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Studies on the molecular mechanisms underlying the transition from cell division to cell differentiation

Research Project

Project/Area Number 26291061
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Plant molecular biology/Plant physiology
Research InstitutionNara Institute of Science and Technology

Principal Investigator

UMEDA Masaaki  奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (80221810)

Co-Investigator(Kenkyū-buntansha) 高橋 直紀  奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (40553623)
Co-Investigator(Renkei-kenkyūsha) SEKI Motoaki  理化学研究所, 環境資源科学研究センター, チームリーダー (80281624)
FUKAO Yoichiro  立命館大学, 生命科学部, 准教授 (80432590)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords発生・分化 / 植物ホルモン / 細胞分裂 / DNA倍加 / クロマチン / 発現制御 / ゲノム / 植物 / シグナル伝達
Outline of Final Research Achievements

In this study, we revealed the mechanisms underlying the transition from cell division to cell differentiation by conducting functional analyses of KRPs, which are involved in degradation of B-type response regulators, and by analyzing the epigenetic regulation in triggering DNA polyploidization in roots. We found that some KRPs are expressed in the transition zone in roots and play an important role in an early onset of cell differentiation in response to DNA damage. Our results also indicated the possibility that auxin controls chromatin structure, thereby being associated with the transition from cell division to cell differentiation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(30 results)

All 2017 2016 2015 2014 Other

All Journal Article (12 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 11 results,  Acknowledgement Compliant: 10 results,  Open Access: 2 results) Presentation (16 results) (of which Int'l Joint Research: 7 results,  Invited: 5 results) Remarks (2 results)

  • [Journal Article] Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote2017

    • Author(s)
      Ueda M, Aichinger E, Gong W, Groot E, Verstraeten I, Vu LD, De Smet I, Higashiyama T, Umeda M, Laux T
    • Journal Title

      Genes Dev.

      Volume: 31 Pages: 617-627

    • DOI

      10.1101/gad.292409.116

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] DNA damage inhibits lateral root formation by upregulating cytokinin biosynthesis genes in Arabidopsis thaliana.2016

    • Author(s)
      Davis, M.M., Ogita, N., Inagaki, S., Takahashi, N., Umeda, M.
    • Journal Title

      Genes Cells

      Volume: 21 Pages: 1195-1208

    • DOI

      10.1111/gtc.12436

    • NAID

      120006537391

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis.2016

    • Author(s)
      Weimer, A.K., Biedermann, S., Harashima, H., Roodbarkelari, F., Takahashi, N., Foreman, J., Guan, Y., Pochon, G., Heese, M., Van Damme, D., Sugimoto, K., Koncz, C., Doerner, P., Umeda, M., Schnittger, A.
    • Journal Title

      EMBO J.

      Volume: 35 Pages: 2068-2086

    • DOI

      10.15252/embj.201593083

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Combination of synthetic chemistry and live-cell imaging identified a rapid cell division inhibitor in tobacco and Arabidopsis thaliana2016

    • Author(s)
      Nambo, M., Kurihara, D., Yamada, T., Nishiwaki-Ohkawa, T., Kadofusa, N., Kimata, Y., Kuwata, K., Umeda, M. and Ueda, M.
    • Journal Title

      Plant Cell Physiol

      Volume: 57 Pages: 2255-2268

    • DOI

      10.1093/pcp/pcw140

    • NAID

      120006220249

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cytrap marker systems for in vivo visualization of cell cycle progression in Arabidopsis2016

    • Author(s)
      Sugamata Aki, S. and Umeda, M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 1370 Pages: 51-57

    • DOI

      10.1007/978-1-4939-3142-2_4

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Cyclin-dependent kinase-activating kinases CDKD;1 and CDKD;3 are essential for preserving mitotic activity in Arabidopsis thaliana2015

    • Author(s)
      Takatsuka, H., Umeda-Hara, C. and Umeda, M.
    • Journal Title

      Plant J.

      Volume: 82 Pages: 1004-1017

    • DOI

      10.1111/tpj.12872

    • NAID

      120006537393

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana2015

    • Author(s)
      Chen, P. and Umeda, M.
    • Journal Title

      Genes Cells

      Volume: 20 Pages: 636-646

    • DOI

      10.1111/gtc.12255

    • NAID

      120006537392

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Transcriptional repression by MYB3R proteins regulates plant organ growth.2015

    • Author(s)
      Kobayashi K, Suzuki T, Iwata E, Nakamichi N, Suzuki T, Chen P, Ohtani M, Ishida T, Hosoya H, Müller S, Leviczky T, Pettkó-Szandtner A, Darula Z, Iwamoto A, Nomoto M, Tada Y, Higashiyama T, Demura T, Doonan JH, Hauser MT, Sugimoto K, Umeda M, Magyar Z, Bögre L, Ito M
    • Journal Title

      EMBO J

      Volume: 34 Pages: 1992-2007

    • DOI

      10.15252/embj.201490899

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Epigenetic control of cell division and cell differentiation in the root apex2015

    • Author(s)
      Takatsuka, H. and Umeda, M.
    • Journal Title

      Front. Plant Sci.

