Comparison of the effect to cancer metastasis between photon and particle beam
Project/Area Number |
26290055
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Tumor therapeutics
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Research Institution | Osaka University |
Principal Investigator |
koizumi masahiko 大阪大学, 医学(系)研究科(研究院), 教授 (90186594)
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Co-Investigator(Kenkyū-buntansha) |
松浦 成昭 大阪大学, 医学(系)研究科(研究院), 教授 (70190402)
出水 祐介 神戸大学, 医学(系)研究科(研究院), 准教授 (50452496)
不破 信和 横浜市立大学, 医学(系)研究科(研究院), その他 (50156981)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
Keywords | がん転移 / 炭素イオン線 / 陽子線 / 遊走能 / 浸潤能 / SUN / CD44 / X線 / 陽子 / がん幹細胞 / 細胞遊走・浸潤 / がん移転 / 細胞遊走 |
Outline of Final Research Achievements |
The cell migration and invasion capability were evaluated after X, carbon ion or proton beam irradiation on each cancer cell lines (lung, breast, pancreatic and prostate cancer). Low dose X-irradiation enhanced the cell migration and invasion. Carbon ion beam inhibited the capability dose dependently. Proton beam had unique character. Low dose proton irradiation enhanced the cell migration and invasion, on the other hand, high dose inhibited the metastatic potentials. The expression of nuclear membrane protein SUN was increased by X-irradiation. Carbon ion beam didn't have ability that increased the expression of SUN. We have demonstrated that particle therapy has inhibited the cancer metastatic potentials compared with photon therapy.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Inhibitory Effects of Dopamine Receptor D1 Agonist on Mammary Tumor and Bone Metastasis.2017
Author(s)
Minami K, Liu S, Liu Y, Chen A, Wan Q, Na S, Li BY, Matsuura N, Koizumi M, Yin Y, Gan L, Xu A, Li J, Nakshatri H, Yokota H.
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 45686-45686
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Multicenter Study of Carbon-Ion Radiation Therapy for Mucosal Melanoma of the Head and Neck: Subanalysis of the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS) Study (1402 HN).2017
Author(s)
Koto M, Demizu Y, Saitoh JI, Suefuji H, Tsuji H, Okimoto T, Ohno T, Shioyama Y, Takagi R, Nemoto K, Nakano T, Kamada T
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Journal Title
Int J Radiat Oncol Biol Phys.
Volume: 97(5)
Issue: 5
Pages: 1054-1060
DOI
Related Report
Peer Reviewed
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[Journal Article] Using Proton Beam Therapy in the Elderly Population: A Snapshot of Current Perception and Practice.2017
Author(s)
Thariat J, Sio T, Blanchard P, Patel S, Demizu Y, Ampil F, Guihard S, Miller RC, Karlsson U, Krengli M, Giap H, Nguyen N.
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Journal Title
Int J Radiat Oncol Biol Phys.
Volume: 3016(17)
Issue: 4
Pages: 30007-30007
DOI
Related Report
Peer Reviewed
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[Journal Article] Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan.2017
Author(s)
Demizu Y, Mizumoto M, Onoe T, Nakamura N, Kikuchi Y, Shibata T, Okimoto T, Hideyuki S, Akimoto T, Ono K, Daimon T, Murayama S.
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Journal Title
Cancer Sci.
Volume: [Epub ahead of print]
Issue: 5
Pages: 233-237
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] The integrin-binding defective FGF2 mutants potently suppress FGF2 signaling and angiogenesis.2017
Author(s)
Mori S, Hatori N, Kawaguchi N, Hamada Y, Shih TC, Wu CY, Lam KS, Matsuura N, Yamamoto H, Takada YK, Takada Y.
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Journal Title
Biosci Rep.
Volume: [Epub ahead of print]
Issue: 2
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Micrometastasis Volume in Lymph Nodes Determines Disease Recurrence Rate of Stage II Colorectal Cancer: A Prospective Multicenter Trial.2016
Author(s)
Yamamoto H, Murata K, Fukunaga M, Ohnishi T, Noura S, Miyake Y, Kato T, Ohtsuka M, Nakamura Y, Takemasa I, Mizushima T, Ikeda M, Ohue M, Sekimoto M, Nezu R, Matsuura N, Monden M, Doki Y, Mori M.
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Journal Title
Clin Cancer Res.
Volume: 22(13)
Issue: 13
Pages: 3201-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Long-term results of intraoperative extracorporeal irradiation of autogenous bone grafts on primary bone and soft tissue malignancies.2015
Author(s)
Hayashi K, Araki N, Koizumi M, Suzuki O, Seo Y, Naka N, Isohashi F, Myoui A, Yoshioka Y, Teshima T, Ueda T, Yoshikawa H, Ogawa K.
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Journal Title
Acta Oncol.
Volume: 54(1)
Issue: 1
Pages: 138-141
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Uterine cervical cancer displaying tumor-related leukocytosis: a distinct clinical entity with radioresistant feature2014
Author(s)
Mabuchi, S. Matsumoto, Y. Kawano, M. Minami, K. Seo, Y. Sasano, T. Takahashi, R. Kuroda, H. Hisamatsu, T. Kakigano, A. Hayashi, M. Sawada, K. Hamasaki, T. Morii, E. Kurachi, H. Matsuura, N. Kimura, T.
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Journal Title
J Natl Cancer Inst
Volume: 106
Issue: 7
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Treatment Outcomes of Particle Radiotherapy Using Protons or Carbon Ions as a Single-Modality Therapy for Adenoid Cystic Carcinoma of the Head and Neck2014
Author(s)
Masaru Takagi,Yusuke Demizu, Naoki Hashimoto, Masayuki Mima, Kazuki Terashima, Osamu Fujii, Dongcun Jin, Yasue Niwa, Koichi Morimoto, Takashi Akagi, Takashi Daimon, Ryohei Sasaki, Yoshio Hishikawa, Mitsuyuki Abe, Masao Murakami, and Nobukazu Fuwa
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Journal Title
Radiotherapy and Oncology,
Volume: 113(3)
Issue: 3
Pages: 364-370
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Limited impact of breathing motion, interplay effect and set-up/range uncertainties in IMPT for advanced stage NSCLC2015
Author(s)
Inoue T, van Dijk L.V., Widder J, Takegawa H, Koizumi M, Takashina M, Saito A.I., Sasai K, van’t Veld A.A., Langendijk J.A., Korevaar E.W.
Organizer
54th Annual Conference of Proton Therapy Co-Operative Group
Place of Presentation
San Diego, USA
Year and Date
2015-05-18
Related Report
Int'l Joint Research
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