• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular mechnisms underlying the layer and column specific target recongnition in the visual system axons

Research Project

Project/Area Number 26291047
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Developmental biology
Research InstitutionTokyo Institute of Technology

Principal Investigator

Suzuki Takashi  東京工業大学, 生命理工学院, 准教授 (60612760)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords神経遺伝学 / ショウジョウバエ / 軸索投射 / 受容体型膜タンパク質 / 軸索間相互作用 / 神経生物学 / 神経回路形成 / カドヘリン / リガンド・受容体 / 視神経系 / 発生・分化 / 神経科学 / シグナル伝達 / 脳・神経 / 遺伝子 / 発生生物学 / 軸索誘導 / 視覚神経系
Outline of Final Research Achievements

A detailed functional analysis of fmi mutant in the pupal stages revealed that the Fmi promotes the extension of filopodia and that Gogo has a function to antagonize that effect. This supressive function of Gogo helps the R8 axons to maintain their distance and prevent them from bundling. In the later half of the pupal stage, when Gogo expression become down regulated, filopodia extension promoted by Fmi takes place. These data suggest that Gogo function to suppress the filopodia extension contributes to shape the axonal array with a constant distance among axons at the surface of the target ganglion.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(14 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (12 results) (of which Int'l Joint Research: 8 results)

  • [Journal Article] Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance.2015

    • Author(s)
      Organisti C, Hein I, Grunwald Kadow IC*, Suzuki T*
    • Journal Title

      Genes Cells

      Volume: 20 Pages: 50-67

    • DOI

      10.1111/gtc.12202

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell surface control of the layer specific targeting in the Drosophila visual system.2014

    • Author(s)
      Hakeda-Suzuki S, Suzuki T
    • Journal Title

      Genes Genet Syst.

      Volume: 89 Pages: 9-15

    • NAID

      130004137822

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Two receptor tyrosine phosphatases dictate the depth of final axonal stabilizing layer in the Drosophila visual system.2016

    • Author(s)
      Hakeda-Suzuki, S., Takechi H, Suzuki, T
    • Organizer
      第39回日本分子生物学会(MBSJ2016)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The transmembrane protein Golden goal recognizes the correct column at the medulla neuropil border during R8 axons targeting.2016

    • Author(s)
      Takechi, S. Hakeda-Suzuki and T. Suzuki.
    • Organizer
      第39回日本分子生物学会(MBSJ2016)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Two receptor tyrosine phosphatases dictate the depth of final axonal stabilizing layer in the Drosophila visual system.2016

    • Author(s)
      Hakeda-Suzuki, S., Takechi H, Suzuki, T.
    • Organizer
      日本ショウジョウバエ研究会 (JDRC12)
    • Place of Presentation
      立教大学、東京
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] The transmembrane protein Golden goal recognizes the correct column at the medulla neuropil border during R8 axons targeting.2016

    • Author(s)
      H. Takechi, S. Hakeda-Suzuki and T. Suzuki.
    • Organizer
      日本ショウジョウバエ研究会 (JDRC12)
    • Place of Presentation
      立教大学、東京
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Two Receptor Tyrosine Phosphatases Dictate the Depth of Final Axonal Stabilizing Layer in the Drosophila Visual System2016

    • Author(s)
      Hakeda-Suzuki, S., Takechi, H., Suzuki, T
    • Organizer
      NeuroFly2016
    • Place of Presentation
      Crete Island, Greece
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The two protein tyrosine phosphatases Lar and Ptp69D create a safety net in Drosophila photoreceptor axon wiring.2016

    • Author(s)
      Hakeda-Suzuki, S., Takechi H, Suzuki, T
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The two receptor tyrosine phosphatases Lar 案dPtp69D create a safety net in Drosophila photoreceptor axon wiring2016

    • Author(s)
      Satoko Hakeda-Suzuki, Hiorki Takechi, Takashi Suzuki
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience
    • Place of Presentation
      Pacifico Yokohama
    • Year and Date
      2016-07-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A combinatorial role of the two receptor tyrosine phosphatases in the Drosophila photoreceptor targeting2015

    • Author(s)
      Satoko Hakeda-Suzuki, Hiorki Takechi, Takashi Suzuki
    • Organizer
      24th European Drosophila Research Conference
    • Place of Presentation
      Heidelberg Convention Center
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A role of the two receptor tyrosine phosphatases, Lar and Ptp69D, in the photoreceptor axon targeting2015

    • Author(s)
      Satoko Hakeda-Suzuki, Hiorki Takechi, Takashi Suzuki
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience
    • Place of Presentation
      Kobe Convention Center
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A role of the two receptor tyrosine phosphatases, Lar and Ptp69D, in the photoreceptor axon targeting2015

    • Author(s)
      Satoko Hakeda-Suzuki, Hiroki Takechi, Takashi Suzuki
    • Organizer
      The 48th Annual Meeting of the Japanese Society of Developmental Biologists
    • Place of Presentation
      Tsukba International Congress Center
    • Year and Date
      2015-06-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A combinatorial role of the two protein phosphatases, Lar nd Ptp69D, in the photoreceptor axon targeting2014

    • Author(s)
      Satoko Hakeda-Suzuki, Fu Kusakawa, Takashi Suzuki
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Year and Date
      2014-11-24 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] A combinational role of the two protein tyrosine phosphatases, Lar and Ptp69D, in the photoreceptor axon targeting.2014

    • Author(s)
      Satoko Hakeda-Suzuki, Fu Kusakawa, Takashi Suzuki.
    • Organizer
      JDRC11
    • Place of Presentation
      石川県金沢市金沢歌劇座
    • Year and Date
      2014-06-05 – 2014-06-07
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi