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Development of metal nano particle catalysis toward functional molecular synthesis

Research Project

Project/Area Number 26288051
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Synthetic chemistry
Research InstitutionOsaka University

Principal Investigator

ARISAWA Mitsuhiro  大阪大学, 薬学研究科, 准教授 (40312962)

Project Period (FY) 2014-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords有機化学 / 薬学 / ナノ材料 / 環境技術 / 合成化学
Outline of Final Research Achievements

The structural analysis of the palladium nanoparticle catalyst SAPdNp developed by the research representatives succeeded, and it turned out that the excellent function of SAPdNp is structurally rational. We also succeeded in developing novel nickel nanoparticle catalysts such as SANiNp as rare element reduction type and alternative type organometallic catalysts. Furthermore, we succeeded in developing a microwave device suitable for metal nanoparticle catalyst. As a result of these research results, we succeeded in finding ligand-free Suzuki-Miyaura coupling of aryl chloride using metal nanoparticle catalyst and continuous irradiation microwave device.

Academic Significance and Societal Importance of the Research Achievements

従来の触媒に比べ、金属ナノパーティクル(Np)は表面積が広く、より高活性であることから、より温和な環境調和的条件で反応が進行する特徴を有している。一方、研究代表者らが開発した硫黄修飾金担持型パラジウムナノ粒子触媒SAPdNpは各種カップリング反応などにリガンドフリーで機能する新触媒であり、産業界でも使用されているが、SAPdNpの構造が不明であることから、より活性の高い触媒や、別の金属ナノ粒子触媒の開発が困難な状況であった。今回、本触媒の構造解析に成功し、新規ニッケルNp触媒SANiNpなどの開発に成功した点で学術的意義がある。また、マイクロウエーブ装置の開発にも成功した点で社会的意義がある。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (129 results)

All 2019 2018 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (3 results) Journal Article (36 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 36 results,  Open Access: 17 results,  Acknowledgement Compliant: 25 results) Presentation (84 results) (of which Int'l Joint Research: 29 results,  Invited: 8 results) Book (3 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] ケンブリッジ大学(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ケンブリッジ大学(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ブリュッセル自由大学(ベルギー)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in Caenorhabditis elegans.2019

    • Author(s)
      Hada Kazumasa、Hirota Keiko、Inanobe Ai、Kako Koichiro、Miyata Mai、Araoi Sho、Matsumoto Masaki、Ohta Reiya、Arisawa Mitsuhiro、Daitoku Hiroaki、Hanada Toshikatsu、Fukamizu Akiyoshi
    • Journal Title

      J. Biol. Chem.

      Volume: 294 Issue: 9 Pages: 3091-3099

    • DOI

      10.1074/jbc.ra118.004726

    • NAID

      120007133475

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metal-Free Nitrogen-Containing Polyheterocyclic Near-Infrared (NIR) Absorption Dyes: Synthesis, Absorption Properties, and Theoretical Calculation of Substituted 5-Methylisoindolo[2,1-a]quinolines2019

    • Author(s)
      Fujii Yuki、Suwa Yukinori、Wada Yuki、Takehara Tsunayoshi、Suzuki Takeyuki、Kawashima Yusuke、Kawashita Norihito、Takagi Tatsuya、Fujioka Hiromichi、Arisawa Mitsuhiro
    • Journal Title

      ACS Omega

      Volume: 4 Issue: 3 Pages: 5064-5075

    • DOI

      10.1021/acsomega.9b00315

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Highly Discriminative and Chemoselective Deprotection/Transformations of Acetals with the Combination of Trialkylsilyl Triflate/2,4,6-Collidine2018

    • Author(s)
      Reiya Ohta, Nao Matsumoto, Yoshifumi Ueyama, Yuichi Kuboki, Hiroshi Aoyama, Kenichi Murai, Mitsuhiro Arisawa, Tomohiro Maegawa, Hiromichi Fujioka
    • Journal Title

      JOURNAL OF ORGANIC CHEMISTRY

      Volume: 83 Issue: 12 Pages: 6432-6443

    • DOI

      10.1021/acs.joc.8b00675

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cascade Multiple Diels?Alder Reactions of Styrene Derivatives with Maleimide or Maleic Anhydride2018

    • Author(s)
      Yoshioka Shohei、Aoyama Hiroshi、Fujioka Hiromichi、Arisawa Mitsuhiro
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 83 Issue: 12 Pages: 6599-6606

    • DOI

      10.1021/acs.joc.8b00890

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Chiral cis-Cyclopropane Bearing Indole and Chromone as Potential TNFα Inhibitors2018

    • Author(s)
      Kanada Ryutaro、Tanabe Makoto、Muromoto Ryuta、Sato Yukina、Kuwahara Tomoki、Fukuda Hayato、Arisawa Mitsuhiro、Matsuda Tadashi、Watanabe Mizuki、Shuto Satoshi
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 83 Issue: 15 Pages: 7672-7682

    • DOI

      10.1021/acs.joc.8b00466

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of histamine H3/H4 receptor ligands with a cyclopropane scaffold2018

    • Author(s)
      Watanabe Mizuki、Kobayashi Takaaki、Ito Yoshihiko、Fukuda Hayato、Yamada Shizuo、Arisawa Mitsuhiro、Shuto Satoshi
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 28 Issue: 23-24 Pages: 3630-3633

    • DOI

      10.1016/j.bmcl.2018.10.041

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reusable Immobilized Iron(II) Nanoparticle Pre-Catalysts for Ligand-Free Kumada Coupling2018

    • Author(s)
      Toshiki Akiyama, Yuki Wada, Kellie Jenkinson, Tetsuo Honma, Kazuki Tsuruta, Yusuke Tamenori, Hitoshi Haneoka, Tsunayoshi Takehara, Takeyuki Suzuki, Kenichi Murai, Hiromichi Fujioka, Yoshihiro Sato, Andrew E. H. Wheatley, Mitsuhiro Arisawa
    • Journal Title

      Acs Applied Nano Materials

      Volume: 1 Issue: 12 Pages: 6950-6958

    • DOI

      10.1021/acsanm.8b01742

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Design and Synthesis of N1,N8-Diacetylspermidine Analogues having a Linker with Desired Functional Groups2018

    • Author(s)
      Reiya Ohta, Akihiro Oguro, Kazuhiro Nishimura, Kenichi Murai, Hiromichi Fujioka, Mitsuhiro Arisawa.
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 17 Issue: 4 Pages: 867-875

    • DOI

      10.1039/c8ob02900h

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Palladium-Catalyzed Seven-Membered Silacycle Construction: 1,7-Enyne Hydroxycyclization To Give a Benzosilepine Skeleton2018

    • Author(s)
      Takamoto Kohei、Yoshioka Shohei、Fujioka Hiromichi、Arisawa Mitsuhiro
    • Journal Title

      Organic Letters

      Volume: 20 Issue: 7 Pages: 1773-1776

    • DOI

      10.1021/acs.orglett.8b00271

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and Synthesis of Cyclopropane Congeners of Resolvin E2, an Endogenous Proresolving Lipid Mediator, as Its Stable Equivalents2016

    • Author(s)
      Fukuda, H; Muromoto, R.; Takakura, Y.; Ishimura, K.; Kanada, R.; Fushihara, D.; Tanabe, M.; Matsubara, K.; Hirao, T.; Hirashima, K.; Abe, Arisawa, M.; Matsuda, T.; Shuto, S.
    • Journal Title

      Org. Lett.

