Interaction between the higher-order motor areas and the basal ganglia in associating cognition and action
| Project/Area Number |
26290012
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurophysiology / General neuroscience
|
|---|
| Research Institution | Tokyo Metropolitan Institute of Medical Science |
|---|
Principal Investigator |
HOSHI Eiji 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 (50407681)
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
|---|
| Keywords | 前頭葉 / 大脳基底核 / 行動決定 / 動作選 / 意思決定 / 前頭連合野 / システム神経科学 / 記憶 / 認知 / 行動 / 運動 |
|---|
| Outline of Final Research Achievements |
In the process of choosing and executing behavior it is suggested that the multiple areas in the frontal cortex and the basal ganglia play a crucial role. However, the underlying neural mechanisms in terms of functions and networks remain elusive. In the analysis of functions, we found a functional gradient within the frontal cortex. We also found that in making decisions the frontal cortex plays a primary role, while the basal ganglia are mainly involved in retrieving a decision made by other areas, such as the frontal cortex. Further, by comparing neurons in a cortical motor area and the thalamic reticular nucleus, a gateway in the cortico-basal ganglia network, and we found that this nucleus plays a role as an activity filter. In the analysis of networks, we found that a cortical area receives diverse inputs from multiple territories of the basal ganglia. Altogether, these results further revered functional and structural mechanisms underlying behavioral control.
|
Report
(5 results)
Research Products
(12 results)
