Creation of next-generation magnetic resonance brain function measurement technology to accelerate the brain research

• Project/Area Number: 26282223
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Brain biometrics
• Research Institution: National Institute of Information and Communications Technology
• Principal Investigator: Liu Guoxiang 国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳機能解析研究室, 研究マネージャー (40358817)
• Co-Investigator(Kenkyū-buntansha): 吉岡 芳親 大阪大学, 先導的学際研究機構, 教授 (00174897) ; 西本 伸志 国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳情報通信融合研究室, 主任研究員 (00713455) ; 黄田 育宏 国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳機能解析研究室, 主任研究員 (60374716) ; 上口 貴志 国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳機能解析研究室, 主任研究員 (80403070)
• Project Period (FY): 2014-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000); Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
• Keywords: fMRI / 非侵襲的脳活動計測 / 脳機能

Outline of Final Research Achievements

1. We developed a new MRI measurement method for performing ultra-high spatial resolution brain function measurements (fMRI). The developed method improves distortion and signal loss in functional imaging at ultra-high field 7T MRI. The proposed method improves the signal to noise ratio (SNR) allowing us to increase the spatial resolution (~ 0.5 mm isotropic).
2. We developed a new temperature monitoring technique to safely use the multi-channel RF parallel transmission (pTx) technology at 7T MRI. Temperature monitoring is essential for ensuring the safety limit at 7T MRI while achieving local ultra-high spatial resolution fMRI. The proposed technique can detect a temperature change of 0.05 degree or less.
3. We developed a new technique for whole brain recording of human brain activity under various cognitive task execution with fMRI and predicted brain activity under conditions including new cognitive task and decoding technology.

Academic Significance and Societal Importance of the Research Achievements

現在の一般的な脳機能画像(fMRI)の解像度は3mm程度、計測感度のきわめて高い超高磁場MRIを用いても1～2mmが限界である。一方で、神経活動の機能単位である皮質のカラム構造はおおむね0.5～0.8mm程度の大きさ、また皮質の各層は薄いところで0.2mm程度の厚みをもつため、現在の計測技術ではカラムをほぼ解像できないが、本研究では独自の安全化技術を開発し、そのうえでソフト・ハード両面から計測技術を飛躍的に高精度化できた。この成果は脳計測研究の未来像を大きく変えるものである。

Research Products

• [Journal Article] Brain tissue segmentation based on MP2RAGE multi-contrast images in 7 T MRI. (2019)
  • Author(s): Choi US, Kawaguchi H, Matsuoka Y, Kober T, Kida I
  • Journal Title: PLOS ONE Volume: 14 Pages: 0210803-0210803
  • DOI: 10.1371/journal.pone.0210803
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment (2018)
  • Author(s): Ono E,Murota H,Mori Y,Yoshioka Y,Nomura Y,Munetsugu T,Yokozeki H,Katayama I
  • Journal Title: PLOS ONE Volume: 13 Pages: 0195960-0195960
  • DOI: 10.1371/journal.pone.0195960
  • Peer Reviewed / Open Access
• [Journal Article] Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder (2018)
  • Author(s): Yamashita Kazuya、Kinoshita Makoto、Miyamoto Katsuichi、Namba Akiko、Shimizu Mikito、Koda Toru、Sugimoto Tomoyuki、Mori Yuki、Yoshioka Yoshichika、Nakatsuji Yuji、Kumanogoh Atsushi、Kusunoki Susumu、Mochizuki Hideki、Okuno Tatsusada
  • Journal Title: J Neuroinflammation Volume: 15 Pages: 125-125
  • DOI: 10.1186/s12974-018-1162-0
  • Peer Reviewed / Open Access
• [Journal Article] Inflammatory projections after focal brain injury trigger neuronal network disruption: An 18F-DPA714 PET study in mice (2018)
  • Author(s): Hosomi S, Watabe T, Mori Y, Koyama Y, Adachi S, Hoshi N, Ohnishi M, Ogura H, Yoshioka Y, Hatazawa J, Yamashita T, Shimazu T.
