Molecular mechanisms of astrocyte heterogeneity
Project/Area Number |
26290021
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Tanaka Kohichi 東京医科歯科大学, 難治疾患研究所, 教授 (80171750)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | アストロサイト / ゲノム編集 / 脳神経疾患 / 神経科学 / 脳・神経 |
Outline of Final Research Achievements |
Astrocytes were thought to be a homogenous population of cells. However, several studies have demonstrated that astrocytes from different regions show heterogeneity in their expression of ion channels and coupling molecules. To dissect astrocyte heterogeneity, we decode the origin of astrocytes in different brain regions. To elucidate the embryonic origins of astrocyte in a specific brain region, we applied a recombinase-based intersectional genetic strategy in mice. Astrocytes in dorsal forebrain, thalamus, hypothalamus, cerebellum/midbrain, and spinal cord are derived from Emx1-, Olig3-, Nkx2.1-, En1, Hoxb8-positive domain of the ventricular zone, respectively. In addition, intersectional approach can control the activity of astrocytes in a region-specific manner. We can demonstrate that astrocytes in different brain regions contribute to different brain functions.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Association of impaired neuronal migration with cognitive deficits in extremely preterm infants.2017
Author(s)
Kubo K, Deguchi K, Nagai T, Ito Y, Yoshida K, Endo T, Benner S, Shan W, Kitazawa A, Aramaki M, Ishii K, Shin M, Matsunaga Y, Hayashi K, Kakeyama M, Tohyama C, Tanaka KF, Tanaka K, Takashima S, Nakayama M, Itoh M, Hirata Y, Antalffy B, Armstrong DD, Yamada K, Inoue K, Nakajima K
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Journal Title
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effect of geranylgeranylacetone on the protection of retinal ganglion cells in a mouse model of normal tension glaucoma.2016
Author(s)
Dong Z, Shinmei Y, Dong Y, Inafuku S, Fukuhara J, Ando R, Kitaichi N, Kanda A, Tanaka K, Noda K, Harada T, Chin S, Ishida S.
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Journal Title
Heliyon
Volume: 2
Issue: 10
Pages: e00191-e00191
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Gene cassette knock-in in mammalian cells and zygotes by enhanced MMEJ.2016
Author(s)
Aida T, Nakade S, Sakuma T, Izu Y, Oishi A, Mochida K, Ishikubo H, Usami T, Aizawa H, Yamamoto T, Tanaka K.
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Journal Title
BMC Genomics
Volume: 17
Issue: 1
Pages: 979-979
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.2015
Author(s)
Ageta-Ishihara N, Yamazaki M, Konno K, Nakayama H, Abe M, Hashimoto K, Nishioka T, Kaibuchi K, Hattori S, Miyakawa T, Tanaka K, Huda F, Hirai H, Hashimoto K, Watanabe M, Sakimura K, Kinoshita M.
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Journal Title
Nat Commun.
Volume: 6
Issue: 1
Pages: 10090-10090
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Neuronal heterotopias affect the activities of distant brain areas and lead to behavioral deficits2015
Author(s)
Kazuhiro Ishii, Ken-ichiro Kubo, Toshihiro Endo, Keitaro Yoshida, Seico Benner, Yukiko Ito, Hidenori Aizawa, Michihiko Aramaki, Akihiro Yamanaka, Kohichi Tanaka, Norio Takata, Kenji Tanaka, Masaru Mimura, Chiahru Tohyama, Masaki Kakeyama, and Kazunori Nakajima
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Journal Title
Journal of Neuroscience
Volume: 35
Issue: 36
Pages: 12432-45
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice.2015
Author(s)
Aida T, Yoshida J, Nomura M, Tanimura A, Iino Y, Soma M, Bai N, Ito Y, Cui W, Aizawa H, Yanagisawa M, Nagai T, Takata N, Tanaka KF, Takayanagi R, Kano M, Gotz M, Hirase H, Tanaka K.
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Journal Title
Neuropsychopharmacology
Volume: in press
Issue: 7
Pages: 1660-1660
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Arundic acid attenuates retinal ganglion cell death by increasing glutamate/aspartate transporter expression in a model of normal tension glaucoma.2015
Author(s)
Yanagisawa, M., Aida, T., Takeda, T., Namekata, K., Harada, T., Shinagawa, R. and *Tanaka. K.