      Volume: 18 Issue: 24 Pages: 6224-6227

    • DOI

      10.1021/acs.orglett.6b02612

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Design, Synthesis, and Identification of 4α-azidoethyl-Cyclic ADP-Carbocyclic-Ribose as a Highly Potent Analogue of Cyclic ADP-Ribose a Ca2+-mobilizing Second Messenger2016

    • Author(s)
      Sato, T.; Watanabe, M.; Tsuzuki, T.; Takano, S.; Murayama, T.; Sakurai, T.; Kameda, T.; Arisawa, M.; Fukuda, H.; Shuto, S.
    • Journal Title

      J. Med. Chem.

      Volume: 59 Issue: 15 Pages: 7282-7286

    • DOI

      10.1021/acs.jmedchem.6b00437

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Highly Sensitive Measurement of Inositol 1,4,5-Trisphosphate by Using a New Fluorescent Ligand and Ligand Binding Domain Combination2016

    • Author(s)
      Oura, T.; Murata, K.; Morita, T.; Nezu, A.; Arisawa, M.; Shuto, S.; Tanimura, A.
    • Journal Title

      ChemBioChem

      Volume: 17 Issue: 16 Pages: 1509-1512

    • DOI

      10.1002/cbic.201600096

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Self-assembled Multi-layer Stabilized Nickel Nanoparticle Catalyst for Ligand-free Cross-coupling Reactions: in situ Metal Nanoparticle and Nanospace Simultaneous Organization2016

    • Author(s)
      Naoyuki Hoshiya, Katsumasa Fujiki, Takahisa Taniguchi, Tetsuo Honma, Yusuke Tamenori, Mincen Xiao, Nozomi Saito, Mami Yokoyama, Akira Ishii, Hiromichi Fujioka, Satoshi Shuto, Yoshihiro Sato, Mitsuhiro Arisawa
    • Journal Title

      Adv. Synth. Catal.

      Volume: 358 Issue: 15 Pages: 2449-2459

    • DOI

      10.1002/adsc.201600024

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Non-metathesis Heterocycle Formation by Ruthenium-Catalyzed Intramolecular [2+2] Cycloaddition of Allenamide-enes to Azabicyclo[3.1.1]heptanes2016

    • Author(s)
      Tomomi Nada, Yusuke Yoneshige, Yasuhiro Ii, Takashi Matsumoto, Hiromichi Fujioka, Satoshi Shuto, Mitsuhiro Arisawa
    • Journal Title

      ACS Catalysis

      Volume: 6 Issue: 5 Pages: 3168-3171

    • DOI

      10.1021/acscatal.6b00628

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction2016

    • Author(s)
      Hayato Fukuda, Saki Ito, Kenji Watari, Chihiro Mogi, Mitsuhiro Arisawa, Fumikazu Okajima, Hitoshi Kurose, Satoshi Shuto
    • Journal Title

      ACS Med. Chem. Lett.

      Volume: 7 Issue: 5 Pages: 493-497

    • DOI

      10.1021/acsmedchemlett.6b00014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Development of a Sulfur-modified Glass-supported Pd Nanoparticle Catalyst for the Suzuki-Miyaura Coupling2016

    • Author(s)
      Mincen Xiao, Naoyuki Hoshiya, Katsumasa Fujiki, Tetsuo Honma, Yusuke Tamenori, Satoshi Shuto, Hiromichi Fujioka, Mitsuhiro Arisawa
    • Journal Title

      Chem. Pharm. Bull.

    • NAID

      130005253911

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Kazuki Urakawa, Michinori Sumimoto, Mitsuhiro Arisawa, Masaki Matsuda, Hayato Ishikawa2016

    • Author(s)
      Redox Switching of Orthoquinone-Containing Aromatic Compounds using Gas Energy
    • Journal Title

      Angew. Chem. Int. Ed

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Double Carbonylation of Aryl Iodides with Amines under an Atmospheric Pressure of Carbon Monoxide Using Sulfur- Modified Au-Supported Palladium2015

    • Author(s)
      Nozomi Saito Takahisa Taniguchi, Naoyuki Hoshiya, Satoshi Shuto, Mitsuhiro Arisawa, Yoshihiro Sato
    • Journal Title

      Green Chem.

      Volume: 17 Issue: 4 Pages: 2358-2361

    • DOI

      10.1039/c4gc02469a

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Safe Removal of the Allyl Protecting Groups of Allyl Esters using a Recyclable, Low-leaching and Ligand-free Palladium Nanoparticle Catalyst2015

    • Author(s)
      Koji Takagi, Hayato Fukuda, Satoshi Shuto, Akira Otaka, Mitsuhiro Arisawa
    • Journal Title

      Adv. Synth. Catal.

      Volume: 357 Issue: 9 Pages: 2119-2124

    • DOI

      10.1002/adsc.201500055

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Construction of a chiral quaternary carbon center by a radical cyclization/ring-enlargement reaction: synthesis of 4α-azidoethyl carbocyclic ribose, a key unit for the synthesis of cyclic ADP- ribose derivatives of biological importance2015

    • Author(s)
      Takatoshi Sato, Takayoshi Tsuzuki, Satoshi Takano, Kohtaro Kato, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto
    • Journal Title

      Tetrahedron

      Volume: 71 Issue: 33 Pages: 5407-5413

    • DOI

      10.1016/j.tet.2015.05.084

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of 7-Deaza-cyclic Adenosine-5′-diphosphate-carbocyclic-ribose and Its 7-Bromo Derivative as Intracellular Ca2+-Mobilizing Agents2015

    • Author(s)
      Satoshi Takano, Takayoshi Tsuzuki, Takashi Murayama, Takashi Sakurai, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto
    • Journal Title

      J. Org. Chem.

      Volume: 80 Issue: 13 Pages: 6619-6627

    • DOI

      10.1021/acs.joc.5b00723

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of Enyne Metathesis/Isomerization/Diels-Alder One-pot Reaction for Novel Near- Infrared (NIR) Dye Core2015

    • Author(s)
      Kohei Yamashita, Yuki Fujii, Shohei Yoshioka, Hiroshi Aoyama, Hirofumi Tsujino, Tadayuki Uno, Hiromichi Fujioka, Mitsuhiro Arisawa
    • Journal Title

      Chem. Eur. J.