      Volume: 6 Pages: 1178-1178

    • DOI

      10.3389/fpls.2015.01178

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hormonal control of cell division and elongation along differentiation trajectories in roots2014

    • Author(s)
      Takatsuka, H. and Umeda, M.
    • Journal Title

      J. Exp. Bot.

      Volume: 65 Pages: 2633-2643

    • DOI

      10.1093/jxb/ert485

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cytokinins promote onset of endoreplication by controlling cell cycle machinery2014

    • Author(s)
      Takahashi, N. and Umeda, M.
    • Journal Title

      Plant Signaling & Behavior

      Volume: 9

    • DOI

      10.4161/psb.29396

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A dual-color marker system for in vivo visualization of cell cycle progression in Arabidopsis2014

    • Author(s)
      Yin, K., Ueda, M., Takagi, H., Kajihara, T., Sugamata Aki, S., Nobusawa, T., Umeda-Hara, M. Umeda
    • Journal Title

      Plant J.

      Volume: 80 Pages: 541-552

    • DOI

      10.1111/tpj.12652

    • NAID

      120006537394

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Control of the cell cycle in two distinct cell files of the root epidermis2017

    • Author(s)
      杉山輝樹、高塚大知、梅田正明
    • Organizer
      第58回日本植物生理学会年会
    • Place of Presentation
      鹿児島大(鹿児島県鹿児島市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Roles of epigenetic regulation in inducing endoreplication in plants2017

    • Author(s)
      高塚大知、梅田正明
    • Organizer
      Plant Organ Growth Symposium 2017
    • Place of Presentation
      Centro de Congresos, Elche, Spain
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hormonal control of genome integrity in roots2017

    • Author(s)
      梅田正明、高橋直紀
    • Organizer
      Plant Organ Growth Symposium 2017
    • Place of Presentation
      Centro de Congresos, Elche, Spain
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Control of the cell cycle in two distinct cell files of the root epidermis2016

    • Author(s)
      杉山輝樹、高塚大知、梅田正明
    • Organizer
      International Conference on Arabidopsis Research
    • Place of Presentation
      Gyeongju Hwabaek International Convention Center, Gyeongju, Korea
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of auxin in controlling chromatin structure2016

    • Author(s)
      Aida Nazlyn Nazari、高塚大知、梅田正明
    • Organizer
      International Conference on Arabidopsis Research
    • Place of Presentation
      Gyeongju Hwabaek International Convention Center, Gyeongju, Korea
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chromatin structure controls the competence of endoreplication2016

    • Author(s)
      高塚大知、梅田正明
    • Organizer
      International Conference on Arabidopsis Research
    • Place of Presentation
      Gyeongju Hwabaek International Convention Center, Gyeongju, Korea
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hormonal control of genome integrity in the root meristem2016

    • Author(s)
      梅田正明
    • Organizer
      International Conference on Arabidopsis Research
    • Place of Presentation
      Gyeongju Hwabaek International Convention Center, Gyeongju, Korea
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 根におけるB-type ARRの空間的発現を制御するKISS ME DEADLY遺伝子の発現解析2016

    • Author(s)
      野口博史、高塚大知、梅田正明
    • Organizer
      第57回日本植物生理学会年会
    • Place of Presentation
      岩手大(岩手県盛岡市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Roles of auxin in controlling chromatin structure2016

    • Author(s)
      Aida Nazlyn Nazari、高塚大知、梅田正明
    • Organizer
      第57回日本植物生理学会年会
    • Place of Presentation
      岩手大(岩手県盛岡市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Control of the cell cycle in two distinct cell files of the root epidermis2016

    • Author(s)
      杉山輝樹、高塚大知、梅田正明
    • Organizer
      第57回日本植物生理学会年会
    • Place of Presentation
      岩手大(岩手県盛岡市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Maintenance of genome integrity in root stem cells under DNA stress2016

    • Author(s)
      高橋直紀、藤本啓介、梅田正明
    • Organizer
      第57回日本植物生理学会年会
    • Place of Presentation
      岩手大(岩手県盛岡市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Roles of epigenetic regulation in inducing DNA polyploidization in plants2016

    • Author(s)
      高塚大知、梅田正明
    • Organizer
      Keystone Symposia "Plant Epigenetics: From Genotype to Phenotype"
    • Place of Presentation
      Sagebrush Inn & Suites, Taos, New Mexico, USA
    • Year and Date
      2016-02-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 根端分裂組織のサイズ制御機構2015

    • Author(s)
      高橋直紀、丸池加奈子、高塚大知、梅田正明
    • Organizer
      日本植物学会第79回大会
    • Place of Presentation
      朱鷺メッセ・新潟コンベンションセンター(新潟県新潟市中央区)
    • Year and Date
      2015-09-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 極性をもった根の細胞成長の制御メカニズム2015

    • Author(s)
      高塚大知、梅田正明
    • Organizer
      日本植物学会第79回大会
    • Place of Presentation
      朱鷺メッセ・新潟コンベンションセンター(新潟県新潟市中央区)
    • Year and Date
      2015-09-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Epidermal cells elongate with polarity in Arabidopsis roots2015

    • Author(s)
      高塚大知、梅田正明
    • Organizer
      第56回日本植物生理学会年会
    • Place of Presentation
      東京農業大(東京都世田谷区)
    • Year and Date
      2015-03-16 – 2015-03-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cytokinins promote rapid cell elongation in Arabidopsis roots2014

    • Author(s)
      高塚大知、梅田正明
    • Organizer
      Auxins and Cytokinins in Plant Development International Symposium 2014
    • Place of Presentation
      プラハ(チェコ)
    • Year and Date
      2014-06-29 – 2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Remarks] 植物成長制御研究室ホームページ

    • URL

      http://bsw3.naist.jp/umeda/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 植物成長制御研究室ホームページ

    • URL

      http://bsw3.naist.jp/umeda/index.html

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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