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Establishment of novel non-invasive therapy for siRNA-induced vasculogenesis using sonoporation techniques, nano-size drug delivery systems

Research Project

Project/Area Number 26282148
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Medical systems
Research InstitutionSaga University

Principal Investigator

Teramoto Noriyoshi  佐賀大学, 医学部, 教授 (40294912)

Co-Investigator(Kenkyū-buntansha) 小玉 哲也  東北大学, その他の研究科, 教授 (40271986)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords医用システム / 低侵襲治療システム / 血管新生学 / 核酸医薬 / siRNA / 薬理学 / 核酸 / 血管新生 / ナノ医工学
Outline of Final Research Achievements

Due to an aging population and the increasingly westernized diet of Japanese people, it will be essential to combat the increasing incidence of associated lifestyle-related diseases such as atherosclerosis and type 2 diabetes. For example, it is well known that atherosclerosis produces narrowing of blood vessels in the leg, which may lead to severe symptoms including gangrene. For the medical treatment of impeded blood flow (e.g. arteriosclerosis obliterans, Buerger's disease) both drug treatment and/or invasive surgical interventions (stenting, bypass graft surgery, etc.) are required.
Therefore, the aim of the present research project is to establish a novel non-invasive therapy for siRNA-induced vasculogenesis by the use of nano-size drug delivery systems, which is designed to stimulate the collateral circulation in compromised tissues. This technique will also be applicable in organ transplant and regenerative medicine.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (17 results)

All 2017 2016 2015 2014 Other

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 8 results,  Acknowledgement Compliant: 5 results) Presentation (6 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Remarks (3 results)

  • [Journal Article] ZD0947, a sulphonylurea receptor modulator, detects functional sulphonylurea receptor subunits in murine vascular smooth muscle ATP-sensitive K+ channels.2017

    • Author(s)
      Yamamoto T, Takahara K, Uchida K, Teramoto N
    • Journal Title

      European Journal of Pharmacology

      Volume: 800 Pages: 34-39

    • DOI

      10.1016/j.ejphar.2017.02.023

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ZD0947, a novel and potent ATP-sensitive K+ channel opener, on smooth muscle-type ATP-sensitive K+ channels.2016

    • Author(s)
      Mori K, Yamashita Y, Teramoto N
    • Journal Title

      European Journal of Pharmacology

      Volume: 791 Pages: 773-779

    • DOI

      10.1016/j.ejphar.2016.09.038

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Selective Blocking Effects of 4,9-Anhydrotetrodotoxin, Purified from a Crude Mixture of Tetrodotoxin Analogues, on NaV1.6, Channels and Its Chemical Aspects2015

    • Author(s)
      Noriyoshi Teramoto* and Mari Yotsu-Yamashita
    • Journal Title

      Marine Drugs

      Volume: 13 Issue: 2 Pages: 984-995

    • DOI

      10.3390/md13020984

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular analysis of ATP-sensitive K+ channel subunits expressed in mouse portal vein2015

    • Author(s)
      Yamamoto T, Takahara K, Inai T, Node K, Teramoto N
    • Journal Title

      Vascul Pharmacol

      Volume: 75 Pages: 29-39

    • DOI

      10.1016/j.vph.2015.06.018

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular analysis of ATP-sensitive K⁺ channel subunits expressed in mouse vas deferens myocytes.2014

    • Author(s)
      Iwasa K, Zhu HL, Shibata A, Maehara Y, Teramoto N.
    • Journal Title

      British Journal of Pharmacology

      Volume: 171 Issue: 1 Pages: 145-157

    • DOI

      10.1111/bph.12437

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle.2014

    • Author(s)
      Sidaway P, Teramoto N.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 4 Pages: e93803-e93803

    • DOI

      10.1371/journal.pone.0093803

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] SMAD2 disruption in meuse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sengitive K+ channel activity.2014

    • Author(s)
      Nomura M, Zhu HL, Wang L, Morinaga H, Takayanagi R, Teramoto N.
    • Journal Title

      Diabetologia

      Volume: 57 Issue: 1 Pages: 157-166

    • DOI

      10.1007/s00125-013-3062-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of constitutive active form of ActRIB in pancreas beta cells leads to impaired insulin secretion in mice.2014

    • Author(s)
      Nomura M, Morinaga H, Hei-lay Z, Wang L, Hasuzawa N, Takayanagi R, Teramoto N
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 450 Issue: 1 Pages: 440-446

    • DOI

      10.1016/j.bbrc.2014.05.141

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Actions of ZD0947 on the activity of ATP-sensitive K+ channels in murine vascular smooth muscles.2017

    • Author(s)
      Tadashi Yamamoto, Kohei Takahara, Keiichiro Uchida, Noriyoshi Teramoto
    • Organizer
      日本薬理学会 年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of 4,9-anhydroTTX on voltage-gated Na+ channels expressed in murine vas deferent myocytes.2017

    • Author(s)
      Noriyoshi Teramoto, Tadashi Yamamoto, Keiichiro Uchida, Tetsuichiro Inai, Mari Yotsu-Yamashita
    • Organizer
      日本薬理学会 年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular analysis of ATP-sensitive K+ channel subunits expressed in mouse portal vein.2016

    • Author(s)
      Yamamoto T, Teramoto N
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular analysis of ATP-sensitive K+ channel subunits expressed in mouse portal vein.2015

    • Author(s)
      Yamamoto T, Teramoto N
    • Organizer
      第68回日本薬理学会西南部会
    • Place of Presentation
      下関
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス膵β細胞においてアクチビン1B受容体シグナル活性はATP感受性K+チャネルの減弱化を介してインスリン分泌を抑制する2014

    • Author(s)
      寺本 憲功, 野村 政壽
    • Organizer
      第67回日本薬理学会西南部会
    • Place of Presentation
      北九州市
    • Year and Date
      2014-11-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞内シグナル応答の可視化2014

    • Author(s)
      寺本 憲功
    • Organizer
      第59回 日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉市
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Remarks] 佐賀大学 医学部 薬理学

    • URL

      http://www.pharmacology.med.saga-u.ac.jp/YAKURIHP/Top_Page.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 佐賀大学 教員総覧データベース 寺本憲功

    • URL

      http://evalwww.cc.saga-u.ac.jp/search/IST

    • Related Report
      2014 Annual Research Report
  • [Remarks] 佐賀大学 医学部 薬理学HP

    • URL

      http://www.pharmacology.med.saga-u.ac.jp/YAKURIHP/Top_Page.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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