The role of macrophage circadian clock gene in anti-inflammatory effects of exercise

• Project/Area Number: 26282186
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Kyorin University
• Principal Investigator: Kizaki Takako 杏林大学, 医学部, 教授 (00322446)
• Co-Investigator(Renkei-kenkyūsha): OHNO Hideki 杏林大学, 医学部, 名誉教授 (00133819) ; SAKURAI Takuya 杏林大学, 医学部, 講師 (20353477) ; OGASAWARA Junetsu 旭川医科大学, 医学部, 講師 (20415110) ; SHIRATO Ken 杏林大学, 医学部, 助教 (60559384)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: マクロファージ / 運動 / 炎症反応 / 老化 / 時計遺伝子 / 炎症生反応 / 炎症性反応

Outline of Final Research Achievements

Hyperglycemia is associated with chronic low-grade systemic inflammation. In this study, we examined the effects of high-glucose on the regulation of inflammation by the circadian clock gene, Rev-erbα.
High-glucose-cultured macrophages showed an increased expression of phosphorylated Rev-erbα in the nucleus as compared low glucose-cultured cell, although such differences were not observed at the mRNA level. O-linked N-acetylglucosamine (O-GlcNAc) transferase knockdown abolished the high glucose-induced reduction of proteasome activity as well as nuclear accumulation of Rev-erbα. In addition, Rev-erbαknockdown significantly recovered the attenuation of lipopolysaccharide-stimulated production of IL-10 in response to high-glucose culture. These findings suggest that high-glucose condition induces the nuclear accumulation of Rev-erbα via reducing proteasome activity, resulting in the increased inflammation by the suppression of IL-10 expression.

Research Products

• [Journal Article] Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue. (2017)
  • Author(s): Sakurai T, Ogasawara J, Shirato K, Izawa T, Oh-ishi S, Ishibashi Y, Radak Z, Ohno H, Kizaki T
  • Journal Title: Oxid Med Cell Longev. Volume: 2017 Pages: 9410954-9410954
  • DOI: 10.1155/2017/9410954
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Regular Voluntary Exercise Potentiates Interleukin-1ß and Interleukin-18 Secretion by Increasing Caspase-1 Expression in Murine Macrophages (2017)
  • Author(s): Shirato K, Imaizumi K, Sakurai T, Ogasawara J, Ohno H, Kizaki T
  • Journal Title: Mediators Inflamm. Volume: 2017 Pages: 9290416-9290416
  • DOI: 10.1155/2017/9290416
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regular exercise improves inflammatory responses by resident or recruited macrophages against bacterial pathogens (2017)
  • Author(s): Shirato K, Sato S, Imaizumi K, Sakurai T, Ogasawara J, Oh-ishi S, Ohno H, Kizaki T
  • Journal Title: Macrophage Volume: 4 Pages: 1-7
  • DOI: 10.14800/macrophage.1533
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] NEU1 sialidase controls gene expression and secretion of IL-6 and MCP-1through NF- κB pathway in 3T3-L1 adipocytes (2017)
