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Neural mechanisms based on predictive coding in frontal cortex during cognitive tasks

Research Project

Project/Area Number 26290001
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionTohoku University

Principal Investigator

Mushiake Hajime  東北大学, 医学系研究科, 教授 (80219849)

Project Period (FY) 2014-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Keywords前頭葉 / 前頭前野 / 大脳皮質運動野 / 神経科学 / 運動野 / 脳・神経 / 脳と神経 / ゼロ細胞 / 頭頂連合野
Outline of Final Research Achievements

According to predictive coding, the brain is constantly generating and updating a working model. In each region, the predicting model is compared to the sensory input or feedback signals. If they match, the model is maintained, but if they do not match, a Prediction Error is sent back up the network and the model is updated. Our hypothesis is beta and gamma rhythms reflect these processes.
In the present study, beta and high-gamma activities in frontal areas of monkeys were analyzed during performance of a bimanual task that required updating and maintenance of the memory of action sequences. Beta power was attenuated during early delay periods of updating trials but was increased during maintenance trials, while there was a reciprocal increase in high-gamma power during updating trials. In conclusion, beta rhythm is related to top-down signals and contribute to maintain the current model. In contrast, gamma rhythm is related to bottom-up signals to update current models.

Academic Significance and Societal Importance of the Research Achievements

ベータ波は パーキンソン病などの脳疾患で更新しており、前頭葉と基底核でベータ波の同期が認められる事が知られている。このベータ波の意義は、我々の今回の結果に従えば予測符号化の、維持機構が強まり、逆に予測誤差で更新する機構が障害された状態と解釈できる。すなわち健常者での神経機構とパーキンソン病の神経系機構には、共通の神経基盤があり、そのバランスが崩れた状態と考えられる。このような予測符号化の神経機構の理解が、病態の新たな理解や治療方法の提案に貢献できると考えられる。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(36 results)

All 2020 2018 2017 2016 2015 2014 Other

All Journal Article (13 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 13 results,  Open Access: 11 results,  Acknowledgement Compliant: 10 results) Presentation (21 results) (of which Int'l Joint Research: 9 results,  Invited: 3 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Optogenetic study of the response interaction among multi-afferent inputs in the barrel cortex of rats.2020

    • Author(s)
      Liu Y, Ohshiro T, Sakuragi S, Koizumi K, Mushiake H, Ishizuka T, Yawo H.
    • Journal Title

      Scientific reports

      Volume: 9 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41598-019-40688-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Optogenctic activation of the sensorimotor cortex reveals "local inhibitory and global excitatory" inputs to the basal ganglia.2017

    • Author(s)
      Ozaki M, Sano H, Sato S, Ogura M, Mushiake H, Chiken S, Nakao N, Nambu A.
    • Journal Title

      Cereb Cortex.

      Volume: 27 Pages: 5716-5726

    • DOI

      10.1093/cercor/bhx234

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intended arm use influences interhemispheric correlation of β-oscillations in primate medial motor areas.2017

    • Author(s)
      Nakajima T, Arisawa H, Hosaka R, Mushiake H.
    • Journal Title

      Journal of Neurophysiology

      Volume: 118 Pages: 2865-2883

    • DOI

      10.1152/jn.00379.2016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Suppression ofBeta Oscillations in the Primate Supplementary Motor Complex Reflects a Volatile State During the Updating of Action Sequences.2016

    • Author(s)
      Hosaka R, Nakajima T, Aihara K, Yamaguchi Y, Mushiake H.
    • Journal Title

      Cerebral Cortex

      Volume: 26 Pages: 3442-3452

    • DOI

      10.1093/cercor/bhv163

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Representation of behavioral tactics and tactics-action transformation in the primate medial prefrontal cortex2016

    • Author(s)
      Yoshiya Matsuzaka, Jun Tanji, and Hajime Mushiake
    • Journal Title

      J Neurosci.

