Development of metal nano particle catalysis toward functional molecular synthesis
Project/Area Number |
26288051
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Synthetic chemistry
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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Keywords | 有機化学 / 薬学 / ナノ材料 / 環境技術 / 合成化学 |
Outline of Final Research Achievements |
The structural analysis of the palladium nanoparticle catalyst SAPdNp developed by the research representatives succeeded, and it turned out that the excellent function of SAPdNp is structurally rational. We also succeeded in developing novel nickel nanoparticle catalysts such as SANiNp as rare element reduction type and alternative type organometallic catalysts. Furthermore, we succeeded in developing a microwave device suitable for metal nanoparticle catalyst. As a result of these research results, we succeeded in finding ligand-free Suzuki-Miyaura coupling of aryl chloride using metal nanoparticle catalyst and continuous irradiation microwave device.
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Academic Significance and Societal Importance of the Research Achievements |
従来の触媒に比べ、金属ナノパーティクル(Np)は表面積が広く、より高活性であることから、より温和な環境調和的条件で反応が進行する特徴を有している。一方、研究代表者らが開発した硫黄修飾金担持型パラジウムナノ粒子触媒SAPdNpは各種カップリング反応などにリガンドフリーで機能する新触媒であり、産業界でも使用されているが、SAPdNpの構造が不明であることから、より活性の高い触媒や、別の金属ナノ粒子触媒の開発が困難な状況であった。今回、本触媒の構造解析に成功し、新規ニッケルNp触媒SANiNpなどの開発に成功した点で学術的意義がある。また、マイクロウエーブ装置の開発にも成功した点で社会的意義がある。
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Report
(6 results)
Research Products
(129 results)
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[Journal Article] Highly Discriminative and Chemoselective Deprotection/Transformations of Acetals with the Combination of Trialkylsilyl Triflate/2,4,6-Collidine2018
Author(s)
Reiya Ohta, Nao Matsumoto, Yoshifumi Ueyama, Yuichi Kuboki, Hiroshi Aoyama, Kenichi Murai, Mitsuhiro Arisawa, Tomohiro Maegawa, Hiromichi Fujioka
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Journal Title
JOURNAL OF ORGANIC CHEMISTRY
Volume: 83
Issue: 12
Pages: 6432-6443
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Reusable Immobilized Iron(II) Nanoparticle Pre-Catalysts for Ligand-Free Kumada Coupling2018
Author(s)
Toshiki Akiyama, Yuki Wada, Kellie Jenkinson, Tetsuo Honma, Kazuki Tsuruta, Yusuke Tamenori, Hitoshi Haneoka, Tsunayoshi Takehara, Takeyuki Suzuki, Kenichi Murai, Hiromichi Fujioka, Yoshihiro Sato, Andrew E. H. Wheatley, Mitsuhiro Arisawa
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Journal Title
Acs Applied Nano Materials
Volume: 1
Issue: 12
Pages: 6950-6958
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Design and Synthesis of Cyclopropane Congeners of Resolvin E2, an Endogenous Proresolving Lipid Mediator, as Its Stable Equivalents2016
Author(s)
Fukuda, H; Muromoto, R.; Takakura, Y.; Ishimura, K.; Kanada, R.; Fushihara, D.; Tanabe, M.; Matsubara, K.; Hirao, T.; Hirashima, K.; Abe, Arisawa, M.; Matsuda, T.; Shuto, S.
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Journal Title
Org. Lett.
Volume: 18
Issue: 24
Pages: 6224-6227
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Design, Synthesis, and Identification of 4α-azidoethyl-Cyclic ADP-Carbocyclic-Ribose as a Highly Potent Analogue of Cyclic ADP-Ribose a Ca2+-mobilizing Second Messenger2016
Author(s)
Sato, T.; Watanabe, M.; Tsuzuki, T.; Takano, S.; Murayama, T.; Sakurai, T.; Kameda, T.; Arisawa, M.; Fukuda, H.; Shuto, S.