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Journal Title
Cell Death and Disease
Volume: 6
Issue: 3
Pages: e1693-e1693
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Valproic acid prevents retinal degeneration in a murine model of normal tension glaucoma2015
Author(s)
Kimura, A., Guo, X., Noro, T., Harada, C., Tanaka, K., Namekata, K. and Harada, T
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Journal Title
Neuroscience Letters
Volume: 588
Pages: 108-113
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Neuronal heterotopias affect the activities of distant brain areas and lead to behavioral deficits2015
Author(s)
Kazuhiro Ishii, Ken-ichiro Kubo1, Toshihiro Endo, Keitaro Yoshida, Seico Benner, Yukiko Ito, Hidenori Aizawa, Michihiko Aramaki, Akihiro Yamanaka, Kohichi Tanaka, Norio Takata, Kenji F. Tanaka, Masaru Mimura, Chiharu Tohyama, Masaki Kakeyama, and Kazunori Nakajima
Organizer
Neuroscience 2105
Place of Presentation
シカゴ(イリノイ州・米国)
Year and Date
2015-10-17
Related Report
Int'l Joint Research
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[Presentation] Analyses of the pathological roles of the altered brain cytoarchitectures with ectopic neurons2015
Author(s)
Ken-ichiro Kubo, Kazuhiro Ishii, Toshihiro Endo, Keitaro Yoshida, Seico Benner, Yukiko Ito, Hidenori Aizawa, Michihiko Aramaki, Akihiro Yamanaka, Kohichi Tanaka, Norio Takata, Kenji F. Tanaka, Masaru Mimura, Chiharu Tohyama, Masaki Kakeyama, and Kazunori Nakajima
Organizer
第58回日本神経化学会大会
Place of Presentation
大宮ソニックシティ(さいたま市・埼玉県)
Year and Date
2015-09-11
Related Report
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[Presentation] Cloning-free genome editing in mice2015
Author(s)
Kohichi Tanaka, Tomomi Aida, Keiho Chiyo, Takako Usami, Harumi Ishikubo, Risa Imahashi, Yusaku Wada, Kenji F. Tanaka, Tetsushi Sakuma, Takashi Yamamoto
Organizer
第38回日本神経科学大会
Place of Presentation
神戸ポートアイランド(神戸市・兵庫県)
Year and Date
2015-07-28
Related Report
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[Presentation] Glial dysfunction in the mouse habenula causes depressive behaviors and sleep disturbance2014
Author(s)
Wangpeng Cui, Hiroaki Mizukami, Michiko Yanagisawa, Tomomi Aida, Masatoshi Nomura, Yoshikazu Isomura, Ryoichi Takayanagi, Keiya Ozawa, Kohichi Tanaka, Hidenori Aizawa
Organizer
Annual Meeting of the Society for Neuroscience
Place of Presentation
Washington, DC(米国)
Year and Date
2014-11-19
Related Report
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[Presentation] Enhancement of glutamate clearance via cortical glial glutamate transport (GLT-1) induced resiliency to stress2014
Author(s)
Mouna Banasr, Ashley E Lepack, Jaime Maldonado-Aviles, Carly L Kiselycznyk, Vanja Duric, Jie Zhang, Stacey Wilber, Kohichi Tanaka, PRalph J DiLeone, Ronald S Duman, Gerard Sanacora
Organizer
Annual Meeting of the Society for Neuroscience
Place of Presentation
Washington, DC(米国)
Year and Date
2014-11-19
Related Report
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[Presentation] Deficiency of glutamate transporter in astrocyte increases brain excitability and induces Tourette’s Syndrome-like excessive repetitive behaviours in mice2014
Author(s)
Tomomi Aida, Junichi Yoshida, Masatoshi Nomura, Asami Tanimura, Yusuke Iino, Miho Soma, Ning Bai, Yukiko Ito, Wangpeng Cui, Hidenori Aizawa, Terumi Nagai, Norio Takata, Ryoichi Takayanagi, Masanobu Kano, Magdalena Götz, Hajime Hirase, Kohichi Tanaka
Organizer
Annual Meeting of the Society for Neuroscience
Place of Presentation
Washington, DC(米国)
Year and Date
2014-11-18
Related Report
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[Presentation] Glial glutamate transporter GLT-1 determines sensitivity to the cortical spreading depression2014
Author(s)
Hidenori Aizawa, Weinan Sun, Yukiko Ito, Saori Toyoda, Wangpeng Cui, Tomomi Aida, Masatoshi Nomura, Michiko Yanagisawa, Ryoichi Takayanagi, Kohichi Tanaka
Organizer
Annual Meeting of the Society for Neuroscience
Place of Presentation
Washington, DC(米国)
Year and Date
2014-11-16
Related Report
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