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Creation of Material Transformation Systems Based on Macromolecular Recognition

Research Project

Project/Area Number 26288061
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Polymer chemistry
Research InstitutionOsaka University

Principal Investigator

Hashidzume Akihito  大阪大学, 理学(系)研究科(研究院), 教授 (70294147)

Co-Investigator(Kenkyū-buntansha) 佐藤 尚弘  大阪大学, 理学(系)研究科(研究院), 教授 (10196248)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords高分子認識 / 物質変換システム / 結合形成反応 / ホルモース反応 / 逆ミセル / ボロン酸化合物 / 銅(I)アジド-アルキン環化付加 / 3-アジド-1-プロピン / 銅(I)触媒アジドアルキン環化付加 / スルホン酸ポリマー / ボロン酸ポリマー / 両親媒性高分子 / 銅触媒アジドアルキン環化付加 / 多分岐高分子 / 両親媒性高分子自己組織体 / 重合
Outline of Final Research Achievements

Chemical reactions in biological systems exhibit high efficiency and selectivity based on molecular recognition of macromolecules and molecular assemblies. Using molecular recognition of macromolecules and molecular assemblies, we have carried out bond forming reactions, i.e., formose reaction and copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). Aiming at control of formose reaction, i.e., the formation of monosaccharides from formaldehyde, we have utilized reverse micelles, boronic acid compounds, and microwave irradiation. All the cases have indicated selective formation of products. In order to realize selective CuAAC polymerization based on macromolecular recognition, we have also prepared soluble oligomers from insoluble 1-azide-3-propyne oligomers.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (50 results)

All 2017 2016 2015 2014 Other

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 5 results,  Acknowledgement Compliant: 6 results) Presentation (31 results) (of which Int'l Joint Research: 9 results,  Invited: 6 results) Book (5 results) Remarks (4 results)

  • [Journal Article] Formose Reaction Accelerated in Aerosol-OT Reverse Micelles2016

    • Author(s)
      Makoto Masaoka, Tomohiro Michitaka, and Akihito Hashidzume
    • Journal Title

      Beilstein Journal of Organic Chemistry

      Volume: 12 Pages: 2663-2667

    • DOI

      10.3762/bjoc.12.262

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Formose reaction controlled by boronic acid compounds2016

    • Author(s)
      Toru Imai, Tomohiro Michitaka, and Akihito Hashidzume
    • Journal Title

      Beilstein Journal of Organic Chemistry

      Volume: 12 Pages: 2668-2672

    • DOI

      10.3762/bjoc.12.263

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Macroscopic Self-assembly Based on Complementary Interaction between Nucleobase Pairs2015

    • Author(s)
      M. Nakahata, Y. Takashima, A. Hashidzume and A. Harada
    • Journal Title

      Chemistry – A European Journal

      Volume: 21 Issue: 7 Pages: 2770-2774

    • DOI

      10.1002/chem.201404674

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Water-Induced Formation of Reverse Micelles from Diblock Copolymer of Styrene and N-Isopropylacrylamide in 1,2-Dichloroethane2015

    • Author(s)
      Arai, T.; Hashidzume, A.; Sato, T.
    • Journal Title

      Macromolecules

      Volume: 48 Issue: 12 Pages: 4055-4062

    • DOI

      10.1021/acs.macromol.5b00480

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Quarternization of 3-Azido-1-propyne Oligomer Obtained by Copper(I)-Catalyzed Azide-Alkyne Cycloaddition Polymerization2015

    • Author(s)
      Shun Nakano, Akihito Hashidzume, and Takahiro Sato
    • Journal Title

      Beilstein J. Org. Chem.

      Volume: 11 Pages: 1037-1042

    • DOI

      10.3762/bjoc.11.116

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Light-Controlled Release System Based on Molecular Recognition of Cyclodextrins2015

    • Author(s)
      Lee, I. E. T.; Hashidzume, A.; Harada, A.
    • Journal Title

      Macromol. Rapid Commun.