  • Journal Title: Clinical Volume: 20 Pages: 946-954
  • DOI: 10.1016/j.nicl.2018.09.031
  • NAID: 120006543327
  • Peer Reviewed / Open Access
• [Journal Article] Mapping stimulus feature selectivity in macaque V1 by two-photon Ca 2+ imaging: Encoding-model analysis of fluorescence responses to natural movies (2018)
  • Author(s): Ikezoe Koji、Amano Mahya、Nishimoto Shinji、Fujita Ichiro
  • Journal Title: NeuroImage （印刷中） Volume: 印刷中 Pages: 1-12
  • DOI: 10.1016/j.neuroimage.2018.01.009
  • Peer Reviewed / Open Access
• [Journal Article] Decoding naturalistic experiences from human brain activity via distributed representations of words. (2018)
  • Author(s): Nishida S, Nishimoto S
  • Journal Title: NeuroImage （印刷中） Volume: － Pages: 232-242
  • DOI: 10.1016/j.neuroimage.2017.08.017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Preoperative brain temperature imaging on proton magnetic resonance spectroscopy predicts hemispheric ischemia during carotid endarterectomy for unilateral carotid stenosis with inadequate collateral blood flow (2018)
  • Author(s): Tsutsui Shouta、Nanba Takamasa、Yoshioka Yoshichika、Sasaki Makoto、Fujiwara Shunrou、Kobayashi Masakazu、Yoshida Kenji、Miyoshi Kenya、Sato Shinpei、Ogasawara Kuniaki
  • Journal Title: Neurol Res Volume: 印刷中 Pages: 617-623
  • DOI: 10.1080/01616412.2018.1457130
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] BMP-2/7 heterodimer strongly induces bone regeneration in the absence of increased soft tissue inflammation (2018)
  • Author(s): Kaito Takashi、Morimoto Tokimitsu、Mori Yuki、Kanayama Sadaaki、Makino Takahiro、Takenaka Shota、Sakai Yusuke、Otsuru Satoru、Yoshioka Yoshichika、Yoshikawa Hideki
  • Journal Title: The Spine Journal Volume: 18 Pages: 139-146
  • DOI: 10.1016/j.spinee.2017.07.171
  • Peer Reviewed / Open Access
• [Journal Article] Apparent brain temperature imaging with multi-voxel proton magnetic resonance spectroscopy compared with cerebral blood flow and metabolism imaging on positron emission tomography in patients with unilateral chronic major cerebral artery steno-occlusive disease (2017)
  • Author(s): Nanba T, Nishimoto H, Yoshioka Y, Murakami T, Sasaki M, Uwano I, Fujiwara S, Terasaki K, Ogasawara K
  • Journal Title: Neuroradiology Volume: 59 Pages: 923-935
  • DOI: 10.1007/s00234-017-1890-3
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal observations of progressive cardiac dysfunction in a cardiomyopathic animal model by self-gated cine imaging based on 11.7-T magnetic resonance imaging (2017)
  • Author(s): Saito Shigeyoshi、Tanoue Minori、Masuda Kasumi、Mori Yuki、Nakatani Satoshi、Yoshioka Yoshichika、Murase Kenya
  • Journal Title: Scientific Reports Volume: 7 Pages: 9106-9106
  • DOI: 10.1038/s41598-017-09755-4
  • Peer Reviewed / Open Access
• [Journal Article] Eye movement-invariant representations in the human visual system (2017)
  • Author(s): Nishimoto S, Huth AG, Bilenko NY, Gallant JL
  • Journal Title: Journal of Vision Volume: 17:11 Pages: 11-11
  • DOI: 10.1167/17.1.11
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lining up brains via a common representational space (2016)
  • Author(s): Nishimoto S, Nishida S
  • Journal Title: Trends in Cognitive Sciences. Volume: 20(8):565-7 Pages: 565-567
  • DOI: 10.1016/j.tics.2016.06.001
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Decoding the semantic content of natural movies from human brain activity (2016)
  • Author(s): Huth G A, Lee T, Nishimoto S, Bilenko Y N, Vu T A, Gallant L J
  • Journal Title: Front. Syst. Neurosci. Volume: 10: 81
  • DOI: 10.3389/fnsys.2016.00081
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Functional Subdomains within Scene-Selective Cortex: Parahippocampal Place Area, Retrosplenial Complex, and Occipital Place Area (2016)
  • Author(s): Cukur T, Huth G A, Nishimoto S, Gallant L J
  • Journal Title: The Journal of Neuroscience Volume: 36 Pages: 10257-10273
  • DOI: 10.1523/jneurosci.4033-14.2016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of diffusion-weighted imaging in human brain using readout-segmented EPI and PROPELLER turbo spin echo with single-shot EPI at 7 T MRI (2016)
  • Author(s): Kida I, Ueguchi T, Matsuoka Y, Zhou K, Stemmer A, Porter D
  • Journal Title: Investigative Radiology Volume: 未定 Pages: 435-439
  • DOI: 10.1097/rli.0000000000000248
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Brain temperature measured by 1H-magnetic resonance spectroscopy in acute and subacute carbon monoxide poisoning patients (2016)
  • Author(s): Fujiwara S, Yoshioka Y, Matsuda T, Nishimoto H, Murakami T, Ogawa A, Ogasawara K, Beppu T.
