢
    • Organizer
      第63回高分子学会年次大会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-28 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 側鎖-側鎖間の炭素数を制御した新規PMEA類似体の合成とその抗血栓性評価2014

    • Author(s)
      戸来奎介,福田考作,小林慎吾,田中賢
    • Organizer
      第63回高分子学会年次大会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-28 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] regio選択的な開環メタセシス重合による定序性ポリ(3,4-ジメトキシシクロオクテン)の合成とその抗血栓性評価2014

    • Author(s)
      福田考作,戸来奎介,小林慎吾,田中賢
    • Organizer
      第63回高分子学会年次大会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-28 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 選択的な開環メタセシス重合を用いた新規PTHFA 類似体の合成とその血液適合性評価2014

    • Author(s)
      片岡真依子,岩田幸久,小林慎吾,田中賢
    • Organizer
      第63回高分子学会年次大会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-28 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] DSC Study of Hydrated Aliphatic Carbonyl Polymers2014

    • Author(s)
      Meng-Yu TSAI,Yuto INOUE,Takayuki OTA,Kazuki FUKUSHIMA,Masaru TANAKA
    • Organizer
      第63回高分子学会年次大会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-28 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抗血栓性脂肪族ポリカーボネートの細胞接着性と生分解性2014

    • Author(s)
      井上裕人,佐藤千香子,佐々木彩乃,福島和樹,田中賢
    • Organizer
      第63回高分子学会年次大会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-28 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Book] New Design Concept of Dialyzer Biomaterials: How to Find Biocompatible Polymers Based on the Biointerfacial Water Structure, Scientific Aspects of Dialysis2016

    • Author(s)
      .M. Tanaka
    • Total Pages
      7
    • Publisher
      Karger
    • Related Report
      2016 Annual Research Report
  • [Remarks] 九州大学田中研究室HP

    • URL

      http://www.soft-material.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 田中研HP

    • URL

      http://www.soft-material.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 田中研究室HP

    • URL

      http://www.bio-material.jp/

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 医療用具用重合体用単量体組成物、及び、医療用具重合体2015

    • Inventor(s)
      田中 賢
    • Industrial Property Rights Holder
      田中 賢
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-236069
    • Filing Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌細胞接着剤及び癌細胞の検出方法2015

    • Inventor(s)
      田中 賢
    • Industrial Property Rights Holder
      田中 賢
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-236068
    • Filing Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 医療用具用材料、並びに、それを用いた医療用具、抗血栓性材料及び細胞培養基材2014

    • Inventor(s)
      田中 賢
    • Industrial Property Rights Holder
      田中 賢
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-08-01
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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