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Optogenetic countrol of visual perception

Research Project

Project/Area Number 26290011
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Benucci Andrea  国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (50722352)

Research Collaborator Tsubota Tadashi  
Aoki Ryo  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywordsneural circuits / behavioral training / decision-making / cortex / optogenetics / two-photon imaging / Vision / animal cognition / decision making / fluorescent imaging / visual cortex / cortical plasticity / Visual Processing / Decision making / Cortex / Optogenetics / Optical Imaging / mouse / imaging / electrophysiology / behavior
Outline of Final Research Achievements

We have developed a new platform for mouse behavioral training which is high-throughput, fully automated, and features voluntary head fixation. We have used several of these setups to provide evidence mice can use perceptual concepts in sensory-based decision making tasks, a complex cognitive skill so far undemonstrated in this mammalian species. We have also developed a technology for simultaneous imaging and optogenetic perturbations of cortical networks at near single cell resolution. With this technology we are studying the in-vivo rules of functional plasticity in the cortex of adult mice.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(4 results)

All 2016 2015

All Journal Article (1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Local and global contributions to hemodynamic activity in mouse cortex2016

    • Author(s)
      Pisauro, M.A., Benucci, A., Carandini, M.
    • Journal Title

      J Neurophysiol

      Volume: 115(6) Pages: 2931-6

    • DOI

      10.1152/jn.00125.2016

    • Related Report
      2016 Annual Research Report
  • [Presentation] Fully automated training fixed mice.2015

    • Author(s)
      Ryo Aoki
    • Organizer
      Annual Meeting of Society for Neuroscience, 2015
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Studying perceptual learning in mice with a fully-automated training system for voluntary head fixation.2015

    • Author(s)
      Andrea Benucci
    • Organizer
      Sanford University School of Medicine
    • Place of Presentation
      Sanford University School of Medicine, USA
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Patent(Industrial Property Rights)] Fully-automated, high-throuput system for voluntary head fixation in mice2016

    • Inventor(s)
      Andrea Benucci
    • Industrial Property Rights Holder
      Andrea Benucci
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-06-29
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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