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Development of Mechanical Electro-Magneto Nerve Regeneration Device with Biocompatible Piezoelectric Material MgSiO3

Research Project

Project/Area Number 26289010
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Materials/Mechanics of materials
Research InstitutionDoshisha University

Principal Investigator

NAKAMACHI EIJI  同志社大学, 生命医科学部, 教授 (60099893)

Co-Investigator(Kenkyū-buntansha) 森田 有亮  同志社大学, 生命医科学部, 教授 (80368141)
萩原 明郎  同志社大学, 生命医科学部, 教授 (90198648)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords生体適合材料 / 再生用デバイス / 電磁場刺激 / 力学刺激 / 神経細胞PC12 / 神経軸索伸展 / コンピュータシミュレーション / 細胞周辺環境 / 力学・電磁場 / 軸索伸展 / 神経再生 / 圧電材料
Outline of Final Research Achievements

We developed a Mechanical Electro-Magneto Nerve Regeneration Device with Biocompatible Piezoelectric Material MgSiO3, as demonstrated below: (1) Cellular Automaton Simulation code. (2) Bio-MEMS device for activate the axonal extension of nerve cell PC12 to study the influence of cell interval and zenith corner angle. (3) Multi-layer diaphragm using the biocompatible piezoelectric material MgSiO3 to generate mechanical static electro magneto field. (4) AC magneto field stimulation device for PC12 axonal extension acceleration. (5) Electro magneto mechanical stimulation device in the extra-cellular environment to activate PC12 cell and axonal extension. We confirmed that increases of 25.2% in case of mechanical stimulation, 37.4% in the uniform magneto field stimulation and 70.0% in the mechanical electro magneto hybrid stimulation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(23 results)

All 2018 2017 2016 2015 2014

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 6 results,  Acknowledgement Compliant: 4 results) Presentation (15 results) (of which Int'l Joint Research: 8 results)

  • [Journal Article] Physical and Biological Properties of a Novel Anti-adhesion Material Made of Thermally Cross-linked Gelatin Film: Investigation of the Usefulness as Anti-adhesion Material2018

    • Author(s)
      Tsunehito Horii, Hiroyuki Tsujimoto, Hiroe Miyamoto, Koki Yamanaka, Shota Tanaka, Hiroko Torii, Yuki Ozamoto, Hideki Takamori, Eiji Nakamachi, Yoshito Ikada, Akeo Hagiwara
    • Journal Title

      J Biomedical Materials Research B

      Volume: - Pages: 689-696

    • DOI

      10.1002/jbm.b.33880

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biocompatible Aurivillius-like layered ferroelectric BaIn2Ta2O92017

    • Author(s)
      Yayoi Fujimoto, Eiji Nakamachi, Yusuke Morita
    • Journal Title

      Ceramics International

      Volume: - Pages: 1-4

    • DOI

      10.1016/j.ceramint.2017.03.024

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Multiphoton microscope measurement based biphasic multiscale analyses of knee joint articular cartilage and chondrocyte by using visco‐anisotropic hyperelastic finite element method and smoothed particle hydrodynamics method2017

    • Author(s)
      Nakamachi E, Noma T, Nakahara K, Tomita Y, Morita Y.
    • Journal Title

      Int J Numer Meth Biomed Engng.

      Volume: e2864. Pages: 1-23

    • DOI

      10.1002/cnm.2864

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a bio-microelectromechanical system device for axonal extension evaluation by PC12D patterning using a dielectrophoresis method2015

    • Author(s)
      Nakamachi, E., Murakami, S., Koga, H. and Morita, Y.
    • Journal Title

      Journal of Micro/Nanolith. MEMS MOEMS

      Volume: 14(2)

    • DOI

      10.1117/1.jmm.14.2.025004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phase-field modeling for axonal extension of nerve cells2015

    • Author(s)
      TAKAKI, T., NAKAGAWA, K., MORITA, Y. and NAKAMACHI, E.
    • Journal Title

      Mechanical Engineering Journal

      Volume: 2(3) Issue: 3 Pages: 15-00063-15-00063

    • DOI

      10.1299/mej.15-00063

    • NAID

      130005076459

    • ISSN
      2187-9745
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 再生の足場材料を用いた癒着防止材熱架橋ゼラチンフィルムの有用性-セプラフィルムとの比較-2015

    • Author(s)
      堀井常人、辻本 洋行、辻美咲、阿部里恵、宮本博恵、山中皓暉、鳥井裕子、小座本雄軌、高森秀樹、鈴木 周子、森田 真一郎、筏 義人、萩原 明於
    • Journal Title

      日本再生医療学会雑誌

      Volume: 14 Pages: 313-313

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 再生の足場材料を用いた癒着防止材-熱架橋gelatin filmの癌の腹膜播種性転移に与える影響について-2015

    • Author(s)
      宮本博恵、辻本 洋行、山中皓暉、韓沛、川澄あかり、王震、田中翔大、増井亮仁、堀井常人、鳥井裕子、小座本雄軌、高森秀樹、鈴木 周子、森田 真一郎、筏 義人、萩原 明於
    • Journal Title

      日本再生医療学会雑誌

      Volume: 14 Pages: 346-346

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of microarray device for functional evaluation of PC12D cell axonal extension ability2014

    • Author(s)
      4.Nakamachi, E., Yanagimoto, J., Murakami, S. and Morita, Y.
    • Journal Title

      Journal of Micro/Nanolith. MEMS MOEMS

      Volume: 13(2)

