| Budget Amount *help |
¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
The diagnosis of atherosclerosis in the early stage is crucial for preventing degeneration of arteries. In the early stage of atherosclerosis, the arterial wall becomes rough due to endothelial cell proliferation and degeneration of the internal elastic layer. For the early diagnosis of atherosclerosis, our group has proposed a method to estimate the micron-order luminal surface roughness of the carotid artery. In the present study, a technique was developed that suppresses error in estimating surface roughness caused by the movement of a carotid artery during one cardiac cycle. The average surface roughness of the carotid artery estimated by the proposed method was 2.33 μm in three young subjects (from 20 to 30 years old) and 3.36 μm in three older subjects (from 50 to 65 years old). These results show the high potential of the proposed method for accurate estimation of the minute surface roughness of the carotid artery.
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