  • Author(s): Natori Y, Nasui M, Edo K, Sato S, Sakurai T, Kizaki T, Kihara-Negishi F
  • Journal Title: J Biochem Volume: ー
  • DOI: 10.1093/jb/mvx006
  • NAID: 40021299838
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Screening for seemingly healthy newborns with congenital cytomegalovirus infection by quantitative real-time polymerase chain reaction using newborn urine: an observational study (2017)
  • Author(s): Yamaguchi A1, Oh-Ishi T1, Arai T1, Sakata H2,3, Adachi N1, Asanuma S1, Oguma E1, Kimoto H4, Matsumoto J5, Fujita H6, Uesato T6, Fujita J6, Shirato K, Ohno H, Kizaki T
  • Journal Title: BMJ Open Volume: 7
  • DOI: 10.1136/bmjopen-2016-013810
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Enzyme-treated asparagus extract prevents hydrogen peroxide-induced pro-inflammatory responses by suppressing p65 nuclear translocation in skin L929 fibroblasts (2016)
  • Author(s): Shirato K, Takanari J, Sakurai T, Ogasawara J, Imaizumi K, Ohno H, Kizaki T
  • Journal Title: Nat Prod Commun Volume: 11 Pages: 1883-1888
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 加齢性慢性炎症性疾患に対する運動効果：マクロファージ時計遺伝子をプローブとして (2016)
  • Author(s): 木崎節子，楊國昌，櫻井拓也，小笠原準悦，白土健
  • Journal Title: 杏林医学会雑誌 Volume: 47
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Enzyme-Treated Asparagus Extract Attenuates Hydrogen Peroxide-Induced Matrix Metalloproteinase-9 Expression in Murine Skin Fibroblast L929 Cells (2016)
  • Author(s): Shirato K, Takanari J, Ogasawara J, Sakurai T, Imaizumi K, Ohno H, Kizaki T
  • Journal Title: Natural Product Communications Volume: 11
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cerebral artery blood flow and oxygenation in the frontal lobe region in response to a judo chokehold (shimewaza) (2016)
  • Author(s): Haga S, Sakurai T, Hamaoka T, Esaki K, Ueya K, Toshinai K, Miyazaki H, Ogasawara J, Shirato K, Hashimoto N, Kastumura T, Nioka S, Chance B, Yamaguchi I, Kizaki T, Ohno H
  • Journal Title: Journal of Exercise, Sports & Orthopedics Volume: 3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effect of Circadian Rhythm on Clinical and Pathophysiological Conditions and Inflammation. (2015)
  • Author(s): Kizaki T, Sato S, Shirato K, Sakurai T, Ogasawara J, Izawa T, Ohira Y, Suzuki K, Ohno H
  • Journal Title: Crit. Rev. Immunol. Volume: 35 Pages: 261-275
  • DOI: 10.1615/critrevimmunol.2015014925
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Habitual exercise training acts as a physiological stimulator for constant activation of lipolytic enzymes in rat primary white adipocytes (2015)
  • Author(s): Ogasawara J, Izawa T, Sakurai T, Shirato K, Ishibashi Y, Ohira Y, Ishida H, Ohno H, Kizaki T
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 465 Pages: 348-353
  • DOI: 10.1016/j.bbrc.2015.06.157