      Volume: 23 Issue: 48 Pages: 17491-17494

    • DOI

      10.1002/chem.201502313

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] One-pot Olefin Isomerization/ Aliphatic Enamine Ring-closing Metathesis/ Oxidation/ 1,3-Dipolar Cycloaddition for the Synthesis of Isoindolo[1,2-a]isoquinolines2015

    • Author(s)
      Yuki Fujii, Tsunayoshi Takehara, Takeyuki Suzuki, Hiromichi Fujioka, Satoshi Shuto, Mitsuhiro Arisawa
    • Journal Title

      Adv. Synth. Catal.

      Volume: 357 Issue: 18 Pages: 4055-4062

    • DOI

      10.1002/adsc.201500680

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stereoselective Construction of 2,7-Disubstituted fused-Bis Tetrahydrofuran Skeletons: Biomimetic-Type Synthesis and Biological Evaluation of (±)-and (.)-Aplysiallene and Their Derivatives2015

    • Author(s)
      Maki Yamakawa, Takeshi Kurachi, Yusuke Yoshikawa, Mitsuhiro Arisawa, Yuichiro Okino, Kuniaki Suzuki, and Hiromichi Fujioka
    • Journal Title

      J. Org. Chem.

      Volume: 80 Issue: 20 Pages: 10261-10277

    • DOI

      10.1021/acs.joc.5b01882

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characterization of imidazopyridine compounds as negative allosteric modulators of proton-sensing GPR4 in extracellular acidification-induced responses2015

    • Author(s)
      Ayaka Tobo, Masayuki Tobo, Takashi Nakakura, Masashi Ebara, Hideaki Tomura, Chihiro Mogi, Dong-Soon Im, Naoya Murata, Atsushi Kuwabara, Saki Ito, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto, Michio Nakaya, Hitoshi Kurose, Koichi Sato, Fumikazu Okajima
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 6 Pages: e0129334-e0129334

    • DOI

      10.1371/journal.pone.0129334

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Formation of self-assembled multi-layer stable palladium nanoparticles for ligand-free coupling reactions2015

    • Author(s)
      Mitsuhiro Arisawa, Mohammad Al-Amin, Tetsuo Honma, Yusuke Tamenori, Satoshi Arai, Naoyuki Hoshiya, Takatoshi Sato, Mami Yokoyama, Akira Ishii, Masaki Takeguchi, Tsuyoshi Miyazaki, Masashi Takeuchi, Tomohiro Maruko, Satoshi Shuto
    • Journal Title

      RSC Adv.

      Volume: 5 Issue: 1 Pages: 676-683

    • DOI

      10.1039/c4ra11215f

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nickel-Catalyzed Suzuki-Miyaura Coupling of a Tertiary Iodocyclopropane with Wide Boronic Acid Substrate Scope: Coupling Reaction Outcome Depends on Radical Species Stability2015

    • Author(s)
      Keisuke Yotsuji, Naoyuki Hoshiya, Takaaki Kobayashi, Hayato Fukuda, Hiroshi Abe, Mitsuhiro Arisawa and Satoshi Shuto
    • Journal Title

      Adv. Synth. Catal.

      Volume: 357 Issue: 5 Pages: 1022-1028

    • DOI

      10.1002/adsc.201401000

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 芳香族エナミドメタセシス反応の開発:生物活性多置換インドール化合物の設計・合成・機能評価2015

    • Author(s)
      有澤光弘、西田篤司、周東智
    • Journal Title

      有機合成化学協会誌

      Volume: 73 Pages: 254-265

    • NAID

      130005065812

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Safe Removal of the Allyl Protecting Groups of Allyl Esters using a Recyclable, Low-leaching and Ligand-free Palladium Nanoparticle Catalyst2015

    • Author(s)
      Koji Takagi, Hayato Fukuda, Satoshi Shuto, Akira Otaka, Mitsuhiro Arisawa
    • Journal Title

      Adv. Synth. Catal.

      Volume: 357

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Rational hopping of a peptidic scaffold into non-peptidic scaffolds: structurally novel potent proteasome inhibitors derived from a natural product, belactosin A2014

    • Author(s)
      Shuhei Kawamura, Yuka Unno, Takatsugu Hirokawa, Akira Asai, Mitsuhiro Arisawa and Satoshi Shuto
    • Journal Title

      Chem. Commun.

      Volume: 50 Pages: 2445-2447

    • NAID

      120005525210

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Palladium-Nanoparticle-Catalyzed Direct Ethynylation of Aliphatic Carboxylic Acid Derivatives via C(sp3)-H Bond Functionalization2014

    • Author(s)
      Mohammad Al-Amin, Mitsuhiro Arisawa, Satoshi Shuto, Yusuke Ano, Mamoru Tobisu, Naoto Chatani
    • Journal Title

      Adv. Synth. Catal.

      Volume: 356 Issue: 7 Pages: 1631-1637

    • DOI

      10.1002/adsc.201301180

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ligandーfree Suzuki-Miyaura Coupling with Sulfur-modified Gold-supported Palladium in the Synthesis of a Conformationally-Restricted Cyclopropane Compound Library with Three-Dimensional Diversity2014

    • Author(s)
      Mitsuhiro ARISAWA
    • Journal Title

      ACS Combi. Sci.

      Volume: 16 Issue: 5 Pages: 215-220

    • DOI

      10.1021/co4001138

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Palladium-Nanoparticle-Catalyzed 1,7-Palladium Migration Involving C-H Activation, Followed by Intramolecular Amination: Regioselective Synthesis of N1-Arylbenzotriazoles and an Evaluation of Their Inhibitory Activity Towards Indoleamine 2,3-Dioxygenase2014

    • Author(s)
      Koji Takagi, Mohammad Al-Amin, Naoyuki Hoshiya, Johan Wouters, Hiroshi Sugimoto, Yoshitsugu Shiro, Hayato Fukuda, Satoshi Shuto, Mitsuhiro Arisawa
    • Journal Title

      J. Org. Chem.

      Volume: 79 Issue: 13 Pages: 6366-6371

    • DOI

      10.1021/jo5009838

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Development of a New Class of Proteasome Inhibitors with an Epoxyketone Warhead: Rational Hybridization of Non-peptidic Belactosin Derivatives and Peptide Epoxyketones2014

    • Author(s)
      Shuhei Kawamura, Yuka Unno, Akira Asai, Mitsuhiro Arisawa, Satoshi Shuto
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 22 Issue: 12 Pages: 3091-3095

    • DOI

      10.1016/j.bmc.2014.04.032

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor2014

    • Author(s)
      Takaaki Kobayashi, Akihiro Suemasa, Arisa Igawa, Soichiro Ide, Hayato Fukuda, Hiroshi Abe, Mitsuhiro Arisawa, Masabumi Minami, Satoshi Shuto
    • Journal Title

      ACS Med. Chem. Lett.

      Volume: 5 Issue: 8 Pages: 889-893

    • DOI

      10.1021/ml500134k

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Investigation of the Non-Covalent Binding Mode of Covalent Proteasome Inhibitors around the Transition State by Combined Use of Cyclopropylic Strain-Based Conformational Restriction and Computational Modeling2013

    • Author(s)
      Shuhei KAWAMURA
    • Journal Title

      J. Med. Chem.

      Volume: 56 Issue: 14 Pages: 5829-5842

    • DOI

      10.1021/jm400542h

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Ru-Catalyzed 1,6-Enyne Cycloisomerization of Functionalized Olefin for 2,3-Disubstituted Indole and Benzo[b]furan Synthesis2018

    • Author(s)
      Ohno, S; Takamoto, K.; Fujioka, H.; Arisawa, M.
    • Organizer
      XXVIII International Conference on Organometallic Chemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Iron Nanoparticles-catalyzed Ligand-free Kumada Coupling2018

    • Author(s)
      Akiyama, T.; Honma, T.; Tamenori, Y.; Fujioka, H.; Sato, Y.; Arisawa, M.
    • Organizer
      XXVIII International Conference on Organometallic Chemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Transition Metal Catalyzed 7-Membered and 6-Membered Silacyclic Compounds Synthesis2018

    • Author(s)
      Yoshioka, S.; Takamoto, K.; Fujioka, H.; Arisawa, M.
    • Organizer
      XXVIII International Conference on Organometallic Chemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design and Synthesis of Polyamine Analogues to Obtain Their Aptamers2018

    • Author(s)
      Ohta, R.; Oguro, A.; Nishimura, K.; Fujioka, H.; Arisawa, M.
    • Organizer
      XXII International Conference on Organic Synthesis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Selective Transformation of β‐Disubstituted Enones and Ynones in the Presence of β‐Monosubstituted Enones2018

    • Author(s)
      Morita, K.; Ohta, R.; Murai,K.; Arisawa, M.; Fujioka, H.
    • Organizer
      XXII International Conference on Organic Synthesis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Iron(II) Nanoparticle-Catalyzed Ligand-Free Kumada Coupling2018

    • Author(s)
      Akiyama, T.; Honma, T.; Tamenori, Y.; Fujioka, H.; Sato, Y.; Arisawa, M.
    • Organizer
      8th Spanish-Portuguese-Japanese Organic Chemistry Symposium (8th SPJ-OCS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Transition Metal Catalyzed 7-Membered and 6-Membered Silacyclic Compounds Synthesis2018

    • Author(s)
      Ohno, S.; Murai, K.; Fujioka, H.; Arisawa, M.
    • Organizer
      8th Spanish-Portuguese-Japanese Organic Chemistry Symposium (8th SPJ-OCS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemoselective Transformations of Aromatic Methoxymethyl Ethers with Combination of Trialkylsilyl Trifrate and 2,2’-Bipyridyl2018

    • Author(s)
      Yanagihara, M.; Ohta, R.; Murai, K.; Arisawa, M.; Fujioka, H.
    • Organizer
      IKCOC-14
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Selective Transformation of β‐Disubstituted Enones and Ynones in the Presence of β‐Monosubstituted Enones2018

    • Author(s)
      Wada, Y.; Fujii, Y.; Takehara, T.; Suzuki, T.; Murai, K.; Fujioka, H.; Arisawa, M.
    • Organizer
      IKCOC-14
    • Related Report
      2018 Annual Research Report
  • [Presentation] Self-assembled Pd-nanoparticles Catalyzed Reactions2018

    • Author(s)
      Hirabayashi, S.; Xiao, M.; Akiyama, T.; Yamada, M.; Murai, K.; Fujioka, H.; Arisawa, M.
    • Organizer
      IKCOC-14
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of Highly Efficient Metal Nano-particle Catalyst toward Drug Discovery2017

    • Author(s)
      Arisawa, M.
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ピリジン環への位置選択的トリフルオロメチル化反 応の開発2017

    • Author(s)
      kuboki, Y.; Ohta, R.; Arisawa, M.; Fujhioka, H.
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 鉄ナノ粒子触媒を用いたリガンドフリー熊田カップ リング反応の開発2017

    • Author(s)
      Akiyama, T.; Taniguchi, T.; Honma, T.; Tamenori, Y.; Sato, Y.; Fujioka, H.; Arisawa, M.
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] ホスホニウム塩中間体を用いた one-pot エーテル環 合成法の開発2017

    • Author(s)
      Morita, K.; Ohta, R.; Aoyama, H.; Arisawa, M.; Fujioka, H.
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Palladium-catalyzad migratory cycloisomerization of N-allyl-o-allenylaniline delivatives2017

    • Author(s)
      Ii, Y.; Aoyama, H.; Fujioka, H.; Arisawa, M.
    • Organizer
      19th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis, OMCOS 19
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] One-pot Enyne metathesis/Diels-Alder/Oxidation to Six-membered Silacycles with a Multi-ring Core: Discovery of a Novel fluorophore2017

    • Author(s)
      Yoshioka, S.; Fujii, Y.; Tsujino, H.; Uno, T.; Fujioka, H.; Arisawa, M.
    • Organizer
      19th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis, OMCOS 19
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recyclable, Low-Leaching, and Ligand-Free Suzuki?Miyaura Coupling Using Ruthenium(0) Nanoparticles2017

    • Author(s)
      Akiyama,T.; Taniguchi, T.; Honma, T.; Tamenori, Y.; Fujioka, H.; Sato, Y.; Arisawa, M.
    • Organizer
      19th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis, OMCOS 19
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of Novel Nitrogen-containing Polyheterocycles Via Ruthenium-catalyzed One-pot Metathesis / Non-metathesis Reaction2017

    • Author(s)
      Fujii, Y.; Yamashita, K.; Yoshioka, S.; Shuto, S.; Fujioka, H.; Arisawa, M.
    • Organizer
      18th Tetrahedron Symposium - Asia Edition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Highly Discriminative Two-type Transformations of α,β-Unsaturated Esters in the Presence of Enones and Concise Synthesis of Oxacyclic Compounds2017

