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Interaction between the higher-order motor areas and the basal ganglia in associating cognition and action

Research Project

Project/Area Number 26290012
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

HOSHI Eiji  公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 (50407681)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords前頭葉 / 大脳基底核 / 行動決定 / 動作選 / 意思決定 / 前頭連合野 / システム神経科学 / 記憶 / 認知 / 行動 / 運動
Outline of Final Research Achievements

In the process of choosing and executing behavior it is suggested that the multiple areas in the frontal cortex and the basal ganglia play a crucial role. However, the underlying neural mechanisms in terms of functions and networks remain elusive. In the analysis of functions, we found a functional gradient within the frontal cortex. We also found that in making decisions the frontal cortex plays a primary role, while the basal ganglia are mainly involved in retrieving a decision made by other areas, such as the frontal cortex. Further, by comparing neurons in a cortical motor area and the thalamic reticular nucleus, a gateway in the cortico-basal ganglia network, and we found that this nucleus plays a role as an activity filter. In the analysis of networks, we found that a cortical area receives diverse inputs from multiple territories of the basal ganglia. Altogether, these results further revered functional and structural mechanisms underlying behavioral control.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (12 results)

All 2017 2016 Other

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 2 results) Remarks (2 results)

  • [Journal Article] 増大特集 ブロードマン領野の現在地 動作制御機能の中枢2017

    • Author(s)
      中山義久・星 英司
    • Journal Title

      BRAIN and NERVE

      Volume: 69 Issue: 4 Pages: 327-337

    • DOI

      10.11477/mf.1416200749

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2017-04-01
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Visuomotor signals for reaching movements in the rostro-dorsal sector of the monkey thalamic reticular nucleus.2017

    • Author(s)
      Saga Y, Nakayama Y, Inoue K, Yamagata T, Hashimoto M, Tremblay L, Takada M, Hoshi E
    • Journal Title

      Eur J Neurosci

      Volume: 印刷中 Issue: 9 Pages: 1186-1199

    • DOI

      10.1111/ejn.13421

    • NAID

      120006305932

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Area- and band-specific representations of hand movements by local field potentials in the caudal cingulate motor area and supplementary motor area of monkeys2016

    • Author(s)
      Osamu Yokoyama, Yoshihisa Nakayama, Eiji Hoshi
    • Journal Title

      Journal of Neurophysiology

      Volume: 115 Issue: 3 Pages: 1156-1176

    • DOI

      10.1152/jn.00882.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Origins of multisynaptic projections from the basal ganglia to the forelimb region of the ventral premotor cortex in macaque monkeys.2016

    • Author(s)
      Ishida H, Inoue K, Takada M, Hoshi E
    • Journal Title

      Eur J Neurosci

      Volume: 43 Issue: 2 Pages: 258-269

    • DOI

      10.1111/ejn.13127

    • NAID

      120005997650

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Area-specific involvement of frontal areas and the basal ganglia in goal-directed behavior in monkeys2017

    • Author(s)
      Yoshihisa Nakayama, Tomoko Yamagata, Nariko Arimura, Eiji Hoshi
    • Organizer
      The 47th annual meeting of the Society for Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 行動ゴール達成過程における複数脳領域の関与の比較2017

    • Author(s)
      中山義久・山形朋子・有村奈利子・星 英司
    • Organizer
      日本心理学会第81回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Fronto-basal ganglia network involved in the process of achieving behavioral goal2017

    • Author(s)
      Yoshihisa Nakayama, Tomoko Yamagata, Nariko Arimura, Eiji Hoshi
    • Organizer
      日本神経科学学会第40回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Supplementary eye field neurons dynamically control the size of spatial attention2017

    • Author(s)
      Osamu Yokoyama, Eiji Hoshi, Yukio Nishimura
    • Organizer
      日本神経科学学会第40回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Motor commands transferred from the deep cerebellar nuclei to the motor cortex2017

    • Author(s)
      Nobuya Sano, Yoshihisa Nakayama, Eiji Hoshi, Satomi Chiken, Atsushi Nambu, Yukio Nishimura
    • Organizer
      日本神経科学学会第40回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cells of origin of multisynaptic projections from amygdala to ventral premotor cortex in macaques2017

    • Author(s)
      Hiroaki Ishida, Ken-ichi Inoue, Eiji Hoshi, Masahiko Takada
    • Organizer
      International school of neuroscience: Elements of primate neuronal networks in the connectome era
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 前頭葉機能プロジェクトWebサイト

    • URL

      https://frontal-lobe.jp

    • Related Report
      2015 Annual Research Report
  • [Remarks] 前頭葉機能プロジェクトウェブサイト

    • URL

      http://www.igakuken.or.jp/frontal-lobe/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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