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Melatonin promotes adipogenesis and mitochondrial biogenesis in 3T3-L1 preadipocytes (2015)
  • Author(s): Kato H, Tanaka G, Masuda S, Ogasawara J, Sakurai T, Kizaki T, Ohno H, Izawa T
  • Journal Title: Journal of Pineal Research Volume: 59 Pages: 267-275
  • DOI: 10.1111/jpi.12259
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells. (2015)
  • Author(s): Ogasawara J, Izawa T, Sakurai T, Sakurai T, Shirato K, Ishibashi Y, Ishida H, Ohno H, Kizaki T
  • Journal Title: Journal of Obesity Volume: 2015 Pages: 1-10
  • DOI: 10.1155/2015/473430
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Macrophage deficiency in osteopetrotic (op/op) mice inhibits activation of satellite cells and prevents hypertrophy in single soleus fibers (2015)
  • Author(s): Ohira T, Wang XD, Ito T, Kawano F, Goto K, Izawa T, Ohno H, Kizaki T, Ohira Y
  • Journal Title: The American Journal of Physiology - Cell Physiology Volume: 308
  • Peer Reviewed / Open Access
• [Journal Article] ETAS, an enzyme- treated asparagus extract, attenuates amyloid β-induced cellular disorder in PC12 cells. (2014)
  • Author(s): Junetsu Ogasawara, Tomohiro Ito, Koji Wakame, Kentaro Kitadate, Takuya Sakurai, Shogo Sato, Yoshinaga Ishibashi, Tetsuya Izawa, Kazuto Takahashi, Hitoshi Ishida, Ichiro Takabatake, Takako Kizaki, Hideki Ohno
  • Journal Title: Natural Product Communcations Volume: 9 Pages: 561-564
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The effects of long-term exercise on cerebral function and the maintenance of concentration in the elderly. (2014)
  • Author(s): Shukoh Haga, Takuya Sakurai, Shogo Sato, Michiko Sasahara, Fumio Aita, Kazuki Esaki, Koji Toshinai, Etsuo Ueya, Noboru Hashimoto, Junetsu Ogasawara, Takako Kizaki, Yoshinaga Ishibashi, Tomonobu Sakurai, Shuji Oh-ishi, Hideki Ohno, Eimatsu Takakuwa
  • Journal Title: Journal of Exercise, Sports & Orthopedics Volume: 1 Pages: 6-11
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Direct and indirect suppression of interleukin-6 gene expression in murine macrophages by nuclear orphan receptor REV-ERBα. (2014)
  • Author(s): Sato S, Sakurai T, Ogasawara J, Shirato K, Ishibashi Y, Oh-ishi S, Imaizumi K, Haga S, Hitomi Y, Izawa T, Ohira Y, Ohno H & Kizaki T
  • Journal Title: The Scientific World Journal Volume: 2014 Pages: 685854-685854
  • DOI: 10.1155/2014/685854
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A Circadian Clock Gene, Rev-erbα, Modulates the Inflammatory Function of Macrophages through the Negative Regulation of Ccl2 Expression. (2014)
  • Author(s): Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T.
  • Journal Title: The Journal of Immunology Volume: 192 Pages: 407-417
  • DOI: 10.4049/jimmunol.1301982
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Enzyme-treated Asparagus officinalis extract shows neuroprotective effects and attenuates cognitive impairment in senescence- accelerated mice. (2014)
