Immunostimulatory endogenous and exogenous compounds: Synthesis, functional analysis and development of immunomodulatory designed compounds
Project/Area Number |
26282211
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Biomolecular chemistry
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Research Institution | Keio University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
井貫 晋輔 慶應義塾大学, 理工学部, 助教 (70736272)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
|
Keywords | 複合脂質 / 複合糖質 / 免疫調節 / 有機合成 / 自然免疫 / 獲得免疫 / 国際研究者交流 / アメリカ:イタリア:イギリス:ドイツ |
Outline of Final Research Achievements |
In this study, we first aimed to develop the chemical synthesis of exogenous and endogenous molecules responsible for cooperation between innate immunity and adaptive immunity, and also to analyze the function with using the synthesized compounds. We also aimed to design and produce new-types of molecules that can modulate the immune system. Namely, we first synthesized natural immunomodulatory compounds (especially glyco-conjugates and lipid-conjugates), and then analyzed the structure-activity relationships in the immunomodulatory activities and also the interaction with the recognition protein. Based on these results, the immunomodulatory functions of the natural and designed molecules were successfully shown.
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Report
(4 results)
Research Products
(139 results)
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[Journal Article] Discovery of a Novel Scaffold as an Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Based on the Pyrrolopiperazinone Alkaloid, Longamide B.2016
Author(s)
Shiokawa, Z., Kashiwabara, E., Yoshidome, D., Fukase, K., Inuki, S., Fujimoto, Y.
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Journal Title
ChemMedChem.
Volume: 11
Pages: 2682-2689
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Isolated Polar Amino Acid Residues Modulate Lipid Binding in the Large Hydrophobic Cavity of CD1d.2016
Author(s)
Inuki, S., Aiba, T., Hirata, N., Ichihara, O., Yoshidome, D., Kita, S., Maenaka, K., Fukase, K., Fujimoto, Y.
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Journal Title
ACS Chem. Biol.
Volume: 11
Pages: 3132-3139
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Characterization of a novel D-glycero-D-talo-oct-2-ulosonic acid-substituted lipid a moiety in the lipopolysaccharide produced by the acetic acid bacterium Acetobacter pasteurianus NBRC 3283.2016
Author(s)
Hashimoto, M., Ozono, M., Furuyashiki, M., Baba, R., Hashiguchi, S., Suda, Y., Fukase, K., Fujimoto, Y.
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Journal Title
J. Biol. Chem.
Volume: 291
Pages: 21184-21194
DOI
Related Report
Peer Reviewed
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[Journal Article] Regioselective Phosphorylation of myo-Inositol with BINOL-Derived Phosphoramidites, and Its Application for Protozoan Lysophosphatidylinositol2016
Author(s)
Aiba, T., Sato, M., Umegaki, D., Iwasaki, T., Kambe, N., Fukase, K., Fujimoto, Y.
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Journal Title
Org. Biomol. Chem.
Volume: 14
Pages: 6672-6675
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Synthesis of characteristic Mycobacterium peptidoglycan (PGN) fragments utilizing with chemoenzymatic preparation of meso-diaminopimelic acid (DAP), and their modulation of innate immune responses2016
Author(s)
Wang, Q., Matsuo, Y., Pradipta, A. R., Inohara, N., Fujimoto, Y., Fukase, K.
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Journal Title
Org. Biomol. Chem.
Volume: 14
Pages: 1013-1023
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Efficient synthesis of (-)-hanishin, (-)-longamide B, and (-)-longamide B Methyl Ester via piperazinone formation with 1,2-cyclic sulfamidates2016
Author(s)
Shiokawa, Z., Inuki, S., Fukase, K., Fujimoto, Y.
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Journal Title
Synlett
Volume: 27
Pages: 616-620
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Synthesis and Biological Activity of Inositol Phospholipid as NKT Cell Modulator2015
Author(s)
Aiba, T., Suehara, S., Bernin, H., Lotter, H., Inuki, S., Fukase, K., Fujimoto, Y.
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Journal Title
Glycoconjugate J.
Volume: 32
Pages: 301
DOI
Related Report
Int'l Joint Research
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[Presentation] Bacterial cell surface glyco- and lipid-peptide molecules; Synthesis and their immunological functions2016
Author(s)
Youhei Arai, Ippei Ohta, Kohei Yokoyama, Qi Feng, Qianqian Wang, NIng Wang, Kazumi Tomizawa, Inuki Shinsuke, Kazuya Kabayama, Koichi Fukase, Yukari Fujimoto
Organizer
The 16th Akabori Conference
Place of Presentation
六甲山ホテル(兵庫県・神戸市)
Year and Date
2016-05-22 – 2016-05-26
Related Report
Int'l Joint Research / Invited
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[Presentation] 生体防御の制御分子を探る2016
Author(s)
藤本ゆかり
Organizer
生命化学研究会 ポストコンファレンス
Place of Presentation
雲仙観光ホテル (長崎県雲仙市)
Year and Date
2016-01-09 – 2016-01-10
Related Report
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[Presentation] Synthetic studies on funiculosin2015
Author(s)
Keisuke Sato, Shinsuke Inuki, Yukari Fujimoto
Organizer
The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
Place of Presentation
Honolulu (USA)
Year and Date
2015-12-15 – 2015-12-20
Related Report
Int'l Joint Research
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[Presentation] Characterization of LPS/lipid A from Alcaligenes sp.2015
Author(s)
Keisuke Mizote, Atsushi Shimoyama, Naoko Shibata, Flanviana D. Lorenzo, Yukari Fujimoto, Antonio Molinaro, Jun Kunisawa, Hiroshi Kiyono, Koichi Fukase
Organizer
The 7th Asian Community of Glycoscience and Glycotechnology (7th ACGG)
Place of Presentation
ホテル松島大観荘 (宮城県・松島町)
Year and Date
2015-11-12 – 2015-11-15
Related Report
Int'l Joint Research
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[Presentation] シクロプロパン含有脂質の合成研究2015
Author(s)
石橋俊一、井貫晋輔、藤本ゆかり
Organizer
第32回有機合成化学セミナー
Place of Presentation
ニューウェルシティ湯河原 (静岡県熱海市)
Year and Date
2015-09-15 – 2015-09-17
Related Report
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[Presentation] Synthesis of Inositol Phospholipids as an NKT Cell Modulator2014
Author(s)
Toshihiko Aiba, Masaki Sato, Daichi Umegaki, Shou Nakagawa, Shinji Tanaka, Masato Kitamura, Shinsuke Inuki, Koichi Fukase, Yukari Fujimoto
Organizer
Joint Meeting of the Society for Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR) (SFG-JSCR 2014)
Place of Presentation
Honolulu(USA)
Year and Date
2014-11-16 – 2014-11-19
Related Report
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[Presentation] Modulation of Immune Responses via TLR4/MD-2 with Synthetic Isoprenoids2014
Author(s)
Keisuke Mizote, Akinori Saeki, Hiroe Honda, Naoki Okamoto, Takahito Kimura, Yoshinori Nagai, Kiyoshi Takatsu, Yukari Fujimoto, Koichi Fukase
Organizer
Joint Meeting of the Society for Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR) (SFG-JSCR 2014)
Place of Presentation
Honolulu(USA)
Year and Date
2014-11-16 – 2014-11-19
Related Report
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