Development of tissue regeneration technology of respiratory system
| Project/Area Number |
26290068
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical genome science
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Kurisaki Akira 国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 上級主任研究員 (60346616)
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| Co-Investigator(Kenkyū-buntansha) |
高田 仁実 国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 研究員 (80641068)
石嶺 久子 国立研究開発法人産業技術総合研究所, 幹細胞工学研究センター, 研究員 (90736737)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 幹細胞 / 分化 / 細胞 / 遺伝子 / 転写因子 / 肺 / 再生 / タンパク / 疾患 |
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| Outline of Final Research Achievements |
Stem cell differentiation technologies using pluripotent stem cells, especially iPS cells, are currently applied for understanding of intractable diseases, drug discovery, and development of regenerative medicine. In this research, we have developed a novel differentiation method that generates lung progenitor cells from somatic cells in vitro. We have screened transcription factors selectively expressed in the developing lung, and found several transcription factors that can induce differentiation of somatic tissue cells into lung progenitor cells. The generated progenitor cells can further differentiate into various lung tissue cells in vitro. This novel differentiation method could be used as a basic technology for the regeneration of respiratory system in the near future.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] A role for KLF4 in promoting the metabolic shift via TCL1 during induced pluripotent stem cell generation.2017
Author(s)
Nishimura K, Aizawa S, Nugroho FL, Shiomitsu E, Tran YTH, Bui PL, Borisova E, Sakuragi Y, Takada H, Kurisaki A, Hayashi Y, Fukuda A, Nakanishi M, Hisatake K
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Journal Title
Stem Cell Reports
Volume: 8
Pages: 787-801
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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