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Evaluation of causa association between diabetes and cancer by Mendelian randomization analysis

Research Project

Project/Area Number 26290046
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Tumor biology
Research InstitutionNational Cancer Center Japan

Principal Investigator

Tsugane Shoichiro  国立研究開発法人国立がん研究センター, 社会と健康研究センター, 社会と健康研究センター長 (40179982)

Co-Investigator(Kenkyū-buntansha) 岩崎 基  国立研究開発法人国立がん研究センター, 社会と健康研究センター, 部長 (60392338)
後藤 温  東京女子医科大学, 医学部, 助教 (80644822)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Keywords疫学研究 / がんの危険因子 / 糖尿病 / 予防医学
Outline of Final Research Achievements

We conducted a Mendelian randomization (MR) analysis among approximately 3,750 incident cancer cases and 13,000 subcohort participants in the Japan Public Health Center-based Prospective Study (JPHC Study) to investigate an association between diabetes mellitus and cancer incidence. Using 29 single nucleotide polymorphisms as instrumental variables, the MR analysis indicated no association between diabetes and cancer. In site-specific analyses, no associations were found for pancreatic, liver, or colorectal cancer. Our findings suggest that diabetes per se may not be a true risk factor for cancer.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (5 results)

All 2017 2016 2015 2014 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (1 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] The association between plasma C-peptide concentration and the risk of prostate cancer: a nested case-control study within a Japanese population-based prospective study.2017

    • Author(s)
      Kiyabu GY, Sawada N, Iwasaki M, Yamaji T, Shimazu T, Sasazuki S, Inoue M, Tsugane S; JPHC Study Group
    • Journal Title

      Eur J Cancer Prev.

      Volume: 印刷中 Issue: 5 Pages: 461-467

    • DOI

      10.1097/cej.0000000000000363

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High hemoglobin A1c levels within the non‐diabetic range are associated with the risk of all cancers2016

    • Author(s)
      Goto A, Noda M, Sawada N, Kato M, Hidaka A, Mizoue T, Shimazu T, Yamaji T, Iwasaki M, Sasazuki S, Inoue M, Kadowaki T, Tsugane S
    • Journal Title

      Int J Cancer.

      Volume: 138 Issue: 7 Pages: 1741-1745

    • DOI

      10.1002/ijc.29917

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasma insulin, C-peptide and blood glucose and the risk of gastric cancer: the Japan Public Health Center-based prospective study.2015

    • Author(s)
      Hidaka A, Sasazuki S, Goto A, Sawada N, Shimazu T, Yamaji T, Iwasaki M, Inoue M, Noda M, Tajiri H, Tsugane S; JPHC Study Group.
    • Journal Title

      Int J Cancer

      Volume: 136 Issue: 6 Pages: 1402-10

    • DOI

      10.1002/ijc.29098

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] メンデリアンランダマイゼーション法による因果関係評価2014

    • Author(s)
      後藤温
    • Organizer
      がん予防学術大会 2014東京
    • Place of Presentation
      国立がん研究センター
    • Year and Date
      2014-06-13 – 2014-06-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Remarks] 多目的コホート研究

    • URL

      http://epi.ncc.go.jp/jphc/index.html

    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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