Interaction between the higher-order motor areas and the basal ganglia in associating cognition and action

• Project/Area Number: 26290012
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: HOSHI Eiji 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 (50407681)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: 前頭葉 / 大脳基底核 / 行動決定 / 動作選 / 意思決定 / 前頭連合野 / システム神経科学 / 記憶 / 認知 / 行動 / 運動

Outline of Final Research Achievements

In the process of choosing and executing behavior it is suggested that the multiple areas in the frontal cortex and the basal ganglia play a crucial role. However, the underlying neural mechanisms in terms of functions and networks remain elusive. In the analysis of functions, we found a functional gradient within the frontal cortex. We also found that in making decisions the frontal cortex plays a primary role, while the basal ganglia are mainly involved in retrieving a decision made by other areas, such as the frontal cortex. Further, by comparing neurons in a cortical motor area and the thalamic reticular nucleus, a gateway in the cortico-basal ganglia network, and we found that this nucleus plays a role as an activity filter. In the analysis of networks, we found that a cortical area receives diverse inputs from multiple territories of the basal ganglia. Altogether, these results further revered functional and structural mechanisms underlying behavioral control.

Research Products

• [Journal Article] Visuomotor signals for reaching movements in the rostro-dorsal sector of the monkey thalamic reticular nucleus. (2017)
  • Author(s): Saga Y, Nakayama Y, Inoue K, Yamagata T, Hashimoto M, Tremblay L, Takada M, Hoshi E
  • Journal Title: European Journal of Neuroscience Volume: 印刷中 Pages: 1186-1199
  • DOI: 10.1111/ejn.13421
  • NAID: 120006305932
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 動作制御機能の中枢 (2017)
  • Author(s): 中山義久・星 英司
  • Journal Title: BRAIN and NERVE Volume: 69 Issue: 4 Pages: 327-337
  • DOI: 10.11477/mf.1416200749
  • ISSN: 1344-8129, 1881-6096
• [Journal Article] Area- and band-specific representations of hand movements by local field potentials in the caudal cingulate motor area and supplementary motor area of monkeys (2016)
  • Author(s): Osamu Yokoyama, Yoshihisa Nakayama, Eiji Hoshi
  • Journal Title: J. Neurophysiol. Volume: 115 Pages: 1156-1176
  • DOI: 10.1152/jn.00882.2015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Origins of multisynaptic projections from the basal ganglia to the forelimb region of the ventral premotor cortex in macaque monkeys. (2016)
  • Author(s): Ishida H, Inoue K, Takada M, Hoshi E
  • Journal Title: Eur. J. Neurosci. Volume: 43 Pages: 258-269
  • DOI: 10.1111/ejn.13127
  • NAID: 120005997650
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Area-specific involvement of frontal areas and the basal ganglia in goal-directed behavior in monkeys (2017)
  • Author(s): Yoshihisa Nakayama, Tomoko Yamagata, Nariko Arimura, Eiji Hoshi
  • Organizer: The 47th annual meeting of the Society for Neuroscience
  • Int'l Joint Research
• [Presentation] 行動ゴール達成過程における複数脳領域の関与の比較 (2017)
  • Author(s): 中山義久・山形朋子・有村奈利子・星 英司
  • Organizer: 日本心理学会第81回大会
• [Presentation] Fronto-basal ganglia network involved in the process of achieving behavioral goal (2017)
  • Author(s): Yoshihisa Nakayama, Tomoko Yamagata, Nariko Arimura, Eiji Hoshi
  • Organizer: 日本神経科学学会第40回大会
• [Presentation] Supplementary eye field neurons dynamically control the size of spatial attention (2017)
  • Author(s): Osamu Yokoyama, Eiji Hoshi, Yukio Nishimura
  • Organizer: 日本神経科学学会第40回大会
• [Presentation] Motor commands transferred from the deep cerebellar nuclei to the motor cortex (2017)
  • Author(s): Nobuya Sano, Yoshihisa Nakayama, Eiji Hoshi, Satomi Chiken, Atsushi Nambu, Yukio Nishimura
  • Organizer: 日本神経科学学会第40回大会
• [Presentation] Cells of origin of multisynaptic projections from amygdala to ventral premotor cortex in macaques (2017)
  • Author(s): Hiroaki Ishida, Ken-ichi Inoue, Eiji Hoshi, Masahiko Takada
  • Organizer: International school of neuroscience: Elements of primate neuronal networks in the connectome era
  • Int'l Joint Research
• [Remarks] 前頭葉機能プロジェクトWebサイト
  • URL: https://frontal-lobe.jp
• [Remarks] 前頭葉機能プロジェクトウェブサイト
  • URL: http://www.igakuken.or.jp/frontal-lobe/