High-dimensional structure of chromatin and transcription regulation
| Project/Area Number |
26291006
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Ishii Shunsuke 国立研究開発法人理化学研究所, 石井分子遺伝学研究室, 上席研究員 (00124785)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | ヘテロクロマチン / ATF7 / ストレス / エピゲノム変化 / クロマチン / 高次構造 / 転写制御 / エピゲノム / ユークロマチン / 環境因子 / 脂肪細胞 / 代謝系遺伝子 |
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| Outline of Final Research Achievements |
High-dimensional structure of chromatin has an important role for transcription regulation. Chromatin consists of the heterochromatin, which is localized close to the centromere and telomere, and the euchromatin. We found that ATF7 contributes to heterochromatin formation by recruiting histone H3K9 methyltransferases, and that the stress-induced phosphorylation of ATF7 by p38 causes the disruption of heterochromatin and transcriptional induction. This effect was maintained for long period. Thus, it was shown that ATF7 plays an important role for regulation of the high-dimensional structure of chromatin.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory.2015
Author(s)
Yoshida K, Maekawa T, Zhu Y, Renard-Guillet C, Ishibashi K,Chatton B, Inoue K, Uchiyama T, Yamada T, Ohno N, Shirahige K, Okada-Hatakeyama M, Ishii S.
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Journal Title
Nat. Immunol.
Volume: 16(10)
Pages: 1034-1043
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] T396I Mutation of Mouse Sufu Reduces the Stability and Activity of Gli3 Repressor2015
Author(s)
Makino S, Zhulyn O, Mo R, Puviindran V, Zhang X, Murata T, Fukumura R, Ishitsuka Y, Kotaki H, Matsumaru D, Ishii S, Hui C.C, Gondo Y
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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