| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
|
|---|
| Outline of Final Research Achievements |
In this project, we carried out structural and biochemical studies on intramembrane cleaving protease (I-CLiP) that catalyzes the regulated intramembrane proteolysis (RIP) so as to elucidate molecular mechanism by which I-CLiP recognizes its substrate membrane protein in the trans-membrane and juxta-membrane regions. Specifically, we studied on bacterial RsePs belonging to the site-2 protease family. It has been shown by our work that bacterial RsePs possess a characteristc intramembrane β-sheet implicated in the substrate binding. Our results contributed to a further understanding of conformational change of substrate membrane proteins within the transmembrane region.
|
