Development of selective modulators for synaptic receptors in the central nervous system
| Project/Area Number |
26282216
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Yokohama City University |
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Principal Investigator |
Oikawa Masato 横浜市立大学, 生命ナノシステム科学研究科, 教授 (70273571)
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| Co-Investigator(Kenkyū-buntansha) |
酒井 隆一 北海道大学, 水産科学研究科(研究院), 教授 (20265721)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | AMPA型受容体 / 多様性指向型有機合成 / モジュレーター / 神経科学 / 作用標的 |
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| Outline of Final Research Achievements |
Ionotropic glutamate receptors (iGluR) play a central role in the excitatory neurotransmission in the central nervous system. In the present study, we have studied synthesis and evaluation of the inhibitory nature of the analogs of our original ligand IKM-159, to develop novel compound that would be used for therapeutic treatment of neuronal disorders.
We first developed synthetic route for diverse analogs of IKM-159, and we identified IKM-154 acts as an excitatory agent in vivo. Like the inhibitory IKM-159, the excitatory IKM-154 is supposed to be also a ligand for AMPA receptor which is one of the subtype protein of iGluR. With IKM-154 and IKM-159 in hand, it is now possible to explore the detailed biological function and the macinery of AMPA receptor, by selective activation and inactivation.
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Report
(4 results)
Research Products
(58 results)
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[Presentation] 神経科学に貢献する有機合成化学2016
Author(s)
○及川雅人 千葉まなみ 板垣ひより 石川裕一
Organizer
第60回日本薬学会関東支部大会
Place of Presentation
東京大学（東京都文京区）
Year and Date
2016-09-17
Related Report
Invited
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