  • Journal Title: Neuroradiology Volume: 58 Pages: 27-32
  • Peer Reviewed
• [Journal Article] Mono- and dinuclear gadolinium(III) complexes of tris(4-carboxy-3-benzyl-3-azabutyl) amine: Synthesis and relaxation properties (2016)
  • Author(s): Yoshimasa Makita, Masashi Inoue, Natsuki Katayama, Hsien-Han Lee, Taro Abe, Chizuko Inui-Yamamoto, Yuki Mori, Yoshichika Yoshioka, Yoshitomo Honda, Shoko Gamoh, Kimishige Shimizutani, Shin-ichi Fujiwara, Akiya Ogawa
  • Journal Title: Polyhedron Volume: 107 Pages: 148-152
  • DOI: 10.1016/j.poly.2015.12.064
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Shearing Distortion Correction for EPI at 7T MRI (2015)
  • Author(s): Liu G, Ueguchi T. Kuribayashi H.
  • Journal Title: Journal of Advances in Information Technology Volume: 6 Pages: 151-154
  • DOI: 10.12720/jait.6.3.151-154
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Discriminative Structured Feature Engineering for Macroscale Brain Connectomes (2015)
  • Author(s): Pu J, Wang J, Yu W, Shen Z, Lv Q, Zeljic K, Zhang C, Sun B, Liu G, Wang Z
  • Journal Title: IEEE Transactions on Medical Imaging Volume: 34 Pages: 2333-2342
  • DOI: 10.1109/tmi.2015.2431294
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Phenylboronic Acid-based ¹⁹F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change (2015)
  • Author(s): Hiroshi NONAKA, Qi AN, Fuminori SUGIHARA, Tomohiro DOURA, Akira TSUCHIYA, Yoshichika YOSHIOKA, and Shinsuke SANDO
  • Journal Title: Anal. Sci. Volume: 31 Issue: 4 Pages: 331-335
  • DOI: 10.2116/analsci.31.331
  • NAID: 130005061536
  • ISSN: 0910-6340, 1348-2246
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A novel peroxisome proliferator-activated receptor (PPAR) α agonist and PPAR γ antagonist, Z-551, ameliorates high-fat diet-induced obesity and metabolic disorders in mice. (2015)
  • Author(s): Shiomi Y, Yamauchi T, Iwabu M, Okada-Iwabu M, Nakayama R, Orikawa Y, Yoshioka Y, Tanaka K, Ueki K, Kadowaki T
  • Journal Title: J. Biol. Chem. Volume: 290 Pages: 14567-14581
  • DOI: 10.1074/jbc.m114.622191
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Factors affecting the chemical exchange saturation transfer of Creatine as assessed by 11.7 T MRI (2015)
  • Author(s): Saito S, Mori Y, Tanki N, Yoshioka Y, Murase K
  • Journal Title: Radiol Phys Technol Volume: 8 Pages: 146-152
  • Peer Reviewed
• [Journal Article] Brain and arterial abnormalities following prenatal X-ray irradiation in mice assessed by magnetic resonance imaging and angiography (2015)
  • Author(s): Saito S, Sawada K, Mori Y, Yoshioka Y, Murase K
  • Journal Title: Congenit Anom Volume: 55 Pages: 103-106
  • Peer Reviewed
• [Journal Article] Mesoporous Silica Nanoparticles for 19F Magnetic Resonance Imaging, Fluorescence Imaging, and Drug Delivery (2015)
  • Author(s): Nakamura T, Sugihara F, Matsushita H, Yoshioka Y, Mizukami S, Kikuchi K
  • Journal Title: Chem Sci Volume: 6 Pages: 1986-1990
  • Peer Reviewed
• [Journal Article] モデリングアプローチを用いた自然視知覚下脳活動の定量理解 (2014)
  • Author(s): 西本伸志
  • Journal Title: Clinical Neuroscience Volume: 32 Pages: 1192-1193
• [Journal Article] Early monocular defocus disrupts the normal development of receptive-field structure in v2 neurons of macaque monkeys. (2014)
  • Author(s): Tao X, Zhang B, Shen G, Wensveen J, Smith EL 3rd, Nishimoto S, Ohzawa I, Chino YM.
