| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
Long term uptake of anti-diabetes drug, metformin, has been shown to reduce cancer incidence and mortality. However, the underlying mechanism of this effect is not yet understood. Immune system against cancers, particularly, CD8T cells (killer cells) undergoes exhaustion in tumors, which allows for tumor growth. We found that metformin reactivates exhausted CD8T cells in tumors to fight against cancer cells through elevation of their glycolysis, leading to the retardation of tumor growth.
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