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The system for fine tuning of signal transduction that maintains the robustness in morphogenesis

Research Project

Project/Area Number 26291050
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Developmental biology
Research InstitutionNara Institute of Science and Technology

Principal Investigator

Bessho Yasumasa  奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (70261253)

Co-Investigator(Kenkyū-buntansha) 中畑 泰和  奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (50390810)
松井 貴輝  奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (60403333)
Co-Investigator(Renkei-kenkyūsha) Sakumura Yuichi  奈良先端科学技術大学院大学, バイオサイエンス研究科, 准教授 (50324968)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords形態形成 / 体節形成 / ロバスト性 / Notch / 遺伝子発現 / 体節 / 発生・分化 / 発現制御 / シグナル伝達
Outline of Final Research Achievements

During development, the body of the embryo is formed in a precise manner, although embryos are exposed to fluctuation of external environment. In this research project, we attempted to uncover the mechanism of robustness of the morphogenesis in embryo, using somite formation in vertebrate as a model. In the presomitic mesoderm, which is the primordium of somites, the expression of a group of genes oscillates under the Notch signaling, and this oscillatory expression controls the periodic somite segmentation. Each cell in the presomitic mesoderm can generate this oscillatory gene expression and its phase is synchronized among the cells, thus the machinery of the synchronization should be a key mechanism of the robustness in somite formation. In this project, we analyzed the knockout embryos of Nrarp, which is a feedback regulator of Notch signaling, and revealed that the fine tuning of Notch signal activity plays a critical role in the robustness of the morphogenesis of somites.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (21 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (17 results)

  • [Journal Article] Analyzing ERK Signal Dynamics During Zebrafish Somitogenesis2017

    • Author(s)
      Matsui T, BesshoY
    • Journal Title

      Methods in Molecular Biology

      Volume: 1487 Pages: 367-378

    • DOI

      10.1007/978-1-4939-6424-6_27

    • ISBN
      9781493964222, 9781493964246
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The circadian NAD+ metabolism: Impact on chromatin remodeling and aging.2016

    • Author(s)
      Nakahata Y, Bessho Y
    • Journal Title

      BioMed Research International

      Volume: 2016 Pages: 3208429-3208429

    • DOI

      10.1155/2016/3208429

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell collectivity regulation within migrating cell cluster during Kupffer's vesicle formation in zebrafish2015

    • Author(s)
      Takaaki Matsui, Hiroshi Ishikawa, Yasumasa Bessho
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 3 Pages: 27-27

    • DOI

      10.3389/fcell.2015.00027

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hes7 3’UTR is required for somite segmentation function2014

    • Author(s)
      Takeshi Fujimuro, Takaaki Matsui, Yasuhide Nitanda, Tatsuro Matta, Yuichi Sakumura, Michiko Saito, Kenji Kohno, Yasukazu Nakahata and Yasumasa Bessho
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 6462-6462

    • DOI

      10.1038/srep06462

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Molecular Mechanism to Lengthen the Circadian Period by Low NAD+2016

    • Author(s)
      Ashimori A, Nakahata Y, Matsui T, Bessho Y
    • Organizer
      第23回日本時間生物学会学術大会
    • Place of Presentation
      名古屋大学豊田講堂、愛知県名古屋市
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] The Impact of Decrease in NAD+ with Cellular Senscence on the Period of Circadian Gene Expression2016

    • Author(s)
      Iwamoto S, Nakahata Y, Ashimori A, Matsui T, Bessho Y
    • Organizer
      第23回日本時間生物学会学術大会
    • Place of Presentation
      名古屋大学豊田講堂、愛知県名古屋市
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] Molecular Mechanism to Lengthen the Circadian Period by Low NAD+2016

    • Author(s)
      Ashimori A, Nakahata Y, Matsui T, Bessho Y
    • Organizer
      International Symposium on Biological Thythms
    • Place of Presentation
      名古屋大学豊田講堂、愛知県名古屋市
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] The Impact of Decrease in NAD+ with Cellular Senscence on the Period of Circadian Gene ExpressionT2016

    • Author(s)
      Iwamoto S, Nakahata Y, Ashimori A, Matsui T, Bessho Y
    • Organizer
      International Symposium on Biological Thythms
    • Place of Presentation
      名古屋大学豊田講堂、愛知県名古屋市
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dynamics of cellular behavior during zebrafish development2016

    • Author(s)
      Bessho Y
    • Organizer
      KRIPIK-SciFiMaS 2016 International Conference
    • Place of Presentation
      Purwokerto, Indonesia
    • Year and Date
      2016-05-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Organ size regulation Zebrafish laterality organ2016

    • Author(s)
      Hiroshi Ishikawa, Sohei Yamada, Takanori Iino, Yasumasa Bessho, Yoichiroh
    • Organizer
      CDB Symposium 2016
    • Place of Presentation
      理化学研究所多細胞システム形成研究センター(兵庫県神戸市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細胞内NAD+による概日時計遺伝子発現変動の制御2016

    • Author(s)
      中畑泰和、別所康全
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 弾性性質を利用した創傷治癒機構の解明2016

    • Author(s)
      山田 壮平, 別所 康全, 細川 陽一郎, 松井 貴輝
    • Organizer
      第5回細胞競合コロキウム
    • Place of Presentation
      北海道大学医学部学友会館フラテ(北海道札幌市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] NAD+の減少は、概日時計遺伝子発現周期の延長を惹起する2015

    • Author(s)
      Atsushige Ashimori, Yasukazu Nakahata, Takaaki Matsui, Yasumasa Bessho
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 概日時計機構および細胞老化におけるNAD+/NAMPTの影響2015

    • Author(s)
      中畑 泰和, 芦森 温茂, 松井 貴輝, 別所 康全
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Reduction of intracellular NAD+ promotes the extension of periods of circadian clock genes2015

    • Author(s)
      Atsushige Ashimori, Yasukazu Nakahata, Takaaki Matsui, Yasumasa Bessho
    • Organizer
      日本時間生物学会学術大会
    • Place of Presentation
      東京大学本郷キャンパス伊藤国際学術研究センター(東京都文京区)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Mechanical property of epithelial cells affects speed of wound healing2015

    • Author(s)
      Sohei Yamada, Takanori Iino, Yasumasa Bessho, Yoichiro Hosokawa,Takaaki Matsui
    • Organizer
      1st International Symposium on Cell Competition
    • Place of Presentation
      京都大学芝蘭会館(京都府京都市)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] The mechanism of the biological clock that controls animal development2015

    • Author(s)
      Yasumasa Bessho
    • Organizer
      The 4th International Conference on Pharmacy and Advanced Pharmaceutical Sciences
    • Place of Presentation
      Yogyakarta, Indonesia
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] ゼブラフィッシュの創傷治療メカニズム2014

    • Author(s)
      山田 壮平、飯野 敬矩、別所 康全、細川 陽一郎、松井 貴輝
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 正常に機能するクッペル胞を形成するために必要な最小細胞数2014

    • Author(s)
      石川 寛、山田 壮平、田原 直幸、細川 陽一郎、別所 康全、松井 貴輝
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゼブラフィッシュCelf1は内胚葉形成の増殖・移動を調節することで、膵臓や肝臓の形成を制御する2014

    • Author(s)
      田原 直幸、別所 康全、松井 貴輝
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] A negative feedback loop of Nrarp provides robustness to the somite segmentation clock2014

    • Author(s)
      Nitanda Y, Kim W, Matsui T, Nakahata Y, Sakumura Y, Bessho Y
    • Organizer
      The 62nd NIBB Conference Force in Development
    • Place of Presentation
      Okazaki, Japan
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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