  • Author(s): Takuya Sakurai, Tomohiro Ito, Koji Wakame, Kentaro Kitadate, Takashi Arai, Junetsu Ogasawara, Takako Kizaki, Shogo Sato, Yoshinaga Ishibashi, Tomonori Fujiwara, Kimio Akagawa, Hitoshi Ishida, Hideki Ohno
  • Journal Title: Natural Product Communications Volume: 9 Pages: 101-106
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 低酸素誘導性因子（HIF）と低酸素 (2014)
  • Author(s): 白土健、大野秀樹、木崎節子
  • Journal Title: THE LUNG perspectives Volume: 22 Pages: 96-96
• [Presentation] 肥満による脂肪組織のプロサイモシンα発現増加は運動によって減弱される (2017)
  • Author(s): 櫻井拓也，小笠原準悦，白土健，石橋義永，井澤鉄也，大石修司，芳賀脩光，大野秀樹，木崎節子
  • Organizer: 第87回日本衛生学会学術総会
  • Place of Presentation: 宮崎
  • Year and Date: 2017-03-26
• [Presentation] 習慣的運動によるマウス炎症性マクロファージのIL-1βとIL-18分泌亢進のメカニズム (2017)
  • Author(s): 白土健，櫻井拓也，小笠原準悦，石橋義永，大石修司，今泉和彦，大野秀樹，木崎節子
  • Organizer: 第87回日本衛生学会学術総会
  • Place of Presentation: 宮崎
  • Year and Date: 2017-03-26
• [Presentation] 酸化ストレスによる皮膚線維芽細胞の炎症性応答に対するETASの予防効果 (2017)
  • Author(s): 白土健，高成準，櫻井拓也，小笠原準悦，石橋義永，今泉和彦，大野秀樹，木崎節子
  • Organizer: 第87回日本衛生学会学術総会
  • Place of Presentation: 宮崎
  • Year and Date: 2017-03-26
• [Presentation] トレイルランレースが酸化ストレスにおよぼす影響 (2017)
  • Author(s): 髙濵矩子，西尾聖剛，杉山康司，村田真一，祝原豊，辻川比呂斗，白土健，櫻井拓也，木崎節子，大野秀樹，長澤純一
  • Organizer: 第169回日本体力医学会関東地方会
  • Place of Presentation: 東京
  • Year and Date: 2017-03-18
• [Presentation] マウス炎症性マクロファージのサイトカイン分泌能に及ぼす習慣的自発性運動の効果 (2016)
  • Author(s): 白土健，櫻井拓也，小笠原準悦，木本紀代子，大野秀樹，木﨑節子
  • Organizer: 第45回杏林医学会総会
  • Place of Presentation: 三鷹
  • Year and Date: 2016-11-19
• [Presentation] 酵素処理アスパラガス抽出物はH2O2による皮膚線維芽細胞株L929のp65核内移行を抑制することにより炎症性応答を軽減する (2016)
  • Author(s): 白土健，高成準，櫻井拓也，小笠原準悦，今泉和彦，大野秀樹，木崎節子
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-25
• [Presentation] マウスマクロファージのインフラマソーム依存性サイトカイン分泌は自発性走運動により増強される (2016)
  • Author(s): 白土健，櫻井拓也，小笠原準悦，大石修司，今泉和彦，大野秀樹，木崎節子
  • Organizer: 第71回日本体力医学会大会
  • Place of Presentation: 岩手
  • Year and Date: 2016-09-23
• [Presentation] 運動は肥満による脂肪組織のプロサイモシンα発現増加を減弱させる (2016)
  • Author(s): 櫻井拓也，小笠原準悦，白土健，石橋義永，井澤鉄也，大石修司，芳賀脩光，今泉和彦，大野秀樹，木崎節子
  • Organizer: 第71回日本体力医学会大会
  • Place of Presentation: 岩手
  • Year and Date: 2016-09-23
• [Presentation] Neuroprotective effect of ETAS on cellular disorder in HT22 hippocampal cells (2016)
  • Author(s): Ogasawara J, Takanari J, Shirato K, Sakurai T, Ishibashi Y, Ohno H, Kizaki T
  • Organizer: The 24th Annual Meeting of International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2016-07-09
  • Int'l Joint Research
• [Presentation] Suppressive effects of Enzyme-treated Asparagus Extract on hydrogen peroxide-stimulated inflammatory responses in murine L929 skin fibroblasts (2016)
  • Author(s): Shirato K, Takanari J, Sakurai T, Ogasawara J, Ishibashi Y, Imaizumi K, Ohno H, Kizaki T