      Volume: 36 Pages: 3442-3452

    • DOI

      10.1523/jneurosci.4572-15.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Detecting Causality by Combined Use of Multiple Methods: Climate and Brain Examples.2016

    • Author(s)
      Hirata Y, Amigo JM, Matsuzaka Y, Yokota R, Mushiake H, Aihara K
    • Journal Title

      PLOS ONE

      Volume: 11

    • DOI

      10.1371/journal.pone.0158572

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Transplantation of Unique Subpopulation of Fibroblasts, Muse Cells, Ameliorates Experimental2016

    • Author(s)
      Satow, T., Kawase, T., Kitamura, A. , Kajitani ,Y. , Yamaguchi, T. , Tanabe, N. , Otoi, R. , Komuro, T. , Kobayashi, A. , Nagata, H. , Mima, T.,
    • Journal Title

      Stem Cells.

      Volume: 34 Pages: 160-173

    • DOI

      10.1002/stem.2206

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Representation of the Numerosity 'zero' in the Parietal Cortex of the Monkey2015

    • Author(s)
      Okuyama S, .Kuki T, Mushiake H.
    • Journal Title

      Scientific Reports

      Volume: 5 Pages: 10059-3

    • DOI

      10.1038/srep10059

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Suppression of Beta Oscillations in the Primate Supplementary Motor Complex Reflects a Volatile State During the Updating of Action Sequences.2015

    • Author(s)
      Hosaka R, Nakajima T, Aihara K, Yamaguchi Y, Mushiake H
    • Journal Title

      Cereb Cortex. 2015

      Volume: 163 Pages: 1-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Arm-use dependent lateralization of gamma and beta oscillations in primate medial motor areas.2015

    • Author(s)
      Hosaka R, Nakajima T, Aihara K, Yamaguchi Y, Mushiake H.
    • Journal Title

      Neural Netw

      Volume: 62 Pages: 62-66

    • DOI

      10.1016/j.neunet.2014.06.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Spatiotemporal patterns of current source density in the prefrontal cortex of a behaving monkey.2015

    • Author(s)
      Sakamoto K, Kawaguchi N, Yagi K, Mushiake H.
    • Journal Title

      Neural Netw.

      Volume: 62 Pages: 67-72

    • DOI

      10.1016/j.neunet.2014.06.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Surprise signals in the supplementary eye field: fectified prediction errors drive exploration-exploitation transitions.2015

    • Author(s)
      Kawaguchi N, Sakamoto K, Saito N, Furusawa Y, Tanji J, Aoki M, Mushiake H
    • Journal Title

      J Neurophysiol.

      Volume: 113 Pages: 1001-1014

    • DOI

      10.1152/jn.00128.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Representation of the Numerosity “zero” in the Parietal Cortex of the Monkey2015

    • Author(s)
      S. Okuyama, T. Kuki, H. Mushiake
    • Journal Title

      Scientific Report( in press)

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] LFP theta power reflects protecting motor plans from an interruption in primate motor areas2018

    • Author(s)
      Ryosuke Hosaka, Hidenori Watanabe, Toshi Nakajima, and Hajime Mushiake
    • Organizer
      FENS forum, Berlin, German
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] サル運動野のシータパワーの増加は運動計画の割り込みからの保護を反映する2018

    • Author(s)
      保坂 亮介 渡辺 秀典 中島 敏 虫明 元
    • Organizer
      第41回日本神経科学大会 2018年7月26日
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒスタミン神経系による脳血管運動の制御2018

    • Author(s)
      大城 朝一 虫明 元
    • Organizer
      第41回日本神経科学大会 2018年7月28日
    • Related Report
      2018 Annual Research Report
  • [Presentation] 前頭葉内側領域によるパフォーマンスモニタリングと行動調節2017

    • Author(s)
      虫明 元 松坂 義哉
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット脳における内因性光学信号の超低速律動は非アドレナリン非コリン性神経系によって制御を受ける2017

    • Author(s)
      大城 朝一 虫明 元
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラットバレル野2/3層ニューロン応答の時間依存性-オプトジェネティクスによるウィスカ毛嚢のランダム時空間刺激実験2017

    • Author(s)
      劉 越人 櫻木 繁雄 大城 朝一 虫明 元 八尾 寛
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 強化学習における動的行 動価値関数2017