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Journal Title
J. Med. Chem.
Volume: 59
Issue: 15
Pages: 7282-7286
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Self-assembled Multi-layer Stabilized Nickel Nanoparticle Catalyst for Ligand-free Cross-coupling Reactions: in situ Metal Nanoparticle and Nanospace Simultaneous Organization2016
Author(s)
Naoyuki Hoshiya, Katsumasa Fujiki, Takahisa Taniguchi, Tetsuo Honma, Yusuke Tamenori, Mincen Xiao, Nozomi Saito, Mami Yokoyama, Akira Ishii, Hiromichi Fujioka, Satoshi Shuto, Yoshihiro Sato, Mitsuhiro Arisawa
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Journal Title
Adv. Synth. Catal.
Volume: 358
Issue: 15
Pages: 2449-2459
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton- Sensing GPR4 in Extracellular Acidification-Induced Responses2015
Author(s)
Ayaka Tobo, Masayuki Tobo, Takashi Nakakura, Masashi Ebara, Hideaki Tomura, Chihiro Mogi, Dong-Soon Im, Naoya Murata, Atsushi Kuwabara, Saki Ito, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto, Michio Nakaya, Hitoshi Kurose, Koichi Sato, Fumikazu Okajima
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Journal Title
PLoS One.
Volume: 10
Issue: 6
Pages: e0129334-e0129334
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Formation of self-assembled multi-layer stable palladium nanoparticles for ligand-free coupling reactions2015
Author(s)
Mitsuhiro Arisawa, Mohammad Al-Amin, Tetsuo Honma, Yusuke Tamenori, Satoshi Arai, Naoyuki Hoshiya, Takatoshi Sato, Mami Yokoyama, Akira Ishii, Masaki Takeguchi, Tsuyoshi Miyazaki, Masashi Takeuchi, Tomohiro Maruko, Satoshi Shuto
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Journal Title
RSC Adv.
Volume: 5
Issue: 1
Pages: 676-683
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Palladium-Nanoparticle-Catalyzed 1,7-Palladium Migration Involving C-H Activation, Followed by Intramolecular Amination: Regioselective Synthesis of N1-Arylbenzotriazoles and an Evaluation of Their Inhibitory Activity Towards Indoleamine 2,3-Dioxygenase2014
Author(s)
Koji Takagi, Mohammad Al-Amin, Naoyuki Hoshiya, Johan Wouters, Hiroshi Sugimoto, Yoshitsugu Shiro, Hayato Fukuda, Satoshi Shuto, Mitsuhiro Arisawa
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Journal Title
J. Org. Chem.
Volume: 79
Issue: 13
Pages: 6366-6371
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Recyclable, Low-Leaching, and Ligand-Free Suzuki?Miyaura Coupling Using Ruthenium(0) Nanoparticles2017
Author(s)
Akiyama,T.; Taniguchi, T.; Honma, T.; Tamenori, Y.; Fujioka, H.; Sato, Y.; Arisawa, M.
Organizer
19th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis, OMCOS 19
Related Report
Int'l Joint Research
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[Presentation] Palladium Nanoparticle-Catalyzed Carbon(sp<sup>2<sup> and sp<sup>3<sup>)-Hydrogen Bond Functionalizations2016
Author(s)
Takagi, K.; Al-Amin, M.; Hoshiya, N.; Sugimoto, H.; Shiro, Y.; Tobisu, M.; Chatani, N.; Shuto, S.; Arisawa, M.
Organizer
International Symposium on C-O Activation (ISCO-2016)
Place of Presentation
Himeji,Japan
Year and Date
2016-10-25
Related Report
Int'l Joint Research
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[Presentation] Synthetic Study of Laurenidificin2016
Author(s)
Yoshikawa,Y.; Yamakawa, M.; Kobayashi, T.;Arisawa, M.; Fujioka, H.
Organizer
Molecular Chirality Asia 2016
Place of Presentation
Osaka,Japan
Year and Date
2016-04-20
Related Report
Int'l Joint Research
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[Book] 天然有機分子の構築2018
Author(s)
日本化学会、中川 昌子、有澤 光弘
Total Pages
148
Publisher
共立出版
ISBN
9784320044678
Related Report
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