      Volume: 36 Issue: 23 Pages: 2055-2059

    • DOI

      10.1002/marc.201500389

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Manual Control of Catalytic Reactions: Reactions by an Apoenzyme Gel and a Cofactor Gel2015

    • Author(s)
      Kobayashi, Y,: Takashima, Y.; Hashidzume, A.; Yamaguchi, H.; Harada, A.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 16254-16254

    • DOI

      10.1038/srep16254

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Formation of Redox-Responsive Supramolecular Polymeric Materials Based on Host-Guest Interaction at Polymer Side Chain2015

    • Author(s)
      中畑雅樹、高島義徳、橋爪章仁、山口浩靖、原田明
    • Journal Title

      KOBUNSHI RONBUNSHU

      Volume: 72 Issue: 10 Pages: 573-581

    • DOI

      10.1295/koron.2015-0019

    • NAID

      130005104171

    • ISSN
      0386-2186, 1881-5685
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Adhesion Using the Covalent Bond Formation Reaction at the Soft Material Interface2015

    • Author(s)
      関根智子、高島義徳、橋爪章仁、山口浩靖、原田明
    • Journal Title

      KOBUNSHI RONBUNSHU

      Volume: 72 Issue: 10 Pages: 590-596

    • DOI

      10.1295/koron.2015-0040

    • NAID

      130005104178

    • ISSN
      0386-2186, 1881-5685
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase Behavior of Aqueous Solutions of Fumaramide/<i>N</i>-Isopropylacrylamide Copolymers2014

    • Author(s)
      石井直子, 松元亜紀子, 橋爪章仁, 佐藤尚弘
    • Journal Title

      KOBUNSHI RONBUNSHU

      Volume: 71 Issue: 8 Pages: 361-366

    • DOI

      10.1295/koron.71.361

    • NAID

      130004678797

    • ISSN
      0386-2186, 1881-5685
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高分子認識における「高分子らしさ」とは?2017

    • Author(s)
      橋爪章仁
    • Organizer
      高分子学会九州支部フォーラム
    • Place of Presentation
      福岡大学(福岡)
    • Year and Date
      2017-03-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Formose Reaction Controlled by Boronic Acid Compounds2016

    • Author(s)
      Tomohiro Michitaka, Toru Imai, Akihito Hashidzume
    • Organizer
      12th Handai Nanoscience and Nanotechnology International Symposium
    • Place of Presentation
      Knowledge Captial Congres Convention Center(大阪)
    • Year and Date
      2016-12-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 精密高分子を用いた高分子性の理解と利用を目指して2016

    • Author(s)
      橋爪章仁
    • Organizer
      第87回高分子若手研究会【関西】
    • Place of Presentation
      神戸大学百年記念館(神戸)
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Characterization of Micellar Aggregates of Amphiphilic Polymers2016

    • Author(s)
      Akihito Hashidzume,
    • Organizer
      The 10th Korea-Japan Joint Symposium on Polymer Science 2016
    • Place of Presentation
      Gwangju Institute of Science and Technology (GIST)(Gwangju, Korea)
    • Year and Date
      2016-08-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 3-アジド-1-プロピン誘導体の銅(I)触媒アジド・アルキン環化付加 (CuAAC) 重合:2-アジド-3-ブチン酸t-ブチルのCuAAC重合による可溶性ポリマーの合成2016

    • Author(s)
      原田達也・橋爪章仁
    • Organizer
      第60回高分子研究発表会(神戸)
    • Place of Presentation
      兵庫県民会館(神戸)
    • Year and Date
      2016-07-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Formose Reaction Controlled by Boronic Acid Residues2016

    • Author(s)
      Toru Imai, Tomohiro Michitaka, and Akihito Hashidzume
    • Organizer
      第65回高分子学会年次大会
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] A Light-Controlled Release System Based on Molecular Recognition of Cyclodextrins2016

    • Author(s)
      Isaac Eng Ting Lee, Akihito Hashidzume, Akira Harada
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      同志社大学京田辺キャンパス(京田辺)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Macromolecular recognition: Interaction of cyclodextrins with polymer side chains2015

    • Author(s)
      Akihito Hashidzume, Akira Harada
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
    • Place of Presentation
      Hilton Hawaian Village (Honolulu, HI)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Solubilization of 3-azido-1-propyne oligomers prepared by copper(I)-catalyzed azide-alkyne cycloaddition polymerization and characterization of the soluble oligomers in dilute solution2015