    • Author(s)
      片倉 世雄 坂本 一寛 虫明 元
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳機能イメージングのための極微細蛍光内視鏡イメージングシステム2017

    • Author(s)
      小山内 実 大川 宜昭 坂本 一寛 三輪 秀樹 菊田 里美 田村 篤史 佐藤 正晃 大倉 正道 小島 太郎 幸村 裕治 中井 淳一 林 康紀 柳川 右千夫 井ノ口 馨 本間 経康 虫明 元
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Tactics-Action Transformation and Individual Roles played by Supplementary Motor Area, Pre-Supplementary Motor Area and Post Medial Prefrontal Cortex2017

    • Author(s)
      Muhammad Ali Haider Awan Hajime Mushiake Yoshiya Matsuzak
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] サル内側前頭前野による刺激から行動戦術、アクションへの変換2017

    • Author(s)
      松坂 義哉 アワン ムハマド・アリ・ハイダー 虫明 元
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウスにおける海馬シータ波と走行速度の相関と時間関係2017

    • Author(s)
      片山 統裕 中澤 邑支朗 町田 祉永 中尾 光之 虫明 元
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 人の多様性を支える脳の働き2017

    • Author(s)
      虫明 元
    • Organizer
      第27回日本医療社会福祉学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] サル運動野のLFPシータパワーの増加は運動の記憶を反映する2017

    • Author(s)
      保坂 亮介,渡辺 秀典,中島 敏,虫明 元
    • Organizer
      第94回生理学会
    • Place of Presentation
      アクトシティ浜松 浜松市
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 形操作課題中のサル外側前頭前野と背側運動前野LFP間の相互作用2016

    • Author(s)
      坂本 一寛 川口 典彦 虫明 元
    • Organizer
      39回日本神経科学会 パシフィコ横浜
    • Place of Presentation
      パシフィコ横浜 横浜市
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Maintenance and updating of behavior in the medial frontal areas2015

    • Author(s)
      H Mushiake
    • Organizer
      NTNU-Tohoku Univ. Brain Science
    • Place of Presentation
      Sendai 東北大学脳科学センター
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Representational transition from behavioral tactics into action by neurons in primate posterior medial prefrontal cortex2015

    • Author(s)
      Y. MATSUZAKA, A. SASAGAWA, H. MUSHIAKE
    • Organizer
      SFN
    • Place of Presentation
      Chicago USA
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Two types of representations for numerosity ‘zero’ in the parietal cortex of the monkey2015

    • Author(s)
      S. OKUYAMA, H. MUSHIAKE
    • Organizer
      SFN
    • Place of Presentation
      Chicago USA
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Two types of representations for numerosity ‘zero’ in the Parietal Cortex of the Monkey2015

    • Author(s)
      S. OKUYAMA1, H. MUSHIAKE
    • Organizer
      SFN
    • Place of Presentation
      Chicago USA
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Performance monitoring and behavioral adjustment in the medial frontal areas2015

    • Author(s)
      H. MUSHIAKE
    • Organizer
      Asia-Pacific Conference on Vision (APCV) (国際会議)
    • Place of Presentation
      Singapore
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cooperativity between working memory and behavioral planning in the monkey prefrontal cortex2015

    • Author(s)
      Sakamoto K, Saito N , Yoshida S, Mushiake H
    • Organizer
      IBRO
    • Place of Presentation
      Brazil Rio de Janeiro
    • Year and Date
      2015-07-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 形操作課題中のサル前頭前野の局所場電位2014

    • Author(s)
      川口 典彦,坂本 一寛,八木 耕平,青木 正志,虫明 元
    • Organizer
      37回日本神経科学会
    • Place of Presentation
      横浜 パシフィコ横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Book] 学ぶ脳2018

    • Author(s)
      虫明 元
    • Total Pages
      126
    • Publisher
      岩波書店
    • ISBN
      4000296728
    • Related Report
      2018 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科 生体システム生理学分野

    • URL

      http://www.neurophysiology.med.tohoku.ac.jp/

    • Related Report
      2017 Annual Research Report 2015 Annual Research Report

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Published: 2014-04-04   Modified: 2020-03-30  

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