    • Author(s)
      Morita, K.; Ohta, R.; Yahata, K.; Arisawa, M.; Fujioka, H.
    • Organizer
      18th Tetrahedron Symposium - Asia Edition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design and Synthesis of (+)-Hypusine Analogue to Obtain its RNA Aptamers2017

    • Author(s)
      Ohta, R.; Oguro, A.; Nishimura, K.; Fujioka, H.; Arisawa, M.
    • Organizer
      18th Tetrahedron Symposium - Asia Edition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 機能性分子合成を指向した有機金属触媒並びにワンポット反応の開発2017

    • Author(s)
      Arisawa, M.
    • Organizer
      明治薬科大学若手研究者講話会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 機能性分子合成を指向した有機金属触媒並びにワンポット反応の開発2017

    • Author(s)
      Arisawa, M.
    • Organizer
      日本薬学会東海支部特別講演会
    • Place of Presentation
      岐阜
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Aplysiallene の新規合成法の開発とNa+/K+ ATPase 阻害活性研究2016

    • Author(s)
      Yoshikawa, Y.; Yamakawa, M.; Kobayashi, T.; Suzuki, K.; Okino, Y.; Arisawa, M.; Fujioka, H.
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] (+)-Laurenidificin の全合成と構造決定2016

    • Author(s)
      Yoshikawa, Y.; Yamakawa, M.; Kobayashi, T.; Arisawa, M.; Fujioka, H.
    • Organizer
      第42回反応と合成の進歩シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 芳香族エナミドの 1,6 -エニン環化異性化反応を用いた多置換インドール合成法の開発2016

    • Author(s)
      Takamoto, K.; Hyogo, N.; Ohno, S.; Fujioka, H.; Arisawa, M.
    • Organizer
      第42回反応と合成の進歩シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Palladium Nanoparticle-Catalyzed Carbon(sp<sup>2<sup> and sp<sup>3<sup>)-Hydrogen Bond Functionalizations2016

    • Author(s)
      Takagi, K.; Al-Amin, M.; Hoshiya, N.; Sugimoto, H.; Shiro, Y.; Tobisu, M.; Chatani, N.; Shuto, S.; Arisawa, M.
    • Organizer
      International Symposium on C-O Activation (ISCO-2016)
    • Place of Presentation
      Himeji,Japan
    • Year and Date
      2016-10-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エノン存在下α,β不飽和エステル選択的変換法の開発と環状エーテル合成への応用2016

    • Author(s)
      Morita, K.; Ohta, R.; Aoyama, H.; Arisawa, M.; Fujioka, H.
    • Organizer
      第46回 複素環化学討論会
    • Place of Presentation
      金沢
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] ルテニウムナノ粒子触媒を用いたリガンドフリー鈴木-宮浦反応の開発2016

    • Author(s)
      Akiyama, T.; Honma, T.; Fujioka, H.; Sato, Y.; Arisawa, M.
    • Organizer
      第46回 複素環化学討論会
    • Place of Presentation
      金沢
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] ルテニウムヒドリド触媒を用いたエノールエーテ ルの 1,6-エイン環化異性化反応の開発2016

    • Author(s)
      Ohno, S.; Takamoto, K.; Fujioka, H.; Arisawa, M.
    • Organizer
      第 63 回 有機金属化学討論会
    • Place of Presentation
      東京
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] ノンメタセシス反応を利用したアザビシクロ[3.1.1]ヘプテンの合成;ルテニウム触媒を用いたアレナ ミドーエンの分子内[2+2]環化付加反応2016

    • Author(s)
      Ii, Y.; Yoneshige, Y.; Nada, T.; Matsumoto, T.; Fujioka, H.; Shuto, S.; Arisawa, M.
    • Organizer
      第 63 回 有機金属化学討論会
    • Place of Presentation
      東京
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthesis of novel polycyclic nitrogen-containing compounds via ruthenium-catalyzed one-pot metathesis / non-metathesis reaction2016

    • Author(s)
      Fujii, Y.; Yamashita, K.; Yoshioka, S.; Shuto, S.; Fujioka, H.; Arisawa, M.
    • Organizer
      27th International Conference on Organometallic Chemistry (ICOMC 2016)
    • Place of Presentation
      Melbourne,Australia
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nickel-Catalyzed Hydrocarboxylation of Alkynes and Styrenes Using Sulfur-Modified Au-Supported Nickel Nanoparticles Catalyst2016

    • Author(s)
      Taniguchi, T.; Saito, N.; Hoshiya, N.; Fujiki, K.; Shuto, S.; Fujioka, H.; Arisawa M.; Sato, Y.
    • Organizer
      27th International Conference on Organometallic Chemistry (ICOMC 2016)
    • Place of Presentation
      Melbourne,Australia
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non-metathesis heterocycle formation by ruthenium-catalyzed intramolecular [2+2] cycloaddition of allenamide-enes to azabicyclo[3.1.1]heptanes2016

    • Author(s)
      Arisawa, M.; Yoneshige, Y.; Nada, T.; Shuto, S.; Fujioka, H.
    • Organizer
      27th International Conference on Organometallic Chemistry (ICOMC 2016)
    • Place of Presentation
      Melbourne,Australia
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ruthenium-Catalyzed 1,6-Enyne Cycloisomerization of Phenyl Enol Ether: Synthesis of 2,3-Disubstituted Benzo[b]furans2016

    • Author(s)
      Ohno, S.; Takamoto, K.; Fujioka, H.; Arisawa, M.
    • Organizer
      The 20th International Symposium on Homogeneous Catalysis (ISHC XX)
    • Place of Presentation
      Kyoto,Japan
    • Year and Date
      2016-07-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non-Metathesis Heterocycle Formation by Ruthenium-Catalyzed Intramolecular [2+2] Cycloaddition of Allenamide-enes to Azabicyclo[3.1.1]heptanes2016

    • Author(s)
      Arisawa, M.; Yoneshige, Y.; Nada, T.; Ii, Y.; Shuto, S.; Fujioka, H.
    • Organizer
      The 20th International Symposium on Homogeneous Catalysis (ISHC XX)
    • Place of Presentation
      Kyoto,Japan
    • Year and Date
      2016-07-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 硫黄修飾金担持型ニッケル触媒SANiの開発と二酸化炭素固定化反応への利用2016

    • Author(s)
      Taniguchi, T.; Saito, N.; Hoshiya, N.; Fujiki, K.; Shuto, S.; Fujioka, H.; Arisawa, M.; Sato, Y.
    • Organizer
      第14回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] メタセシス/ノンメタセシス連続反応の開発とそれを用いた新規多環式含窒素ヘテロ環化合物の合成及び機能解析2016

    • Author(s)
      Fujii, Y.; Yamashita, K.; Yoshioka, S.; Fujioka, H.; Shuto, S.; Arisawa, M.
    • Organizer
      第14回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthetic Study of Laurenidificin2016

