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How much does cognitive remediation therapy for schizophrenia contribute to neuralplasticity?

Research Project

Project/Area Number 26285155
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Clinical psychology
Research InstitutionKanazawa University (2015-2017)
University of Toyama (2014)

Principal Investigator

Matsui Mie  金沢大学, 国際基幹教育院, 教授 (70209485)

Co-Investigator(Renkei-kenkyūsha) SUZUKI Michio  富山大学, 大学院医学薬学研究部(医学), 教授 (40236013)
Research Collaborator INADA Yuna  
TAKAHASHI Michio  
HIGUCHI Yuko  
OTSUKA Sadao  
MIURA Kayoko  
HOSHINO Takatoshi  
UWANO Teruko  
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Keywords統合失調症 / 認知機能改善療法 / NIRS / 神経心理機能 / 記憶方略 / 脳機能 / 神経可塑性 / BDNF / 記憶 / グループ・アプローチ / 脳画像 / グループアプローチ
Outline of Final Research Achievements

The aim of the present study was to examine the effectiveness and applicability of compensatory cognitive training (CCT) in Japanese patients with schizophrenia. CCT is a manualized, group-based training that coaches compensatory strategies in four cognitive domains (prospective memory, attention, verbal memory, and executive functions). Cognitive, functional, and clinical symptom measures were implemented at baseline, post-treatment, and 3-month follow-up. Our study suggests that CCT has beneficial effects on cognitive performance, improving functional outcomes in Japanese patients with schizophrenia. Furthermore, it was suggested that improvement of cognitive function by CTT may be related to neural plasticity based on brain function and biological indicators such as BDNF.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(52 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (31 results) (of which Int'l Joint Research: 4 results,  Invited: 8 results) Book (3 results) Remarks (1 results) Funded Workshop (2 results)

  • [Int'l Joint Research] カリフォルニア大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] カリフォルニア大学(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 統合失調症の認知機能改善療法2018

    • Author(s)
      松井三枝, 稲田祐奈, 蝦名昂大
    • Journal Title

      精神科

      Volume: 32 Pages: 204-210

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 統合失調症の理解と心理学:神経心理学からの紹介2018

    • Author(s)
      松井三枝
    • Journal Title

      心理学評論

      Volume: 60 Pages: 237-253

    • NAID

      130007618092

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症の認知機能障害2018

    • Author(s)
      松井三枝
    • Journal Title

      行動科学

      Volume: 56 Pages: 103-116

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 精神疾患を対象とした神経心理学的アプローチ2017

    • Author(s)
      松井三枝
    • Journal Title

      神経心理学

      Volume: 33 Pages: 94-103

    • NAID

      130005708075

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 前頭葉・実行機能プログラム (Frontal/Executive Program: FEP) 日本語版の紹介2017

    • Author(s)
      大宮秀淑、傳田健三、山家研二、松本出、宮島真貴、松井三枝
    • Journal Title

      精神医学

      Volume: 59 Pages: 275-281

    • NAID

      40021134329

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of cognitive remediation therapy using the frontal/executive program for treating chronic schizophrenia.2016

    • Author(s)
      Omiya H, Yamashita K, Miyata T, Hatakeyama Y, Miyajima M, Yambe K, Matsumoto I, Matsui M, Toyomaki A, Denda K
    • Journal Title

      Open Psychology Journal

      Volume: 9 Pages: 121-128

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] the frontal/executive program for autism spectrum disorder.2016

    • Author(s)
      Omiya H, Yamashita K, Miyata T, Yambe K, Matsui M, Denda K
    • Journal Title

      The International Journal of Psychiatry in Medicine

      Volume: 51 Pages: 223-235

    • DOI

      10.1177/0091217416651254

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 自閉スペクトラム症に対する前頭葉/実行機能プログラムを用いた認知機能改善療法の効果研究2016

    • Author(s)
      宮島真貴、大宮秀淑、山家研司、松井三枝、傳田健三
    • Journal Title

      作業療法

      Volume: 36 Pages: 22-31

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 代償的認知トレーニング (Compensatory Cognitive Training : CCT) 日本語版の紹介2016

    • Author(s)
      松井三枝、大塚貞男
    • Journal Title

      精神医学

      Volume: 58 Pages: 245-253

    • NAID

      40020764835

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] (Compensatory Cognitive Training : CCT) 日本語版の紹介2016

    • Author(s)
      松井三枝、大塚貞男
    • Journal Title

      精神医学

      Volume: 58 Pages: 245-253

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 前頭葉/実行機能プログラムが有効であった成人期自閉スペクトラム症の1例2015

    • Author(s)
      宮島真貴、大宮秀淑、山下聖子、松井三枝、山家研司、傳田健三
    • Journal Title

      最新精神医学

      Volume: 20 Pages: 169-175

    • NAID

      40022410698

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 前頭葉/実行機能プログラム(FEP)を用いた認知機能改善療法(CRT)に関する実践的研究2014

    • Author(s)
      大宮秀淑、山下聖子、宮田友樹、畠山雪恵、山家研司、松本出、松井三枝、豊巻敦人、傳田健三
    • Journal Title

