Application of hydrogen absorption/release characteristics of sulfur-poisoning nanoparticles to cancer detection

• Project/Area Number: 26289255
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Structural/Functional materials
• Research Institution: Nagoya University
• Principal Investigator: Yagi Shinya 名古屋大学, 未来材料・システム研究所, 教授 (20284226)
• Co-Investigator(Kenkyū-buntansha): 吉田 朋子 名古屋大学, エコトピア科学研究所, 准教授 (90283415)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: ナノ粒子 / 水素吸放出 / ガン検知 / 硫黄被毒 / Rhナノ粒子 / 酸素被毒 / Pdナノ粒子 / XPS測定 / ガス中蒸発法 / 生体・医療・福祉材料 / がんスクリーニング / XAFS分析 / 金ナノ粒子 / 硫黄分子吸着 / XAFS測定

Outline of Final Research Achievements

We have fabricated the nanoparticles of Rh and Pd by gas evaporation method. The particle sizes of both Rh and Pd are estimated to be approximately 1-4 nm. Although a sulfur-containing molecules (mainly thiol-based molecules) adsorbed on the Rh nanoparticle surface chemically adsorbs but the adsorbed molecules does not show a dissociation reaction. Moreover the Rh nanoparticles does not show the hydrogen absorbing/releasing reaction. On the other hand, for the Pd nanoparticles, it is found that the hydrogen absorbing/releasing reaction rate is remarkably slow in comparison with the rate for without sulfur poisoning. Based on this result, we are planning to continue applying to cancer screening in the future.