  • Journal Title: The Journal of Neuroscience Volume: 34 Pages: 13840-13854
  • DOI: 10.1523/jneurosci.1992-14.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] In vivo magnetic resonance imaging at 11.7 Tesla visualized the effects of neonatal transection of infraorbital nerve upon primary and secondary trigeminal pathways in rats (2014)
  • Author(s): Ooi Y, Inui-Yamamoto C, Suzuki T, Nakadate H, Nagase Y, Seiyama A, Yoshioka Y, Seki J
  • Journal Title: Brain Res Volume: 1579 Pages: 84-92
  • Peer Reviewed
• [Journal Article] Diffusion Tensor Imaging of Brain Abnormalities Induced by Prenatal Exposure to Radiation in Rodents (2014)
  • Author(s): Saito S, Sawada K, Hirose M, Mori Y, Yoshioka Y, Murase K
  • Journal Title: PLoS ONE Volume: 9(9)
  • Peer Reviewed
• [Journal Article] A new mouse allele of glutamate receptor delta 2 with cerebellar atrophy and progressive ataxia (2014)
  • Author(s): Miyoshi Y, Yoshioka Y, Suzuki K, Miyazaki T, Koura M, Saigoh K, Kajimura N, Monobe Y, Kusunoki S, Matsuda J, Watanabe M, Hayasaka N
  • Journal Title: PLoS ONE Volume: 9(9)
  • Peer Reviewed
• [Journal Article] A short-wavelength infrared emiting multimodal probe for non-invasive visualization of phagocyte cell migration in living mice (2014)
  • Author(s): Tsukasaki Y, Komatsuzaki A, Mori Y, Ma Q, Yoshioka Y, Jin T
  • Journal Title: Chem Comm Volume: 50 Pages: 14356-14359
  • Peer Reviewed
• [Journal Article] From cartoon to real time MRI: in vivo monitoring of phagocyte migration in mouse brain (2014)
  • Author(s): Mori Y, Chen T, Fujisawa T, Kobashi S, Ohno K, Yoshida S, Tago Y, Komai Y, Hata Y, Yoshioka Y
  • Journal Title: Scientific Reports Volume: 4
  • Peer Reviewed
• [Presentation] EPI based MR thermometry and real-time monitoring for parallel RF transmission at 7T (2019)
  • Author(s): Liu G, Shah A, Ueguchi T
  • Organizer: Annual Meeting ISMRM2019
  • Int'l Joint Research
• [Presentation] T1w MPRAGE transformation based on distortion-matched anatomy for high-resolution fMR (2019)
  • Author(s): Shah A, Ueguchi T,Liu G
  • Organizer: Annual Meeting ISMRM2019
  • Int'l Joint Research
• [Presentation] EPI based distortion- and resolution-matched T1-Like anatomy for submillimeter-resolution fMRI at 7T (2019)
  • Author(s): Shah A,Liu G, Ueguchi T
  • Organizer: OHBM2019
  • Int'l Joint Research
• [Presentation] Investigating Depth-Dependent Activity in Submillimeter-Resolution fMRI at 7T with Native-Space Transformed T1w MPRAGE Anatomy (2019)
  • Author(s): Shah A,Liu G, Ueguchi T
  • Organizer: ICMRI 2019
  • Int'l Joint Research
• [Presentation] Prediction of outcome in bilateral common carotid artery occlusion rats by intravoxel incoherent motion analysis at 11.7 Tesla (2019)
  • Author(s): Fujiwara S, Mori Y, de la Mora DM, Ogasawara K, Yoshioka Y.
  • Organizer: European Stroke Conference 2018
  • Int'l Joint Research
• [Presentation] Assessment of cerebral ischemic changes in rats using different diffusion-weighted signal models for intravoxel incoherent motion analysis at 11.7T (2019)
  • Author(s): Fujiwara S, Mori Y, de la Mora DM, Yoshida K, Ogasawara K, Yoshioka Y.
