Development of Mechanical Electro-Magneto Nerve Regeneration Device with Biocompatible Piezoelectric Material MgSiO3
| Project/Area Number |
26289010
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Materials/Mechanics of materials
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| Research Institution | Doshisha University |
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Principal Investigator |
NAKAMACHI EIJI 同志社大学, 生命医科学部, 教授 (60099893)
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| Co-Investigator(Kenkyū-buntansha) |
森田 有亮 同志社大学, 生命医科学部, 教授 (80368141)
萩原 明郎 同志社大学, 生命医科学部, 教授 (90198648)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 生体適合材料 / 再生用デバイス / 電磁場刺激 / 力学刺激 / 神経細胞PC12 / 神経軸索伸展 / コンピュータシミュレーション / 細胞周辺環境 / 力学・電磁場 / 軸索伸展 / 神経再生 / 圧電材料 |
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| Outline of Final Research Achievements |
We developed a Mechanical Electro-Magneto Nerve Regeneration Device with Biocompatible Piezoelectric Material MgSiO3, as demonstrated below: (1) Cellular Automaton Simulation code. (2) Bio-MEMS device for activate the axonal extension of nerve cell PC12 to study the influence of cell interval and zenith corner angle. (3) Multi-layer diaphragm using the biocompatible piezoelectric material MgSiO3 to generate mechanical static electro magneto field. (4) AC magneto field stimulation device for PC12 axonal extension acceleration. (5) Electro magneto mechanical stimulation device in the extra-cellular environment to activate PC12 cell and axonal extension. We confirmed that increases of 25.2% in case of mechanical stimulation, 37.4% in the uniform magneto field stimulation and 70.0% in the mechanical electro magneto hybrid stimulation.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Physical and Biological Properties of a Novel Anti-adhesion Material Made of Thermally Cross-linked Gelatin Film: Investigation of the Usefulness as Anti-adhesion Material2018
Author(s)
Tsunehito Horii, Hiroyuki Tsujimoto, Hiroe Miyamoto, Koki Yamanaka, Shota Tanaka, Hiroko Torii, Yuki Ozamoto, Hideki Takamori, Eiji Nakamachi, Yoshito Ikada, Akeo Hagiwara
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Journal Title
J Biomedical Materials Research B
Volume: -
Pages: 689-696
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Development of IKVAV Modified PLLA Guide Tube Having Undirectional Fibers on Inner Surface to Enhance Axonal Extension2016
Author(s)
Akizawa, Y., Morita, Y., Hsu, Y., Yamaoka, T. and Nakamachi, E.
Organizer
Proc. of ASME2016, International Mechanical Engineering Congress & Exposition
Place of Presentation
Phenix, AZ, USA
Year and Date
2016-11-14
Related Report
Int'l Joint Research
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