Research Products

• [Int'l Joint Research] Diamond Light Source(イギリス)
• [Journal Article] Hydrogen Storage of Pd/Mg composite Nanoparticles Fabricated by Gas Evaporation Method (2016)
  • Author(s): Satoshi Ogawa, Hiroyuki Suzuki, Chie Tsukada, Tomoko Yoshida, Shinya Yagi
  • Journal Title: e-J. Surf. Sci. Nanotech. Volume: 14 Issue: 0 Pages: 150-153
  • DOI: 10.1380/ejssnt.2016.150
  • NAID: 130005151355
  • ISSN: 1348-0391
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 金属ナノ粒子を用いた水素吸蔵材料の分光学的手法による化学状態分析 (2015)
  • Author(s): 小川智史，内山直樹，藤本大志，金井友美，八木伸也
  • Journal Title: 日本金属学会誌 Volume: 79 Pages: 118-123
  • NAID: 130004786489
  • Peer Reviewed
• [Journal Article] Hydrogen Storage Property of the Pd Nanoparticle with Clean Surfaces Studied by QCM (2015)
  • Author(s): Satoshi Ogawa, Taishi Fujimoto, Tomomi Kanai, Naoki Uchiyama, Chie Tsukada, Tomoko Yoshida, Shinya Yagi
  • Journal Title: e-Journal of Surface Science and Nanotechnology Volume: 13 Pages: 343-346
  • NAID: 130005083978
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hydrogen storage property of materials composed of Mg nanoparticles and Ni nanoparticles fabricated by gas evaporation method (2015)
  • Author(s): Taishi Fujimoto, Satoshi Ogawa, Tomomi Kanai, Naoki Uchiyama, Tomoko Yoshida, Shinya Yagi
  • Journal Title: International Journal of Hydrogen Energy Volume: 40 Pages: 11890-11894
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hydrogen storage of binary nanoparticles composed of Mg and Pd (2015)
  • Author(s): Satoshi Ogawa, Taishi Fujimoto, Tsuyoshi Mizutani, Masahiro Ogawa, Naoki Uchiyama, Kazuo Kato, Toshiaki Ohta, Tomoko Yoshida, Shinya Yagi
  • Journal Title: International Journal of Hydrogen Energy Volume: 40 Pages: 11895-11901
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Spectroscopic and morphological studies on interaction between gold nanoparticle and liposome constructed with phosphatidylcholine (2015)
  • Author(s): C. Tsukada, T. Tsuji, K. Matsuo, T. Nomoto, G. Kutluk, M. Sawada, S. Ogawa, T. Yoshida, S. Yagi
  • Journal Title: IOP Conference Series: Materials Science and Engineering Volume: 76 Pages: 012001-3
  • DOI: 10.1088/1757-899x/76/1/012001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Vulcanization reaction of squalene and S8 powder studied by Sulfur K-edge NEXFAS under liquid phase (2015)
  • Author(s): S. Yagi, Y. Menjo, C. Tsukada, S. Ogawa, G. Kutluk, H. Namatame and M. Taniguchi
  • Journal Title: IOP Conference Series: Materials Science and Engineering Volume: 76 Pages: 012004-6
  • DOI: 10.1088/1757-899x/76/1/012004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] In situ ultraviolet-visible absorbance measurement during and after solution plasma sputtering for preparation of colloidal gold nanoparticles (2014)
  • Author(s): T. Mizutani, T. Murai, H. Nameki, T. Yoshida, S. Yagi
  • Journal Title: Jpn. J. Appl. Phys. Volume: 53
  • NAID: 210000144617
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Preparation of gold nanoparticles included in anatase-phase titania by solution plasma method (2014)
  • Author(s): T. Mizutani, T. Murai, T. Nomoto, H. Nameki, T. Yoshida, S. Yagi
  • Journal Title: Surf. Interface Anal. Volume: 46 Pages: 1125-1128
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 液中プラズマ法で作製したAuナノ粒子のCs吸着剤への応用検討 (2017)
  • Author(s): 塚田千恵、吉田光、小川智史、吉越章隆、八木伸也、矢板毅
  • Organizer: 第30回日本放射光学会
  • Place of Presentation: 神戸芸術センター(兵庫県神戸市)
  • Year and Date: 2017-01-07
• [Presentation] In-situ XAFSによるMg-Pdナノ粒子の水素吸放出時における局所状態変化分析 (2016)
  • Author(s): 小川智史、藤本大志、水谷剛士、小川雅裕、与儀千尋、加藤和男、太田俊明、吉田朋子、八木伸也
  • Organizer: XAFS討論会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2016-09-06
• [Presentation] Nanoparticles for Hydrogen Storage Application : Pd, Ni and Mg Nanoparticles (2015)
  • Author(s): Satoshi Ogawa, Hiroyuki Suzuki, Chie Tsukada, Tomoko Yoshida and Shinya Yagi
  • Organizer: International Symposium on EcoTopia Science ’15
  • Place of Presentation: Nagoya University, Nagoya, Aichi, Japan
  • Year and Date: 2015-11-27
  • Int'l Joint Research
• [Presentation] Preparation and photocatalytic activity of cholorine-free gold nanoparticles on titanium oxide by solution plasma method (2015)
  • Author(s): Tsuyoshi Mizutani, Satoshi Ogawa, Muneaki Yamamoto, Hirofumi Nameki, Tomoko Yoshida, and Shinya Yagi
  • Organizer: International Symposium on EcoTopia Science ’15
  • Place of Presentation: Nagoya University, Nagoya, Aichi, Japan
  • Year and Date: 2015-11-27
  • Int'l Joint Research
• [Presentation] 放射光XAFSによる水素吸蔵ナノ粒子の分析 (2015)
  • Author(s): 小川智史
  • Organizer: 第 7 回 SPring-8 萌芽的研究支援ワークショップ
  • Place of Presentation: キャンパス・イノベーションセンター東京
  • Year and Date: 2015-10-28
• [Presentation] Spectroscopic characterization of Pd/Mg nanoparticles during hydrogen absorption (2015)
  • Author(s): Satoshi Ogawa, Chie Tsukada, Masahiro Ogawa, Toshiaki Ohta, Tomoko Yoshida, Shinya Yagi
  • Organizer: 10th International Symposium on Atomic Level Characterizations for New Materials and Devices ’15
  • Place of Presentation: Kunibiki Messe, Matsue, Shimane, Japan
  • Year and Date: 2015-10-25
  • Int'l Joint Research
• [Presentation] Fabrication of Au nanorods by solution plasma method (2015)
  • Author(s): Chie Tsukada, Tsuyoshi Mizutani, Satoshi Ogawa, Hirofumi Nameki, Shinya Yagi
  • Organizer: 10th International Symposium on Atomic Level Characterizations for New Materials and Devices ’15
  • Place of Presentation: Nagoya University, Nagoya, Aichi, Japan
  • Year and Date: 2015-10-25
  • Int'l Joint Research
• [Presentation] Photocatalytic activity of gold nanoparticles on titanium oxide prepared by solution plasma method (2015)
  • Author(s): Tsuyoshi Mizutani, Satoshi Ogawa, Muneaki Yamamoto, Hirofumi Nameki, Tomoko Yoshida, and Shinya Yagi
  • Organizer: European Conference on Surface Science (ECOSS 31)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2015-08-31
  • Int'l Joint Research
• [Presentation] Formation mechanism of nanoparticles prepared by electrode during solution plasma using pulsed high voltage (2015)
  • Author(s): T. Mizutani, T. Murai, T. Nomoto, H. Nameki, T. Yoshida, S. Yagi
  • Organizer: 7th International Symposium on Advanced Plasma Science and its Applications for Nitrides and Nanomaterials (ISPlasma 2015)
  • Place of Presentation: 日本(名古屋市)
  • Year and Date: 2015-03-02 – 2015-03-06
• [Presentation] Adsorption behavior between phosphatidylcholine(PC) and gold nanoparticle studied by XAFS and TEM (2014)
  • Author(s): C. Tsukada, T. Tsuji, K. Matsuo, T. Nomoto, G. Kutluk, M. Sawada, S. Ogawa, T. Yoshida, S. Yagi
  • Organizer: International Conference on Solid Films and Surfaces (ICSFS17)
  • Place of Presentation: ブラジル（リオデジャネイロ）
  • Year and Date: 2014-09-08 – 2014-09-11
• [Presentation] In-situ UV-Vis investigation of the formation of gold nanoparticles by the solution plasma spattering (2014)
  • Author(s): T. Mizutani, T. Murai, H. Nameki, T. Yoshida, S. Yagi
  • Organizer: European Conference on Surface Science (ECOSS 30)
  • Place of Presentation: トルコ（アンタルヤ）
  • Year and Date: 2014-08-31 – 2014-09-05