    • Author(s)
      Akihito Hashidzume, Asami Mori, Shun Nakano, Tomoaki Nakamura, Takahiro Sato
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
    • Place of Presentation
      Hawaian Convention Center (Honolulu, HI)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Formose reaction in the presence of water soluble polymers2015

    • Author(s)
      Tomohiro Michitaka, Akihito Hashidzume, Takahiro Sato
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
    • Place of Presentation
      Hawaian Convention Center (Honolulu, HI)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Control of formose reaction using phenylboronic acid residue2015

    • Author(s)
      Toru Imai, Akihito Hashidzume, Takahiro Sato
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
    • Place of Presentation
      Hawaian Convention Center (Honolulu, HI)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intra- and intermolecular interactions and self-assembly of an amphiphilic alternating copolymer in aqueous solution: complexation with cyclodextrin2015

    • Author(s)
      Rintaro Takahashi, Takahiro Sato, Ken Terao, Akihito Hashidzume
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
    • Place of Presentation
      Hawaian Convention Center (Honolulu, HI)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Self-assembly behavior of crosslinked poly(sodium acrylate) microparticles based on molecular recognition2015

    • Author(s)
      Takahiro Itami, Akihito Hashidzume, Hiroyasu Yamaguchi, Akira Harada
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
    • Place of Presentation
      Hawaian Convention Center (Honolulu, HI)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of Micellar Aggregates Formed from Amphiphilic Polymers2015

    • Author(s)
      Akihito Hashidzume
    • Organizer
      iCeMS International Symposium, Hierarchical Dynamics in Soft Materials and Biological Matter
    • Place of Presentation
      Yoshida Campus, Kyoto University(Kyoto)
    • Year and Date
      2015-09-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Copper(I)-Catalyzed Azide-Alkyne Cycloaddition Polymerization of 3-Azido-1-propyne Derivatives and Solubilization of the Oligomers Obtained2015

    • Author(s)
      Akihito Hashidzume, Tomoaki Nakamura, Shun Nakano, Asami Mori, Takahiro Sato
    • Organizer
      第64回高分子討論会
    • Place of Presentation
      東北大学川内キャンパス(川内)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 両親媒性交互共重合体とシクロデキストリンの水溶液中における複合体形成,2015

    • Author(s)
      高橋倫太郎・佐藤尚弘・寺尾 憲・橋爪章仁
    • Organizer
      第64回高分子討論会
    • Place of Presentation
      東北大学川内キャンパス(川内)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Formose Reaction Controled by Water-Soluble Polymers2015

    • Author(s)
      Tomohiro Michitaka, Akihito Hashidzume, Takahiro Sato
    • Organizer
      第64回高分子討論会
    • Place of Presentation
      東北大学川内キャンパス(川内)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 分子認識を基盤としたマイクロ粒子の自己組織化挙動2015

    • Author(s)
      伊丹隆浩, 橋爪章仁, 山口浩靖, 原田 明
    • Organizer
      第64回高分子討論会
    • Place of Presentation
      東北大学川内キャンパス(川内)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] ボロン酸残基によるホルモース反応の制御2015

    • Author(s)
      今井 徹・橋爪章仁・佐藤尚弘
    • Organizer
      第64回高分子討論会
    • Place of Presentation
      東北大学川内キャンパス(川内)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] ポリスルホン酸ナトリウムを用いたホルモース反応の制御2015

    • Author(s)
      道堯智裕・橋爪章仁・佐藤尚弘
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 3-アジド-1-プロピンの銅触媒アジド-アルキン環化付加重合を利用したブロック共重合体の合成と特性化2015

    • Author(s)
      森 麻美・橋爪章仁・佐藤尚弘
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Macromolecular Recognition: Recognition of Polymer Side Chains by Cyclodextrin2015

    • Author(s)
      Akihito Hashidzume and Akira Harada
    • Organizer
      The 11th International Conference of Computational Methods in Sciences and Engineering(ICCMSE 2015)
    • Place of Presentation
      Metropolitan Hotel (Athens, Greece)
    • Year and Date
      2015-03-20 – 2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 3-アジド-1-プロピン誘導体の銅(I)触媒アジドアルキン環化付加重合と得られたポリマーのキャラクタリゼーション2014