  • Organizer: The 32nd International Congress and Exhibition on Computer Assisted Radiology and Surgery (CARS2018)
  • Int'l Joint Research
• [Presentation] A brain-mediated computational model to estimate perceptual experiences evoked by arbitrary naturalistic visual scenes (2019)
  • Author(s): Satoshi Nishida, Shinji Nishimoto
  • Organizer: Vision Science Society 2019
  • Int'l Joint Research
• [Presentation] Modeling human visual responses with a U-shaped deep neural network for motion flow-field estimation (2019)
  • Author(s): Atsushi Wada, Satoshi Nishida, Hiroshi Ando, Shinji Nishimoto
  • Organizer: 2018 Conference on Cognitive Computational Neuroscience
  • Int'l Joint Research
• [Presentation] Block-interleaved Segmentated EPI for voxel-wise high-resolution fMRI studies at 7T (2018)
  • Author(s): Liu G, Shah A, Ueguchi T
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB 2018
  • Int'l Joint Research
• [Presentation] Optimized parameters for MP2RAGE images on 7-T MRI (2018)
  • Author(s): Choi US, Kawaguchi H, Matsuoka Y, Kober T, Kida I
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB 2018
  • Int'l Joint Research
• [Presentation] Transforming T1w anatomy into functional space using full brain IR-EPI for high-resolution fMRI at 7T (2018)
  • Author(s): Shah A, Ueguchi T,Liu G
  • Organizer: OHBM2018
  • Int'l Joint Research
• [Presentation] Fast brain tissue segmentation based on MP2RAGE at 7T MRI (2018)
  • Author(s): Choi US, Kawaguchi H, Matsuoka Y, Kober T, Kida I
  • Organizer: OHBM2018
  • Int'l Joint Research
• [Presentation] Segmented EPI reconstruction based on physiological information for fMRI studies (2017)
  • Author(s): Liu G, Ueguchi T
  • Organizer: The 25th Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Int'l Joint Research
• [Presentation] Relation Between Brain Temperature and Cerebral Perfusion and Metabolism in Human Brain (2017)
  • Author(s): Fujiwara S, Beppu T, Ogasawara K, Yoshioka Y.
  • Organizer: The 25th Annual Meeting of International Society for Magnetic Resonance in Medicine, Honolulu, HI, USA, 2017/4/22-27
  • Int'l Joint Research
• [Presentation] Feasibility of 1H-MRS brain temperature map to detect hemodynamic abnormality in patients with unilateral chronic major cerebral artery steno-occlusive disease (2017)
  • Author(s): NanbaT, Ogasawara K, Nishimoto H, Ishigaki D, Yoshioka Y, Murakami T, Sasaki M, Kobayashi M, Yoshida K, Uwano I, Fujiwara S, Terasaki K, Ogawa A
  • Organizer: The 25th Annual Meeting of International Society for Magnetic Resonance in Medicine, Honolulu, HI, USA
  • Int'l Joint Research
• [Presentation] Quantitative four-dimensional motility tracking of individual immune cells in living mouse brain (2017)
  • Author(s): Mori Y, de la Mora DM, Tashita A, Kobashi S, Kida I, Hata Y, Yoshioka Y
  • Organizer: The 25th Annual Meeting of International Society for Magnetic Resonance in Medicine, Honolulu, HI, USA
  • Int'l Joint Research
• [Presentation] Development of small-sized dielectric pads for improved RF field homogeneity in MR imaging of the brain at 7 T (2017)
  • Author(s): Ueguchi T, Kida I, Yamada S, Liu G
  • Organizer: The 113th Scientific Meeting of the Japan Society of Medical Physics
  • Int'l Joint Research
• [Presentation] Umami ingestion modulates functional connectivity in the human brain: A resting-state fMRI study (2017)
  • Author(s): Kida I, Nawa NE, Matsuoka Y, Leibnitz K
  • Organizer: OHBM2017
  • Int'l Joint Research
• [Presentation] Linking neuroscience and machine learning via latent features of natural stimuli (2017)
  • Author(s): Nishimoto S
  • Organizer: Gatsby-Kakenhi Joint Workshop on AI and Neuroscience
• [Presentation] Quantitative comparison of original versus accelerated NODDI maps of the brain (2016)
  • Author(s): Ueguchi T, Kida I, Kobayashi Y, Okada K, Kadono Y, Yamada S, Liu G
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 大宮ソニックシティ，埼玉県さいたま市
  • Year and Date: 2016-09-09
• [Presentation] Motion correction in k-space for pixel-wise fMRI studies (2016)
  • Author(s): Liu G, Ueguchi T.
