Evaluation of causa association between diabetes and cancer by Mendelian randomization analysis

• Project/Area Number: 26290046
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: National Cancer Center Japan
• Principal Investigator: Tsugane Shoichiro 国立研究開発法人国立がん研究センター, 社会と健康研究センター, 社会と健康研究センター長 (40179982)
• Co-Investigator(Kenkyū-buntansha): 岩崎 基 国立研究開発法人国立がん研究センター, 社会と健康研究センター, 部長 (60392338) ; 後藤 温 東京女子医科大学, 医学部, 助教 (80644822)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
• Keywords: 疫学研究 / がんの危険因子 / 糖尿病 / 予防医学

Outline of Final Research Achievements

We conducted a Mendelian randomization (MR) analysis among approximately 3,750 incident cancer cases and 13,000 subcohort participants in the Japan Public Health Center-based Prospective Study (JPHC Study) to investigate an association between diabetes mellitus and cancer incidence. Using 29 single nucleotide polymorphisms as instrumental variables, the MR analysis indicated no association between diabetes and cancer. In site-specific analyses, no associations were found for pancreatic, liver, or colorectal cancer. Our findings suggest that diabetes per se may not be a true risk factor for cancer.

Research Products

• [Journal Article] The association between plasma C-peptide concentration and the risk of prostate cancer: a nested case-control study within a Japanese population-based prospective study. (2017)
  • Author(s): Kiyabu GY, Sawada N, Iwasaki M, Yamaji T, Shimazu T, Sasazuki S, Inoue M, Tsugane S; JPHC Study Group
  • Journal Title: Eur J Cancer Prev. Volume: 印刷中
  • DOI: 10.1097/cej.0000000000000363
  • Peer Reviewed
• [Journal Article] High hemoglobin A1c levels within the non‐diabetic range are associated with the risk of all cancers (2016)
  • Author(s): Goto A, Noda M, Sawada N, Kato M, Hidaka A, Mizoue T, Shimazu T, Yamaji T, Iwasaki M, Sasazuki S, Inoue M, Kadowaki T, Tsugane S
  • Journal Title: Int J Cancer. Volume: 138 Pages: 1741-1745
  • DOI: 10.1002/ijc.29917
  • Peer Reviewed / Open Access
• [Journal Article] Plasma insulin, C-peptide and blood glucose and the risk of gastric cancer: the Japan Public Health Center-based prospective study. (2015)
  • Author(s): Hidaka A, Sasazuki S, Goto A, Sawada N, Shimazu T, Yamaji T, Iwasaki M, Inoue M, Noda M, Tajiri H, Tsugane S; JPHC Study Group.
  • Journal Title: Int J Cancer Volume: 136 Pages: 1402-10
  • DOI: 10.1002/ijc.29098
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] メンデリアンランダマイゼーション法による因果関係評価 (2014)
  • Author(s): 後藤温
  • Organizer: がん予防学術大会 2014東京
  • Place of Presentation: 国立がん研究センター
  • Year and Date: 2014-06-13 – 2014-06-14
  • Invited
• [Remarks] 多目的コホート研究
  • URL: http://epi.ncc.go.jp/jphc/index.html