Elucidation of mechanisms of metabolic disorder-associated genes by the integration of genomic and non-genomic approaches
| Project/Area Number |
26290067
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical genome science
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
Kato Norihiro 国立研究開発法人国立国際医療研究センター, その他部局等, その他 (80293934)
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| Co-Investigator(Kenkyū-buntansha) |
並河 徹 島根大学, 医学部, 教授 (50180534)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMURA TADASHI 国立国際医療研究センター, 研究所, 室長 (00333790)
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| Research Collaborator |
TAKEUCHI FUMIHIKO 国立国際医療研究センター, 研究所, 室長
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 疾患モデル生物ゲノム / 遺伝子 / トランスクリプトーム / ゲノム / エピゲノム / マイクロアレイ / mRNA |
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| Outline of Final Research Achievements |
To narrow down the possible list of causative genes at loci or chromosomal regions, where genetic associations are detected through exploratory analyses such as genome-wide association study (GWAS) and to further elucidate the biological mechanisms of mRNA expression changes by such causative genes, we have addressed three principal themes in the case of metabolic disorders as follows. First, we have performed fine mapping of loci, which are found to be associated with metabolic disorders phenotypes in the inbred rats, thereby narrowing down the list of causative genes. Second, we have investigated impacts of epigenomic changes, in particular, DNA methylation changes, on the regulation of mRNA expression. Third, we have evaluated clinical significance of microRNA, another key component of epigenomic changes, in the gene-environment interaction and have successfully found its usefulness as a pathological biomarker.
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Report
(4 results)
Research Products
(21 results)