      臨床精神医学

      Volume: 43 Pages: 1525-1532

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性期統合失調症患者に対する認知機能改善療法(CRT)の効果研究―前頭葉/実行機能プログラム(FEP)による症例報告2014

    • Author(s)
      大宮秀淑、山家研司、松本出、松井三枝、傳田健三
    • Journal Title

      精神科治療学

      Volume: 29 Pages: 811-816

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Subjective and objective cognitive impairment in schizophrenia.2018

    • Author(s)
      Matsui M, Ebina K, Inada Y, Nakada S, Kadomoto E, Higuchi Y, Suzuki M
    • Organizer
      International Neuropsychological Society 46th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 統合失調症における認知機能の主観評価と客観評価2018

    • Author(s)
      蝦名昂大,松井三枝,稲田祐奈,中田翔太郎,門本笑花,樋口悠子,鈴木道雄
    • Organizer
      第193回北陸精神神経学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 統合失調症患者における認知予備能とQOLの関連の検討2018

    • Author(s)
      稲田祐奈,松井三枝,蝦名昂大,中田翔太郎,五十嵐由香梨,門本笑花,樋口悠子,鈴木道雄
    • Organizer
      第13回日本統合失調症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 統合失調症患者の認知機能における洞察2018

    • Author(s)
      蝦名昂大,松井三枝,稲田祐奈,中田翔太郎,門本笑花,樋口悠子,鈴木道雄
    • Organizer
      第13回日本統合失調症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 統合失調症の認知機能障害2018

    • Author(s)
      松井三枝
    • Organizer
      Kanazawa Hokuriku認知科学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 統合失調症患者の認知機能における主観評価と客観評価2017

    • Author(s)
      蝦名昂大, 松井三枝, 稲田祐奈, 中田翔太郎, 門本笑花, 大塚貞男, 樋口悠子, 鈴木道雄
    • Organizer
      第12回日本統合失調症学会
    • Place of Presentation
      米子
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Presentation] 認知の障害と問題克服の試み2017

    • Author(s)
      松井三枝
    • Organizer
      金沢大学人文学類・認知科学合同シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-20
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Invited
  • [Presentation] 統合失調症の認知機能障害.2017

    • Author(s)
      松井三枝
    • Organizer
      第33回日本行動科学学会ウインターカンファレンスin石川
    • Place of Presentation
      白山市
    • Year and Date
      2017-02-27
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Invited
  • [Presentation] 統合失調症の認知機能へのアプローチ2017

    • Author(s)
      松井三枝
    • Organizer
      平成28年度北海道大学ニューロサイエンス・ミーテイング講演会
    • Place of Presentation
      札幌
    • Year and Date
      2017-02-03
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Invited
  • [Presentation] 認知機能からみたこころの健康へのアプローチ:精神・神経疾患2017

    • Author(s)
      松井三枝
    • Organizer
      第81回日本心理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 統合失調症の認知機能へのアプローチ2017

    • Author(s)
      松井三枝
    • Organizer
      第81回日本心理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 統合失調症患者の認知機能に対する洞察2017

    • Author(s)
      蝦名昂大, 松井三枝, 稲田祐奈, 中田翔太郎, 門本笑花, 樋口悠子, 鈴木道雄
    • Organizer
      第81回日本心理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 統合失調症患者における認知機能の主観評価と客観評価2017

    • Author(s)
      蝦名昂大, 松井三枝, 稲田祐奈, 中田翔太郎, 門本笑花, 樋口悠子, 鈴木道雄
    • Organizer
      第17回精神疾患と認知機能研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 統合失調症患者の主観的認知機能2017

    • Author(s)
      蝦名昂大, 松井三枝, 稲田祐奈, 中田翔太郎, 門本笑花, 樋口悠子, 鈴木道雄
    • Organizer
      北陸心理学会第52回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 統合失調症の認知機能へのアプローチ2016

    • Author(s)
      松井三枝
    • Organizer
      日本心理学会公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2016-11-26
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Invited
  • [Presentation] 精神疾患を対象としたアプローチ、シンポジウム「心理学からみた症候学」2016

    • Author(s)
      松井三枝
    • Organizer
      第40回日本神経心理学会
    • Place of Presentation
      熊本
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 統合失調症の心理社会的介入の実際とこれから、自主シンポジウム2016

    • Author(s)
      松井三枝、徳里海智子、金城美穂、大塚貞男、永井康司
    • Organizer
      日本心理臨床学会第35回秋季大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Presentation] 統合失調症の認知機能改善へのアプローチ:より効果的な介入方法の構築に向けてー2016

    • Author(s)
      大宮秀淑、松井三枝、平安良二
    • Organizer
      日本心理臨床学会第35回秋季大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Presentation] Cognitive remediation therapy for schizophrenia, Symposium2016

    • Author(s)
      Matsui M, Sato S, Mogami T, Kikuchi A, Kurtz M
    • Organizer
      The 31st International Congress of Psychology
    • Place of Presentation
      Yokohama
    • Year and Date
      2016-07-24
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Compensatory cognitive training for schizophrenia, Symposium2016