  • Organizer: The 22nd Annual meeting of Human Brain Mapping
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2016-06-27
  • Int'l Joint Research
• [Presentation] Motion correction in k-space for pixel-wise fMRI studies (2016)
  • Author(s): Liu G, Ueguchi T
  • Organizer: OHBM2016
  • Place of Presentation: Plaexpo Exhibition and Conress Centre Geneva, Switzerland
  • Year and Date: 2016-06-26
  • Int'l Joint Research
• [Presentation] Neuronal activities concerning the conditioned taste aversion with immune reactions (2016)
  • Author(s): Inui-Yamamoto C, Sugihara F, Chen T, Wakisaka S, Yoshioka Y.
  • Organizer: The 17th International Symposium on Olfaction and Taste (ISOT2016)
  • Place of Presentation: PACIFICO Yokohama, 神奈川県横浜市
  • Year and Date: 2016-06-05
  • Int'l Joint Research
• [Presentation] Potential source of MRI signal change during transcranial direct current stimulation (2016)
  • Author(s): Liu G, Ueguchi T, Kida I, Odaka K, Kobayashi Y.
  • Organizer: The 24th Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Singapore
  • Year and Date: 2016-05-10
  • Int'l Joint Research
• [Presentation] Potential Source of MRI Signal Change During Transcranial Direct Current Stimulation (2016)
  • Author(s): Liu G, Ueguchi T. Kida I. Okada K. Kobayashi Y.
  • Organizer: The 24rd Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Suntec Singapore Convention centre. Singapore City. Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] etection of neuronal activities concerning the retrieval of the conditioned taste aversion with lipopolysaccharide (2016)
  • Author(s): Inui-Yamamoto C, Sugihara F, Mori Y, Chen T, Cheng Z, Yoshioka Y.
  • Organizer: The 24rd Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Suntec Singapore Convention centre. Singapore City. Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Ultra-high-field MR imaging of the human brain: spatially-inhomogeneous magnetization transfer effects in multislice acquisition (2016)
  • Author(s): Ueguchi T, Kida I, Liu G
  • Organizer: The 111th Scientific Meeting of the Japan Society of Medical Physics (JSMP)
  • Place of Presentation: パシフィコ横浜，神奈川県横浜市
  • Year and Date: 2016-04-14
  • Int'l Joint Research
• [Presentation] Modeling and decoding of natural visual experiences (2016)
  • Author(s): Nishimoto S.
  • Organizer: Formal DCC lecture Donders Institute
  • Place of Presentation: Nijmegen, Netherlands
  • Invited
• [Presentation] Detection of white matter activation using diffusion weighted imaging by a 7Tesla human MRI system (2015)
  • Author(s): Kida I, Ueguchi T, Matsuoka Y, Zhou K & Stemmer A.
  • Organizer: 45th Annual Meeting of Society of Neuroscience
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] SPIOを用いたループス腎炎の評価 (2015)
  • Author(s): 陳挺, 森勇樹, 程振宇, Soyoung Lee, Barry Ripley, 岸本忠三, 乾千珠子, 多胡善幸, 吉田慎一, 大野工司, 吉岡芳親
  • Organizer: 第43日本磁気共鳴医学会大会
  • Place of Presentation: 東京,東京ドームホテル
  • Year and Date: 2015-09-10
• [Presentation] 脳温計測のためのクモ膜下腔 DWI thermometry の開発 (2015)
  • Author(s): 藤原俊朗, 吉岡芳親, 松田豪, 西本英明, 村上寿孝, 小川彰, 小笠原邦昭, 別府高明
  • Organizer: 第43日本磁気共鳴医学会大会
  • Place of Presentation: 東京,東京ドームホテル
  • Year and Date: 2015-09-10
• [Presentation] マルチスライス撮像に伴うMT効果：7T脳画像での評価 (2015)
  • Author(s): 上口貴志，黄田育宏，松岡雄一郎，劉国相
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京,東京ドームホテル
  • Year and Date: 2015-09-10
• [Presentation] Modeling of brain activity during natural vision: object and beyond. International 脳・数理モデル化の現在と問題点、そして未来予想：実験神経科学の視点から (2015)
  • Author(s): Nishimoto S.
  • Organizer: 第25回日本神経回路学会
  • Place of Presentation: 東京,電気通信大学
  • Year and Date: 2015-09-01
  • Invited
• [Presentation] Ghost correction for EPI at gradient insert system (2015)
  • Author(s): Liu G, Ueguchi T
  • Organizer: ISMRM 2015 Annual Meeting
  • Place of Presentation: Metro Toronto Convention Centre, Toronto, Canada
  • Year and Date: 2015-05-30 – 2015-06-05
• [Presentation] The intraoral stimulus increases the regional brain temperature in the insular cortex of rats: a proton MR spectroscopy study (2015)
  • Author(s): Inui-Yamamoto C, Shimura T, Ohzawa I, Yoshioka Y.
