Neural mechanisms based on predictive coding in frontal cortex during cognitive tasks
| Project/Area Number |
26290001
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Keywords | 前頭葉 / 前頭前野 / 大脳皮質運動野 / 神経科学 / 運動野 / 脳・神経 / 脳と神経 / ゼロ細胞 / 頭頂連合野 |
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| Outline of Final Research Achievements |
According to predictive coding, the brain is constantly generating and updating a working model. In each region, the predicting model is compared to the sensory input or feedback signals. If they match, the model is maintained, but if they do not match, a Prediction Error is sent back up the network and the model is updated. Our hypothesis is beta and gamma rhythms reflect these processes.
In the present study, beta and high-gamma activities in frontal areas of monkeys were analyzed during performance of a bimanual task that required updating and maintenance of the memory of action sequences. Beta power was attenuated during early delay periods of updating trials but was increased during maintenance trials, while there was a reciprocal increase in high-gamma power during updating trials. In conclusion, beta rhythm is related to top-down signals and contribute to maintain the current model. In contrast, gamma rhythm is related to bottom-up signals to update current models.
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| Academic Significance and Societal Importance of the Research Achievements |
ベータ波は パーキンソン病などの脳疾患で更新しており、前頭葉と基底核でベータ波の同期が認められる事が知られている。このベータ波の意義は、我々の今回の結果に従えば予測符号化の、維持機構が強まり、逆に予測誤差で更新する機構が障害された状態と解釈できる。すなわち健常者での神経機構とパーキンソン病の神経系機構には、共通の神経基盤があり、そのバランスが崩れた状態と考えられる。このような予測符号化の神経機構の理解が、病態の新たな理解や治療方法の提案に貢献できると考えられる。
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Report
(6 results)
Research Products
(36 results)
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[Journal Article] Transplantation of unique subpopulation of fibroblasts, muse cells, ameliorates experimental stroke possibly via robust neuronal differentiation.2016
Author(s)
Satow, T., Kawase, T., Kitamura, A. , Kajitani ,Y. , Yamaguchi, T. , Tanabe, N. , Otoi, R. , Komuro, T. , Kobayashi, A. , Nagata, H. , Mima, T.,
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Journal Title
Stem Cells.
Volume: 34
Pages: 160-173
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Book] 学ぶ脳2018
Author(s)
虫明 元
Total Pages
126
Publisher
岩波書店
ISBN
4000296728
Related Report
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