    • Author(s)
      Yoshikawa,Y.; Yamakawa, M.; Kobayashi, T.;Arisawa, M.; Fujioka, H.
    • Organizer
      Molecular Chirality Asia 2016
    • Place of Presentation
      Osaka,Japan
    • Year and Date
      2016-04-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] GABAトランスポーターサブタイプ特異的な新規阻害薬候補化合物の薬理活性評価2016

    • Author(s)
      佐藤孝行,井川ありさ,圓山智嘉史,末政亮大,小林嵩明,有澤光弘,井手聡一郎,周東智,南雅文
    • Organizer
      日本薬学会136年会
    • Place of Presentation
      神奈川県、横浜市(パシフィコ横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] エインメタセシス/Diels-Alder/酸化の3連続ワンポット反応を用いた新規含ケイ素多環式化合物の合成2016

    • Author(s)
      吉岡祥平,藤居由基,藤岡弘道,有澤光弘
    • Organizer
      日本薬学会136年会
    • Place of Presentation
      神奈川県、横浜市(パシフィコ横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Microwaveとガラス担持型 Pdナノ粒子触媒を用いたブロモベンゼンの鈴木-宮浦カップリング反応の開発2016

    • Author(s)
      Mincen Xiao,藤岡弘道,有澤光弘
    • Organizer
      日本薬学会136年会
    • Place of Presentation
      神奈川県、横浜市(パシフィコ横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 硫黄修飾金担持型ルテニウム触媒を用いたリガンドフリー鈴木-宮浦反応の開発2016

    • Author(s)
      秋山敏毅,藤岡弘道,佐藤美洋,有澤光弘
    • Organizer
      日本薬学会136年会
    • Place of Presentation
      神奈川県、横浜市(パシフィコ横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Syntheses of orthoquinone containing aromatic compounds and their redox chromism2016

    • Author(s)
      URAKAWA, Kazuki; SUMIMOTO, Michinori; ARISAWA, Mitsuhiro; MATSUDA, Masaki; ISHIKAWA, Hayato
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      京都府、京田辺市(同志社大学)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of Sulfur-Modified Au-Supported Nickel Catalyst (SANi) and Its Application to Catalytic Carboxylation of Multiple Bonds2016

    • Author(s)
      TANIGUCHI, Takahisa; SAITO, Nozomi; HOSHIYA, Naoyuki; FUJIKI, Katsumasa; SHUTO, Satoshi; FUJIOKA, Hiromichi; ARISAWA, Mitsuhiro; SATO, Yoshihiro
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      京都府、京田辺市(同志社大学)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 機能性分子合成を指向した有機金属触媒並びにワンポット反応の開発2016

    • Author(s)
      Arisawa, M.
    • Organizer
      熊本大学大学院自然科学研究科特別講演会
    • Place of Presentation
      熊本
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 硫黄修飾金担持型ルテニウムナノ粒子触媒の開発とリガンドフリー鈴木-宮浦反応への応用2016

    • Author(s)
      Akiyama, T.; Honma, T.; Fujioka, H.; Sato, Y.; Arisawa, M.
    • Organizer
      第36回有機合成若手セミナー「明日の有機合成を担う人のために」
    • Place of Presentation
      京都
    • Related Report
      2016 Annual Research Report
  • [Presentation] ケトホスホニウム塩形成を利用したエノン存在下でのα,βー不飽和エステルのオレフィン部位選択的変換法の開発2016

    • Author(s)
      Morita, K.; Ohta, R.; Aoyama, H.; Arisawa, M.; Fujioka, H.
    • Organizer
      第36回有機合成若手セミナー「明日の有機合成を担う人のために」
    • Place of Presentation
      京都
    • Related Report
      2016 Annual Research Report
  • [Presentation] β 位置換様式の異なるエノン間の識別的変換反応の開発とその応用2016

    • Author(s)
      Morita, K.; Ohta, R.; Watanabe, K.; Aoyama, H.; Arisawa, M.; Fujioka, H.
    • Organizer
      第66回 日本薬学会近畿支部総会・大会
    • Place of Presentation
      高槻
    • Related Report
      2016 Annual Research Report
  • [Presentation] 置換オキシインドール及び置換 3,4-ジヒドロキノリノンの合成2016

    • Author(s)
      Miyata, K.; Xiao, M.; Fujioka, H.; Arisawa, M.
    • Organizer
      第66回 日本薬学会近畿支部総会・大会
    • Place of Presentation
      高槻
    • Related Report
      2016 Annual Research Report
  • [Presentation] 芳香族エナミドを用いる多置換インドール合成法の開発2016

    • Author(s)
      Takamoto, K.; Hyogo, N.; Ohno, S.; Fujioka, H.; Arisawa, M.
    • Organizer
      第66回 日本薬学会近畿支部総会・大会
    • Place of Presentation
      高槻
    • Related Report
      2016 Annual Research Report
  • [Presentation] (-)-Aplysiallene およびその誘導体合成とNa+/K+ ATPase 阻害活性研究2015

    • Author(s)
      山川真希,吉川祐介,鈴木邦明,沖野雄一郎,有澤光弘,藤岡弘道
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉県、千葉市(幕張国際研修センター)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] A One-Pot Olefin Isomerization / Aliphatic Enamine Ring-Closing Metathesis (RCM) / Oxidation / 1,3-Dipolar Cycloaddition for the Synthesis of Isoindolo[1,2-a] isoquinolines2015

    • Author(s)
      Yuki Fujii, Hiromichi Fujioka, Satoshi Shuto, Mitsuhiro Arisawa
    • Organizer
      第13回国際有機化学京都会議:IKCOC-13
    • Place of Presentation
      京都府、京都市(リーガロイヤルホテル京都)
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pd(II)-Catalyzed Directing Group-Mediated Arylation and Alkylation of Tertiary C(sp3)-H Bond on Chiral Cyclopropanes2015

    • Author(s)
      Naoyuki Hoshiya, Kei Takenaka, Mitsuhiro Arisawa, Satoshi Shuto, Jun’ichi Uenishi
    • Organizer
      第13回国際有機化学京都会議:IKCOC-13
    • Place of Presentation
      京都府、京都市(リーガロイヤルホテル京都)
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sulfur-Modified Au-Supported Nickel Nanoparticles Catalyst (SANi)-Catalyzed Hydrocarboxylation of Alkynes2015

    • Author(s)
      Takahisa Taniguchi, Nozomi Saito, Naoyuki Hoshiya, Katsumasa Fujiki, Satoshi Shuto, Hiromichi Fujioka, Mitsuhiro Arisawa, Yoshihiro Sato
    • Organizer
      第13回国際有機化学京都会議:IKCOC-13
    • Place of Presentation
      京都府、京都市(リーガロイヤルホテル京都)
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ru-Catalyzed 1,6-Enyne Cycloisomerization of Aromatic Enamide, New Strategy toward 2,3Disubstituted Indole2015

