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Mechanisms of memory consolidation in sleep

Research Project

Project/Area Number 26285161
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Experimental psychology
Research InstitutionUniversity of Tsukuba

Principal Investigator

Pavlides Constantine  筑波大学, 人間系, 教授 (50712808)

Co-Investigator(Kenkyū-buntansha) 小川 園子  筑波大学, 人間系, 教授 (50396610)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywordssleep / memory / hippocampus / amygdala / fear conditioning / sharp wave ripples / PKA phosphorylation / memory;hippocampus
Outline of Final Research Achievements

In the proposed studies we tested whether various gene cascades (e.g., MAPK, PKA) are activated specifically in sleep for the consolidation of fear memory, along with the time-course of the activation. Of these, we found that there was an increase in PKA phosphorylation during sleep in the hippocampus of contextual fear conditioned animals, however, the results approached but were not statistically significant. We did not find a differential time-course of PKA activation at the 0-4h vs 4-8h time points. Inhibition of PKA in the dorsal hippocampus produced a disturbance in fear memory, while activation of PKA in sleep-deprived animals reversed the sleep-deprivation suppression of fear memory. We are currently testing whether sharp wave ripples (SPWr), which occur during learning and in sleep, modulate memory consolidation by their effects on PKA expression. We observed that eliminating SPWr suppressed PKA phosphorylation in the hippocampus and in turn disrupted long-term fear memory.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(16 results)

All 2018 2017 2016 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results)

  • [Journal Article] Fear memory consolidation in sleep requires protein kinase A2018

    • Author(s)
      Cho J, Sypniewski KA, Arai S, Yamada K, Ogawa S and Pavlides C.
    • Journal Title

      Learn Mem

      Volume: 25 Pages: 241-246

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Neural, hormonal and experiential control of sex-typical expression of social behavior.2015

    • Author(s)
      Ogawa, S., Tsuda, M.C., Sano, K., Tsukahara, S., and Musatov, S.
    • Journal Title

      Interdisciplinary Information Sciences

      Volume: 21 Pages: 181-187

    • DOI

      10.4036/iis.2015.b.02

    • NAID

      110009966526

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Sharp wave ripples modulate memory consolidation in sleep via activation of the cAMP signaling pathway2018

    • Author(s)
      Pavlides, C. Cho, J. Sypniewski, K.A.
    • Organizer
      Japan Physiol. Soc. Abstract
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of sharp wave-ripple suppression in sleep on contextual fear memory.2017

    • Author(s)
      Sypniewki K. Cho J. Pavlides C.
    • Organizer
      The 40th annual meeting of the Japanese Neuroscience Society
    • Place of Presentation
      Makuhari Messe, Chiba
    • Year and Date
      2017-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Neuronal functional organization in fear memory2017

    • Author(s)
      Cho J. Pavlides C.
    • Organizer
      The 40th annual meeting of the Japanese Neuroscience Society
    • Place of Presentation
      Makuhari Messe, Chiba
    • Year and Date
      2017-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Mechanisms underlying memory consolidation in sleep.2017

    • Author(s)
      Pavlides C. Cho J. Sypniewki K.
    • Organizer
      The 26th annual meeting of the International Behavioral Neuroscience Society
    • Place of Presentation
      The Grand Prince Hotel, Hiroshima
    • Year and Date
      2017-06-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hippocampal sharp wave ripple effects on protein kinase A activity in sleep. .2016

    • Author(s)
      Sypniewki K. Cho J. Pavlides C.
    • Organizer
      The 39th annual meeting of the Japanese Neuroscience Society
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Hippocampal sharp wave ripple effects on protein kinase A activity in sleep.2016

    • Author(s)
      Sypniewki K. Cho J. Pavlides C.
    • Organizer
      The 39th annual meeting of the Japanese Neuroscience Society.
    • Place of Presentation
      パシフィコ横浜、神奈川県、横浜市
    • Year and Date
      2016-07-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Fear conditioning induced protein kinase A activation in sleep.2016

    • Author(s)
      Pavlides, C., Arai, S., Cho, J., Yamada, K., and Ogawa, S.
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan.
    • Place of Presentation
      札幌コンベンションセンター、北海道、札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Life-long action of steroid hormones on the regulation of social behavior2015

    • Author(s)
      Sonoko Ogawa
    • Organizer
      Animal Behavior Meeting in Beijing
    • Place of Presentation
      Chinese Academy of Sciences, Beijing, China
    • Year and Date
      2015-10-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neural, Hormonal and Experiential Control of Social and Emotional Behavior.2015

    • Author(s)
      Sonoko Ogawa
    • Organizer
      In Parvo- and Magnocellular Symposiumin Sendai
    • Place of Presentation
      Gonryo Kaikan, Miyagi, Sendai
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The Role of Protein Kinase A (PKA) in Memory Consolidation in Sleep2015

    • Author(s)
      Cho,J., Krzysztof, S., Arai, S., Yamada, K., Pavlides, C.
    • Organizer
      The 38th Annual Meeting of The Japan Neuroscience Society
    • Place of Presentation
      Kobe
    • Year and Date
      2015-07-28 – 2015-07-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Life Long Action of Steroid Hormones on the Regulation of Social Behavior.2015

    • Author(s)
      Sonoko Ogawa
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience Society,
    • Place of Presentation
      神戸国際会議場、兵庫県、神戸市
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The Role of Protein Kinase A (PKA) in Memory Consolidation in Sleep.2015

    • Author(s)
      Cho J. Sypniewski K. Arai S. Yamada K. Pavlides C. T
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      神戸国際会議場、兵庫県、神戸市
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Functional neuronal organization in the hippocampus and neocortex in a non-spatial, working memory task.2014

    • Author(s)
      Cho,J., Ogawa, S., Pavlides, C.
    • Organizer
      The 37th Annual Meeting of The Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional neuronal organization in the hippocampus and neocortex in a non-spatial, working memory task.2014

    • Author(s)
      Cho, J., Arai, S., Ogawa, S., Pavlides, C.
    • Organizer
      The 21st Meeting of the Japanese Society for Behavioral Neuroendocrinology
    • Place of Presentation
      Saitama
    • Year and Date
      2014-09-03 – 2014-09-05
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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