  • Organizer: The 24th Annual Meeting of International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Sapporo,Japan
  • Year and Date: 2016-07-09
  • Int'l Joint Research
• [Presentation] 肥満による脂肪組織のリモデリングに対するプロサイシンαの役割 (2016)
  • Author(s): 櫻井拓也，小笠原準悦，白土健，石橋義永，井澤鉄也，大石修司，芳賀脩光，大野秀樹，木崎節子
  • Organizer: 第86回日本衛生学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2016-05-11
• [Presentation] 酸化ストレスによる皮膚線維芽細胞のMMP発現誘導に対するETASの効果 (2016)
  • Author(s): 白土健，高成準，小笠原準悦，櫻井拓也，石橋義永，今泉和彦，大野秀樹，木崎節子
  • Organizer: 第86回日本衛生学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2016-05-11
• [Presentation] PC12細胞の神経突起形成に及ぼすETAS(enzyme-treated asparagus extract)の効果 (2016)
  • Author(s): 小笠原準悦，高成準，白土健，櫻井拓也，大野秀樹，木崎節子
  • Organizer: 第86回日本衛生学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2016-05-11
• [Presentation] Acute swimming exercise can acceletate the browning of skeletal muscle in interscapular region (2016)
  • Author(s): Ogasawara J, Sakurai T, Shirato K, Ishibashi Y, , Ohno H, Kizaki T
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌
  • Year and Date: 2016-03-22
• [Presentation] マクロファージのO-結合型N-アセチルグルコサミン修飾調節機構に及ぼす運動トレーニングの影響 (2015)
  • Author(s): 白土 健、櫻井拓也、小笠原準悦、今泉和彦、谷口直之、大野秀樹、木崎節子
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] 加齢性慢性炎症性疾患に対する運動効果：マクロファージ時計遺伝子をプローブとして (2015)
  • Author(s): 白土 健、櫻井拓也、小笠原準悦、楊 國昌、大野秀樹、木﨑節子
  • Organizer: 第44回杏林医学会総会
  • Place of Presentation: 三鷹
  • Year and Date: 2015-11-21
• [Presentation] マウス腹腔マクロファージのO-結合型N-アセチルグルコサミン修飾に及ぼす自発性走運動の影響 (2015)
  • Author(s): 白土 健、櫻井拓也、小笠原準悦、石橋義永、今泉和彦、大野秀樹、木崎節子
  • Organizer: 第70回日本体力医学会大会
  • Place of Presentation: 和歌山
  • Year and Date: 2015-09-18
• [Presentation] 時計遺伝子の発現リズムに基づいた運動トレーニングが脂肪分解反応に及ぼす影響 (2015)
  • Author(s): 加藤久詞、田中剛貴、増田慎也、高倉久志、小笠原準悦、櫻井拓也、木崎節子、大野秀樹、井澤鉄也
  • Organizer: 第70回日本体力医学会大会
  • Place of Presentation: 和歌山
  • Year and Date: 2015-09-18
• [Presentation] The TGF-β-TIMP1 pathway, which inhibits glucose uptake in adipocytes, is attenuated by exercise training (2015)
  • Author(s): Sakurai T, Ogasawara J, Shirato K, Ishibashi Y, Ozawa T, Ohira Y, Imaizumi K, Ohno H, Kizaki T
  • Organizer: The 16th International Biochemistry of Exercise Conference (IBEC 2015)
  • Place of Presentation: Sao Paulo, Brazil
  • Year and Date: 2015-09-07
  • Int'l Joint Research
• [Presentation] Effect of acute swimming exercise on switching action of PRDM16 in skeletal muscles (2015)
  • Author(s): Ogasawara J, Izawa T, Sakurai T, Shirato K, Kato H, Ishibashi Y, Ohira Y, Ohno H, Kizaki T
  • Organizer: The 16th International Biochemistry of Exercise Conference (IBEC 2015)
  • Place of Presentation: Sao Paulo, Brazil
  • Year and Date: 2015-09-07
  • Int'l Joint Research
• [Presentation] Voluntary exercise reduces O-linked N-acetylglucosamine levels in murine macrophages (2015)