    • Author(s)
      Matsui M, Otsuka S, Hoshino T, Miura K, Takahashi M
    • Organizer
      The 31st International Congress of Psychology
    • Place of Presentation
      Yokohama
    • Year and Date
      2016-07-24
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Do neuropsychological case studies belong to the past? Why are cases studies majorities in Japan?, Symposium2016

    • Author(s)
      Midorikawa A, Koyama S, Ramon L, Matsui M
    • Organizer
      The 31st International Congress of Psychology
    • Place of Presentation
      Yokohama
    • Year and Date
      2016-07-24
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cognitive remediation therapy focusing upon the strategy coaching for Japanese patients with schizophrenia2015

    • Author(s)
      Matsui M, Otsuka S, Hoshino T, Miura K, Higuchi Y, Suzuki M
    • Organizer
      15th International Congress on Schizophrenia Research
    • Place of Presentation
      Colorado Springs
    • Year and Date
      2015-03-29 – 2015-04-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 統合失調症の認知機能改善療法の実践ー前頭葉・実行機能プログラムによるアプローチ2015

    • Author(s)
      松井三枝
    • Organizer
      第34回日本社会精神医学会
    • Place of Presentation
      富山
    • Year and Date
      2015-03-05 – 2015-03-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Cognitive remediation therapy focusing upon the strategy coaching in schizophrenia2015

    • Author(s)
      Matsui M, Otsuka S, Hoshino T, Miura K, Higuchi Y, Suzuki M
    • Organizer
      International Neuropsychological Society 43rd Annual Meeting
    • Place of Presentation
      Denver, Colorado
    • Year and Date
      2015-02-04 – 2015-02-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 統合失調症患者における記憶の組織化と前頭前野の脳活動ーNIRSによる活動2014

    • Author(s)
      越智大輔、松井三枝,大塚貞男、星野貴俊、石井政栄、樋口悠子,高橋努、鈴木道雄
    • Organizer
      第14回精神疾患と認知機能研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 統合失調症の認知機能は社会機能に影響を及ぼすか2014

    • Author(s)
      松井三枝
    • Organizer
      第14回精神疾患と認知機能研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 統合失調症への代償的方略に着目した認知機能改善療法の効果2014

    • Author(s)
      松井三枝、大塚貞男,星野貴俊,三浦佳代子,樋口悠子,鈴木道雄
    • Organizer
      第38回日本神経心理学会学術集会
    • Place of Presentation
      山形
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] A practical study on cognitive remediation therapy (CRT) using the frontal/executive program (FEP) for patients with schizophrenia2014

    • Author(s)
      Ohmiya H, Yamashita K, Miyata T, Hatakeyama Y, Yambe K, Matsumoto I, Matsui M, Toyomaki A, Denda K
    • Organizer
      XVI World Congress of Psychiatry
    • Place of Presentation
      Madrid
    • Year and Date
      2014-09-14 – 2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 統合失調症患者における運転特性と認知機能2014

    • Author(s)
      星野貴俊、松井三枝
    • Organizer
      日本心理学会第78回大会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-10 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高次脳機能障害患者における自動車運転評価ー近赤外線分光法(NIRS)を用いた検討2014

    • Author(s)
      越智大輔、松井三枝、星野貴俊、小野田佑美、吉野修、野村忠雄
    • Organizer
      第19回認知神経学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 統合失調症患者における自動車運転行動と日常的認知機能2014

    • Author(s)
      星野貴俊、松井三枝
    • Organizer
      第110回日本精神神経学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] 病気のひとのこころー医療のなかでの心理学2018

    • Author(s)
      松井三枝・井村修(編)日本心理学会(監修)
    • Total Pages
      186
    • Publisher
      誠信書房
    • ISBN
      9784414311204
    • Related Report
      2017 Annual Research Report
  • [Book] 前頭葉・実行機能プログラム(FEP)~認知機能改善のためのトレーニング実践マニュアル(Ann Delahunty、Rodney Morice)・臨床家ガイド付き~2015

    • Author(s)
      松井三枝、柴田多美子、少作隆子
    • Total Pages
      691
    • Publisher
      新興医学出版社
    • Related Report
      2014 Annual Research Report
  • [Book] 臨床神経心理学的検査法、下山晴彦(編集代表)誠信心理学辞典新版2014

    • Author(s)
      松井三枝
    • Total Pages
      4
    • Publisher
      誠信書房
    • Related Report
      2014 Annual Research Report
  • [Remarks] 認知リハビリテーションの開発・実施と効果研究

    • URL

      http://neuropsychol.w3.kanazawa-u.ac.jp/research/

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Funded Workshop] Cognitive remediation therapy for schizophrenia, Symposium2016

    • Place of Presentation
      横浜パシフィコ
    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] Cognitive remediation therapy for schizophrenia, Symposium2016

    • Place of Presentation
      横浜パシフィコ
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2022-02-16  

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