  • Organizer: The 23rd Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Diffusion-weighted thermometry using subarachnoid space cerebrospinal fluid in subacute carbon monoxide poisoning patients (2015)
  • Author(s): Fujiwara S, Yoshioka Y, Matsuda T, Nishimoto H, Murakami T, Ogawa A, Ogasawara K, Sasaki M, Beppu T
  • Organizer: The 23rd Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Visualization of Lupus Nephritis using SPIO (2015)
  • Author(s): Chen T, Mori Y, Cheng Z, Lee S, Ripley B, Kishimoto T, Inui-Yamamoto C, Sugihara F, Kitagaki N, Tago Y, Yoshida S, Ohno K, Yoshioka Y
  • Organizer: The 23rd Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] In vivo Monitoring of Immune Cell Kinetics with Tme-Lapse MRI in the Ischemic Lesion of Mouse Brain (2015)
  • Author(s): Mori Y, Chen T, Yoshioka Y.
  • Organizer: The 23rd Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Ghost Artifact Reduction for EPI at 7T (2015)
  • Author(s): Liu G, Ueguchi T
  • Organizer: OHBM's 2015 Annual Meeting
  • Place of Presentation: HAWAII CONVENTION CENTER, Honolulu, Hawaii, US
  • Year and Date: 2015-05-14 – 2015-05-18
• [Presentation] Improved T1 correction for cardiac-triggered fMRI at ultra-high field (2015)
  • Author(s): Ueguchi T, Kida I, Liu G.
  • Organizer: The 109th Scientific Meeting of the Japan Society of Medical Physics
  • Place of Presentation: 横浜、Pacifico Yokohama
  • Year and Date: 2015-04-16
• [Presentation] Macroscopic functional organization of natural visual representation in the human visual cortex (2015)
  • Author(s): Nishimoto S
  • Organizer: 第120回日本解剖学会総会･全国学術集会・第92回日本生理学会大会 合同大会
  • Place of Presentation: 神戸国際会議場、兵庫県、神戸市
  • Year and Date: 2015-03-22
  • Invited
• [Presentation] Shearing Distortion Correction for EPI at 7T MRI (2015)
  • Author(s): Liu G, Ueguchi T, Kuribayashi H
  • Organizer: 2015 3rd International Conference on Bioinformatics and Computational Biology
  • Place of Presentation: Hong Kong、China
  • Year and Date: 2015-03-12 – 2015-03-13
• [Presentation] Encoding and decoding: extending receptive field analysis to study natural vision (2015)
  • Author(s): Nishimoto S
  • Organizer: International Symposium on Neural Mechanisms of Vision and Cognition
  • Place of Presentation: 大阪大学脳情報通信融合研究センター、大阪府、吹田市
  • Year and Date: 2015-03-02
  • Invited
• [Presentation] High resolution fMRI at 7T (2014)
  • Author(s): Liu G
  • Organizer: 8th International Symposium on Nanomedicine
  • Place of Presentation: 愛媛大学南加記念ホール、愛媛県、松山市
  • Year and Date: 2014-12-06
  • Invited
• [Presentation] 超高磁場心拍同期fMRI：TRの変動に対する実効フリップ角を考慮したロバストな信号強度補正 (2014)
  • Author(s): 上口貴志，黄田育宏，劉国相
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: ホテルグランヴィア京都、京都府、京都市
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] ヒト7T fMRIを用いた自然動画刺激下における高解像脳活動イメージング (2014)
  • Author(s): 西本伸志，上口貴志，黄田育宏，劉国相
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: ホテルグランヴィア京都、京都府、京都市
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] 7T MRIでのオンラインEPI歪み補正 (2014)
  • Author(s): 劉国相，上口貴志，栗林秀人
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: ホテルグランヴィア京都、京都府、京都市
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] 脳活動のモデル化と知覚体験の可視化 (2014)
  • Author(s): 西本伸志
  • Organizer: 第23回日本バイオイメージング学会学術集会
  • Place of Presentation: 大阪大学銀杏会館、大阪府、吹田市
  • Year and Date: 2014-09-04
  • Invited
• [Presentation] In vivo MRI monitoring of inflammatory alterations and cellular dynamics in the central nervous system (2014)