  • Author(s): Shirato K, Sakurai Y, Ogasawara J, Ishibashi Y, Kato H, Izawa T, Ohira Y, Imaizumi K, Ohno H, Kizaki T
  • Organizer: The 16th International Biochemistry of Exercise Conference (IBEC 2015)
  • Place of Presentation: Sao Paulo, Brazil
  • Year and Date: 2015-09-07
  • Int'l Joint Research
• [Presentation] ETASはPC12細胞の神経突起の形成を促進する (2015)
  • Author(s): 小笠原準悦、高成 準、白土 健、櫻井拓也、大野秀樹、木崎節子
  • Organizer: 第25回体力・栄養・免疫学会大会
  • Place of Presentation: 東京
  • Year and Date: 2015-08-22
• [Presentation] Enzyme-treated asparagus extract attenuates hydrogen peroxide-induced matrix metalloproteinase-9 expression in murine dermal fibroblast L929 (2015)
  • Author(s): Shirato K, Takanari J, Ogasawara J, Sakurai T, Ishibashi Y, Imaizymi K, Ohno H, Kizaki T
  • Organizer: The 23rd International Congress on Nutrition and Intergrative Medicine (ICNIM 2015)
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2015-07-25
  • Int'l Joint Research
• [Presentation] 富士登山に対する酸化ストレスセンサーの変動 (2015)
  • Author(s): 西尾聖剛、笹尾真美、白土 健、小笠原準悦、櫻井拓也、木﨑節子、長澤純一
  • Organizer: 第23回日本運動生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-25
• [Presentation] 運動トレーニングは脂肪組織のTGF-β-TIMP1経路を減弱させる (2015)
  • Author(s): 櫻井拓也、小笠原準悦、白土 健、石橋義永、井澤鉄也、大野秀樹、木崎節子
  • Organizer: 第164回日本体力医学会関東地方会
  • Place of Presentation: 横浜
  • Year and Date: 2015-07-11
• [Presentation] Enzyme-treated asparagus extract (ETAS) induced heat shock protein 70 expression and attenuates stress (2015)
  • Author(s): Ogasawara J, Shirato K, Sakurai T, Ohno H, Kizaki T
  • Organizer: The 12th Asian Congress of Nutrition (ACN 2015)
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2015-05-14
  • Int'l Joint Research / Invited
• [Presentation] ブライト脂肪細胞の形成を修飾する持久的走運動トレーニングの効果 (2015)
  • Author(s): 小笠原準悦、櫻井拓也、白土健、石橋義永、井澤鉄也、大石修司、芳賀脩光、大野秀樹、木崎節子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 脂肪細胞の糖取り込みを抑制するTGF-β-TIMP1経路は運動によって減弱される (2015)
  • Author(s): 櫻井拓也、小笠原準悦、白土健、石橋義永、井澤鉄也、大石修司、芳賀脩光、大野秀樹、木崎節子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 高グルコースによるマクロファージ炎症反応の亢進における時計遺伝子Rev-erbαの役割 (2015)
  • Author(s): 白土健、櫻井拓也、小笠原準悦、石橋義永、佐藤章悟、今泉和彦、大野秀樹、木崎節子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 3T3-L1細胞におけるメラトニン添加はミトコンドリア新生を促すか (2015)
  • Author(s): 加藤久詞、田中剛貴、柴原拓哉、増田慎也、小笠原準悦、櫻井拓也、木崎節子、大野秀樹、井澤鉄也
  • Organizer: 第29回日本体力医学会近畿地方会
  • Place of Presentation: 京都
  • Year and Date: 2015-01-24
• [Presentation] 運動トレーニングが脂肪組織の発生遺伝子と骨形成タンパク質に及ぼす影響 (2015)
  • Author(s): 柴原拓哉、加藤久詞、田中剛貴、増田慎也、小笠原準悦、櫻井拓也、木崎節子、大野秀樹、井澤鉄也
  • Organizer: 第29回日本体力医学会近畿地方会
  • Place of Presentation: 京都
  • Year and Date: 2015-01-24
• [Presentation] 運動トレーニングが脂肪組織のポジティブモデリングにおよぼす影響 (2015)
  • Author(s): 田中剛貴、加藤久詞、柴原拓哉、増田慎也、小笠原準悦、櫻井拓也、木崎節子、大野秀樹、井澤鉄也
  • Organizer: 第29回日本体力医学会近畿地方会
  • Place of Presentation: 京都
  • Year and Date: 2015-01-24
• [Presentation] 高グルコース培養によるマクロファージの時計遺伝子Rev-erbαの発現変化とその生理的役割 (2014)