    • DOI

      10.1117/1.jmm.13.2.023013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Development of IKVAV Modified PLLA Guide Tube Having Undirectional Fibers on Inner Surface to Enhance Axonal Extension2016

    • Author(s)
      Akizawa, Y., Morita, Y., Hsu, Y., Yamaoka, T. and Nakamachi, E.
    • Organizer
      Proc. of ASME2016, International Mechanical Engineering Congress & Exposition
    • Place of Presentation
      Phenix, AZ, USA
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of the Gradient Magnetic Field Stimulation on Extracellular Matrix Synthesis of Chondrocyte2016

    • Author(s)
      Saito, T., Morita, Y. and Nakamachi, E.
    • Organizer
      Proc. of ASME2016, International Mechanical Engineering Congress & Exposition
    • Place of Presentation
      Phenix, AZ, USA
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of hybrid Electromagnetic and Mechanical Stimulation System for Enhancement of Nerve Axonal Extension2016

    • Author(s)
      Matsumoto, K., Morita, Y. and Nakamachi, E.
    • Organizer
      Proc. of ASME2016, International Mechanical Engineering Congress & Exposition
    • Place of Presentation
      Phenix, AZ, USA
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Dielectrophoresis Aided Cell Patterning Device for Elucidation of Nerve-network Generation Mechanism2016

    • Author(s)
      Koga, H., Morita, Y. and Nakamachi, E.
    • Organizer
      Proc. of Int. Symposium on Advanced Science and Technology in Experimental Mechanics ISEM2016
    • Place of Presentation
      Ho-Chimin, Vietnum
    • Year and Date
      2016-11-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of the Magnetic Force-Induced Dual Vibration Energy Harvester Using a Unimorph Cantilever2015

    • Author(s)
      Umaba, M., Morita, Y. and Nakamachi, E.
    • Organizer
      Society of Photo-Optical Instrumentation Engineers (SPIE) MICRO+NANO MATERIALS, DEVICE, AND APPLICATIONS
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2015-12-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Bio-MEMS Thermal Device to Generate Nerve Axonal Injury Model for Assessment of Regenerative Medicine2015

    • Author(s)
      Kamimori, S., Okuda, R., Morita, Y. and Nakamachi, E.
    • Organizer
      ASME 2015 International Mechanical Engineering Congress & Exposition(IMECE 2015)IMECE2015-512862015
    • Place of Presentation
      Houston, Texas, USA
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Multi-layered Cellular Automata Model to Predict Nerve Axonal Extension2015

    • Author(s)
      Nakayama, A., Yamamoto. T., Morita, Y. and Nakamachi, E.
    • Organizer
      ICCB 2015 Ⅵ International Conference Computational Bioengineering
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2015-09-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MOLECULAR DESIGN OF NEW BIOCOMPATIBLE AURIVILLUS-LIKE LAYERED PEROVSKITE FERROELECTRICS BY FIRST-PRINCIPLE CALCULATION2015

    • Author(s)
      Fujimoto,Y., Nakamachi, E.and Morita,Y.
    • Organizer
      XXⅣINTERNATIONAL MATERIALS RESEARCH CONGRESS
    • Place of Presentation
      Cancun, Mexico
    • Year and Date
      2015-08-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経軸索伸展制御のため細胞周辺熱環境デバイスの開発2015

    • Author(s)
      深谷航史,森田有亮,仲町英治
    • Organizer
      日本機械学会第27回バイオエンジニアリング講演会論文集
    • Place of Presentation
      新潟,日本
    • Year and Date
      2015-01-09 – 2015-01-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of PLLA Porous Fiber Scaffold by Electrospinning for Tissue Engineering2014

    • Author(s)
      Narisada, R., Morita, Y., Katayama, Y. and Nakamachi, E.
    • Organizer
      ASME 2014 International Mechanical Engineerinng Congress & Exposition
    • Place of Presentation
      Montreal, CANADA
    • Year and Date
      2014-11-17 – 2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] PC12Dパターニングのための誘電泳動法を用いたBio-MEMSデバイスの開発2014

    • Author(s)
      村上愼彌,森田有亮,仲町英治
    • Organizer
      日本機械学会第6回マイクロナノ工学シンポジウム
    • Place of Presentation
      島根,日本
    • Year and Date
      2014-10-20 – 2014-10-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fabrication of MgSiO3 Thin Film by RF Magnetron Sputtering Method to Accelerate Bone Formation2014

    • Author(s)
      Nakasaki, S., Morita, Y., Katayama, T. and Nakamachi, E.
    • Organizer
      Biomedical Engineering Society 2014 Annual Meeting
    • Place of Presentation
      San Antonio, US
    • Year and Date
      2014-10-07 – 2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of PLLA Hollow Fiber Scaffold by Electrospinning for Cartilage Regeneration2014

    • Author(s)
      Minamimoto, K., Morita, Y.,Katayama,T. and Nakamachi, E.
    • Organizer
      Biomedical Engineering Society 2014 Annual Meeting
    • Place of Presentation
      San Antonio, US
    • Year and Date
      2014-10-07 – 2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Evaluation of Piezoelectric Property by Using First-Principles Calculations of A-Site Substitution MgSiO3 Mixed Crystal2014

    • Author(s)
      Yoshioka, N., and Nakamachi, E.
    • Organizer
      36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Chicago, US
    • Year and Date
      2014-08-26 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of Electromagnetic Stimulation Loading Bio-Reactor for Peripheral Nerve Tissue Regeneration2014

    • Author(s)
      Okuda, O. and Nakamachi, E.
    • Organizer
      36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Chicago, US
    • Year and Date
      2014-08-26 – 2014-08-30
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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