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Repetitive spinalmagnetic sustains the effect of exercise in Parkinson's disease

Research Project

Project/Area Number 26282167
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionDepartment of Clinical Research, National Hospital Organization Tokushima National Hospital

Principal Investigator

Mitsui Takao  独立行政法人国立病院機構徳島病院(臨床研究部), その他部局等, 臨床研究部長 (80294726)

Co-Investigator(Kenkyū-buntansha) 川村 和之  独立行政法人国立病院機構徳島病院(臨床研究部), その他部局等, その他 (10450959)
黒田 由紀子  独立行政法人国立病院機構徳島病院(臨床研究部), その他部局等, 研究員 (70398014)
有井 敬治  独立行政法人国立病院機構徳島病院(臨床研究部), その他部局等, その他 (70644855)
Co-Investigator(Renkei-kenkyūsha) KAJI Ryuji  徳島大学, 大学院医歯薬学研究部, 教授 (00214304)
Research Collaborator KAWAMICHI Kouji  
SHIMAMURA Makiko  
YABUTA Eigo  
OKAMOTO Kazuhisa  
KOMORI Itsumi  
UESUGI Tomoko  
KAMATA Tsuyoshi  
OOE Hiromi  
SHINGAI Yuri  
MIYATA Nana  
KAWAMICHI Kumiko  
MIYAKE Sayaka  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywordsパーキンソン病 / リハビリテーション / 反復脊髄磁気刺激(rTSMS) / 反復脊髄磁気刺激 / 反復磁気刺激 / rTSMS / 姿勢異常 / 腰曲がり / camptocormia
Outline of Final Research Achievements

We examined the effect of repetitive spinal magnetic stimulation (rTSMS) on the bent posture and parkinsonian disability scale in patients with Parkinson's disease (PD) complicated with camptocormia. We intermittently performed rTSMS twice weekly for 4 weeks and investigated whether bent angle and motor symptoms were improved. The subjects were 104 PD patients. We randomized them into two groups; rTSMS group performing magnetic stimulation and rehabilitation and control group performing only the latter. As a result, in the rTSMS group, the bent angle and Unified Parkinson's Disease Rating Scale (UPDRS) part 3 improved favorably over 3 months. This result suggests that rTSMS enhances the effect of rehabilitation on PD.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (19 results)

All 2017 2016 2015 2014

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (12 results) (of which Invited: 4 results)

  • [Journal Article] ミトコンドリアDNAおよびその遺伝形質、ミトコンドリア病2017

    • Author(s)
      三ツ井 貴夫
    • Journal Title

      ハリソン内科学

      Volume: 5 Pages: 460-460

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Medical examination of patients with SMON in Tokushima of 2016.2017

    • Author(s)
      Takao Mitsui , Toshio Inui , Yutaka Matsuka , Erika Hosokawa , Chihiro Ohara , Nana Urayama , Kazuhisa Okamoto , Yuri Shingai , Miwa Takahashi , Harunobu Shima , Mariko Inoue , Yui Mukaiyama , Hiromi Sato
    • Journal Title

      J Tokus Natl Hosp

      Volume: 8 Pages: 9-11

    • NAID

      40021230913

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of intravascular malignant lymphoma in the brain that occurred with subacute monoplegia of the right leg.2017

    • Author(s)
      Takao Mitsui, Arisa Shimizu
    • Journal Title

      J Tokus Natl Hosp

      Volume: 8 Pages: 35-38

    • NAID

      40021231017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adductor laryngeal exhaling dystonia in progressive supranuclear palsy2015

    • Author(s)
      Kawamura K, Arii Y, Inui T, Mitsui T.
    • Journal Title

      Neurology

      Volume: 84(5) Pages: 545-545

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A homozygous mutation of VWA3B causes cerebellar ataxia with intellectual disability2015

    • Author(s)
      Kawarai T, Tajima A, Kuroda Y, Saji N, Orlacchio A, Terasawa H, Shimizu H, Kita Y, Izumi Y, Mitsui T, Imoto I, Kaji R
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 8 Pages: 309828-309828

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adductor laryngeal exhaling dystonia in progressive supranuclear palsy2015

    • Author(s)
      Kawamura K, Arii Y, Inui T, and Mitsui T
    • Journal Title

      Neurology

      Volume: 84 Issue: 5 Pages: 545-545

    • DOI

      10.1212/wnl.0000000000001206

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immediate effect of spinal magnetic stimulation on camptocormia in Parkinson's disease.2014

    • Author(s)
      Arii Y, Sawada Y, Kawamura K, Miyake S, Taichi Y, Izumi Y, Kuroda Y, Inui T, Kaji R, Mitsui T.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 未定 Issue: 11 Pages: 1221-1226

    • DOI

      10.1136/jnnp-2014-307651

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] パーキンソン病の治療:エクササイズの重要性について2017

    • Author(s)
      三ツ井 貴夫
    • Organizer
      第3回北陸地区国立病院機構 パーキンソン病講演会
    • Place of Presentation
      金沢都ホテル(金沢市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病における反復脊髄磁気刺激療法2017

    • Author(s)
      三ツ井 貴夫
    • Organizer
      第73回徳島神経疾患症例検討会-西部地区-
    • Place of Presentation
      国立病院機構徳島病院(吉野川市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Parkin is involved in miR132 processing2016

    • Author(s)
      三ツ井 貴夫
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2016-05-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Parkin is involved in miR 132 processing2016

    • Author(s)
      三ツ井 貴夫
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(神戸市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] パーキンソン病の治療-リハビリテーションを中心に-2016

    • Author(s)
      三ツ井 貴夫
    • Organizer
      ノウリアスト学術講演会
    • Place of Presentation
      マリトピア佐賀(佐賀市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病におけるリハビリテーション2016

    • Author(s)
      三ツ井 貴夫
    • Organizer
      西区 パーキンソン病講演会
    • Place of Presentation
      北祐会神経内科病院(札幌市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病治療におけるリハビリテーション2016

    • Author(s)
      三ツ井 貴夫
    • Organizer
      第2回京都神経難病リハビリテーション研究会
    • Place of Presentation
      メルパルク京都(京都市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 呼気時に限定した喉頭ジストニアを呈した進行性核上性麻痺の一例2014

    • Author(s)
      川村 和之
    • Organizer
      徳島神経病学学術講演会
    • Place of Presentation
      ホテルグランドパレス徳島
    • Year and Date
      2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 近年の潮流である「持続性ドパミン刺激(CDS)」について2014

    • Author(s)
      三ツ井 貴夫
    • Organizer
      大塚製薬学術講演会
    • Place of Presentation
      ホテルクレメント徳島
    • Year and Date
      2014-10-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] パーキンソン関連疾患とリハビリテーション2014

    • Author(s)
      三ツ井 貴夫
    • Organizer
      堺市医療講演会
    • Place of Presentation
      堺市健康福祉プラザ
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] HLA-DRトランスジェニックマウスを用いた多発性硬化症の病態解析2014

    • Author(s)
      川村 和之
    • Organizer
      京都大学大学院医学研究科 脳病態生理学講座 臨床神経学
    • Place of Presentation
      京都大学医学部付属病院
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] パーキンソン病の治療と問題点2014

    • Author(s)
      三ツ井 貴夫
    • Organizer
      阿波吉野川支部・名西支部薬剤師会
    • Place of Presentation
      セントラルホテル鴨島
    • Year and Date
      2014-09-16
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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