  • Author(s): 白土健、櫻井拓也、小笠原準悦、木本紀代子、高橋和人、住谷由計、石田均、大野秀樹、木﨑節子
  • Organizer: 第43回杏林医学会総会
  • Place of Presentation: 三鷹
  • Year and Date: 2014-11-15
• [Presentation] マクロファージ時計遺伝子Rev-erbαの発現に及ぼす高血糖の影響 (2014)
  • Author(s): 白土健、櫻井拓也、小笠原準悦、佐藤章吾、今泉和彦、大野秀樹、木崎節子
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 脂肪細胞の分化及び脂肪滴形成に及ぼすメラトニンの影響 (2014)
  • Author(s): 田中剛貴、加藤久詞、柴原拓哉、高倉久志、増田慎也、稗田睦子、白土健、小笠原準悦、櫻井拓也、木﨑節子、大野秀樹、井澤鉄也
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 運動によって減少するTGF-β-TIMP1経路は脂肪細胞の糖取り込みに関与する (2014)
  • Author(s): 櫻井拓也、小笠原準悦、白土健、石橋義永、井澤鉄也、大野秀樹、木崎節子
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 走運動トレーニングはブライト脂肪細胞の形成を促進するか (2014)
  • Author(s): 小笠原準悦、櫻井拓也、白土健、長澤純一、井澤鉄也、大野秀樹、木崎節子
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 時計遺伝子の発現リズムに合わせたイソプロテレノール刺激が脂肪分解反応に及ぼす影響 (2014)
  • Author(s): 加藤久詞、柴原拓哉、田中剛貴、増田慎也、高倉久志、稗田睦子、白土健、小笠原準悦、櫻井拓也、木﨑節子、大野秀樹、井澤鉄也
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 運動トレーニングが脂肪組織のホメオテイック遺伝子と骨形成タンンパク質に及ぼす影響 (2014)
  • Author(s): 柴原拓哉、加藤久詞、田中剛貴、増田慎也、高倉久志、稗田睦子、白土健、小笠原準悦、櫻井拓也、木﨑節子、大野秀樹、井澤鉄也
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] アルツハイマー病発症リスクを軽減する運動効果 (2014)
  • Author(s): 櫻井拓也、小笠原準悦、白土健、藤原智徳、赤川公朗、大野秀樹、木崎節子
  • Organizer: 第７回脳・内分泌系から運動の意義を考える会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-18
  • Invited
• [Presentation] ETAS, an enzyme-treated asparagus extract, has the ability to enhance both the differentiation and the neurite outgrowth in PC12 cells (2014)
  • Author(s): Junetsu Ogsawara, Jun Takanari, Takuya Sakurai, Ken Shirato, Yoshinaga Ishibashi, Junichi Nagasawa, Tetsuya Izawa, Hideki Ohno, Takako Kizaki
  • Organizer: The 22nd ICNIM
  • Place of Presentation: Sapporo
  • Year and Date: 2014-07-26 – 2014-07-27
• [Presentation] マクロファージ炎症性応答に及ぼすグルコサミンの効果とメカニズム (2014)
  • Author(s): 白土健、木﨑節子、櫻井拓也、小笠原準悦、大野秀樹、今泉和彦
  • Organizer: 第161回日本体力医学会関東地方会
  • Place of Presentation: 坂戸
  • Year and Date: 2014-07-26
• [Presentation] リポ多糖刺激に伴うマクロファージ炎症性応答に及ぼすグルコサミンの抑制作用とメカニズム (2014)
  • Author(s): 白土健、木﨑節子、大野秀樹、今泉和彦
  • Organizer: 第68回日本栄養・食糧学会大会
  • Place of Presentation: 札幌
  • Year and Date: 2014-05-31 – 2014-06-01
• [Presentation] アスパラガス茎熱水抽出物（ETAS）はアミロイドβによる細胞障害性を抑制する (2014)
  • Author(s): 小笠原準悦、伊藤知洋、高成準、三浦健人、櫻井拓也、井澤鉄也、中野法彦、長澤純一、木崎節子、大野秀樹
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] 運動は肥満による脂肪組織の線維化関連因子の発現増加を減弱させる (2014)
  • Author(s): 櫻井拓也、小笠原準悦、木崎節子、白土健、石橋義永、斎藤大蔵、大石修司、芳賀脩光、鈴木健二、大野秀樹
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山
  • Year and Date: 2014-05-25 – 2014-05-27
• [Book] 山歩きと健康管理の秘訣 (2015)
  • Author(s): 大野秀樹、野口いづみ、木崎節子
  • Total Pages: 242
  • Publisher: 朝日印刷工業
• [Book] 活性酸素の本当の姿 (2014)
  • Author(s): 大野秀樹、木崎節子
  • Total Pages: 175
  • Publisher: ナップ
• [Book] 第22回統合医療機能性食品国際会議議事録 (2014)
  • Author(s): 小笠原準悦、高成準、櫻井拓也、白土健、石橋義永、長澤純一、井澤鉄也、大野秀樹、 木崎節子
  • Total Pages: 174
  • Publisher: AHCC研究会