Basic principles of voltage sensing
| Project/Area Number |
26291030
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | イオンチャネル / 生理学 / 膜電位 |
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| Outline of Final Research Achievements |
In this study, we tried to clarify voltage-sensing mechanism of the voltage-gated channels which generate and regulate bioelectronic signals as represented by the heartbeat and brain functions. We focused on the voltage-gated H+ channel consisting of a minimum voltage-sensor unit, and analyzed the voltage-sensor movement by membrane voltage and the structural rearrangement toward the channel opening. We demonstrated the molecular basis of the voltage-sensing mechanism.
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Report
(5 results)
Research Products
(26 results)
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[Journal Article] Conductance of P2X4 receptor is determined by conformational equilibrium in the transmembrane region2016
Author(s)
Minato Y, Suzuki S , Hara T, Kofuku Y, Kasuya G, Fujiwara Y, Igarashi S, Suzuki E, Nureki O, Hattori M, Ueda T, Shimada I
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Journal Title
Proceedings of the National Academy of Sciences
Volume: 発行中
Pages: 4741-4746
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Crystal structures of the TRIC trimeric intracellular cation channel orthologues.2016
Author(s)
Kasuya G, Hiraizumi M, Maturana AD, Kumazaki K, Fujiwara Y, Liu K, Nakada-Nakura Y, Iwata S, Tsukada K, Komori T, Uemura S, Goto Y, Nakane T, Takemoto M, Kato HE, Yamashita K, Wada M, Ito K, Ishitani R, Hattori M, Nureki O.
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Journal Title
Cell Research
Volume: 26
Pages: 1288-1301
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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