    • Author(s)
      橋爪章仁・佐藤尚弘
    • Organizer
      第23回ポリマー材料フォーラム
    • Place of Presentation
      奈良県新公会堂(奈良)
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] フェニルボロン酸残基によるホルモース反応の制御2014

    • Author(s)
      今井 徹・道堯智裕・橋爪章仁・佐藤尚弘
    • Organizer
      第4回CSJ化学フェスタ
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2014-10-14 – 2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 逆ミセルを反応場としたホルモース反応2014

    • Author(s)
      道堯智裕・正岡 誠・橋爪章仁・佐藤尚弘
    • Organizer
      第4回CSJ化学フェスタ
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2014-10-14 – 2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 逆ミセルを反応場としたホルモース反応2014

    • Author(s)
      道堯智裕・正岡 誠・今井 徹・橋爪章仁・佐藤尚弘
    • Organizer
      第63回高分子討論会
    • Place of Presentation
      長崎大学文教キャンパス(長崎)
    • Year and Date
      2014-09-24 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 分子を認識するヒドロゲルの創製と機能化2014

    • Author(s)
      橋爪章仁
    • Organizer
      第60回高分子講演会〔東海〕
    • Place of Presentation
      アクトシティー研修交流センター(浜松)
    • Year and Date
      2014-09-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] フマルアミド/N-イソプロピルアクリルアミド共重合体水溶液の相挙動2014

    • Author(s)
      石井直子・橋爪章仁・佐藤尚弘
    • Organizer
      第60回高分子研究発表会(神戸)
    • Place of Presentation
      兵庫県民会館(神戸)
    • Year and Date
      2014-07-24 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 3-アジド-1-プロピンの銅触媒アジド-アルキン環化付加重合を利用した可溶性オリゴマーの合成2014

    • Author(s)
      中野 駿・橋爪章仁・佐藤尚弘
    • Organizer
      第60回高分子研究発表会(神戸)
    • Place of Presentation
      兵庫県民会館(神戸)
    • Year and Date
      2014-07-24 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 銅触媒アジド-アルキン環化付加重合を利用した両親媒性ブロック共重合体の合成2014

    • Author(s)
      森 麻美・橋爪章仁・佐藤尚弘
    • Organizer
      第60回高分子研究発表会(神戸)
    • Place of Presentation
      兵庫県民会館(神戸)
    • Year and Date
      2014-07-24 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] フェニルボロン酸残基によるホルモース反応の制御2014

    • Author(s)
      今井 徹・道堯智裕・渡邊陽介・橋爪章仁・佐藤尚弘
    • Organizer
      第60回高分子研究発表会(神戸)
    • Place of Presentation
      兵庫県民会館(神戸)
    • Year and Date
      2014-07-24 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Book] Chemoresponsive Materials: Stimulation by Chemical Biological Signals2015

    • Author(s)
      Akira Harada and Akihito Hashidzume
    • Total Pages
      41
    • Publisher
      Royal Society of Chemistry
    • Related Report
      2015 Annual Research Report
  • [Book] International Conference of Computational Methods in Sciences and Engineering 2015 (ICCMSE 2015)2015

    • Author(s)
      Akihito Hashidzume and Akira Harada
    • Total Pages
      4
    • Publisher
      AIP Publishing
    • Related Report
      2015 Annual Research Report
  • [Book] Encyclopedia of Polymeric Nanomaterials(分担執筆)2014

    • Author(s)
      Akihito Hashidzume and Akira Harada
    • Total Pages
      4
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] Molecular Machines and Motors(分担執筆)2014

    • Author(s)
      Akihito Hashidzume, Hiroyasu Yamaguchi, and Akira Harada
    • Total Pages
      40
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] 超分子材料の設計と応用展開(分担執筆)2014

    • Author(s)
      橋爪章仁
    • Total Pages
      10
    • Publisher
      シーエムシー出版
    • Related Report
      2014 Annual Research Report
  • [Remarks] 研究業績|づめラボ

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/hashidzume/dzumelab_jpn/pubs_jpn.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] Publications @ MAPS

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/hashidzume/dzumelab_eng/pubs_eng.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 大阪大学 大学院理学研究科 高分子科学専攻 高分子精密科学研究室

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/hashidzume/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 佐藤研究室|大阪大学理学研究科高分子科学専攻

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/sato/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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