Optogenetic countrol of visual perception
| Project/Area Number |
26290011
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Benucci Andrea 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (50722352)
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| Research Collaborator |
Tsubota Tadashi
Aoki Ryo
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | neural circuits / behavioral training / decision-making / cortex / optogenetics / two-photon imaging / Vision / animal cognition / decision making / fluorescent imaging / visual cortex / cortical plasticity / Visual Processing / Decision making / Cortex / Optogenetics / Optical Imaging / mouse / imaging / electrophysiology / behavior |
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| Outline of Final Research Achievements |
We have developed a new platform for mouse behavioral training which is high-throughput, fully automated, and features voluntary head fixation. We have used several of these setups to provide evidence mice can use perceptual concepts in sensory-based decision making tasks, a complex cognitive skill so far undemonstrated in this mammalian species. We have also developed a technology for simultaneous imaging and optogenetic perturbations of cortical networks at near single cell resolution. With this technology we are studying the in-vivo rules of functional plasticity in the cortex of adult mice.
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Report
(4 results)
Research Products
(4 results)