  • Author(s): Mori Y, Arima Y, Chen T, Zhu D, Komai Y, Nurakami M, Yoshioka Y, Fujisawa T, Kobashi S, Hata
  • Organizer: World Automation Congress 2014
  • Place of Presentation: Kona, Hawaii, USA
  • Year and Date: 2014-08-03 – 2014-08-07
• [Presentation] Near-infrared fluorescent nanoprobes for noninvasive multimodal tissue imaging (2014)
  • Author(s): Nakane Y, Jin T, Mori Y, Yoshioka Y, Ma Q
  • Organizer: World Automation Congress 2014
  • Place of Presentation: Kona, Hawaii, USA
  • Year and Date: 2014-08-03 – 2014-08-07
• [Presentation] Neural substrates for the retrieval of conditioned taste aversion revealed by manganese-enhanced MRI (2014)
  • Author(s): Inui T, Shimura T, Inui-Yamamoto C, Yoshioka Y, Ohzawa I
  • Organizer: World Automation Congress 2014
  • Place of Presentation: Kona, Hawaii, USA
  • Year and Date: 2014-08-03 – 2014-08-07
• [Presentation] Changes in regional brain temperature induced by increase in neuronal activity in rats (2014)
  • Author(s): Inui-Yamamoto C, Shimura T, Seiyama A, Ohzawa I, Yoshioka Y
  • Organizer: World Automation Congress 2014
  • Place of Presentation: Kona, Hawaii, USA
  • Year and Date: 2014-08-03 – 2014-08-07
• [Presentation] モデリングアプローチを用いた自然視知覚下脳活動の定量理解 (2014)
  • Author(s): 西本伸志
  • Organizer: 生理学研究所研究会 「視知覚の現象・機能・メカニズム - 生理学的、心理物理学的、計算論的アプローチ」
  • Place of Presentation: 生理学研究所、埼玉県、和光市
  • Year and Date: 2014-06-19
  • Invited
• [Presentation] Histtologicla correlation of manganese enhancemed MRI in the demyelinating disease model brain (2014)
  • Author(s): Fukunaga M, Masumura M, Koda S, Shimonaga T, Nakamura R, Mori Y, Yoshioka Y
  • Organizer: The 22nd Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Milan, Italy
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] New Magnetic Nanoparticle for Kidney Function. The 22nd Annual Meeting of International Society for Magnetic Resonance in Medicine (2014)
  • Author(s): Yoshioka Y, Chen T, Mori Y, Cheng Z, Kashiwagi Y, Fukunaga M, Kida I, Tago Y, Yoshida S, Ohno K
  • Organizer: The 22nd Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Milan, Italy
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Sequential and time-lapse MRI monitoring of peripheral macrophage recruitment and migration in mouse brain (2014)
  • Author(s): Mori Y, Chen T, Ohno K, Yoshida S, Tago Y, Fujisawa T, Kashiwagi Y, Fukunaga M, Komai Y, Hata Y, Yoshioka Y
  • Organizer: The 22nd Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Milan, Italy
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Cardiac-gating fMRI at ultra-high field: feasibility of signal intensity correction for heart-rate fluctuation (2014)
  • Author(s): Ueguchi T, Kida I, Liu G
  • Organizer: 107th Scientific Meeting of the Japan Society of Medical Physics
  • Place of Presentation: パシフィコ横浜、神奈川県、横浜市
  • Year and Date: 2014-04-10 – 2014-04-13
• [Patent(Industrial Property Rights)] 素材評価方法、及び素材評価装置 (2016)
  • Inventor(s): 8. 西本伸志, 西田知史, 柏岡秀紀
  • Industrial Property Rights Holder: 8. 西本伸志, 西田知史, 柏岡秀紀
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-01-18
• [Patent(Industrial Property Rights)] 温度計測方法、および磁場計測方法 (2015)
  • Inventor(s): 東 高志、劉 国相、滝沢 修、栗林秀人
  • Industrial Property Rights Holder: 国立研究開発法人情報通信研究機構
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-048039
  • Filing Date: 2015-03-11
• [Patent(Industrial Property Rights)] 複合粒子を含む腎機能診断用イメージング剤 (2014)
  • Inventor(s): 多胡善幸・吉田慎一・吉岡芳親・陳挺・森勇樹・大野工司
  • Industrial Property Rights Holder: 大阪大学・京都大学・（株）カネカ
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-181733
  • Filing Date: 2014-09-05