    • Author(s)
      Kohei Takamoto, Norimichi Hyogo, Hiromichi Fujioka, Mitsuhiro Arisawa
    • Organizer
      第13回国際有機化学京都会議:IKCOC-13
    • Place of Presentation
      京都府、京都市(リーガロイヤルホテル京都)
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 1,6-エイン環化異性化反応を用いた2,3-二置換インドール合成法の開発2015

    • Author(s)
      高本康平、兵後訓道、大野祥平、藤岡弘道、有澤光弘
    • Organizer
      第108回有機合成シンポジウム
    • Place of Presentation
      東京都、新宿区(早稲田大学)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] エインメタセシス/異性化/Diels-Alderワンポット反応を用いた新規含窒素多環式化合物の合成とその機能解析2015

    • Author(s)
      山下航平,藤居由基,吉岡祥平,藤岡弘道,有澤光弘
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      大阪府、東大阪市(近畿大学)
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生体内ポリアミン標的RNAアプタマーの取得に向けたハイプシン誘導体の合成2015

    • Author(s)
      太田礼伊也,阿部敬介,小黒明広,西村和洋,有澤光弘,藤岡弘道
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      大阪府、東大阪市(近畿大学)
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] エノールエーテルの 1,6-エイン環化異性化反応の開発 2,3-二置換ベンゾフランの新規合成法2015

    • Author(s)
      大野祥平、高本康平、藤岡弘道、有澤光弘
    • Organizer
      第65回 日本薬学会近畿支部総会
    • Place of Presentation
      大阪府、富田林市(大阪大谷大学)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Grubbs触媒を用いたN-アレニル -o-ビニルアニリン誘導体の分子内[2+2]環化反応新規含窒素複素環骨格アザビシクロ [3.1.1]ヘプタン骨格の構築とその化学変換2015

    • Author(s)
      米重勇祐、名田智美、周東智、藤岡弘道、有澤光弘
    • Organizer
      第65回 日本薬学会近畿支部総会
    • Place of Presentation
      大阪府、富田林市(大阪大谷大学)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] ルテニウムヒドリドを用いた複素環化合物の合成2015

    • Author(s)
      有澤光弘、高本康平、大野祥平、兵後訓道、藤岡弘道
    • Organizer
      平成27年度有機合成化学北陸セミナー
    • Place of Presentation
      富山県、富山市(富山観光ホテル)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 硫黄修飾された金担持型ニッケルナノパーティクルの開発とその有機合成への応用2015

    • Author(s)
      星谷尚亨・藤木勝将・谷口敬寿・周東智・藤岡弘道・齋藤望・佐藤美洋・ 有澤光弘
    • Organizer
      第62回有機金属化学討論会
    • Place of Presentation
      大阪府、吹田市(関西大学)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規オレフィン異性化 /エナミン閉環メタセシス (RCM)/1,3-双極子付加環化ワンポット反応の開発とそれを用いたイソインドロ[1,2-a]イソキノリンの合成2015

    • Author(s)
      藤居由基・嵩原綱吉・鈴木健之・藤岡弘道・周東智・有澤光弘
    • Organizer
      第62回有機金属化学討論会
    • Place of Presentation
      大阪府、吹田市(関西大学)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 1,6-Cycloisomerization to give 2,3-disubstituted indole catalyzed by ruthenium hydride with N- heterocyclic carbene ligand2015

    • Author(s)
      Kohei, Takamoto, Norimichi Hyogo, Hiromichi Fujioka, Mitsuhiro Arisawa
    • Organizer
      第250回アメリカ化学会 ACS National Meeting & Exposition
    • Place of Presentation
      アメリカ合衆国、ボストン
    • Year and Date
      2015-08-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of One-pot Ring-closing(RCM)/ 1,3-Dipolar Reaction Using Ruthenium Carbene Catalysts and Its Application to the Synthesis of Novel Polycyclic Heterocycle2015

    • Author(s)
      Yuki Fujii, Hiromichi Fujioka, Satoshi Shuto, and Mitsuhiro Arisawa
    • Organizer
      21st International Symposium on Olefin Metathesis and RelatedChemistry (ISOM XXI)
    • Place of Presentation
      オーストリア、グラーツ
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of enyne metathesis / isomerization / Diels-Alder one-pot reaction for novel NIR dye2015

    • Author(s)
      Kohei Yamashita, Hiroshi Aoyama, Hiromichi Fujioka, and Mitsuhiro Arisawa
    • Organizer
      21st International Symposium on Olefin Metathesis and RelatedChemistry (ISOM XXI)
    • Place of Presentation
      オーストリア、グラーツ
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nickel-Catalyzed Carboxylation of Alkynes Using Sulfur-Modified Au-Supported Nickel Nanoparticles Catalyst (SANi)2015

    • Author(s)
      Takahisa Taniguchi, Nozomi Saito, Naoyuki Hoshiya, Katsumasa Fujiki, Satoshi Shuto, Tetsuo Honma, Hiromichi Fujioka, Mitsuhiro Arisawa and Yoshihiro Sato
    • Organizer
      18th IUPAC International Symposium on Organometallic ChemistryDirected Towards Organic Synthesis (OMCOS 18)
    • Place of Presentation
      スペイン、バルセロナ
    • Year and Date
      2015-06-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ハイプシン結合RNAアプタマー取得を目的とするハイプシン誘導体の設計と合成2015

    • Author(s)
      阿部 敬介, 小黒 明広, 西村 和洋, 市川 哲也, 藤岡 弘道, 有澤 光弘
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(神戸市)
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 硫黄修飾金担持型ニッケル触媒の開発とアルキンへの二酸化炭素固定化反応の利用2015

    • Author(s)
      谷口 敬寿, 齋藤 望, 星谷 尚亨, 周東 智, 本間 徹生, 藤岡 弘道, 有澤 光弘, 佐藤美洋
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(神戸市)
    • Year and Date
      2015-03-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 硫黄修飾金担持型ニッケル触媒を用いたリガンドフリークロスカップリング反応の開発2015

    • Author(s)
      藤木 勝将, 星谷 尚亨, 谷口 敬寿, 周東 智, 藤岡 弘道, 斎藤 望, 佐藤 美洋, 有澤光弘
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(神戸市)
    • Year and Date
      2015-03-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] エインメタセシス/異性化/Diels-Alder ワンポット反応の開発2015

