Studies on the molecular mechanisms underlying the transition from cell division to cell differentiation
| Project/Area Number |
26291061
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Plant molecular biology/Plant physiology
|
|---|
| Research Institution | Nara Institute of Science and Technology |
|---|
Principal Investigator |
UMEDA Masaaki 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (80221810)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
高橋 直紀 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (40553623)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SEKI Motoaki 理化学研究所, 環境資源科学研究センター, チームリーダー (80281624)
FUKAO Yoichiro 立命館大学, 生命科学部, 准教授 (80432590)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
|---|
| Keywords | 発生・分化 / 植物ホルモン / 細胞分裂 / DNA倍加 / クロマチン / 発現制御 / ゲノム / 植物 / シグナル伝達 |
|---|
| Outline of Final Research Achievements |
In this study, we revealed the mechanisms underlying the transition from cell division to cell differentiation by conducting functional analyses of KRPs, which are involved in degradation of B-type response regulators, and by analyzing the epigenetic regulation in triggering DNA polyploidization in roots. We found that some KRPs are expressed in the transition zone in roots and play an important role in an early onset of cell differentiation in response to DNA damage. Our results also indicated the possibility that auxin controls chromatin structure, thereby being associated with the transition from cell division to cell differentiation.
|
Report
(4 results)
Research Products
(30 results)
-
-
-
[Journal Article] The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis.2016
Author(s)
Weimer, A.K., Biedermann, S., Harashima, H., Roodbarkelari, F., Takahashi, N., Foreman, J., Guan, Y., Pochon, G., Heese, M., Van Damme, D., Sugimoto, K., Koncz, C., Doerner, P., Umeda, M., Schnittger, A.
-
Journal Title
EMBO J.
Volume: 35
Pages: 2068-2086
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
[Journal Article] Combination of synthetic chemistry and live-cell imaging identified a rapid cell division inhibitor in tobacco and Arabidopsis thaliana2016
Author(s)
Nambo, M., Kurihara, D., Yamada, T., Nishiwaki-Ohkawa, T., Kadofusa, N., Kimata, Y., Kuwata, K., Umeda, M. and Ueda, M.
-
Journal Title
Plant Cell Physiol
Volume: 57
Pages: 2255-2268
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
[Journal Article] Transcriptional repression by MYB3R proteins regulates plant organ growth.2015
Author(s)
Kobayashi K, Suzuki T, Iwata E, Nakamichi N, Suzuki T, Chen P, Ohtani M, Ishida T, Hosoya H, Müller S, Leviczky T, Pettkó-Szandtner A, Darula Z, Iwamoto A, Nomoto M, Tada Y, Higashiyama T, Demura T, Doonan JH, Hauser MT, Sugimoto K, Umeda M, Magyar Z, Bögre L, Ito M
-
Journal Title
EMBO J
Volume: 34
Pages: 1992-2007
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
[Journal Article] A dual-color marker system for in vivo visualization of cell cycle progression in Arabidopsis2014
Author(s)
Yin, K., Ueda, M., Takagi, H., Kajihara, T., Sugamata Aki, S., Nobusawa, T., Umeda-Hara, M. Umeda
-
Journal Title
Plant J.
Volume: 80
Pages: 541-552
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