    • Author(s)
      山下 航平, 藤岡 弘道, 有澤 光弘
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(神戸市)
    • Year and Date
      2015-03-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pd および Ni 触媒によるシクロプロパン第三級炭素上への芳香環導入反応 ―効率的化学空間探索型創薬ライブラリーの構築を目指して―2014

    • Author(s)
      星谷尚亨,四辻慶佑,小林嵩明,福田 隼,阿部 洋,有澤光弘,周東 智
    • Organizer
      第40回反応と合成の進歩シンポジウム
    • Place of Presentation
      東北大学萩ホール(仙台市)
    • Year and Date
      2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pd ナノ粒子触媒 SAPd を用いたアリルエステルの脱アリル化反応の開発2014

    • Author(s)
      高木耕治,福田 隼,阿部 洋,周東 智,大高 章,有澤光弘
    • Organizer
      第40回反応と合成の進歩シンポジウム
    • Place of Presentation
      東北大学萩ホール(仙台市)
    • Year and Date
      2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ligand-free Suzuki-Miyaura Coupling with Sulfur-modified Gold-supported Palladium in the Synthesis of a Conformationally-Restricted Cyclopropane Compound Library with Three-Dimensional Diversity2014

    • Author(s)
      Mitsuhiro Arisawa, Takatoshi Sato, Naoyuki Hoshiya, Mohammad Al-Amin, Yuji Kogami and Satoshi Shuto
    • Organizer
      The 2nd International Conference on Organometallics and Catalysis
    • Place of Presentation
      Todaiji Temple Cultural Center(奈良市)
    • Year and Date
      2014-10-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 有機金属触媒を用いた機能性分子の創製2014

    • Author(s)
      有澤光弘
    • Organizer
      名城大学特別講演会
    • Place of Presentation
      名城大学(名古屋市)
    • Year and Date
      2014-10-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 硫黄修飾ガラス担持型パラジウムの開発:リガンドフリーBuchwald-Hartwig 反応2014

    • Author(s)
      XiaoMincen、星谷尚亨、周東 智、藤岡弘道、 有澤光弘
    • Organizer
      第64回 日本薬学会近畿支部総会・大会
    • Place of Presentation
      京都薬科大学(京都市)
    • Year and Date
      2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ring-closing metathesis (RCM)/1,3-dipolar cycloaddition for the synthesis of isoindolo[2,1-a]quinolone structure dye2014

    • Author(s)
      Mitsuhiro Arisawa
    • Organizer
      ETH Zürich – Osaka University Joint-symposium
    • Place of Presentation
      大阪大学基礎工学部Σホール(豊中市)
    • Year and Date
      2014-10-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 硫黄修飾ガラス担持型パラジウムの開発:リガン ドフリーBuchwald-Hartwig 反応2014

    • Author(s)
      肖 玟岑・星谷 尚亨・周東 智・藤岡 弘 道・有澤 光弘
    • Organizer
      第61回有機金属化学討論会
    • Place of Presentation
      九州大学病院キャンパス 医学部 百年講堂(福岡市)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Grubbs 触媒を用いたアレンーエンの分子内[2+2]環 化反応:アザビシクロ[3.1.1]ヘプタン骨格の合成2014

    • Author(s)
      米重 勇祐・名田 智美・周東 智・ 藤岡 弘道・有澤 光弘
    • Organizer
      第61回有機金属化学討論会
    • Place of Presentation
      九州大学病院キャンパス 医学部 百年講堂(福岡市)
    • Year and Date
      2014-09-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] ルテニウムカルベン錯体を用いたワンポット反応の開発と新規多環性複素環骨格の構築2014

    • Author(s)
      藤居 由基 ・加藤 宏茂・福田 隼・阿部 洋 ・藤岡 弘道 ・周東 智 ・有澤 光弘
    • Organizer
      第 44 回 複素環化学討論会
    • Place of Presentation
      札幌市民ホール(札幌市)
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 硫黄修飾金に担持した有機合成用金属ナノ粒子触媒の開発2014

    • Author(s)
      有澤光弘
    • Organizer
      第11回Spring-8産業利用報告会
    • Place of Presentation
      姫路商工会議所(姫路市)
    • Year and Date
      2014-09-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 硫黄修飾金に担持したニッ ケルナノ粒子触媒の開発2014

    • Author(s)
      藤木勝将、星谷尚之、谷口敬寿、 藤岡弘道、周東智、齋藤望、佐藤美洋、有澤光弘
    • Organizer
      第34回有機合成若手セミナー「明日の有機合成を担う人のために」
    • Place of Presentation
      大阪大学会館(豊中市)
    • Year and Date
      2014-08-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] One-Pot Ring-Closing Metathesis (RCM)/1,3-Dipolar Cycloaddition by an Assisted Tandem Ruthenium Catalysis for the Synthesis of an Isoindolo[2,1-a]quinoline Structure Dye2014

    • Author(s)
      Mitsuhiro Arisawa, Yuki Fujii, Hiroshige Kato, Hayato Fukuda, Hiroshi Abe, Hiromichi Fujioka, Satoshi Shuto
    • Organizer
      XXVI International Conference on Organometallic Chemistry (ICOMC 2014)
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Year and Date
      2014-07-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] レゾルビンE2の安定化を指向した構造活性相関研究2014

    • Author(s)
      高倉 夕季 福田 隼 石村 航平 田辺 真人 有澤 光弘 周東 智
    • Organizer
      日本薬学会北海道支部 第141回例会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Book] 天然有機分子の構築2018

    • Author(s)
      日本化学会、中川 昌子、有澤 光弘
    • Total Pages
      148
    • Publisher
      共立出版
    • ISBN
      9784320044678
    • Related Report
      2018 Annual Research Report
  • [Book] ヘテロ環の化学: 基礎と応用2016

    • Author(s)
      Nakagawa, M.; Arisawa, M.
    • Total Pages
      256
    • Publisher
      東京化学同人
    • Related Report
      2016 Annual Research Report
  • [Book] ヘテロ環の化学:基礎と応用2016

    • Author(s)
      中川昌子、有澤光弘
    • Total Pages
      256
    • Publisher
      東京化学同人
    • Related Report
      2015 Annual Research Report
  • [Remarks] 大阪大学・大学院薬学研究科 分子合成化学分野

    • URL

      http://gosei.sakura.ne.jp/gosei/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 大阪大学大学院薬学研究科分子合成化学分野

    • URL

      http://gosei.sakura.ne.jp/gosei/

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] Composite containing catalytic metal nanoparticles, and use for same2016

    • Inventor(s)
      Arisawa,M.;Shuto,S.;Hoshiya,N.
    • Industrial Property Rights Holder
      Arisawa,M.;Shuto,S.;Hoshiya,N.
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-06-09
    • Acquisition Date
      2016-12-22
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2022-02-01  

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